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The janus kinase inhibitor, Jab/SOCS-1, is an interferon-gamma inducible gene and determines the sensitivity to interferons.
Sakamoto H, Kinjyo I, Yoshimura A. Sakamoto H, et al. Leuk Lymphoma. 2000 Jun;38(1-2):49-58. doi: 10.3109/10428190009060318. Leuk Lymphoma. 2000. PMID: 10811447 Review.
The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a variety of cytokines. Among them, we have shown that JAB/SOCS-1 is strongly induced by interferon-gamma and forced expressio …
The CIS family of proteins (also referred as the SOCS or SSI family) has been implicated in the regulation of signal transduction by a varie …
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.
Sakamoto H, Yasukawa H, Masuhara M, Tanimura S, Sasaki A, Yuge K, Ohtsubo M, Ohtsuka A, Fujita T, Ohta T, Furukawa Y, Iwase S, Yamada H, Yoshimura A. Sakamoto H, et al. Blood. 1998 Sep 1;92(5):1668-76. Blood. 1998. PMID: 9716595
M1 leukemic cells stably expressing JAB were also resistant to IFN-gamma and IFN-beta-induced growth arrest. ...Therefore, overexpression of JAB could be, at least in part, a mechanism of IFN resistance....
M1 leukemic cells stably expressing JAB were also resistant to IFN-gamma and IFN-beta-induced growth arrest. ...Therefo …