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Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial.
Nouchi R, Kawata NYS, Saito T, Nouchi H, Kawashima R. Nouchi R, et al. Nutrients. 2023 Oct 30;15(21):4608. doi: 10.3390/nu15214608. Nutrients. 2023. PMID: 37960261 Free PMC article. Clinical Trial.
METHODS: Seventy-two older adults were randomly assigned to 6-MSITC or placebo groups. Participants were asked to take a supplement (6-MSITC or a placebo) for 12 weeks. ...DISCUSSION: This study firstly demonstrates scientific evidence that 6- …
METHODS: Seventy-two older adults were randomly assigned to 6-MSITC or placebo groups. Participants were asked to take a suppl …
Methylsulfinyl Hexyl Isothiocyanate (6-MSITC) from Wasabi Is a Promising Candidate for the Treatment of Cancer, Alzheimer's Disease, and Obesity.
Bartkowiak-Wieczorek J, Malesza M, Malesza I, Hadada T, Winkler-Galicki J, Grzelak T, Mądry E. Bartkowiak-Wieczorek J, et al. Nutrients. 2024 Aug 1;16(15):2509. doi: 10.3390/nu16152509. Nutrients. 2024. PMID: 39125389 Free PMC article. Review.
Methylsulfinyl hexyl isothiocyanate (6-MSITC) isolated from Eutrema japonicum is a promising candidate for the treatment of breast cancer, colorectal and stomach cancer, metabolic syndrome, heart diseases, diabetes, and obesity due to its anti-inflammatory and antio …
Methylsulfinyl hexyl isothiocyanate (6-MSITC) isolated from Eutrema japonicum is a promising candidate for the treatment of br …
Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial.
Oka T, Yamada Y, Lkhagvasuren B, Nakao M, Nakajima R, Kanou M, Hiramatsu R, Nabeshima YI. Oka T, et al. Biopsychosoc Med. 2022 Dec 12;16(1):26. doi: 10.1186/s13030-022-00255-0. Biopsychosoc Med. 2022. PMID: 36510244 Free PMC article.
The present study was conducted to investigate the effectiveness of wasabi extract containing 6-MSITC on ME/CFS in an open-label trial. METHODS: Fifteen patients (3 males, 12 females, 20-58 years old) were orally administered wasabi extract (9.6 mg of 6-MS
The present study was conducted to investigate the effectiveness of wasabi extract containing 6-MSITC on ME/CFS in an open-lab …
6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells.
Shimoyama M, Hosokawa Y, Hosokawa I, Ozaki K, Hosaka K. Shimoyama M, et al. Curr Issues Mol Biol. 2022 Jun 29;44(7):2915-2922. doi: 10.3390/cimb44070201. Curr Issues Mol Biol. 2022. PMID: 35877425 Free PMC article.
6-(Methylsulfinyl) hexyl isothiocyanate (6-MSITC) is a bioactive substance found in wasabi (Wasabia japonica) and has been reported to have some bioactive effects including anticancer and antioxidant effects. ...In this study, we aimed to investigate whether 6
6-(Methylsulfinyl) hexyl isothiocyanate (6-MSITC) is a bioactive substance found in wasabi (Wasabia japonica) and has been rep …
6-(Methylsulfinyl)hexyl isothiocyanate protects acetaldehyde-caused cytotoxicity through the induction of aldehyde dehydrogenase in hepatocytes.
Kitakaze T, Yuan S, Inoue M, Yoshioka Y, Yamashita Y, Ashida H. Kitakaze T, et al. Arch Biochem Biophys. 2020 Jun 15;686:108329. doi: 10.1016/j.abb.2020.108329. Epub 2020 Mar 7. Arch Biochem Biophys. 2020. PMID: 32151565
However, the effect of 6-MSITC on alcohol metabolism has not been studied. In this study, we investigated the effects of 6-MSITC on hepatic ALDH activity and protein expression both in vitro and in vivo. 6-MSITC inhibited ethanol- and ace …
However, the effect of 6-MSITC on alcohol metabolism has not been studied. In this study, we investigated the effects of 6
6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion.
Okamoto T, Akita N, Nagai M, Hayashi T, Suzuki K. Okamoto T, et al. J Nat Med. 2014 Jan;68(1):144-53. doi: 10.1007/s11418-013-0784-x. Epub 2013 Jun 12. J Nat Med. 2014. PMID: 23760613
In this study, we determined the anti-coagulant and anti-inflammatory effects of 6-MSITC on human umbilical vein endothelial cells (HUVECs). 6-MSITC slightly reduced tissue factor expression, but did not alter von Willebrand factor release in activated …
In this study, we determined the anti-coagulant and anti-inflammatory effects of 6-MSITC on human umbilical vein endothelial c …
Allyl isothiocyanate and 6-(methylsulfinyl) hexyl isothiocyanate contents vary among wild and cultivated wasabi (Eutrema japonium).
Yamane K, Yamada-Kato T, Haga N, Ishida K, Murayama S, Kobayashi K, Okunishi I. Yamane K, et al. Breed Sci. 2023 Jun;73(3):237-245. doi: 10.1270/jsbbs.22080. Epub 2023 Jun 15. Breed Sci. 2023. PMID: 37840977 Free PMC article.
(ii) Additionally, the 6-MSITC content in cultivated wasabi was significantly lower in the spring than during other seasons. This result suggested that the 6-MSITC content responds to environmental conditions. (iii) The phylogenetic position and the …
(ii) Additionally, the 6-MSITC content in cultivated wasabi was significantly lower in the spring than during other seasons. T …
Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway.
Yano S, Wu S, Sakao K, Hou DX. Yano S, et al. Biofactors. 2018 May 14. doi: 10.1002/biof.1431. Online ahead of print. Biofactors. 2018. PMID: 29756671
In addition, 6-MSITC increased the ratio of proapoptotic cells in both types of cells with the same fashion in a p53-independent manner. ...Taken together, Wasabi 6-MSITC induced apoptosis of human colorectal cancer cells in p53-independent mitochondri …
In addition, 6-MSITC increased the ratio of proapoptotic cells in both types of cells with the same fashion in a p53-independe …
Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease.
Morroni F, Sita G, Tarozzi A, Cantelli-Forti G, Hrelia P. Morroni F, et al. Brain Res. 2014 Nov 17;1589:93-104. doi: 10.1016/j.brainres.2014.09.033. Epub 2014 Sep 23. Brain Res. 2014. PMID: 25257035
This study was designed to investigate the neuroprotective effects of 6-MSITC in a PD mouse model. Mice were treated with 6-MSITC (5mg/kg twice a week) for four weeks after the unilateral intrastriatal injection of 6-hydroxydopamine (6-OHDA). ...These …
This study was designed to investigate the neuroprotective effects of 6-MSITC in a PD mouse model. Mice were treated with 6
Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers.
Nakajima R, Kanou M, Tokushima M, Iwama Y, Yamana K. Nakajima R, et al. Biopsychosoc Med. 2023 Aug 23;17(1):30. doi: 10.1186/s13030-023-00287-0. Biopsychosoc Med. 2023. PMID: 37612759 Free PMC article.
METHODS: A total of 20 healthy volunteers who were experiencing daily fatigue were given powder containing 6-MSITC (4.8 mg/day of 6-MSITC) extracted from wasabi for 4 weeks. Then, fatigue, sleep, autonomic nervous functioning, stress, and immunity were …
METHODS: A total of 20 healthy volunteers who were experiencing daily fatigue were given powder containing 6-MSITC (4.8 mg/day …
29 results