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A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.
Ghebremariam YT, Erlanson DA, Cooke JP. Ghebremariam YT, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):69-76. doi: 10.1124/jpet.113.206847. Epub 2013 Oct 17. J Pharmacol Exp Ther. 2014. PMID: 24135074 Free PMC article.
In this study, we used biochemical assays to screen LOPAC against human dimethylarginine dimethylaminohydrolase isoform 1 (DDAH1), an enzyme that physiologically metabolizes asymmetric dimethylarginine (ADMA), an endogenous and competitive inhibitor of …
In this study, we used biochemical assays to screen LOPAC against human dimethylarginine dimethylaminohydrolase isoform 1 (DDA …
Investigating the cardio-protective abilities of supplemental L-arginine on parameters of endothelial function in a hypercholesterolemic animal model.
Gad MZ, Abu el Maaty MA, El-Maraghy SA, Fahim AT, Hamdy MA. Gad MZ, et al. J Nutr Sci Vitaminol (Tokyo). 2014;60(3):145-51. doi: 10.3177/jnsv.60.145. J Nutr Sci Vitaminol (Tokyo). 2014. PMID: 25078369 Free article.
Its therapeutic potential is also compared to that of known cardiovascular medications, namely nitroglycerin [a nitric oxide (NO) donor] and enalapril [an angiotensin-converting enzyme (ACE) inhibitor]. ...No agents were capable of modulating se …
Its therapeutic potential is also compared to that of known cardiovascular medications, namely nitroglycerin [a nitric oxid
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