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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1984 1
1985 1
1986 5
1987 1
1988 1
1989 2
1990 4
1991 1
1992 5
1993 1
1994 3
2001 3
2002 5
2003 2
2004 2
2005 4
2006 7
2007 9
2008 13
2009 11
2010 21
2011 17
2012 30
2013 30
2014 31
2015 30
2016 31
2017 36
2018 48
2019 52
2020 40
2021 22
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415 results
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6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-gamma.
Han Q, Yuan Q, Meng X, Huo J, Bao Y, Xie G. Han Q, et al. Oncotarget. 2017 Jun 27;8(26):42001-42006. doi: 10.18632/oncotarget.16719. Oncotarget. 2017. PMID: 28410218 Free PMC article.
In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol was administrated 1 h before LPS treatment. ...In conclusion, 6-Shogaol inhibits LPS-induced inflammation by activating PPAR- …
In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol
Occurrence, biological activity and metabolism of 6-shogaol.
Kou X, Wang X, Ji R, Liu L, Qiao Y, Lou Z, Ma C, Li S, Wang H, Ho CT. Kou X, et al. Food Funct. 2018 Mar 1;9(3):1310-1327. doi: 10.1039/c7fo01354j. Epub 2018 Feb 8. Food Funct. 2018. PMID: 29417118 Review.
The conjugation of the alpha,beta-unsaturated ketone skeleton in the chemical structure of 6-shogaol explicates its higher potency and efficacy than 6-gingerol in terms of antioxidant, anti-inflammatory, anticancer, antiemetic and other bioactivities. ...In a …
The conjugation of the alpha,beta-unsaturated ketone skeleton in the chemical structure of 6-shogaol explicates its higher pot …
Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis.
Zhang M, Xu C, Liu D, Han MK, Wang L, Merlin D. Zhang M, et al. J Crohns Colitis. 2018 Jan 24;12(2):217-229. doi: 10.1093/ecco-jcc/jjx115. J Crohns Colitis. 2018. PMID: 28961808 Free PMC article.
METHODS: We used a versatile single-step surface-functionalising technique to prepare PLGA/PLA-PEG-FA nanoparticles loaded with the ginger active compound, 6-shogaol [NPs-PEG-FA/6-shogaol]. The therapeutic efficacy of NPs-PEG-FA/6-shogaol
METHODS: We used a versatile single-step surface-functionalising technique to prepare PLGA/PLA-PEG-FA nanoparticles loaded with the ginger a …
Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model.
Yocum GT, Hwang JJ, Mikami M, Danielsson J, Kuforiji AS, Emala CW. Yocum GT, et al. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L296-L303. doi: 10.1152/ajplung.00249.2019. Epub 2019 Dec 4. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31800263 Free PMC article.
Interestingly, regulatory T cells (Tregs) utilize cAMP as a mediator of their immunosuppressive effects, and we demonstrate here that 6-shogaol augments the Treg polarization of naive CD4 cells in vitro. Taken together with previous reports, these studies suggest th …
Interestingly, regulatory T cells (Tregs) utilize cAMP as a mediator of their immunosuppressive effects, and we demonstrate here that 6
Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells.
Romero-Arias AC, Sequeda-Castañeda LG, Aristizábal-Pachón AF, Morales L. Romero-Arias AC, et al. Pharmaceuticals (Basel). 2019 Sep 9;12(3):131. doi: 10.3390/ph12030131. Pharmaceuticals (Basel). 2019. PMID: 31505728 Free PMC article.
In the last decade and research on the components of ginger has significantly increased; of these components, 6-shogaol exhibits the greatest potential antitumor capacity. However, the molecular mechanism through which 6-shogaol exerts its effects has …
In the last decade and research on the components of ginger has significantly increased; of these components, 6-shogaol exhibi …
Effects of ginger constituent 6-shogaol on gastroesophageal vagal afferent C-fibers.
Huang Y, Patil MJ, Yu M, Liptak P, Undem BJ, Dong X, Wang G, Yu S. Huang Y, et al. Neurogastroenterol Motil. 2019 Jun;31(6):e13585. doi: 10.1111/nmo.13585. Epub 2019 Apr 4. Neurogastroenterol Motil. 2019. PMID: 30947399 Free PMC article.
Such activation effects were followed by a desensitized response to the second application of 6-shogaol. However, action potential discharges evoked by esophageal mechanical distension, after 6-shogaol perfusion, did not significantly change. Pretreatm …
Such activation effects were followed by a desensitized response to the second application of 6-shogaol. However, action poten …
6-Shogaol protects against ischemic acute kidney injury by modulating NF-kappaB and heme oxygenase-1 pathways.
Han SJ, Kim M, D'Agati VD, Lee HT. Han SJ, et al. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F743-F756. doi: 10.1152/ajprenal.00182.2019. Epub 2019 Jul 17. Am J Physiol Renal Physiol. 2019. PMID: 31313953 Free PMC article.
Furthermore, 6-shogaol induced a cytoprotective chaperone heme oxygenase (HO)-1 via p38 MAPK activation in vitro and in vivo. Consistent with these findings, pretreatment with the HO-1 inhibitor zinc protoporphyrin IX completely prevented 6-shogaol-med …
Furthermore, 6-shogaol induced a cytoprotective chaperone heme oxygenase (HO)-1 via p38 MAPK activation in vitro and in vivo. …
Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis.
Sapkota A, Park SJ, Choi JW. Sapkota A, et al. Biomol Ther (Seoul). 2019 Mar 1;27(2):152-159. doi: 10.4062/biomolther.2018.089. Biomol Ther (Seoul). 2019. PMID: 30001610 Free PMC article.
Administration of 6-shogaol and 6-paradol into EAE mice markedly reduced astrogliosis and microglial activation as key features of immune responses inside the CNS. ...Collectively, these results demonstrate therapeutic efficacy of 6-shogaol or …
Administration of 6-shogaol and 6-paradol into EAE mice markedly reduced astrogliosis and microglial activation as key …
[6]-Shogaol/beta-CDs inclusion complex: preparation, characterisation, in vivo pharmacokinetics, and in situ intestinal perfusion study.
Li R, Bao R, Yang QX, Wang QL, Adu-Frimpong M, Wei QY, Elmurat T, Ji H, Yu JN, Xu XM. Li R, et al. J Microencapsul. 2019 Aug;36(5):500-512. doi: 10.1080/02652048.2019.1649480. Epub 2019 Aug 14. J Microencapsul. 2019. PMID: 31347417
Methods: [6]-Shogaol/beta-CDs inclusion complexes (6-S-beta-CDs) were developed using saturated aqueous solution method and characterised with appropriate techniques. The absorption and bioavailability potential of [6]-shogaol was evaluated via …
Methods: [6]-Shogaol/beta-CDs inclusion complexes (6-S-beta-CDs) were developed using saturated aqueous solution method …
6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulating Oxidative Responses in Human Gingival Fibroblasts.
Nonaka K, Bando M, Sakamoto E, Inagaki Y, Naruishi K, Yumoto H, Kido JI. Nonaka K, et al. Molecules. 2019 Oct 15;24(20):3705. doi: 10.3390/molecules24203705. Molecules. 2019. PMID: 31619000 Free PMC article.
However, the influence of shogaol on DM-associated periodontitis is not well known. In this study, the effects of 6-shogaol on AGEs-induced oxidative and anti-oxidative responses, and IL-6 and ICAM-1 expression in human gingival fibroblasts (HGFs) were …
However, the influence of shogaol on DM-associated periodontitis is not well known. In this study, the effects of 6-shogaol
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