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Year Number of Results
1980 1
1981 1
1983 1
1991 1
1992 1
1994 1
1996 1
1997 1
1998 2
1999 1
2003 1
2004 1
2007 1
2008 1
2009 2
2010 4
2011 2
2013 1
2014 1
2015 2
2016 3
2017 2
2018 1
2019 1
2020 3
2021 0
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A structural view of the initiators for chromosome replication.
On KF, Jaremko M, Stillman B, Joshua-Tor L. On KF, et al. Curr Opin Struct Biol. 2018 Dec;53:131-139. doi: 10.1016/j.sbi.2018.08.003. Epub 2018 Sep 12. Curr Opin Struct Biol. 2018. PMID: 30218786 Free PMC article. Review. No abstract available.
Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor.
Mivelaz M, Cao AM, Kubik S, Zencir S, Hovius R, Boichenko I, Stachowicz AM, Kurat CF, Shore D, Fierz B. Mivelaz M, et al. Mol Cell. 2020 Feb 6;77(3):488-500.e9. doi: 10.1016/j.molcel.2019.10.025. Epub 2019 Nov 21. Mol Cell. 2020. PMID: 31761495 Free PMC article.
Here, we reveal, using single-molecule fluorescence, how the yeast transcription factor Rap1 invades and remodels chromatin. Using a reconstituted chromatin system replicating yeast promoter architecture, we demonstrate that Rap1 can bind nucleosomal DNA within a ch …
Here, we reveal, using single-molecule fluorescence, how the yeast transcription factor Rap1 invades and remodels chromatin. Using a reconst …
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
ENCODE Project Consortium, Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA; NISC Comparative Sequencing Program; Baylor College of Medicine Human Genome Sequencing Center; Washington University Genome Sequencing Center; Broad Institute; Children's Hospital Oakland Research Institute, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VV, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJ. ENCODE Project Consortium, et al. Nature. 2007 Jun 14;447(7146):799-816. doi: 10.1038/nature05874. Nature. 2007. PMID: 17571346 Free PMC article.
Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated …
Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their …
Web-based, participant-driven studies yield novel genetic associations for common traits.
Eriksson N, Macpherson JM, Tung JY, Hon LS, Naughton B, Saxonov S, Avey L, Wojcicki A, Pe'er I, Mountain J. Eriksson N, et al. PLoS Genet. 2010 Jun 24;6(6):e1000993. doi: 10.1371/journal.pgen.1000993. PLoS Genet. 2010. PMID: 20585627 Free PMC article.
The approach takes advantage of the interactivity of the Web both to gather data and to present genetic information to research participants, while taking care to correct for the population structure inherent to this study design. Here we report initial results from …
The approach takes advantage of the interactivity of the Web both to gather data and to present genetic information to research participants …
Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure.
Arvanitis M, Tampakakis E, Zhang Y, Wang W, Auton A; 23andMe Research Team, Dutta D, Glavaris S, Keramati A, Chatterjee N, Chi NC, Ren B, Post WS, Battle A. Arvanitis M, et al. Nat Commun. 2020 Feb 28;11(1):1122. doi: 10.1038/s41467-020-14843-7. Nat Commun. 2020. PMID: 32111823 Free PMC article.
In this study, we present the results of a large scale meta-analysis of heart failure GWAS and replication in a comparable sized cohort to identify one known and two novel loci associated with heart failure. Heart failure sub-phenotyping shows that a new locus in chromo
In this study, we present the results of a large scale meta-analysis of heart failure GWAS and replication in a comparable sized coho …
Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.
Guilbaud G, Rappailles A, Baker A, Chen CL, Arneodo A, Goldar A, d'Aubenton-Carafa Y, Thermes C, Audit B, Hyrien O. Guilbaud G, et al. PLoS Comput Biol. 2011 Dec;7(12):e1002322. doi: 10.1371/journal.pcbi.1002322. Epub 2011 Dec 29. PLoS Comput Biol. 2011. PMID: 22219720 Free PMC article.
Here, we report a quantitative genome-wide analysis of DNA replication kinetics in several human cell types that contradicts this view. ...These results can be explained if origins fire independently of each other but under the control of long-range chromatin …
Here, we report a quantitative genome-wide analysis of DNA replication kinetics in several human cell types that contradicts t …
Site-specific in situ amplification of the integrated polyomavirus genome: a case for a context-specific over-replication model of gene amplification.
Syu LJ, Fluck MM. Syu LJ, et al. J Mol Biol. 1997 Aug 8;271(1):76-99. doi: 10.1006/jmbi.1997.1156. J Mol Biol. 1997. PMID: 9300056
The fate of the genome of the polyoma (Py) tumor virus following integration in the chromosomes of transformed rat FR3T3 cells was re-examined. The viral sequences were integrated at a single transformant-specific chromosomal site in each of 22 transformants tested. …
The fate of the genome of the polyoma (Py) tumor virus following integration in the chromosomes of transformed rat FR3T3 cells was re …
Does the eclipse limit bacterial nucleoid complexity and cell width?
Zaritsky A, Rabinovitch A, Liu C, Woldringh CL. Zaritsky A, et al. Synth Syst Biotechnol. 2017 Nov 29;2(4):267-275. doi: 10.1016/j.synbio.2017.11.004. eCollection 2017 Dec. Synth Syst Biotechnol. 2017. PMID: 29552651 Free PMC article. Review.
Steady-state, bacillary cells grow exponentially by extending length L only, but their constant width W is larger at shorter tau's or longer C's, in proportion to the number of chromosome replication positions n (= C/tau), at least in Escherichia coli …
Steady-state, bacillary cells grow exponentially by extending length L only, but their constant width W is larger at shorter tau's or …
Insufficient levels of the nrdAB-encoded ribonucleotide reductase underlie the severe growth defect of the Δhda E. coli strain.
Babu VMP, Itsko M, Baxter JC, Schaaper RM, Sutton MD. Babu VMP, et al. Mol Microbiol. 2017 May;104(3):377-399. doi: 10.1111/mmi.13632. Epub 2017 Mar 13. Mol Microbiol. 2017. PMID: 28130843 Free PMC article.
The ATP-bound form of the Escherichia coli DnaA replication initiator protein remodels the chromosomal origin of replication, oriC, to load the replicative helicase. ...We used a genetic approach to isolate 9 suppressors of deltahda cold sensiti …
The ATP-bound form of the Escherichia coli DnaA replication initiator protein remodels the chromosomal origin of rep
The SMC complex MukBEF recruits topoisomerase IV to the origin of replication region in live Escherichia coli.
Nicolas E, Upton AL, Uphoff S, Henry O, Badrinarayanan A, Sherratt D. Nicolas E, et al. mBio. 2014 Feb 11;5(1):e01001-13. doi: 10.1128/mBio.01001-13. mBio. 2014. PMID: 24520061 Free PMC article.
IMPORTANCE: Mechanistic understanding of how newly replicated bacterial chromosomes are segregated prior to cell division is incomplete. In this work, we provide in vivo experimental support for the view that topoisomerase IV (TopoIV), which decatenates newly …
IMPORTANCE: Mechanistic understanding of how newly replicated bacterial chromosomes are segregated prior to cell division is i …
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