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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.
Tzelepis K, Koike-Yusa H, De Braekeleer E, Li Y, Metzakopian E, Dovey OM, Mupo A, Grinkevich V, Li M, Mazan M, Gozdecka M, Ohnishi S, Cooper J, Patel M, McKerrell T, Chen B, Domingues AF, Gallipoli P, Teichmann S, Ponstingl H, McDermott U, Saez-Rodriguez J, Huntly BJP, Iorio F, Pina C, Vassiliou GS, Yusa K. Tzelepis K, et al. Cell Rep. 2016 Oct 18;17(4):1193-1205. doi: 10.1016/j.celrep.2016.09.079. Cell Rep. 2016. PMID: 27760321 Free PMC article.
Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have not changed for decades. To identify additional therapeutic targets in AML, we optimize a genome-wide clustered
Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have
Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.
Jaiswal AK, Truong H, Tran TM, Lin TL, Casero D, Alberti MO, Rao DS. Jaiswal AK, et al. Sci Rep. 2021 Jun 23;11(1):13158. doi: 10.1038/s41598-021-92448-w. Sci Rep. 2021. PMID: 34162911 Free PMC article.
Post-transcriptional gene regulation, including that by RNA binding proteins (RBPs), has recently been described as an important mechanism in cancer. We had previously identified a set of RBPs that were highly dysregulated in B-cell acute lymphoblastic leu
Post-transcriptional gene regulation, including that by RNA binding proteins (RBPs), has recently been described as an important mechanism i …
Genome-scale drop-out screens to identify cancer cell vulnerabilities in AML.
Basheer FT, Vassiliou GS. Basheer FT, et al. Curr Opin Genet Dev. 2019 Feb;54:83-87. doi: 10.1016/j.gde.2019.04.004. Epub 2019 May 4. Curr Opin Genet Dev. 2019. PMID: 31063922 Review.
Acute myeloid leukemia (AML) is an aggressive cancer that remains lethal to the majority of sufferers. ...In this review we give an overview of recent advances in identifying novel therapeutic vulnerabilities of AML using CRISPR
Acute myeloid leukemia (AML) is an aggressive cancer that remains lethal to the majority of sufferers. ...In thi