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A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.
Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. Kazak L, et al. Cell. 2015 Oct 22;163(3):643-55. doi: 10.1016/j.cell.2015.09.035. Epub 2015 Oct 22. Cell. 2015. PMID: 26496606 Free PMC article.
We identify arginine/creatine metabolism as a beige adipose signature and demonstrate that creatine enhances respiration in beige-fat mitochondria when ADP is limiting. ...These findings link a futile cycle of crea …
We identify arginine/creatine metabolism as a beige adipose signature and demonstrate that creatine en …
BMP7 Increases UCP1-Dependent and Independent Thermogenesis with a Unique Gene Expression Program in Human Neck Area Derived Adipocytes.
Shaw A, Tóth BB, Arianti R, Csomós I, Póliska S, Vámos A, Bacso Z, Győry F, Fésüs L, Kristóf E. Shaw A, et al. Pharmaceuticals (Basel). 2021 Oct 25;14(11):1078. doi: 10.3390/ph14111078. Pharmaceuticals (Basel). 2021. PMID: 34832860 Free PMC article.
Furthermore, both UCP1-dependent proton leak and UCP1-independent, creatine-driven substrate cycle coupled thermogenesis were augmented upon BMP7 addition. ...Together, our study shows that BMP7 strongly upregulates thermogenesis in human …
Furthermore, both UCP1-dependent proton leak and UCP1-independent, creatine-driven substrate cycle coupled th …