Fredericamycin A, a new antitumor antibiotic. I. Production, isolation and physicochemical properties

J Antibiot (Tokyo). 1981 Nov;34(11):1389-401. doi: 10.7164/antibiotics.34.1389.

Abstract

A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, ultraviolet-visible spectrum and some biological properties of two minor components, fredericamycin B and fredericamycin C, are also described.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / isolation & purification*
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Fermentation
  • Isoquinolines / isolation & purification
  • Spiro Compounds / isolation & purification
  • Streptomyces griseus / metabolism

Substances

  • Antibiotics, Antineoplastic
  • Isoquinolines
  • Spiro Compounds
  • fredericamycin A