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A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin.
Leal LG, Hoggart C, Jarvelin MR, Herzig KH, Sternberg MJE, David A. Leal LG, et al. Mol Genet Genomic Med. 2020 Jun;8(6):e1248. doi: 10.1002/mgg3.1248. Epub 2020 Apr 19. Mol Genet Genomic Med. 2020. PMID: 32307928 Free PMC article.
BACKGROUND: Severe hypercholesterolemia (HC, LDL-C > 4.9 mmol/L) affects over 30 million people worldwide. ...CONCLUSION: The new PRS has a better predictive role in identifying HC of polygenic origin compared to the currently available metho …
BACKGROUND: Severe hypercholesterolemia (HC, LDL-C > 4.9 mmol/L) affects over 30 million people worldwide. ...CONCLUSION: T …
Evidence of a polygenic origin of extreme high-density lipoprotein cholesterol levels.
Motazacker MM, Peter J, Treskes M, Shoulders CC, Kuivenhoven JA, Hovingh GK. Motazacker MM, et al. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1521-8. doi: 10.1161/ATVBAHA.113.301505. Epub 2013 May 16. Arterioscler Thromb Vasc Biol. 2013. PMID: 23685560
OBJECTIVE: There are several known monogenic causes of high and low high-density lipoprotein cholesterol (HDL-C) levels, but traditional sequencing studies have had limited success in identifying mutations in the majority of individuals with extreme HDL-C levels. ...The li …
OBJECTIVE: There are several known monogenic causes of high and low high-density lipoprotein cholesterol (HDL-C) levels, but traditional seq …