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Page 1
The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions.
Kristiansson A, Gram M, Flygare J, Hansson SR, Åkerström B, Storry JR. Kristiansson A, et al. Int J Mol Sci. 2020 Sep 30;21(19):7234. doi: 10.3390/ijms21197234. Int J Mol Sci. 2020. PMID: 33008134 Free PMC article. Review.
Here, we provide an overview of A1M and its potential therapeutic effect in the context of the following erythropoietic and hemolytic conditions: Diamond-Blackfan anemia (DBA), 5q-minus myelodysplastic syndrome (5q-MDS), blood transfusions (including s …
Here, we provide an overview of A1M and its potential therapeutic effect in the context of the following erythropoietic and hemolytic condit …
[Ineffective erythropoiesis in myelodysplastic syndrome].
Iwama A. Iwama A. Rinsho Ketsueki. 2018;59(6):793-797. doi: 10.11406/rinketsu.59.793. Rinsho Ketsueki. 2018. PMID: 29973461 Review. Japanese.
Ineffective hematopoiesis is one of the hallmarks of myelodysplastic syndrome (MDS). Recently, several signaling pathways responsible for inefficient erythropoiesis in MDS have been uncovered. The p53-S100a8/S100a9-TLR4 pathway is involved in ineffective erythropoiesis in …
Ineffective hematopoiesis is one of the hallmarks of myelodysplastic syndrome (MDS). Recently, several signaling pathways responsible …
Immunomodulatory drugs: new options for the treatment of myelodysplastic syndromes.
Castelli R, Cassin R, Cannavò A, Cugno M. Castelli R, et al. Clin Lymphoma Myeloma Leuk. 2013 Feb;13(1):1-7. doi: 10.1016/j.clml.2012.09.016. Epub 2012 Nov 13. Clin Lymphoma Myeloma Leuk. 2013. PMID: 23153925 Review.
BACKGROUND: Myelodysplastic syndromes (MDS) are common adult hematologic disorders characterized by ineffective hematopoiesis with progressive cytopenia and a risk of evolving into currently incurable acute myeloid leukemia. ...IMiDs represent a major advance in the treatm …
BACKGROUND: Myelodysplastic syndromes (MDS) are common adult hematologic disorders characterized by ineffective hematopoiesis with pr …
Lenalidomide in multiple myeloma: current experimental and clinical data.
Cives M, Milano A, Dammacco F, Silvestris F. Cives M, et al. Eur J Haematol. 2012 Apr;88(4):279-91. doi: 10.1111/j.1600-0609.2011.01735.x. Epub 2012 Jan 4. Eur J Haematol. 2012. PMID: 22085323 Review.
It is currently approved in the second-line therapy of multiple myeloma (MM) as well as in myelodysplastic syndrome characterized by 5q minus abnormalities. LEN has been found to be effective in the treatment of both of these conditions and to possess a manag …
It is currently approved in the second-line therapy of multiple myeloma (MM) as well as in myelodysplastic syndrome characterized by …
Advances in the treatment of acute myeloid leukemia: from chromosomal aberrations to biologically targeted therapy.
Lübbert M, Müller-Tidow C, Hofmann WK, Koeffler HP. Lübbert M, et al. J Cell Biochem. 2008 Aug 15;104(6):2059-70. doi: 10.1002/jcb.21770. J Cell Biochem. 2008. PMID: 18613031 Review.
We describe several recent advances in our understanding and treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) including the use of cytogenetics to classify these diseases and to identify therapies that are specific for the abnormalities. ...Very …
We describe several recent advances in our understanding and treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome ( …