A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.
Sci Rep. 2017.
PMID: 29123178
Free PMC article.
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A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.
Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In't Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.
Balhuizen A, et al.
Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2.
Sci Rep. 2017.
PMID: 29123178
Free PMC article.
At the protein level, DPP6 localizes only in beta and alpha cells within the pancreas. We next generated a high-affinity camelid single-domain antibody (nanobody) targeting human DPP6. ...The human DPP6-expressing cells …
At the protein level, DPP6 localizes only in beta and alpha cells within the pancreas. We next generated a high-affinit …
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A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice.
Demine S, Garcia Ribeiro R, Thevenet J, Marselli L, Marchetti P, Pattou F, Kerr-Conte J, Devoogdt N, Eizirik DL.
Demine S, et al.
Diabetologia. 2020 Apr;63(4):825-836. doi: 10.1007/s00125-019-05068-5. Epub 2019 Dec 23.
Diabetologia. 2020.
PMID: 31873789
This is due to the limited availability of non-invasive pancreatic islet imaging techniques. We have previously described that dipeptidyl peptidase 6 (DPP6) is an alpha and beta cell-specific biomarker, and developed a camelid antibody (nanobody …
This is due to the limited availability of non-invasive pancreatic islet imaging techniques. We have previously …
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