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A new reagent for stable thiol-specific conjugation.
Badescu G, Bryant P, Swierkosz J, Khayrzad F, Pawlisz E, Farys M, Cong Y, Muroni M, Rumpf N, Brocchini S, Godwin A. Badescu G, et al. Bioconjug Chem. 2014 Mar 19;25(3):460-9. doi: 10.1021/bc400245v. Epub 2014 Feb 11. Bioconjug Chem. 2014. PMID: 24512057
Monothiol-specific conjugation can be efficient and is often accomplished using maleimide-based reagents. However, maleimide derived conjugates are known to be susceptible to exchange reactions with endogenous proteins. ...Comparative reactions with PE …
Monothiol-specific conjugation can be efficient and is often accomplished using maleimide-based reagents. However, male …
Stable and Rapid Thiol Bioconjugation by Light-Triggered Thiomaleimide Ring Hydrolysis.
Kalia D, Pawar SP, Thopate JS. Kalia D, et al. Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1885-1889. doi: 10.1002/anie.201609733. Epub 2017 Jan 12. Angew Chem Int Ed Engl. 2017. PMID: 28078677
Maleimide-mediated thiol-specific derivatization of biomolecules is one of the most efficacious bioconjugation approaches currently available. ...Herein, we report a new class of maleimides, namely o-CH(2) NH(i) Pr phenyl maleimides, that undergo unprecedente …
Maleimide-mediated thiol-specific derivatization of biomolecules is one of the most efficacious bioconjugation approaches curr …
Cell-surface thiols affect cell entry of disulfide-conjugated peptides.
Aubry S, Burlina F, Dupont E, Delaroche D, Joliot A, Lavielle S, Chassaing G, Sagan S. Aubry S, et al. FASEB J. 2009 Sep;23(9):2956-67. doi: 10.1096/fj.08-127563. Epub 2009 Apr 27. FASEB J. 2009. PMID: 19403512
The cargo and the CPP are often conjugated through a disulfide bridge with the common acceptation that this linker is stable in the extracellular biological medium and should not perturb the internalization process. However, with the use of thiol-specific
The cargo and the CPP are often conjugated through a disulfide bridge with the common acceptation that this linker is stable i …
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