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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1984 1
1985 1
1986 1
1987 1
1988 5
1989 4
1990 5
1991 9
1992 13
1993 11
1994 16
1995 22
1996 40
1997 45
1998 55
1999 87
2000 120
2001 130
2002 152
2003 186
2004 215
2005 219
2006 230
2007 216
2008 222
2009 247
2010 258
2011 289
2012 290
2013 328
2014 328
2015 313
2016 328
2017 352
2018 352
2019 404
2020 288
2021 41
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5,195 results
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Negative Regulation of Cytokine Signaling in Immunity.
Yoshimura A, Ito M, Chikuma S, Akanuma T, Nakatsukasa H. Yoshimura A, et al. Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a028571. doi: 10.1101/cshperspect.a028571. Cold Spring Harb Perspect Biol. 2018. PMID: 28716890 Free PMC article. Review.
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by multiple
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of
New insights into TGF-beta/Smad signaling in tissue fibrosis.
Hu HH, Chen DQ, Wang YN, Feng YL, Cao G, Vaziri ND, Zhao YY. Hu HH, et al. Chem Biol Interact. 2018 Aug 25;292:76-83. doi: 10.1016/j.cbi.2018.07.008. Epub 2018 Jul 11. Chem Biol Interact. 2018. PMID: 30017632 Review.
Smad2 and Smad3 are the two major downstream regulator that promote TGF-beta1-mediated tissue fibrosis, while Smad7 serves as a negative feedback regulator of TGF-beta1/Smad pathway thereby protects against TGF-beta1-mediated fibrosis. This review presents an …
Smad2 and Smad3 are the two major downstream regulator that promote TGF-beta1-mediated tissue fibrosis, while Smad7 serves as a ne
SOCS proteins: negative regulators of cytokine signaling.
Krebs DL, Hilton DJ. Krebs DL, et al. Stem Cells. 2001;19(5):378-87. doi: 10.1634/stemcells.19-5-378. Stem Cells. 2001. PMID: 11553846 Free article. Review.
Cytokines regulate the growth and differentiation of cells by binding to cell-surface receptors and activating intracellular signal transduction cascades such as the JAK-STAT pathway. Cytokine signaling is negatively regulated
Cytokines regulate the growth and differentiation of cells by binding to cell-surface receptors and activating intracellular
The role of JAK/STAT signaling pathway and its inhibitors in diseases.
Xin P, Xu X, Deng C, Liu S, Wang Y, Zhou X, Ma H, Wei D, Sun S. Xin P, et al. Int Immunopharmacol. 2020 Mar;80:106210. doi: 10.1016/j.intimp.2020.106210. Epub 2020 Jan 20. Int Immunopharmacol. 2020. PMID: 31972425 Review.
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. ...In this review, …
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in ma …
B7-H4, a promising target for immunotherapy.
Wang JY, Wang WP. Wang JY, et al. Cell Immunol. 2020 Jan;347:104008. doi: 10.1016/j.cellimm.2019.104008. Epub 2019 Nov 4. Cell Immunol. 2020. PMID: 31733822 Review.
The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally expressed in tumors, inflammation and autoimmune diseases. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation, cytokine
The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally expressed in tumors, inflammation and autoimmune diseas …
Understanding SOCS protein specificity.
Linossi EM, Calleja DJ, Nicholson SE. Linossi EM, et al. Growth Factors. 2018 Aug;36(3-4):104-117. doi: 10.1080/08977194.2018.1518324. Epub 2018 Oct 15. Growth Factors. 2018. PMID: 30318950 Review.
Cytokine signalling is predominantly executed by intracellular proteins known as the Janus kinases (JAKs) and the signal transducers and activators of transcriptions (STATs). ...This is highlighted by the intricate role of the suppressor of cytokine
Cytokine signalling is predominantly executed by intracellular proteins known as the Janus kinases (JAKs) and the signal
Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner.
Sun KY, Xu DH, Xie C, Plummer S, Tang J, Yang XF, Ji XH. Sun KY, et al. Cytokine. 2017 Apr;92:1-11. doi: 10.1016/j.cyto.2017.01.003. Epub 2017 Jan 12. Cytokine. 2017. PMID: 28088611
Furthermore, treatment of the differentiated THP-1 cells with L. paracasei induced the expression of negative regulators of the NF-kappaB signaling pathway, including the deubiquitinating enzyme A20, suppressor of cytokine signaling (SOCS) 1, SO …
Furthermore, treatment of the differentiated THP-1 cells with L. paracasei induced the expression of negative regulators of th …
Negative regulation of cytokine signaling.
Yoshimura A. Yoshimura A. Clin Rev Allergy Immunol. 2005 Jun;28(3):205-20. doi: 10.1385/CRIAI:28:3:205. Clin Rev Allergy Immunol. 2005. PMID: 16129905 Review.
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The …
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytoki
Negative regulation of cytokine signaling.
Greenhalgh CJ, Hilton DJ. Greenhalgh CJ, et al. J Leukoc Biol. 2001 Sep;70(3):348-56. J Leukoc Biol. 2001. PMID: 11527983 Review.
Cytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mechanism of activation. ...Phosphatases have been shown to be involved in these regulatory processes, but more recent research has seen th
Cytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mec
Regulation of cytokine receptor signaling by nuclear hormone receptors: a new paradigm for receptor interaction.
Leung KC. Leung KC. DNA Cell Biol. 2004 Aug;23(8):463-74. doi: 10.1089/1044549041562285. DNA Cell Biol. 2004. PMID: 15307949 Review.
JAK/STAT signaling is terminated by negative regulators including the suppressors of cytokine signaling (SOCSs), protein tyrosine phosphatases, and protein inhibitors of activated STAT. There is a wealth of evidence that nuclear hormone receptor …
JAK/STAT signaling is terminated by negative regulators including the suppressors of cytokine signaling ( …
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