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A pilot study on commonality and specificity of copy number variants in schizophrenia and bipolar disorder.
Chen J, Calhoun VD, Perrone-Bizzozero NI, Pearlson GD, Sui J, Du Y, Liu J. Chen J, et al. Transl Psychiatry. 2016 May 31;6(5):e824. doi: 10.1038/tp.2016.96. Transl Psychiatry. 2016. PMID: 27244233 Free PMC article.
In this work, we conducted whole-genome scanning to identify cross-disorder and disorder-specific copy number variants (CNVs) for these two disorders. ...In addition, the comparison between SZ and BD reveals both specific and common risk …
In this work, we conducted whole-genome scanning to identify cross-disorder and disorder-specific copy number varian
A common microdeletion affecting a hippocampus- and amygdala-specific isoform of tryptophan hydroxylase 2 is not associated with affective disorders.
Hammer C, Degenhardt F, Priebe L, Stütz AM, Heilmann S, Waszak SM, Schlattl A, Mangold E, Hoffmann P, Nöthen MM, Rietschel M, Rappold G, Korbel J, Cichon S, Niesler B; MooDS Consortium. Hammer C, et al. Bipolar Disord. 2014 Nov;16(7):764-8. doi: 10.1111/bdi.12207. Epub 2014 Apr 23. Bipolar Disord. 2014. PMID: 24754353
OBJECTIVES: Copy number variants (CNVs) have been shown to affect susceptibility for neuropsychiatric disorders. To date, studies implicating the serotonergic system in complex conditions have just focused on single nucleotide polymorphisms (SNPs). We therefo …
OBJECTIVES: Copy number variants (CNVs) have been shown to affect susceptibility for neuropsychiatric disorders. To dat …
Structural variation on the human Y chromosome from population-scale resequencing.
Espinosa JR, Ayub Q, Chen Y, Xue Y, Tyler-Smith C. Espinosa JR, et al. Croat Med J. 2015 Jun;56(3):194-207. doi: 10.3325/cmj.2015.56.194. Croat Med J. 2015. PMID: 26088844 Free PMC article.
In all, 5 of the 27 protein-coding gene families on the Y chromosome varied in copy number. CONCLUSIONS: We confirmed that Y-SVs were readily detected from low-coverage sequence data and were abundant on the chromosome. We also reported both common and rare Y …
In all, 5 of the 27 protein-coding gene families on the Y chromosome varied in copy number. CONCLUSIONS: We confirmed that Y-S …
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