Abstract
Double pituitary adenomas are difficult to recognize pre-operatively as only a single mass may be appreciated on imaging. We present herein a giant prolactin-secreting pituitary adenoma in a middle-aged man that had responded partially to dopamine agonist therapy. The excised specimen demonstrated a double adenoma. The prolactin-producing one displayed the expected morphological changes resulting from medical therapy, while the other, a gonadotroph adenoma, did not. The failure of tumor shrinkage can be attributed to the presence of a double adenoma, a previously unreported cause of failure of medical therapy in prolactinoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenoma / pathology*
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Adenoma / therapy
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Adult
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Antineoplastic Agents / therapeutic use
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Breast Neoplasms, Male / pathology
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Cabergoline
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Combined Modality Therapy
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Ergolines / therapeutic use
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Gonadotrophs / pathology*
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Humans
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Male
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Microscopy, Electron, Transmission
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Neoplasms, Multiple Primary / pathology*
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Neoplasms, Multiple Primary / therapy
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Neoplasms, Second Primary / pathology
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Neoplasms, Second Primary / therapy
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Neurofibromatosis 1 / complications
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Neurosurgical Procedures
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Prolactinoma / pathology*
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Prolactinoma / therapy
Substances
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Antineoplastic Agents
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Ergolines
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Cabergoline