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The following term was not found in PubMed: 8-tert-butyl-1-oxaspiro
Unknown field was ignored: [4.5]
Page 1
RIFM fragrance ingredient safety assessment, 1-oxaspiro[4.5]decan-2-one, 8-ethyl-, trans-, CAS Registry Number 91069-40-8.
Api AM, Belsito D, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Jones L, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Patel A, Penning TM, Ritacco G, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S. Api AM, et al. Food Chem Toxicol. 2018 Dec;122 Suppl 1:S633-S640. doi: 10.1016/j.fct.2018.11.003. Epub 2018 Nov 6. Food Chem Toxicol. 2018. PMID: 30408538 Review. No abstract available.
RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, 1-Oxaspiro[4.5]decan-2-one, 8-(1-methylethyl)-, trans-, CAS Registry Number 4625-90-5.
Api AM, Belsito D, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Jones L, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Patel A, Penning TM, Ritacco G, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S. Api AM, et al. Food Chem Toxicol. 2018 Sep;118 Suppl 1:S114-S122. doi: 10.1016/j.fct.2018.06.044. Epub 2018 Jun 21. Food Chem Toxicol. 2018. PMID: 29936281 Review. No abstract available.
RIFM fragrance ingredient safety assessment, 1-oxaspiro[4.5]decan-2-one, 8-methyl-, CAS Registry Number 94201-19-1.
Api AM, Belsito D, Botelho D, Bruze M, Burton GA Jr, Buschmann J, Dagli ML, Date M, Dekant W, Deodhar C, Francis M, Fryer AD, Jones L, Joshi K, La Cava S, Lapczynski A, Liebler DC, O'Brien D, Patel A, Penning TM, Ritacco G, Romine J, Sadekar N, Salvito D, Schultz TW, Sipes IG, Sullivan G, Thakkar Y, Tokura Y, Tsang S. Api AM, et al. Food Chem Toxicol. 2018 Sep;118 Suppl 1:S123-S131. doi: 10.1016/j.fct.2018.06.045. Epub 2018 Jun 22. Food Chem Toxicol. 2018. PMID: 29940281 Review. No abstract available.
Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4.5]decan-2-ones.
Caroon JM, Clark RD, Kluge AF, Nelson JT, Strosberg AM, Unger SH, Michel AD, Whiting RL. Caroon JM, et al. J Med Chem. 1981 Nov;24(11):1320-8. doi: 10.1021/jm00143a012. J Med Chem. 1981. PMID: 7310808
Examination of 8-[2-(3-indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]-decan-2-one (8) and 3 methyl-8-[2-(1,4-benzodioxan-2-yl)-2-hydroxyethyl]-1-oxa-3,8-diazaspiro[4,5]decan-2-one (29) in the dog showed them to be alpha-adrenergic blockers. ...
Examination of 8-[2-(3-indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]-decan-2-one (8) and 3 methyl-8-[2-(1,4-benzodioxan-2-yl …
3-Hy-droxy-8-oxo-3-nor-methyl-chamigrane-2,7-peroxide.
Liu D. Liu D. Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 30;66(Pt 7):o1875. doi: 10.1107/S1600536810024517. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21588070 Free PMC article.
In the title compound, C(14)H(22)O(4) (systematic name: 9-hy-droxy-1,5,5-trimethyl-1,8-epidi-oxy-spiro-[5.5]decan-2-one), which was isolated from the fermentation broth of Steccherinum ochraceum, the two six-membered rings adopt chair conformations and are br …
In the title compound, C(14)H(22)O(4) (systematic name: 9-hy-droxy-1,5,5-trimethyl-1,8-epidi-oxy-spiro-[5.5]decan-2-one
One new spirocyclic lactone and one new benzopyran derivative from Aspergillus terreus.
Li DY, Han P, Wu ZD, Chen CM, Tong QY, Zhu HC, Guo JR, Lai YJ, Zhang YH. Li DY, et al. J Asian Nat Prod Res. 2021 May;23(5):429-435. doi: 10.1080/10286020.2020.1747052. Epub 2020 Apr 15. J Asian Nat Prod Res. 2021. PMID: 32290693
Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. ...
Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway …
Rolapitant Is a Reversible Inhibitor of CYP2D6.
Glass SM, Leddy SM, Orwin MC, Miller GP, Furge KA, Furge LL. Glass SM, et al. Drug Metab Dispos. 2019 Jun;47(6):567-573. doi: 10.1124/dmd.118.085928. Epub 2019 Apr 5. Drug Metab Dispos. 2019. PMID: 30952677 Free PMC article.
Rolapitant [(Varubi), 5S,8S)-8-[[(1R)-1-[3,5 bis(trifluoromethyl phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one] is a high-affinity NK1 receptor antagonist that was approved in September 2015 as a treatment for nausea and vomiting caused by che …
Rolapitant [(Varubi), 5S,8S)-8-[[(1R)-1-[3,5 bis(trifluoromethyl phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2- …
"Biomimetic" Cascade Reactions in Organic Synthesis: Construction of 4-Oxatricyclo[4.3.1.0]decan-2-one Systems and Total Synthesis of 1-O-Methylforbesione via Tandem Claisen Rearrangement/Diels-Alder Reactions.
Nicolaou KC, Li J. Nicolaou KC, et al. Angew Chem Int Ed Engl. 2001 Nov 19;40(22):4264-4268. doi: 10.1002/1521-3773(20011119)40:22<4264::AID-ANIE4264>3.0.CO;2-1. Angew Chem Int Ed Engl. 2001. PMID: 29712093
A further demonstration of the value of "biomimetically" inspired synthetic strategies toward natural products is provided by the title reactions that were developed for the construction of 4-oxatricyclo[4.3.1.0]decan-2-one systems from prochiral aromatic pre …
A further demonstration of the value of "biomimetically" inspired synthetic strategies toward natural products is provided by the title reac …
32 results