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Year Number of Results
1983 1
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1985 1
1986 5
1987 1
1988 1
1989 2
1990 4
1991 1
1992 5
1993 1
1994 3
2001 3
2002 5
2003 2
2004 2
2005 4
2006 7
2007 9
2008 13
2009 11
2010 21
2011 17
2012 30
2013 30
2014 31
2015 30
2016 31
2017 36
2018 49
2019 53
2020 42
2021 35
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6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-gamma.
Han Q, Yuan Q, Meng X, Huo J, Bao Y, Xie G. Han Q, et al. Oncotarget. 2017 Jun 27;8(26):42001-42006. doi: 10.18632/oncotarget.16719. Oncotarget. 2017. PMID: 28410218 Free PMC article.
In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol was administrated 1 h before LPS treatment. ...In conclusion, 6-Shogaol inhibits LPS-induced inflammation by activating PPAR- …
In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol …
Occurrence, biological activity and metabolism of 6-shogaol.
Kou X, Wang X, Ji R, Liu L, Qiao Y, Lou Z, Ma C, Li S, Wang H, Ho CT. Kou X, et al. Food Funct. 2018 Mar 1;9(3):1310-1327. doi: 10.1039/c7fo01354j. Epub 2018 Feb 8. Food Funct. 2018. PMID: 29417118 Review.
The conjugation of the alpha,beta-unsaturated ketone skeleton in the chemical structure of 6-shogaol explicates its higher potency and efficacy than 6-gingerol in terms of antioxidant, anti-inflammatory, anticancer, antiemetic and other bioactivities. ...In a …
The conjugation of the alpha,beta-unsaturated ketone skeleton in the chemical structure of 6-shogaol explicates its higher pot …
Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis.
Zhang M, Xu C, Liu D, Han MK, Wang L, Merlin D. Zhang M, et al. J Crohns Colitis. 2018 Jan 24;12(2):217-229. doi: 10.1093/ecco-jcc/jjx115. J Crohns Colitis. 2018. PMID: 28961808 Free PMC article.
METHODS: We used a versatile single-step surface-functionalising technique to prepare PLGA/PLA-PEG-FA nanoparticles loaded with the ginger active compound, 6-shogaol [NPs-PEG-FA/6-shogaol]. The therapeutic efficacy of NPs-PEG-FA/6-shogaol …
METHODS: We used a versatile single-step surface-functionalising technique to prepare PLGA/PLA-PEG-FA nanoparticles loaded with the ginger a …
Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model.
Yocum GT, Hwang JJ, Mikami M, Danielsson J, Kuforiji AS, Emala CW. Yocum GT, et al. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L296-L303. doi: 10.1152/ajplung.00249.2019. Epub 2019 Dec 4. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31800263 Free PMC article.
Interestingly, regulatory T cells (Tregs) utilize cAMP as a mediator of their immunosuppressive effects, and we demonstrate here that 6-shogaol augments the Treg polarization of naive CD4 cells in vitro. Taken together with previous reports, these studies suggest th …
Interestingly, regulatory T cells (Tregs) utilize cAMP as a mediator of their immunosuppressive effects, and we demonstrate here that 6 …
Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells.
Romero-Arias AC, Sequeda-Castañeda LG, Aristizábal-Pachón AF, Morales L. Romero-Arias AC, et al. Pharmaceuticals (Basel). 2019 Sep 9;12(3):131. doi: 10.3390/ph12030131. Pharmaceuticals (Basel). 2019. PMID: 31505728 Free PMC article.
In the last decade and research on the components of ginger has significantly increased; of these components, 6-shogaol exhibits the greatest potential antitumor capacity. However, the molecular mechanism through which 6-shogaol exerts its effects has …
In the last decade and research on the components of ginger has significantly increased; of these components, 6-shogaol exhibi …
Antifungal and anti-biofilm effects of 6-shogaol against Candida auris.
Kim HR, Eom YB. Kim HR, et al. J Appl Microbiol. 2021 Apr;130(4):1142-1153. doi: 10.1111/jam.14870. Epub 2020 Oct 13. J Appl Microbiol. 2021. PMID: 32981148
The effect of 6-shogaol on established C. auris biofilms was visualized by confocal laser scanning microscopy. ...CONCLUSIONS: The data indicated that 6-shogaol extracted from ginger had antifungal and anti-biofilm effects on C. auris. ...
The effect of 6-shogaol on established C. auris biofilms was visualized by confocal laser scanning microscopy. ...CONCLUSIONS: …
6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway.
Bawadood AS, Al-Abbasi FA, Anwar F, El-Halawany AM, Al-Abd AM. Bawadood AS, et al. Biomed Pharmacother. 2020 Aug;128:110302. doi: 10.1016/j.biopha.2020.110302. Epub 2020 Jun 5. Biomed Pharmacother. 2020. PMID: 32505819 Free article.
The study further shows that treatment with 6-shogaol induced significant and time dependent cell cycle accumulation in G(2)/M-phase. 6-Shogaol also induced significant apoptosis in breast cancer cells. ...CONCLUSION: 6-Shogaol is a promi …
The study further shows that treatment with 6-shogaol induced significant and time dependent cell cycle accumulation in G(2)/M …
Radioiodinated Ginger Compounds (6-gingerol and 6-shogaol) and Incorporation Assays on Breast Cancer Cells.
Karatay KB, Kılçar AY, Derviş E, Müftüler FZB. Karatay KB, et al. Anticancer Agents Med Chem. 2020;20(9):1129-1139. doi: 10.2174/1871520620666200128114215. Anticancer Agents Med Chem. 2020. PMID: 31994470
BACKGROUND: 6-Gingerol (6G) and 6-Shogaol (6S) are the main active components of ginger. 6-Gingerol is known for its anti-metastatic and anti-invasive pharmacological activities on cancer cells, besides, 6-Shogaol also inhibits breast can …
BACKGROUND: 6-Gingerol (6G) and 6-Shogaol (6S) are the main active components of ginger. 6-Gingerol is known for …
6-Shogaol protects against ischemic acute kidney injury by modulating NF-kappaB and heme oxygenase-1 pathways.
Han SJ, Kim M, D'Agati VD, Lee HT. Han SJ, et al. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F743-F756. doi: 10.1152/ajprenal.00182.2019. Epub 2019 Jul 17. Am J Physiol Renal Physiol. 2019. PMID: 31313953 Free PMC article.
Furthermore, 6-shogaol induced a cytoprotective chaperone heme oxygenase (HO)-1 via p38 MAPK activation in vitro and in vivo. Consistent with these findings, pretreatment with the HO-1 inhibitor zinc protoporphyrin IX completely prevented 6-shogaol-med …
Furthermore, 6-shogaol induced a cytoprotective chaperone heme oxygenase (HO)-1 via p38 MAPK activation in vitro and in vivo. …
Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers.
Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S. Huang Y, et al. Neurogastroenterol Motil. 2019 Jun;31(6):e13585. doi: 10.1111/nmo.13585. Epub 2019 Apr 4. Neurogastroenterol Motil. 2019. PMID: 30947399 Free PMC article.
Such activation effects were followed by a desensitized response to the second application of 6-shogaol. However, action potential discharges evoked by esophageal mechanical distension, after 6-shogaol perfusion, did not significantly change. Pretreatm …
Such activation effects were followed by a desensitized response to the second application of 6-shogaol. However, action poten …
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