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Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor.
Toyoda Y, Matsuo H, Takada T. Toyoda Y, et al. Hum Cell. 2024 Jul;37(4):1070-1079. doi: 10.1007/s13577-024-01074-x. Epub 2024 May 15. Hum Cell. 2024. PMID: 38750405
Accumulating evidence indicates that ABCC11 wild type is responsible for the high-secretion phenotypes in human apocrine glands including wet type of earwax and the risk of axillary osmidrosis. Also, a less-functional variant of ABCC11 was reportedly a …
Accumulating evidence indicates that ABCC11 wild type is responsible for the high-secretion phenotypes in human apocrine glands inclu …
Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence.
Toyoda Y, Gomi T, Nakagawa H, Nagakura M, Ishikawa T. Toyoda Y, et al. Biomed Res Int. 2016;2016:7670483. doi: 10.1155/2016/7670483. Epub 2016 Feb 23. Biomed Res Int. 2016. PMID: 27057547 Free PMC article. Review.
Here, we describe a simple isothermal genotyping method capable of detecting single nucleotide polymorphisms (SNPs) in the human ATP-binding cassette (ABC) transporter ABCC11 gene and its application to the clinical diagnosis of axillary osmidrosis. We have r …
Here, we describe a simple isothermal genotyping method capable of detecting single nucleotide polymorphisms (SNPs) in the human ATP-binding …
Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition.
Toyoda Y, Takada T, Miyata H, Ishikawa T, Suzuki H. Toyoda Y, et al. PLoS One. 2016 Jun 9;11(6):e0157172. doi: 10.1371/journal.pone.0157172. eCollection 2016. PLoS One. 2016. PMID: 27281343 Free PMC article.
ABCC11 wild-type is responsible for the high-secretion phenotypes in human apocrine glands, such as that of wet-type ear wax, and the risk of axillary osmidrosis. ...These results suggest that N-linked glycosylation is important for the protein stability of …
ABCC11 wild-type is responsible for the high-secretion phenotypes in human apocrine glands, such as that of wet-type ear wax, and the …
Soy Isoflavone Genistein Inhibits an Axillary Osmidrosis Risk Factor ABCC11: In Vitro Screening and Fractional Approach for ABCC11-Inhibitory Activities in Plant Extracts and Dietary Flavonoids.
Saito H, Toyoda Y, Hirata H, Ota-Kontani A, Tsuchiya Y, Takada T, Suzuki H. Saito H, et al. Nutrients. 2020 Aug 14;12(8):2452. doi: 10.3390/nu12082452. Nutrients. 2020. PMID: 32824087 Free PMC article.
Axillary osmidrosis (AO) is a common chronic skin condition characterized by unpleasant body odors emanating from the armpits, and its aetiology is not fully understood. ...Recent studies have revealed that human ATP-binding cassette transporter C11 (ABCC11) …
Axillary osmidrosis (AO) is a common chronic skin condition characterized by unpleasant body odors emanating from the armpits, …
Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method.
Inoue Y, Mori T, Toyoda Y, Sakurai A, Ishikawa T, Mitani Y, Hayashizaki Y, Yoshimura Y, Kurahashi H, Sakai Y. Inoue Y, et al. J Plast Reconstr Aesthet Surg. 2010 Aug;63(8):1369-74. doi: 10.1016/j.bjps.2009.06.029. Epub 2009 Jul 21. J Plast Reconstr Aesthet Surg. 2010. PMID: 19625231
Axillary osmidrosis (AO) is caused by apocrine glands secretions that are converted to odouriferous compounds by bacteria. ...Although the judgement of the degree of AO prevalence is subjective, the SNP 538G> A in ABCC11 is a good genetic biomarker …
Axillary osmidrosis (AO) is caused by apocrine glands secretions that are converted to odouriferous compounds by bacteria. ... …
Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis.
Toyoda Y, Takada T, Gomi T, Nakagawa H, Ishikawa T, Suzuki H. Toyoda Y, et al. Int J Mol Sci. 2017 Feb 15;18(2):417. doi: 10.3390/ijms18020417. Int J Mol Sci. 2017. PMID: 28212277 Free PMC article.
Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 (ABCC11) gene. ...Furthermore, we examined the expression of ABCC11 pro …
Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorp …
Association between the ABCC11 gene polymorphism and the expression of apolipoprotein D by the apocrine glands in axillary osmidrosis.
Zhu Z, Zhang H, Luo G, Xu N, Pan Z. Zhu Z, et al. Mol Med Rep. 2015 Jun;11(6):4463-7. doi: 10.3892/mmr.2015.3274. Epub 2015 Jan 29. Mol Med Rep. 2015. PMID: 25633187
It has been suggested that the adenosine triphosphate-binding cassette sub-family C member 11 (ABCC11) gene polymorphism and apolipoprotein D (ApoD), an odor precursor carrier, may be important in the formation of axillary odor. ...The present study aimed to investi …
It has been suggested that the adenosine triphosphate-binding cassette sub-family C member 11 (ABCC11) gene polymorphism and apolipop …
A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene.
Nakano M, Miwa N, Hirano A, Yoshiura K, Niikawa N. Nakano M, et al. BMC Genet. 2009 Aug 4;10:42. doi: 10.1186/1471-2156-10-42. BMC Genet. 2009. PMID: 19650936 Free PMC article.
Recently, we identified a single-nucleotide polymorphism (SNP; rs17822931) of the ABCC11 gene as the determinant of the earwax types. In the present study, to determine whether the SNP can serve as a diagnostic marker for axillary osmidrosis (AO), we examined …
Recently, we identified a single-nucleotide polymorphism (SNP; rs17822931) of the ABCC11 gene as the determinant of the earwax types. …
[Correlation between estrogen receptor beta and ABCC11 gene single nucleotide polymorphisms and axillary osmidrosis].
Hu R, Guo Y, Long J. Hu R, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 Mar 28;44(3):329-333. doi: 10.11817/j.issn.1672-7347.2019.03.015. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019. PMID: 30971527 Free article. Chinese.
To explore the correlation between single nucleotide polymorphisms (SNPs) of hormone receptor gene or other related genes and axillary osmidrosis (AO). Methods: Whole blood samples of 219 patients with AO and 159 normal people were collected, and their genomic DNA …
To explore the correlation between single nucleotide polymorphisms (SNPs) of hormone receptor gene or other related genes and axillary …
Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics.
Stevens BR, Roesch LFW. Stevens BR, et al. Sci Rep. 2024 Nov 14;14(1):28037. doi: 10.1038/s41598-024-78711-w. Sci Rep. 2024. PMID: 39543265 Free PMC article.
This "meta-organism" symbiotic mutualism results in sweat either with or without odor (osmidrosis), depending on host ABCC11 gene haplotypes. Apocrine metabolism produces odorless S-glutathione conjugate that is transferred by ABCC11 transporters into secreto …
This "meta-organism" symbiotic mutualism results in sweat either with or without odor (osmidrosis), depending on host ABCC11 g …
15 results