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A mechanism of gene amplification driven by small DNA fragments.
Mukherjee K, Storici F. Mukherjee K, et al. PLoS Genet. 2012;8(12):e1003119. doi: 10.1371/journal.pgen.1003119. Epub 2012 Dec 13. PLoS Genet. 2012. PMID: 23271978 Free PMC article.
We hypothesized that small DNA fragments could be the trigger of DNA amplification events. Following our findings that small fragments of DNA in the form of DNA oligonucleotides can be highly recombinogenic, we have d …
We hypothesized that small DNA fragments could be the trigger of DNA amplification events. Following our …
RNA-Seq comparative study reveals molecular effectors linked to the resistance of Pinna nobilis to Haplosporidium pinnae parasite.
Salis P, Peyran C, Morage T, de Bernard S, Nourikyan J, Coupé S, Bunet R, Planes S. Salis P, et al. Sci Rep. 2022 Dec 8;12(1):21229. doi: 10.1038/s41598-022-25555-x. Sci Rep. 2022. PMID: 36482098 Free PMC article.
Furthermore, the parasite was not detected when we conducted a PCR amplification of a species-specific fragment of the small subunit ribosomal DNA. In parallel, the transcriptomic analysis showed evidence of some parasite RNA indicating that the resist …
Furthermore, the parasite was not detected when we conducted a PCR amplification of a species-specific fragment of the smal …
Hotspot of de novo telomere addition stabilizes linear amplicons in yeast grown in sulfate-limiting conditions.
Hoerr RE, Eng A, Payen C, Di Rienzi SC, Raghuraman MK, Dunham MJ, Brewer BJ, Friedman KL. Hoerr RE, et al. Genetics. 2023 May 26;224(2):iyad010. doi: 10.1093/genetics/iyad010. Genetics. 2023. PMID: 36702776 Free PMC article.
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the amplification or deletion of DNA ( 50 bp) referred to as copy number variation (CNV). ...Many of the linear fragments are s …
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the a …
An improved direct metamobilome approach increases the detection of larger-sized circular elements across kingdoms.
Alanin KWS, Jørgensen TS, Browne PD, Petersen B, Riber L, Kot W, Hansen LH. Alanin KWS, et al. Plasmid. 2021 May;115:102576. doi: 10.1016/j.plasmid.2021.102576. Epub 2021 Apr 17. Plasmid. 2021. PMID: 33872684
Sequencing libraries targeting environmental circular MGEs, referred to as metamobilomes, may broaden our current understanding of the mechanisms behind the mobility, prevalence and content of these elements. However, metamobilomics is affected by a severe bias towards …
Sequencing libraries targeting environmental circular MGEs, referred to as metamobilomes, may broaden our current understanding of the me …