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ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE; Alzheimer’ Disease Genetic Consortium, Schellenberg GD, Fardo DW. Nelson PT, et al. Acta Neuropathol. 2014;127(6):825-43. doi: 10.1007/s00401-014-1282-2. Epub 2014 Apr 27. Acta Neuropathol. 2014. PMID: 24770881 Free PMC article.
Hippocampal sclerosis of aging (HS-Aging) is a high-morbidity brain disease in the elderly but risk factors are largely unknown. We report the first genome-wide association study (GWAS) with HS-Aging pathology as an endophenotype.
Hippocampal sclerosis of aging (HS-Aging) is a high-morbidity brain disease in the elderly but risk factors are
Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology.
Nelson PT, Wang WX, Partch AB, Monsell SE, Valladares O, Ellingson SR, Wilfred BR, Naj AC, Wang LS, Kukull WA, Fardo DW. Nelson PT, et al. J Neuropathol Exp Neurol. 2015 Jan;74(1):75-84. doi: 10.1097/NEN.0000000000000151. J Neuropathol Exp Neurol. 2015. PMID: 25470345 Free PMC article.
Hippocampal sclerosis of aging (HS-Aging) is a common high-morbidity neurodegenerative condition in elderly persons. ...The risk for HS-Aging diagnosis associated with these genetic polymorphisms was not secondary to an associat
Hippocampal sclerosis of aging (HS-Aging) is a common high-morbidity neurodegenerative condition in elderly pers
CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.
Fardo DW, Katsumata Y, Kauwe JSK, Deming Y, Harari O, Cruchaga C; Alzheimer's Disease Neuroimaging Initiative, Nelson PT. Fardo DW, et al. Exp Gerontol. 2017 Apr;90:83-89. doi: 10.1016/j.exger.2017.01.025. Epub 2017 Feb 9. Exp Gerontol. 2017. PMID: 28189700 Free PMC article.
OBJECTIVE: Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide poly …
OBJECTIVE: Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested th …
Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe.
Nho K, Saykin AJ; Alzheimer’s Disease Neuroimaging Initiative, Nelson PT. Nho K, et al. J Alzheimers Dis. 2016;52(1):373-83. doi: 10.3233/JAD-160077. J Alzheimers Dis. 2016. PMID: 27003218 Free PMC article.
Hippocampal sclerosis of aging (HS-Aging) is a common brain disease in older adults with a clinical course that is similar to Alzheimer's disease. ...Genetic variation associated with HS-Aging pathology may represent a non-A
Hippocampal sclerosis of aging (HS-Aging) is a common brain disease in older adults with a clinical course that
Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging.
Nelson PT, Wang WX, Wilfred BR, Wei A, Dimayuga J, Huang Q, Ighodaro E, Artiushin S, Fardo DW. Nelson PT, et al. J Neurochem. 2015 Sep;134(6):1026-39. doi: 10.1111/jnc.13202. Epub 2015 Jul 15. J Neurochem. 2015. PMID: 26115089 Free PMC article.
ABCC9 genetic polymorphisms are associated with increased risk for various human diseases including hippocampal sclerosis of aging. ...ABCC9 gene variants are associated with increased risk for hippocampal s
ABCC9 genetic polymorphisms are associated with increased risk for various human diseases including hippocampal
Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging.
Nelson PT, Katsumata Y, Nho K, Artiushin SC, Jicha GA, Wang WX, Abner EL, Saykin AJ, Kukull WA; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Fardo DW. Nelson PT, et al. Acta Neuropathol. 2016 Dec;132(6):841-858. doi: 10.1007/s00401-016-1641-2. Epub 2016 Nov 4. Acta Neuropathol. 2016. PMID: 27815632 Free PMC article.
These SNPs were identified by separate research groups as risk alleles for non-Alzheimer's neurodegeneration. We found that the rs73069071 risk genotype was associated with hippocampal sclerosis (HS) pathology among people with the rs704180 risk genoty …
These SNPs were identified by separate research groups as risk alleles for non-Alzheimer's neurodegeneration. We found that the rs73069071 r …
Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts.
Hokkanen SRK, Kero M, Kaivola K, Hunter S, Keage HAD, Kiviharju A, Raunio A, Tienari PJ, Paetau A, Matthews FE, Fleming J, Graff C, Polvikoski TM, Myllykangas L, Brayne C; EClipSE Collaboration. Hokkanen SRK, et al. Brain Pathol. 2020 Mar;30(2):364-372. doi: 10.1111/bpa.12773. Epub 2019 Aug 27. Brain Pathol. 2020. PMID: 31376286 Free PMC article.
Limbic-predominant age-related TAR-DNA-binding protein-43 (TDP-43) encephalopathy with hippocampal sclerosis pathology (LATE-NC + HS) is a neurodegenerative disorder characterized by severe hippocampal CA1 neuron loss and TDP-43-pathology, leadi …
Limbic-predominant age-related TAR-DNA-binding protein-43 (TDP-43) encephalopathy with hippocampal sclerosis pathology
TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.
Nelson PT, Gal Z, Wang WX, Niedowicz DM, Artiushin SC, Wycoff S, Wei A, Jicha GA, Fardo DW. Nelson PT, et al. Neurobiol Dis. 2019 May;125:67-76. doi: 10.1016/j.nbd.2019.01.013. Epub 2019 Jan 23. Neurobiol Dis. 2019. PMID: 30682540 Free PMC article.
The pathologies were correlated with hippocampal sclerosis of aging (HS-Aging) linked genotypes. ...This is intriguing because the SLCO1A2/IAPP and ABCC9 risk associated genotypes have been associated with altered expression …
The pathologies were correlated with hippocampal sclerosis of aging (HS-Aging) linked genotypes. ...This …