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Year Number of Results
2010 5
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2013 26
2014 15
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2023 17
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233 results

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7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.
Xue F, Zhao Z, Gu Y, Han J, Ye K, Zhang Y. Xue F, et al. Elife. 2021 Jul 6;10:e64872. doi: 10.7554/eLife.64872. Elife. 2021. PMID: 34227467 Free PMC article.
Mounting evidence supports that brain-derived neurotrophic factor (BDNF) implicates in this process. 7,8-Dihydroxyflavone (7,8-DHF), a plant-derived small molecular TrkB agonist, mimics the functions of BDNF. ...Knockdown of beta-catenin restrained the …
Mounting evidence supports that brain-derived neurotrophic factor (BDNF) implicates in this process. 7,8-Dihydroxyflavone
Utility of 7,8-dihydroxyflavone in preventing astrocytic and synaptic deficits in the hippocampus elicited by PTSD.
Wang J, Gao F, Cui S, Yang S, Gao F, Wang X, Zhu G. Wang J, et al. Pharmacol Res. 2022 Feb;176:106079. doi: 10.1016/j.phrs.2022.106079. Epub 2022 Jan 10. Pharmacol Res. 2022. PMID: 35026406
Previous studies have reported neuroprotective effects of 7,8-dihydroxyflavone (7,8-DHF), a TrkB activator. Here, we investigated the molecular mechanisms underlying pathogenesis of post-traumatic stress disorder (PTSD) using a modified single-prolonge …
Previous studies have reported neuroprotective effects of 7,8-dihydroxyflavone (7,8-DHF), a TrkB activator. Here …
Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets.
Zhang JC, Yao W, Hashimoto K. Zhang JC, et al. Curr Neuropharmacol. 2016;14(7):721-31. doi: 10.2174/1570159x14666160119094646. Curr Neuropharmacol. 2016. PMID: 26786147 Free PMC article. Review.
A recent paper showed that lipopolysaccharide (LPS)-induced inflammation gave rise to depression-like phenotype by altering BDNF-TrkB signaling in the prefrontal cortex, hippocampus, and nucleus accumbens, areas thought to be involved in the antidepressant effects of Tr
A recent paper showed that lipopolysaccharide (LPS)-induced inflammation gave rise to depression-like phenotype by altering BDNF-TrkB
7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development.
Yang S, Zhu G. Yang S, et al. Curr Neuropharmacol. 2022;20(8):1479-1497. doi: 10.2174/1570159X19666210915122820. Curr Neuropharmacol. 2022. PMID: 34525922 Free PMC article. Review.
7,8-Dihydroxyflavone (7,8-DHF) is a kind of natural flavonoid with the potential to cross the blood-brain barrier. 7,8-DHF effectively mimics the effect of brain-derived neurotrophic factor (BDNF) in the brain to selectively activate tyrosine kinase receptor
7,8-Dihydroxyflavone (7,8-DHF) is a kind of natural flavonoid with the potential to cross the blood-brain barrier. 7,8-
7,8-Dihydroxyflavone protects neurons against oxygen-glucose deprivation induced apoptosis and activates the TrkB/Akt pathway.
Zhou Q, Tang H, Bai D, Kong Y. Zhou Q, et al. PeerJ. 2022 Feb 15;10:e12886. doi: 10.7717/peerj.12886. eCollection 2022. PeerJ. 2022. PMID: 35186478 Free PMC article.
BACKGROUND: 7,8-dihydroxyflavone (7,8-DHF), a selective agonist of tropomyosin related kinase receptor B (TrkB), is known to exert protective effects in neurodegenerative diseases. ...CONCLUSION: Our study demonstrates that activation of TrkB si …
BACKGROUND: 7,8-dihydroxyflavone (7,8-DHF), a selective agonist of tropomyosin related kinase receptor B (TrkB), …
7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway.
Yu A, Wang S, Xing Y, Han M, Shao K. Yu A, et al. Int J Med Sci. 2022 Jan 1;19(1):13-24. doi: 10.7150/ijms.65733. eCollection 2022. Int J Med Sci. 2022. PMID: 34975295 Free PMC article.
In this study, we investigated the role of a potent selective TrkB agonist 7,8-dihydroxyfavone (DHF) in rat retinas with RIRI. ...The combined effects of mBDNF/proBDNF increase and TrkB signaling activation lead to reduction of apoptosis level and protection of reti …
In this study, we investigated the role of a potent selective TrkB agonist 7,8-dihydroxyfavone (DHF) in rat retinas with RIRI. ...The …
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the alpha-synuclein 1-103 transgenic mice.
Tian Y, Pan L, Yuan X, Xiong M, Zhang Z, Meng L, Zheng Y, Bu L, Xu X, Zhang Z. Tian Y, et al. Neurobiol Dis. 2022 Jul;169:105736. doi: 10.1016/j.nbd.2022.105736. Epub 2022 Apr 21. Neurobiol Dis. 2022. PMID: 35462005 Free article.
Here we show that alpha-synuclein 1-103 fragment interacts with mitochondria and induces morphological and functional abnormalities of mitochondria. Furthermore, we investigated the protective effects of 7,8-dihydroxyflavone (7,8-DHF) on mitochondrial dysfunc …
Here we show that alpha-synuclein 1-103 fragment interacts with mitochondria and induces morphological and functional abnormalities of mitoc …
The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice.
Johnstone MR, Brady RD, Church JE, Orr D, McDonald SJ, Grills BL. Johnstone MR, et al. J Musculoskelet Neuronal Interact. 2021 Jun 1;21(2):263-271. J Musculoskelet Neuronal Interact. 2021. PMID: 34059571 Free PMC article.
OBJECTIVES: To study the effects of the selective TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), on fracture healing in mice and on an osteoprogenitor cell line, Kusa4b10, in vitro. ...
OBJECTIVES: To study the effects of the selective TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), on fracture heal …
7,8-Dihydroxyflavone Enhanced Colonic Cholinergic Contraction and Relieved Loperamide-Induced Constipation in Rats.
Ma L, Qu Z, Xu L, Han L, Han Q, He J, Luan X, Wang B, Sun Y, He B. Ma L, et al. Dig Dis Sci. 2021 Dec;66(12):4251-4262. doi: 10.1007/s10620-020-06817-y. Epub 2021 Feb 2. Dig Dis Sci. 2021. PMID: 33528684
BACKGROUND: Whether 7,8-dihydroxyflavone (7,8-DHF), a tyrosine kinase receptor B (TrkB) agonist, modulates colonic smooth muscle motility and/or alleviates constipation has not yet been studied. ...ANA-12, a specific TrkB antagonist, not only in …
BACKGROUND: Whether 7,8-dihydroxyflavone (7,8-DHF), a tyrosine kinase receptor B (TrkB) agonist, modulates colon …
The TrkB agonist 7,8-dihydroxyflavone improves sensory-motor performance and reduces lipid peroxidation in old mice.
Keser H, Doğramacı Ş, Şahin E, Sağlam N, Erdem M, Alver A, Aydin-Abidin S. Keser H, et al. Gen Physiol Biophys. 2020 Sep;39(5):471-479. doi: 10.4149/gpb_2020022. Gen Physiol Biophys. 2020. PMID: 33084600
7,8-Dihydroxyflavone (7,8-DHF) is a natural flavonoid compound that act as Trk-B agonist. 7,8-DHF is also a potent antioxidant. ...
7,8-Dihydroxyflavone (7,8-DHF) is a natural flavonoid compound that act as Trk-B agonist. 7,8-DHF is also a potent anti
233 results