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Year Number of Results
1961 1
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1963 2
1964 1
1965 2
1966 1
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1968 2
1971 1
1972 3
1973 1
1975 3
1976 3
1977 1
1978 3
1979 4
1980 4
1981 6
1983 2
1985 4
1986 3
1987 4
1988 2
1989 3
1991 8
1992 4
1993 8
1994 5
1995 7
1996 6
1997 2
1998 5
1999 6
2000 10
2001 6
2002 4
2003 10
2004 11
2005 5
2006 4
2007 9
2008 6
2009 1
2010 7
2011 5
2012 7
2013 11
2014 8
2015 9
2016 8
2017 5
2018 7
2019 6
2020 5
2021 4
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242 results
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Page 1
Characterization of EstZY: A new acetylesterase with 7-aminocephalosporanic acid deacetylase activity from Alicyclobacillus tengchongensis.
Ding J, Zhou Y, Zhu H, Deng M, Gao Y, Yang Y, Huang Z. Ding J, et al. Int J Biol Macromol. 2020 Apr 1;148:333-341. doi: 10.1016/j.ijbiomac.2020.01.151. Epub 2020 Jan 16. Int J Biol Macromol. 2020. PMID: 31954783
Deacetyl-7-aminocephalosporanic acid (D-7-ACA) is required for producing of many semisynthetic beta-lactam antibiotics; therefore, enzymes capable of converting 7-aminocephalosporanic acid (7-ACA) to D-7-ACA present a …
Deacetyl-7-aminocephalosporanic acid (D-7-ACA) is required for producing of many semisynthetic beta-lactam antib …
Using Functionalized Graphene Oxide as Carrier for Immobilization of Glutaryl-7-Aminocephalosporanic Acid Acylase.
Tan Q, Qiu J, Luo X, Chen Y, Liu Y, Wei H, Lu R, Wu D. Tan Q, et al. J Nanosci Nanotechnol. 2019 May 1;19(5):2501-2505. doi: 10.1166/jnn.2019.15832. J Nanosci Nanotechnol. 2019. PMID: 30501746
In the present work, graphene oxide was synthesized successfully and was employed to immobilize glutaryl-7-aminocephalosporanic acid acylase (GLA). The immobilization conditions like pH, temperature, immobilization time, and enzyme/carrier ratio were investig …
In the present work, graphene oxide was synthesized successfully and was employed to immobilize glutaryl-7-aminocephalosporanic
Progress in One-pot Bioconversion of Cephalosporin C to 7-Aminocephalosporanic Acid.
Tan Q, Qiu J, Luo X, Zhang Y, Liu Y, Chen Y, Yuan J, Liao W. Tan Q, et al. Curr Pharm Biotechnol. 2018;19(1):30-42. doi: 10.2174/1389201019666180509093956. Curr Pharm Biotechnol. 2018. PMID: 29745327
The key intermediate for fabricating about twothirds of cephalosporins in clinical use is 7-aminocephalosporanic acid (7-ACA), which is derived from chemical or enzymatic deacylation of the natural antibiotic cephalosporin C (CPC). The chemical deacyla …
The key intermediate for fabricating about twothirds of cephalosporins in clinical use is 7-aminocephalosporanic acid ( …
Improvement of the glutaryl-7-aminocephalosporanic acid acylase activity of a bacterial gamma-glutamyltranspeptidase.
Yamada C, Kijima K, Ishihara S, Miwa C, Wada K, Okada T, Fukuyama K, Kumagai H, Suzuki H. Yamada C, et al. Appl Environ Microbiol. 2008 Jun;74(11):3400-9. doi: 10.1128/AEM.02693-07. Epub 2008 Apr 4. Appl Environ Microbiol. 2008. PMID: 18390671 Free PMC article.
7-Aminocephalosporanic acid (7-ACA) is an important material in the production of semisynthetic cephalosporins, which are the best-selling antibiotics worldwide. 7-ACA is produced from cephalosporin C via glutaryl-7-ACA (GL-7-ACA)
7-Aminocephalosporanic acid (7-ACA) is an important material in the production of semisynthetic cephalosporins,
ANTIBACTERIAL ACTIVITY OF SOME DERIVATIVES OF 7-AMINOCEPHALOSPORANIC ACID AGAINST STAPHYLOCOCCUS AUREUS AND SYNERGISM BETWEEN THESE AND OTHER ANTIBIOTICS.
JAGO M. JAGO M. Br J Pharmacol Chemother. 1964 Feb;22(1):22-33. doi: 10.1111/j.1476-5381.1964.tb01540.x. Br J Pharmacol Chemother. 1964. PMID: 14126054 Free PMC article.
Some degree of cross-resistance was found between the derivatives of 7-aminocephalosporanic acid and those of 6-aminopenicillanic acid. Synergism was observed in vitro between certain derivatives of 7-aminocephalosporanic acid and …
Some degree of cross-resistance was found between the derivatives of 7-aminocephalosporanic acid and those of 6-aminope …
Identification and characterization of an acetyl esterase from Paenibacillus sp. XW-6-66 and its novel function in 7-aminocephalosporanic acid deacetylation.
Ding J, Zhou Y, Zhu H, Deng M, Long L, Yang Y, Wu Q, Huang Z. Ding J, et al. Biotechnol Lett. 2019 Sep;41(8-9):1059-1065. doi: 10.1007/s10529-019-02709-y. Epub 2019 Jul 13. Biotechnol Lett. 2019. PMID: 31302814
OBJECTIVES: To obtain a new acetyl esterase from Paenibacillus sp. XW-6-66 and apply the enzyme to 7-aminocephalosporanic acid (7-ACA) deacetylation. RESULTS: The acetyl esterase AesZY was identified from Paenibacillus sp. ...AesZY was stable at differ …
OBJECTIVES: To obtain a new acetyl esterase from Paenibacillus sp. XW-6-66 and apply the enzyme to 7-aminocephalosporanic a
Penicillin acylase-catalyzed synthesis of N-bromoacetyl-7-aminocephalosporanic acid, the key intermediate for the production of cefathiamidine.
Zhang XL, Zong MH, Li N. Zhang XL, et al. Bioresour Bioprocess. 2016;3(1):49. doi: 10.1186/s40643-016-0127-3. Epub 2016 Nov 19. Bioresour Bioprocess. 2016. PMID: 27917366 Free PMC article.
BACKGROUND: Enzymatic approaches have become promising alternatives to chemical methods for the production of semi-synthetic beta-lactam antibiotics. In this work, enzymatic synthesis of N-bromoacetyl-7-aminocephalosporanic acid (N-bromoacetyl-7-ACA), …
BACKGROUND: Enzymatic approaches have become promising alternatives to chemical methods for the production of semi-synthetic beta-lactam ant …
Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis.
Ding JM, Yu TT, Han NY, Yu JL, Li JJ, Yang YJ, Tang XH, Xu B, Zhou JP, Tang HZ, Huang ZX. Ding JM, et al. J Bacteriol. 2015 Nov 2;198(2):311-20. doi: 10.1128/JB.00471-15. Print 2016 Jan 15. J Bacteriol. 2015. PMID: 26527640 Free PMC article.
Deacetylation of 7-aminocephalosporanic acid (7-ACA) at position C-3 provides valuable starting material for producing semisynthetic beta-lactam antibiotics. ...Sequence alignment revealed that EstD1 is an SGNH hydrolase with the putative catalytic tri …
Deacetylation of 7-aminocephalosporanic acid (7-ACA) at position C-3 provides valuable starting material for pro …
Affinity alkylation of the Trp-B4 residue of the beta -subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130.
Huang X, Zeng R, Ding X, Mao X, Ding Y, Rao Z, Xie Y, Jiang W, Zhao G. Huang X, et al. J Biol Chem. 2002 Mar 22;277(12):10256-64. doi: 10.1074/jbc.M108683200. Epub 2002 Jan 8. J Biol Chem. 2002. PMID: 11782466 Free article.
Glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130 (C130) was irreversibly inhibited in a time-dependent manner by two substrate analogs bearing side chains of variable length, namely 7beta-bromoacetyl aminocephalosporanic acid
Glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130 (C130) was irreversibly inhibited in a time-depende …
D-amino acid oxidase: its potential in the production of 7-aminocephalosporanic acid.
Mujawar SK. Mujawar SK. Hindustan Antibiot Bull. 1999 Feb-Nov;41(1-4):1-14. Hindustan Antibiot Bull. 1999. PMID: 12024974 Review.
In the recent past this enzyme is being recognized for its potential in the commercial production of 7-aminocephalosporanic acid (7-ACA), a starting material for various semisynthetic cephalosporins. ...Both immobilized enzyme and cell preparations are …
In the recent past this enzyme is being recognized for its potential in the commercial production of 7-aminocephalosporanic
242 results