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279 results

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Page 1
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation.
Wang L, Shi R, Wang S, Duan Y, Wang Z, Zheng P, Sun X, Chen X, Ji G, Shen Y, Dong B, Lin Y, Wen T, Tian Q, Guo Z, Hou Y, Wu S, Xiao L, Li M, Xiao L, Wu Q, Meng Y, Liu G, Duan S, Bai X, Liu T, Zhang Z, Zhan P, Lu Z, Xu D. Wang L, et al. Nat Chem Biol. 2025 Jun;21(6):894-905. doi: 10.1038/s41589-024-01825-9. Epub 2025 Jan 29. Nat Chem Biol. 2025. PMID: 39881212
As an enzyme with a critical role in de novo purine synthesis, adenylosuccinate lyase (ADSL) expression is upregulated in various malignancies. However, whether ADSL possesses noncanonical functions that contribute to cancer progression remains poorly understood. .. …
As an enzyme with a critical role in de novo purine synthesis, adenylosuccinate lyase (ADSL) expression is upregulated in various mal …
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion.
Duan Y, Hu Z, Han P, Lei B, Wang S, Wang Z, Hou Y, Lin Y, Li M, Xiao L, Wu Q, Meng Y, Liu G, Lou S, Yang L, Bai X, Duan S, Zhan P, Liu T, Lu Z, Xu D. Duan Y, et al. Nat Cell Biol. 2025 Apr;27(4):668-682. doi: 10.1038/s41556-025-01627-8. Epub 2025 Mar 3. Nat Cell Biol. 2025. PMID: 40033100
Phosphorylated ADSL interacts with STING at the endoplasmic reticulum, where ADSL-produced fumarate binds to STING, leading to the inhibition of cGAMP binding to STING, STING activation and subsequent IRF3-dependent cytokine gene expression. Disrupting the ADSL …
Phosphorylated ADSL interacts with STING at the endoplasmic reticulum, where ADSL-produced fumarate binds to STING, leading to …
ADSL-produced fumarate increases BECN1 dimethylation to promote autophagy and liver tumor growth.
Wang L, Ji G, Duan Y, Zheng P, Hu Z, Wang Z, Xu D. Wang L, et al. Autophagy. 2025 Jul;21(7):1616-1617. doi: 10.1080/15548627.2025.2481125. Epub 2025 Mar 27. Autophagy. 2025. PMID: 40103200 Free PMC article.
However, whether ADSL functions in other oncogenic signaling is largely unknown. Here, our recent study shows that ADSL interacts with BECN1 (beclin 1) to regulate macroautophagy/autophagy upon lipid deprivation. Mechanistically, ADSL is phosphorylated at S14 …
However, whether ADSL functions in other oncogenic signaling is largely unknown. Here, our recent study shows that ADSL intera …
ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation.
Bordi M, Testa B, Compagnucci C, Colasuonno F, Cipressa F, Betterini E, Mancini A, Carsetti C, Salvatori I, Ferraina C, Yang M, De Cegli R, Del Prete E, Veroni C, Rizza S, Mauri S, Ziviani E, Macchiaiolo M, Vecchio D, Panfili FM, Rizza T, Weber G, Carrozzo R, Ferri A, Campello S, Ballabio A, Frezza C, Cestra G, Tartaglia M, Bartuli A, Cecconi F. Bordi M, et al. Cell Rep. 2025 Sep 23;44(9):116230. doi: 10.1016/j.celrep.2025.116230. Epub 2025 Sep 5. Cell Rep. 2025. PMID: 40914938 Free PMC article.
Pathway-specific effects of ADSL deficiency on neurodevelopment.
Dutto I, Gerhards J, Herrera A, Souckova O, Škopová V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, Zikánová M, Pons S, Philipp M, Lüders J, Stracker TH. Dutto I, et al. Elife. 2022 Feb 8;11:e70518. doi: 10.7554/eLife.70518. Elife. 2022. PMID: 35133277 Free PMC article.
Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (ADSLD) causes numerous neurodevelopmental pathologies, including microcephaly and autism spectrum disorder. ...ADSL-deficient chicken …
Adenylosuccinate lyase (ADSL) functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency (A …
INSIG1/2 succination mediated by the moonlighting function of ADSL promotes lipogenesis and liver tumorigenesis.
Duan Y, Wang S, Liu J, Qin W, Shen Y, Hou Y, Sun X, Lin Y, Hu Z, Dong B, Bi Y, Yang H, Li M, Xiao L, Wu Q, Bai X, Wang Y, Li G, Ding Y, Mao Z, Luo Y, Lu Z, Liu T, Xu D, Liu S, Zhan P, Wang Z. Duan Y, et al. Nat Commun. 2026 Mar 15;17(1):4002. doi: 10.1038/s41467-026-70583-0. Nat Commun. 2026. PMID: 41833955 Free PMC article.
Clinically, ADSL phosphorylation and INSIG succination correlate with SREBP-1 activation and poor prognosis in human HCC. In summary, these findings reveal a repurposing mechanism by which tumor cells coordinate glucose metabolism and lipogenesis via a moonlighting functio …
Clinically, ADSL phosphorylation and INSIG succination correlate with SREBP-1 activation and poor prognosis in human HCC. In summary, …
Adenylosuccinate lyase (ADSL) is a pan-cancer prognostic and immune biomarker with distinct roles in hepatocellular carcinoma.
Zhu W, Zeng X, Qin J, Qi X, Zhou W. Zhu W, et al. Discov Oncol. 2025 Nov 18;16(1):2119. doi: 10.1007/s12672-025-03749-9. Discov Oncol. 2025. PMID: 41251948 Free PMC article.
BACKGROUND: The role of ADSL in various types of cancer remains inadequately understood. We encompassed a comprehensive examination of the mechanistic features of ADSL and explored its viability as a broad-spectrum predictor for malignancies. ...Moreover, in a broad …
BACKGROUND: The role of ADSL in various types of cancer remains inadequately understood. We encompassed a comprehensive examination o …
ADSL Deficiency - The Lesser-Known Metabolic Epilepsy in Infancy.
Banerjee A, Bhatia V, Didwal G, Singh AK, Saini AG. Banerjee A, et al. Indian J Pediatr. 2021 Mar;88(3):263-265. doi: 10.1007/s12098-020-03435-4. Epub 2020 Jul 18. Indian J Pediatr. 2021. PMID: 32681428
The authors describe a 13-mo-old girl with compound heterozygous variants in the ADSL gene, presenting as early-onset seizures, severe neurological impairment, development delay, and hypotonia. Neuroimaging revealed cerebral atrophy, delayed myelination and diffusion restr …
The authors describe a 13-mo-old girl with compound heterozygous variants in the ADSL gene, presenting as early-onset seizures, sever …
Silencing of Dicer enhances dacarbazine resistance in melanoma cells by inhibiting ADSL expression.
Yeh YW, Hsu TW, Su YH, Wang CH, Liao PH, Chiu CF, Tseng PC, Chen TM, Lee WR, Tzeng YS. Yeh YW, et al. Aging (Albany NY). 2023 Nov 15;15(22):12873-12889. doi: 10.18632/aging.205207. Epub 2023 Nov 15. Aging (Albany NY). 2023. PMID: 37976135 Free PMC article.
Metabolic alterations in tumor cells may interfere with drug response. Adenylosuccinate lyase (ADSL) is a crucial enzyme in the purine metabolism pathway. An imbalance in ADSL may interfere with the therapeutic efficacy of drugs. We discovered that DTIC treatment en …
Metabolic alterations in tumor cells may interfere with drug response. Adenylosuccinate lyase (ADSL) is a crucial enzyme in the purin …
The prevalence of ADSL (rs3788579) and CYP1A2 (rs17861162) polymorphisms in female breast cancer patients in North-West Iran.
Valizadeh Osalo M, Hosseini P, Charkhian H, Soltanzadeh H, Goharkhany S, Tuncer SB. Valizadeh Osalo M, et al. Discov Oncol. 2024 Mar 3;15(1):59. doi: 10.1007/s12672-024-00919-z. Discov Oncol. 2024. PMID: 38433141 Free PMC article.
This study explores the role of CYP1A2-rs17861162 and ADSL-rs3788579 SNPs in breast cancer risk among Iranian women. METHODS: This study involved 200 female breast cancer patients and 200 healthy controls in North-West Iran. ...In ADSL-rs3788579 SNP, breast cancer p …
This study explores the role of CYP1A2-rs17861162 and ADSL-rs3788579 SNPs in breast cancer risk among Iranian women. METHODS: This st …
279 results