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Table representation of search results timeline featuring number of search results per year.
| Year | Number of Results |
|---|---|
| 1981 | 1 |
| 1984 | 1 |
| 1985 | 1 |
| 1986 | 1 |
| 1987 | 1 |
| 1988 | 5 |
| 1989 | 4 |
| 1990 | 5 |
| 1991 | 9 |
| 1992 | 13 |
| 1993 | 11 |
| 1994 | 16 |
| 1995 | 22 |
| 1996 | 40 |
| 1997 | 45 |
| 1998 | 55 |
| 1999 | 87 |
| 2000 | 120 |
| 2001 | 130 |
| 2002 | 152 |
| 2003 | 186 |
| 2004 | 215 |
| 2005 | 219 |
| 2006 | 230 |
| 2007 | 216 |
| 2008 | 222 |
| 2009 | 247 |
| 2010 | 258 |
| 2011 | 289 |
| 2012 | 290 |
| 2013 | 328 |
| 2014 | 328 |
| 2015 | 313 |
| 2016 | 328 |
| 2017 | 352 |
| 2018 | 352 |
| 2019 | 414 |
| 2020 | 402 |
| 2021 | 383 |
| 2022 | 343 |
| 2023 | 196 |
Search Results
6,084 results
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Negative Regulation of Cytokine Signaling in Immunity.
Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a028571. doi: 10.1101/cshperspect.a028571.
Cold Spring Harb Perspect Biol. 2018.
PMID: 28716890
Free PMC article.
Review.
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by multiple …
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of …
The role of JAK/STAT signaling pathway and its inhibitors in diseases.
Int Immunopharmacol. 2020 Mar;80:106210. doi: 10.1016/j.intimp.2020.106210. Epub 2020 Jan 20.
Int Immunopharmacol. 2020.
PMID: 31972425
Review.
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. ...In this review, …
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in ma …
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities.
Clin Sci (Lond). 2021 Jan 29;135(2):275-303. doi: 10.1042/CS20201213.
Clin Sci (Lond). 2021.
PMID: 33480423
Review.
Therapeutically relevant approaches to directly target the TGF-beta1 pathway (e.g., neutralizing antibodies against TGF-beta1), however, remain elusive in humans. TGF-beta1 signaling is subjected to extensive negative control at the level of TGF-beta1 recepto …
Therapeutically relevant approaches to directly target the TGF-beta1 pathway (e.g., neutralizing antibodies against TGF-beta1), however, rem …
New insights into TGF-β/Smad signaling in tissue fibrosis.
Chem Biol Interact. 2018 Aug 25;292:76-83. doi: 10.1016/j.cbi.2018.07.008. Epub 2018 Jul 11.
Chem Biol Interact. 2018.
PMID: 30017632
Review.
Smad2 and Smad3 are the two major downstream regulator that promote TGF-beta1-mediated tissue fibrosis, while Smad7 serves as a negative feedback regulator of TGF-beta1/Smad pathway thereby protects against TGF-beta1-mediated fibrosis. This review presents an …
Smad2 and Smad3 are the two major downstream regulator that promote TGF-beta1-mediated tissue fibrosis, while Smad7 serves as a ne …
B7-H4, a promising target for immunotherapy.
Cell Immunol. 2020 Jan;347:104008. doi: 10.1016/j.cellimm.2019.104008. Epub 2019 Nov 4.
Cell Immunol. 2020.
PMID: 31733822
Review.
The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally expressed in tumors, inflammation and autoimmune diseases. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation, cytokine …
The coinhibitory molecule B7-H4, an important member of the B7 family, is abnormally expressed in tumors, inflammation and autoimmune diseas …
LPS-induced cytokine production in human monocytes and macrophages.
Crit Rev Immunol. 2011;31(5):379-446. doi: 10.1615/critrevimmunol.v31.i5.20.
Crit Rev Immunol. 2011.
PMID: 22142165
Review.
Here we review the current understanding of LPS effects on human monocyte and macrophage function. We provide an overview of LPS signal transduction with attention given to receptor cooperativity and species differences in LPS responses, as well as the role of tyros …
Here we review the current understanding of LPS effects on human monocyte and macrophage function. We provide an overview of LPS signal …
Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38.
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2116279119. doi: 10.1073/pnas.2116279119. Epub 2022 Mar 1.
Proc Natl Acad Sci U S A. 2022.
PMID: 35238669
Free PMC article.
Whether and how IL-33R is regulated remain enigmatic. Here, we identified ubiquitin-specific protease 38 (USP38) as a negative regulator of IL-33R-mediated signaling. ...We further show that the E3 ubiquitin ligase tumor necrosis factor receptor-associ …
Whether and how IL-33R is regulated remain enigmatic. Here, we identified ubiquitin-specific protease 38 (USP38) as a negative …
Erythropoietin regulation of red blood cell production: from bench to bedside and back.
F1000Res. 2020 Sep 18;9:F1000 Faculty Rev-1153. doi: 10.12688/f1000research.26648.1. eCollection 2020.
F1000Res. 2020.
PMID: 32983414
Free PMC article.
Review.
We now know that an elaborate oxygen-sensing mechanism regulates the production of EPO, which in turn promotes the maturation and survival of erythroid progenitors. Engagement of the EPOR by EPO activates three interconnected signaling pathways that drive RBC …
We now know that an elaborate oxygen-sensing mechanism regulates the production of EPO, which in turn promotes the maturation …
Negative regulation of cytokine signaling.
Clin Rev Allergy Immunol. 2005 Jun;28(3):205-20. doi: 10.1385/CRIAI:28:3:205.
Clin Rev Allergy Immunol. 2005.
PMID: 16129905
Review.
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The …
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytoki …
Negative regulation of cytokine signaling.
J Leukoc Biol. 2001 Sep;70(3):348-56.
J Leukoc Biol. 2001.
PMID: 11527983
Review.
Cytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mechanism of activation. ...Phosphatases have been shown to be involved in these regulatory processes, but more recent research has seen th …
Cytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mec …
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