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Year Number of Results
1985 1
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1994 1
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1999 2
2000 2
2001 2
2002 2
2003 1
2004 7
2005 13
2006 16
2007 20
2008 48
2009 46
2010 66
2011 65
2012 89
2013 103
2014 107
2015 97
2016 88
2017 89
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1,853 results

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Page 1
ACTB in cancer.
Guo C, Liu S, Wang J, Sun MZ, Greenaway FT. Guo C, et al. Clin Chim Acta. 2013 Feb 18;417:39-44. doi: 10.1016/j.cca.2012.12.012. Epub 2012 Dec 22. Clin Chim Acta. 2013. PMID: 23266771 Review.
However, ACTB is closely associated with a variety of cancers and accumulating evidence indicates that ACTB is de-regulated in liver, melanoma, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, ovarian cancers, leukemia and lymphoma. ACT …
However, ACTB is closely associated with a variety of cancers and accumulating evidence indicates that ACTB is de-regulated in …
ACTB Mutations Analysis and Genotype-Phenotype Correlation in Becker's Nevus.
Dai S, Wang H, Lin Z. Dai S, et al. Biomedicines. 2021 Dec 10;9(12):1879. doi: 10.3390/biomedicines9121879. Biomedicines. 2021. PMID: 34944694 Free PMC article.
Recent studies have revealed that BN patients harbored postzygotic ACTB mutations, which were restricted to arrector pili muscle lineage. We screened for ACTB mutations in 20 Chinese patients with BN and found that recurrent mutations (c.C439A or c.C439T) in ACTB …
Recent studies have revealed that BN patients harbored postzygotic ACTB mutations, which were restricted to arrector pili muscle line …
Further delineation of putative ACTB loss-of-function variants: A 4-patient series.
Baumann M, Beaver EM, Palomares-Bralo M, Santos-Simarro F, Holzer P, Povysil G, Müller T, Valovka T, Janecke AR. Baumann M, et al. Hum Mutat. 2020 Apr;41(4):753-758. doi: 10.1002/humu.23970. Epub 2020 Jan 16. Hum Mutat. 2020. PMID: 31898838 Free PMC article.
ACTB encodes beta-cytoplasmic actin, an essential component of the cytoskeleton. Based on chromosome 7p22.1 deletions that include the ACTB locus and on rare truncating ACTB variants, a phenotype resulting from ACTB haploinsufficiency was recently prop …
ACTB encodes beta-cytoplasmic actin, an essential component of the cytoskeleton. Based on chromosome 7p22.1 deletions that include th …
Mutant ACTB mRNA 3'-UTR promotes hepatocellular carcinoma development by regulating miR-1 and miR-29a.
Li Y, Ma H, Shi C, Feng F, Yang L. Li Y, et al. Cell Signal. 2020 Mar;67:109479. doi: 10.1016/j.cellsig.2019.109479. Epub 2019 Dec 14. Cell Signal. 2020. PMID: 31846694
In recent years, studies demonstrate that ACTB has been found to be associated with various tumors. Although ACTB is dysregulated in numerous cancer types, limited data are available on the potential function and mechanism of ACTB in hepatocellular carcinoma …
In recent years, studies demonstrate that ACTB has been found to be associated with various tumors. Although ACTB is dysregula …
ACTB deletions or single-nucleotide loss-of-function variants: expansion and further delineation of the phenotype and review of the literature.
Lesieur-Sebellin M, Wigby K, Schaefer E, Gouronc A, Chatron N, Poulat AL, Putoux A, Goldenberg A, Quibeuf M, Chambon P, Rondeau S, Barcia G, Levy J, Piard J, Kuentz P, Doco-Fenzy M, Bednarek N, Caumes R, Bouquillon S, Le Caignec C, Patat O, Khau Van Kien P, Chiesa J, Delplancq G, Bacrot S, Brisset S, Ginglinger E, Cantagrel V, Lenberg J, Friedman JR, Rio M, Scheidecker S, Malan V. Lesieur-Sebellin M, et al. J Med Genet. 2025 Oct 8:jmg-2025-110631. doi: 10.1136/jmg-2025-110631. Online ahead of print. J Med Genet. 2025. PMID: 41062261
ACTB encodes beta-actin, a highly conserved protein involved in cell motility, structure and integrity. Deletions including ACTB, and, more rarely, single-nucleotide loss-of-function variants in ACTB have been described in patients with a distinct phenotype i …
ACTB encodes beta-actin, a highly conserved protein involved in cell motility, structure and integrity. Deletions including ACTB …
Post-zygotic ACTB mutations underlie congenital smooth muscle hamartomas.
Atzmony L, Ugwu N, Zaki TD, Antaya RJ, Choate KA. Atzmony L, et al. J Cutan Pathol. 2020 Aug;47(8):681-685. doi: 10.1111/cup.13683. Epub 2020 Apr 6. J Cutan Pathol. 2020. PMID: 32170967 Free PMC article.
BACKGROUND: Congenital smooth muscle hamartomas (CSMHs) are benign lesions that share clinical and histopathological features with Becker nevus, a mosaic disorder associated with post-zygotic ACTB mutations. Given the clinical and histopathological overlap between CSMH and …
BACKGROUND: Congenital smooth muscle hamartomas (CSMHs) are benign lesions that share clinical and histopathological features with Becker ne …
ACTB may serve as a predictive marker for the efficacy of lenvatinib in patients with HBV-related early-stage hepatocellular carcinoma following partial hepatectomy: a retrospective cohort study.
Dong W, Zou M, Sheng J, Zhou W, Wang Y, Zhang Y, Li J, Qian Y, Yu H, Lu T, Pan J, Zhu Y, Qu S, Yang Z, Lin Q, Zhao L, Cong W, Xu B, Zhang C, Liu H, Dong H. Dong W, et al. J Gastrointest Oncol. 2023 Dec 31;14(6):2479-2499. doi: 10.21037/jgo-23-942. Epub 2023 Dec 27. J Gastrointest Oncol. 2023. PMID: 38196518 Free PMC article.
The X-Tile was employed to determine the optimal cut-off point of ACTB levels for predicting time to recurrence (TTR). To assess the correlation between ACTB levels and lenvatinib efficacy, a subgroup analysis of TTR was conducted. ...Moreover, the PDXs derived from …
The X-Tile was employed to determine the optimal cut-off point of ACTB levels for predicting time to recurrence (TTR). To assess the …
ACTB::ZMIZ2-rearranged adnexal carcinoma: a second case.
Dehner C, Pissaloux D, Thamphya B, Tirode F, Von Deimling A, Guo RR, Wieland C, de la Fouchardière A, Kervarrec T. Dehner C, et al. Virchows Arch. 2025 Apr;486(4):871-875. doi: 10.1007/s00428-025-04030-8. Epub 2025 Jan 23. Virchows Arch. 2025. PMID: 39847051
Molecular investigation revealed an in frame ACTB::ZMIZ2 fusion transcript. Clustering analysis revealed close proximity of this case with the ACTB::ZMIZ2-fused adnexal tumor previously reported. Herein, we report a second case of adnexal tumor with ACTB::ZMI …
Molecular investigation revealed an in frame ACTB::ZMIZ2 fusion transcript. Clustering analysis revealed close proximity of this case …
Baraitser-Winter Cerebrofrontofacial Syndrome.
Verloes A, Drunat S, Pilz D, Di Donato N. Verloes A, et al. 2015 Nov 19 [updated 2022 Mar 24]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2015 Nov 19 [updated 2022 Mar 24]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 26583190 Free Books & Documents. Review.
Most individuals with BWCFF syndrome reported to date have the disorder as the result of a de novo ACTB or ACTG1 pathogenic variant. If a parent of the proband has the pathogenic variant identified in the proband, the risk to the sibs of inheriting the pathogenic variant i …
Most individuals with BWCFF syndrome reported to date have the disorder as the result of a de novo ACTB or ACTG1 pathogenic variant. …
1,853 results