Abstract
We have used a monoclonal antibody against the murine transferrin receptor to study the expression of the transferrin receptor on the hematopoietic progenitor cells (BFU-E, CFU-E, and CFU-C) present in mouse bone marrow. Elutriation and cell-sorting data are consistent with the hypothesis that most CFU-E are transferrin receptor positive while most BFU-E express much less transferrin receptor. CFU-C comprise both transferrin-receptor-positive and -negative cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Bone Marrow / metabolism*
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Flow Cytometry
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Hematopoietic Stem Cells / metabolism*
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Leukemia, Experimental / immunology
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Mice
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Mice, Inbred BALB C
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Plasmacytoma / immunology
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Rats
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Receptors, Cell Surface / genetics*
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Receptors, Cell Surface / immunology
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Receptors, Cell Surface / metabolism
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Receptors, Transferrin
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Transferrin / metabolism*
Substances
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Antibodies, Monoclonal
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Receptors, Cell Surface
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Receptors, Transferrin
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Transferrin