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A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests.
Johansson H, Lindstedt M, Albrekt AS, Borrebaeck CA. Johansson H, et al. BMC Genomics. 2011 Aug 8;12:399. doi: 10.1186/1471-2164-12-399. BMC Genomics. 2011. PMID: 21824406 Free PMC article.
Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemicals within pharmaceutical and cosmetic industries have stimulated significant research efforts to develop alternative, human cell …
Current test of sensitizing chemicals rely on animal experimentation. New legislations on the registration and use of chemical …
Predicting skin sensitizers with confidence - Using conformal prediction to determine applicability domain of GARD.
Forreryd A, Norinder U, Lindberg T, Lindstedt M. Forreryd A, et al. Toxicol In Vitro. 2018 Apr;48:179-187. doi: 10.1016/j.tiv.2018.01.021. Epub 2018 Jan 31. Toxicol In Vitro. 2018. PMID: 29374571 Free article.
GARD - Genomic Allergen Rapid Detection is a cell based alternative to animal testing for identification of skin sensitizers. ...Within the field of in vitro skin sensitization testing, def …
GARD - Genomic Allergen Rapid Detection is a cell based alternative to animal testing for identifi …
The GARD platform for potency assessment of skin sensitizing chemicals.
Zeller KS, Forreryd A, Lindberg T, Gradin R, Chawade A, Lindstedt M. Zeller KS, et al. ALTEX. 2017;34(4):539-559. doi: 10.14573/altex.1701101. Epub 2017 Apr 12. ALTEX. 2017. PMID: 29156079 Free article.
Contact allergy induced by certain chemicals is a common health concern, and several alternative methods have been developed to fulfill the requirements of European legislation with regard to hazard assessment of potential skin sensitizers. However, validated …
Contact allergy induced by certain chemicals is a common health concern, and several alternative methods have been developed to fulfi …