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Did you mean a genomic direction of travel associated (170 results)?
Dissecting the biological heterogeneity of HER2-positive breast cancer.
Schettini F, Prat A. Schettini F, et al. Breast. 2021 Oct;59:339-350. doi: 10.1016/j.breast.2021.07.019. Epub 2021 Aug 5. Breast. 2021. PMID: 34392185 Free PMC article. Review.
Intrinsic subtyping, along with the quantification of ERBB2 mRNA levels, is associated with higher rates of pathologic complete response across neoadjuvant trials of dual HER2 blockade and might help select patients for de-escalation and escalation treatment strategies. .. …
Intrinsic subtyping, along with the quantification of ERBB2 mRNA levels, is associated with higher rates of pathologic complete respo …
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A, Kivimaki M, Kumari M, Bennett AJ, Groves CJ, Herder C, Koistinen HA, Kinnunen L, Faire U, Bakker SJL, Uusitupa M, Palmer CNA, Jukema JW, Sattar N, Pouta A, Snieder H, Boerwink… See abstract for full author list ➔ Lagou V, et al. Nat Commun. 2021 Jan 5;12(1):24. doi: 10.1038/s41467-020-19366-9. Nat Commun. 2021. PMID: 33402679 Free PMC article.
We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. .. …
We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting i …
Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial.
Bhatt DL, Vaduganathan M, Kandzari DE, Leon MB, Rocha-Singh K, Townsend RR, Katzen BT, Oparil S, Brar S, DeBruin V, Fahy M, Bakris GL; SYMPLICITY HTN-3 Steering Committee Investigators. Bhatt DL, et al. Lancet. 2022 Oct 22;400(10361):1405-1416. doi: 10.1016/S0140-6736(22)01787-1. Epub 2022 Sep 18. Lancet. 2022. PMID: 36130612 Clinical Trial.
The primary safety endpoint was the incidence of all-cause mortality, end stage renal disease, significant embolic event, renal artery perforation or dissection requiring intervention, vascular complications, hospitalisation for hypertensive crisis unrelated to non-adheren …
The primary safety endpoint was the incidence of all-cause mortality, end stage renal disease, significant embolic event, renal artery perfo …
Genomic dissection of travel-associated extended-spectrum-beta-lactamase-producing Salmonella enterica serovar typhi isolates originating from the Philippines: a one-off occurrence or a threat to effective treatment of typhoid fever?
Hendriksen RS, Leekitcharoenphon P, Mikoleit M, Jensen JD, Kaas RS, Roer L, Joshi HB, Pornruangmong S, Pulsrikarn C, Gonzalez-Aviles GD, Reuland EA, Al Naiemi N, Wester AL, Aarestrup FM, Hasman H. Hendriksen RS, et al. J Clin Microbiol. 2015 Feb;53(2):677-80. doi: 10.1128/JCM.03104-14. Epub 2014 Nov 26. J Clin Microbiol. 2015. PMID: 25428145 Free PMC article.
One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. ...The reported strain was similar to a …
One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome …
Missing heritability in Parkinson's disease: the emerging role of non-coding genetic variation.
Ohnmacht J, May P, Sinkkonen L, Krüger R. Ohnmacht J, et al. J Neural Transm (Vienna). 2020 May;127(5):729-748. doi: 10.1007/s00702-020-02184-0. Epub 2020 Apr 4. J Neural Transm (Vienna). 2020. PMID: 32248367 Free PMC article. Review.
The majority of PD-associated genetic variants are located in non-coding regions of the genome. ...The function of gene regulatory elements and the impact of non-coding variants on them, and the means to map these elements on a genome-wide level, will be deli …
The majority of PD-associated genetic variants are located in non-coding regions of the genome. ...The function of gene regula …
A generative model for the behavior of RNA polymerase.
Azofeifa JG, Dowell RD. Azofeifa JG, et al. Bioinformatics. 2017 Jan 15;33(2):227-234. doi: 10.1093/bioinformatics/btw599. Epub 2016 Sep 23. Bioinformatics. 2017. PMID: 27663494 Free PMC article.
To fully dissect this data requires the development of stochastic models that can both deconvolve the stages of polymerase activity and identify significant changes in activity between experiments. ...We provide principled statistics that compute probabilities reminiscent …
To fully dissect this data requires the development of stochastic models that can both deconvolve the stages of polymerase activity a …
Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores.
Coombes BJ, Markota M, Mann JJ, Colby C, Stahl E, Talati A, Pathak J, Weissman MM, McElroy SL, Frye MA, Biernacka JM. Coombes BJ, et al. Transl Psychiatry. 2020 Sep 18;10(1):314. doi: 10.1038/s41398-020-00996-y. Transl Psychiatry. 2020. PMID: 32948743 Free PMC article.
To determine genetic differences between common clinical sub-phenotypes of BD, we performed a systematic polygenic risk score (PRS) analysis using multiple PRSs from a range of psychiatric, personality, and lifestyle traits to dissect differences in BD sub-phenotypes in tw …
To determine genetic differences between common clinical sub-phenotypes of BD, we performed a systematic polygenic risk score (PRS) analysis …
PARP Inhibitor Insensitivity to BRCA1/2 Monoallelic Mutations in Microsatellite Instability-High Cancers.
Sokol ES, Jin DX, Fine A, Trabucco SE, Maund S, Frampton G, Molinero L, Antonarakis ES. Sokol ES, et al. JCO Precis Oncol. 2022 Jun;6:e2100531. doi: 10.1200/PO.21.00531. JCO Precis Oncol. 2022. PMID: 35772050 Free PMC article.
METHODS: A pan-cancer comprehensive genomic profiling cohort (n = 213,199) was examined for overlap between BRCAm and MSI-H status. ...In breast, ovarian, and pancreatic cancers, very few BRCAm occurred in the context of MSI-H; however, in prostate cancer, 12.8% of BRCA1 a …
METHODS: A pan-cancer comprehensive genomic profiling cohort (n = 213,199) was examined for overlap between BRCAm and MSI-H status. . …
Family level variation in Wolbachia-mediated dengue virus blocking in Aedes aegypti.
Terradas G, Allen SL, Chenoweth SF, McGraw EA. Terradas G, et al. Parasit Vectors. 2017 Dec 28;10(1):622. doi: 10.1186/s13071-017-2589-3. Parasit Vectors. 2017. PMID: 29282144 Free PMC article.
The global reach of these viruses is increasing due to an expansion of the mosquito's geographic range and increasing urbanization and human travel. ...All individuals were injected with DENV-2 intrathoracically at 5-6 days of age. Tissues were dissected 7 da …
The global reach of these viruses is increasing due to an expansion of the mosquito's geographic range and increasing urbanization an …
Genetic dissection of HLA-DRB1*15:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for HLA-DRB1*15:01.
Kawasaki A, Kusumawati PA, Kawamura Y, Kondo Y, Kusaoi M, Amano H, Kusanagi Y, Itoh K, Fujimoto T, Tamura N, Hashimoto H, Matsumoto I, Sumida T, Tsuchiya N. Kawasaki A, et al. RMD Open. 2023 May;9(2):e003214. doi: 10.1136/rmdopen-2023-003214. RMD Open. 2023. PMID: 37258043 Free article.
METHODS: Among the XL9 variants, two (rs2105898 and rs9271593) previously associated variants in the European populations and two (rs9271375 and rs9271378) which showed a trend towards association in a Japanese Genome-Wide Association Study were select …
METHODS: Among the XL9 variants, two (rs2105898 and rs9271593) previously associated variants in the European populations and two (rs …
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