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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
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677 results

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Page 1
ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding.
Chen Q, Schafer CT, Mukherjee S, Gustavsson M, Agrawal P, Yao XQ, Kossiakoff AA, Handel TM, Tesmer JJG. Chen Q, et al. bioRxiv [Preprint]. 2023 Jul 19:2023.07.18.549504. doi: 10.1101/2023.07.18.549504. bioRxiv. 2023. PMID: 37502840 Free PMC article. Preprint.
ACKR3 is notable because it does not couple to G proteins and instead is completely biased towards arrestins. ...Our structures also suggest that the 100% bias of ACKR3 for arrestins is driven by the ability of arrestins, but not G proteins, to bind GRK-phosphorylat …
ACKR3 is notable because it does not couple to G proteins and instead is completely biased towards arrestins. ...Our structures also …
Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway.
Ma Z, Zhou F, Jin H, Wu X. Ma Z, et al. Cells. 2024 Jun 13;13(12):1027. doi: 10.3390/cells13121027. Cells. 2024. PMID: 38920657 Free PMC article. Review.
The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple mechanisms, …
The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression …
CXCR4/ACKR3 Phosphorylation and Recruitment of Interacting Proteins: Key Mechanisms Regulating Their Functional Status.
Fumagalli A, Zarca A, Neves M, Caspar B, Hill SJ, Mayor F Jr, Smit MJ, Marin P. Fumagalli A, et al. Mol Pharmacol. 2019 Dec;96(6):794-808. doi: 10.1124/mol.118.115360. Epub 2019 Mar 5. Mol Pharmacol. 2019. PMID: 30837297 Free article. Review.
In addition, we provide an overview of the current knowledge of CXCR4 and ACKR3 post-translational modifications and an exhaustive list of previously identified CXCR4- or ACKR3-interacting proteins. We then describe studies highlighting the importance of the recipro …
In addition, we provide an overview of the current knowledge of CXCR4 and ACKR3 post-translational modifications and an exhaustive li …
Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology.
Chatterjee M. Chatterjee M. Cells. 2022 Jan 9;11(2):213. doi: 10.3390/cells11020213. Cells. 2022. PMID: 35053329 Free PMC article. Review.
The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1alpha are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7. Platelets express CXCR4, ACKR3/CXCR7, and are a vital source of CXCL12/SDF- …
The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1alpha are executed through the canonical GProteinCoupled …
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.
Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M. Rohlfing AK, et al. Nat Commun. 2022 Apr 5;13(1):1823. doi: 10.1038/s41467-022-29341-1. Nat Commun. 2022. PMID: 35383158 Free PMC article.
Loss of platelet ACKR3 enhances tissue injury in ischemic myocardium and brain and aggravates tissue inflammation. Activation of platelet-ACKR3 via specific ACKR3 agonists inhibits platelet activation and thrombus formation and attenuates tissue injury in isc …
Loss of platelet ACKR3 enhances tissue injury in ischemic myocardium and brain and aggravates tissue inflammation. Activation of plat …
Modulators of CXCR4 and CXCR7/ACKR3 Function.
Adlere I, Caspar B, Arimont M, Dekkers S, Visser K, Stuijt J, de Graaf C, Stocks M, Kellam B, Briddon S, Wijtmans M, de Esch I, Hill S, Leurs R. Adlere I, et al. Mol Pharmacol. 2019 Dec;96(6):737-752. doi: 10.1124/mol.119.117663. Epub 2019 Sep 23. Mol Pharmacol. 2019. PMID: 31548340 Review.
SIGNIFICANCE STATEMENT: To investigate the pharmacological modulation of CXCR4 and ACKR3, significant effort has been focused on the discovery and development of a range of ligands, including small-molecule modulators, pepducins, and synthetic peptides. ...This review aims …
SIGNIFICANCE STATEMENT: To investigate the pharmacological modulation of CXCR4 and ACKR3, significant effort has been focused on the …
Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases.
Duval V, Alayrac P, Silvestre JS, Levoye A. Duval V, et al. Front Endocrinol (Lausanne). 2022 Jun 29;13:906586. doi: 10.3389/fendo.2022.906586. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35846294 Free PMC article. Review.
Here, we summarize the structural determinant characteristic of ACKR3, the molecules targeting this receptor and signaling pathways modulated by ACKR3. Finally, we present and discuss recent findings regarding the role of ACKR3 in CVD....
Here, we summarize the structural determinant characteristic of ACKR3, the molecules targeting this receptor and signaling pathways m …
The Role of ACKR3 in Breast, Lung, and Brain Cancer.
Neves M, Fumagalli A, van den Bor J, Marin P, Smit MJ, Mayor F. Neves M, et al. Mol Pharmacol. 2019 Dec;96(6):819-825. doi: 10.1124/mol.118.115279. Epub 2019 Feb 11. Mol Pharmacol. 2019. PMID: 30745320 Free article. Review.
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumor cell proli …
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3 …
Ackr3-Venus knock-in mouse lights up brain vasculature.
Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BL. Ehrlich AT, et al. Mol Brain. 2021 Sep 28;14(1):151. doi: 10.1186/s13041-021-00862-y. Mol Brain. 2021. PMID: 34583741 Free PMC article.
In ACKR3-Venus knock-in mice, we found normal ACKR3 mRNA levels in the brain, suggesting intact gene transcription. ...In conclusion, we have generated Ackr3-Venus knock-in mice with a traceable ACKR3 receptor, which will be a useful tool to the resear …
In ACKR3-Venus knock-in mice, we found normal ACKR3 mRNA levels in the brain, suggesting intact gene transcription. ...In conc …
Functions of the CXCL12 Receptor ACKR3/CXCR7-What Has Been Perceived and What Has Been Overlooked.
Koch C, Engele J. Koch C, et al. Mol Pharmacol. 2020 Nov;98(5):577-585. doi: 10.1124/molpharm.120.000056. Epub 2020 Sep 3. Mol Pharmacol. 2020. PMID: 32883765 Review.
This disease-associated role presently focuses major interest on the two CXCL12 receptors, CXCR4 and atypical chemokine receptor 3 (ACKR3)/CXCR7, as promising therapeutic targets. Major obstacles in these ongoing efforts are confusing reports on the differential use of eit …
This disease-associated role presently focuses major interest on the two CXCL12 receptors, CXCR4 and atypical chemokine receptor 3 (ACKR3 …
677 results