Genetic diversity and epidemiology of hantaviruses in Argentina

J Infect Dis. 1998 Mar;177(3):529-38. doi: 10.1086/514221.

Abstract

Phylogenetic analysis of a 292-nucleotide (nt) fragment of the hantavirus M genome segment from 36 rodent and 13 human samples from three known foci of hantavirus infection in Argentina was conducted. A 1654-nt fragment of the M genome segment was analyzed for 1 representative of 7 genetically distinct hantavirus lineages identified. Additionally, the nt sequence of the complete M genome segments of Lechiguanas, Oran, and Hu39694 hantavirus genotypes was determined. nt sequence comparisons reveal that 7 hantavirus lineages from Argentina differ from each other by 11.5%-21.8% and from Sin Nombre, Bayou, and Black Creek Canal viruses by 23.8%-26.5%. Phylogenetic analyses demonstrate that they form a unique, separate branch within the clade containing other New World sigmodontine-borne hantaviruses. Most Oligoryzomys-borne hantavirus genotypes clearly map together. The Oligoryzomys-borne genotypes Lechiguanas, Oran, and Andes appear to be associated with human disease. Oligoryzomys longicaudatus was identified as the likely rodent reservoir for Andes virus.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Argentina / epidemiology
  • Disease Reservoirs
  • Hantavirus Infections / epidemiology
  • Hantavirus Infections / veterinary*
  • Hantavirus Infections / virology
  • Hantavirus Pulmonary Syndrome / epidemiology
  • Hantavirus Pulmonary Syndrome / virology*
  • Humans
  • Molecular Sequence Data
  • Muridae / virology
  • Orthohantavirus / classification*
  • Orthohantavirus / genetics
  • Phylogeny
  • Rodent Diseases / epidemiology
  • Rodent Diseases / virology*

Associated data

  • GENBANK/AF028029
  • GENBANK/AF028030
  • GENBANK/AF028031
  • GENBANK/AF028032
  • GENBANK/AF028033
  • GENBANK/AF028034
  • GENBANK/AF028035
  • GENBANK/AF028036
  • GENBANK/AF028037
  • GENBANK/AF028038
  • GENBANK/AF028039
  • GENBANK/AF028040
  • GENBANK/AF028041
  • GENBANK/AF028042
  • GENBANK/AF028043
  • GENBANK/AF028044
  • GENBANK/AF028045
  • GENBANK/AF028046
  • GENBANK/AF028047
  • GENBANK/AF028048
  • GENBANK/AF028049
  • GENBANK/AF028050
  • GENBANK/AF028051
  • GENBANK/AF028052
  • GENBANK/AF028053
  • GENBANK/AF028054
  • GENBANK/AF028055
  • GENBANK/AF028056
  • GENBANK/AF028057
  • GENBANK/AF028058