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46 results

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Page 1
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H. Zhang T, et al. Nat Cancer. 2022 Jan;3(1):75-89. doi: 10.1038/s43018-021-00299-1. Epub 2021 Dec 9. Nat Cancer. 2022. PMID: 35121990
alpha-Enolase 1 (ENO1) is a critical glycolytic enzyme whose aberrant expression drives the pathogenesis of various cancers. ENO1 has been indicated as having additional roles beyond its conventional metabolic activity, but the underlying mechanisms and biological conseque …
alpha-Enolase 1 (ENO1) is a critical glycolytic enzyme whose aberrant expression drives the pathogenesis of various cancers. ENO1 has …
MEMO1 binds iron and modulates iron homeostasis in cancer cells.
Dolgova N, Uhlemann EE, Boniecki MT, Vizeacoumar FS, Ara A, Nouri P, Ralle M, Tonelli M, Abbas SA, Patry J, Elhasasna H, Freywald A, Vizeacoumar FJ, Dmitriev OY. Dolgova N, et al. Elife. 2024 Apr 19;13:e86354. doi: 10.7554/eLife.86354. Elife. 2024. PMID: 38640016 Free PMC article.
Importantly, MEMO1 is overexpressed in many types of cancer and was shown to modulate breast cancer metastasis through altered cell motility. ...We conclude that MEMO1 is an iron-binding protein that modulates iron homeostasis in cancer cells....
Importantly, MEMO1 is overexpressed in many types of cancer and was shown to modulate breast cancer metastasis through altered …
The expression of cuproptosis-related genes in hepatocellular carcinoma and their relationships with prognosis.
Zhao X, Chen J, Yin S, Shi J, Zheng M, He C, Meng H, Han Y, Han J, Guo J, Yuan Z, Wang Y. Zhao X, et al. Front Oncol. 2022 Oct 14;12:992468. doi: 10.3389/fonc.2022.992468. eCollection 2022. Front Oncol. 2022. PMID: 36313717 Free PMC article.
Besides, the role of copper was previously recognized in cancer progression. We evaluated the prognostic value of cuproptosis-related gene expression in hepatocellular carcinoma (HCC). ...RESULTS: Elevated ATP7A, SLC25A3, SCO2, COA6, TMEM199, ATP6AP1, LIPT1, DLAT, PDHA1, M …
Besides, the role of copper was previously recognized in cancer progression. We evaluated the prognostic value of cuproptosis-related …
ACO1 and IREB2 downregulation confer poor prognosis and correlate with autophagy-related ferroptosis and immune infiltration in KIRC.
Zhu T, Xiao Z, Yuan H, Tian H, Chen T, Chen Q, Chen M, Yang J, Zhou Q, Guo W, Xue K, Xia M, Bao J, Yang C, Duan H, Wang H, Huang Z, Liu C, Zhou J. Zhu T, et al. Front Oncol. 2022 Aug 17;12:929838. doi: 10.3389/fonc.2022.929838. eCollection 2022. Front Oncol. 2022. PMID: 36059676 Free PMC article.
Meanwhile, there is a paucity of information about the mechanisms and clinical significance of ACO1 and IREB2 downregulation in renal cancers. METHODS: The expression profiles of ACO1 and IREB2 were assessed using multiple public data sets via several bioinfo …
Meanwhile, there is a paucity of information about the mechanisms and clinical significance of ACO1 and IREB2 downregulation in renal …
Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non-Small Cell Lung Cancer.
Mirhadi S, Zhang W, Pham NA, Karimzadeh F, Pintilie M, Tong J, Taylor P, Krieger J, Pitcher B, Sykes J, Wybenga-Groot L, Fladd C, Xu J, Wang T, Cabanero M, Li M, Weiss J, Sakashita S, Zaslaver O, Yu M, Caudy AA, St-Pierre J, Hawkins C, Kislinger T, Liu G, Shepherd FA, Tsao MS, Moran MF. Mirhadi S, et al. Mol Cancer Res. 2023 Jan 3;21(1):36-50. doi: 10.1158/1541-7786.MCR-22-0163. Mol Cancer Res. 2023. PMID: 36214668 Free PMC article.
The ability of a patient tumor to engraft an immunodeficient mouse is the strongest known independent indicator of poor prognosis in early-stage non-small cell lung cancer (NSCLC). Analysis of primary NSCLC proteomes revealed low-level expression of mitochondrial aconitase …
The ability of a patient tumor to engraft an immunodeficient mouse is the strongest known independent indicator of poor prognosis in early-s …
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis.
Shen T, Wang H, Tang B, Zhu G, Wang X. Shen T, et al. RNA Biol. 2023 Jan;20(1):223-234. doi: 10.1080/15476286.2023.2216562. RNA Biol. 2023. PMID: 37221841 Free PMC article. Review.
In this review, we will discuss the functional roles of RNA binding proteins and their lncRNA partners in TCA cycle, with emphasis placed on the cancer progression. A further understanding of RNA binding proteins and their lncRNA partners in TCA cycle, as well as their mol …
In this review, we will discuss the functional roles of RNA binding proteins and their lncRNA partners in TCA cycle, with emphasis placed on …
Genome-wide identification and analysis of epithelial-mesenchymal transition-related RNA-binding proteins and alternative splicing in a human breast cancer cell line.
Mi Y, Dong M, Zuo X, Cao Q, Gu X, Mi H, Xiao F. Mi Y, et al. Sci Rep. 2024 May 23;14(1):11753. doi: 10.1038/s41598-024-62681-0. Sci Rep. 2024. PMID: 38783078 Free PMC article.
By further analysing above EMT-related RBPs and AS in breast cancer tissues in TCGA, it was found that the expression levels of ADAT2, C2orf15, SRP72, PAICS, RBMS3, APOBEC3G, NOA1, ACO1 and the AS of TNC and COL6A3 were significantly correlated with the prognosis of …
By further analysing above EMT-related RBPs and AS in breast cancer tissues in TCGA, it was found that the expression levels of ADAT2 …
Identification of ferroptosis-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches.
Jia Z, Zhang J, Li Z, Ai L. Jia Z, et al. Int J Biol Macromol. 2024 Dec;282(Pt 3):137117. doi: 10.1016/j.ijbiomac.2024.137117. Epub 2024 Oct 31. Int J Biol Macromol. 2024. PMID: 39488307
Utilizing the LASSO and Support Vector Machine Recursive Feature Elimination (SVW-RFE) algorithms, we identified 10 genes-MT1G, MTOR, BRD4, ACO1, SAT1, PEBP1, LPIN1, ATM, SRXN1, and PRDX1-as key biomarker candidates with significant diagnostic potential. ...
Utilizing the LASSO and Support Vector Machine Recursive Feature Elimination (SVW-RFE) algorithms, we identified 10 genes-MT1G, MTOR, BRD4, …
Autophagy induced by mechanical stress sensitizes cells to ferroptosis by NCOA4-FTH1 axis.
Luo C, Liang H, Ji M, Ye C, Lin Y, Guo Y, Zhang Z, Shu Y, Jin X, Lu S, Lu W, Dang Y, Zhang H, Li B, Zhou G, Zhang Z, Chang L. Luo C, et al. Autophagy. 2025 Jun;21(6):1263-1282. doi: 10.1080/15548627.2025.2469129. Epub 2025 Mar 10. Autophagy. 2025. PMID: 39988734
Ferroptosis is an iron-dependent regulated form of cell death implicated in various diseases, including cancers, with its progression influenced by iron-dependent peroxidation of phospholipids and dysregulation of the redox system. ...In conclusion, our findings demonstrat …
Ferroptosis is an iron-dependent regulated form of cell death implicated in various diseases, including cancers, with its progression …
46 results