Abstract
Phylogenetic analysis of a 292-nucleotide (nt) fragment of the hantavirus M genome segment from 36 rodent and 13 human samples from three known foci of hantavirus infection in Argentina was conducted. A 1654-nt fragment of the M genome segment was analyzed for 1 representative of 7 genetically distinct hantavirus lineages identified. Additionally, the nt sequence of the complete M genome segments of Lechiguanas, Oran, and Hu39694 hantavirus genotypes was determined. nt sequence comparisons reveal that 7 hantavirus lineages from Argentina differ from each other by 11.5%-21.8% and from Sin Nombre, Bayou, and Black Creek Canal viruses by 23.8%-26.5%. Phylogenetic analyses demonstrate that they form a unique, separate branch within the clade containing other New World sigmodontine-borne hantaviruses. Most Oligoryzomys-borne hantavirus genotypes clearly map together. The Oligoryzomys-borne genotypes Lechiguanas, Oran, and Andes appear to be associated with human disease. Oligoryzomys longicaudatus was identified as the likely rodent reservoir for Andes virus.
Publication types
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Case Reports
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Argentina / epidemiology
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Disease Reservoirs
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Hantavirus Infections / epidemiology
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Hantavirus Infections / veterinary*
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Hantavirus Infections / virology
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Hantavirus Pulmonary Syndrome / epidemiology
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Hantavirus Pulmonary Syndrome / virology*
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Humans
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Molecular Sequence Data
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Muridae / virology
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Orthohantavirus / classification*
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Orthohantavirus / genetics
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Phylogeny
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Rodent Diseases / epidemiology
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Rodent Diseases / virology*
Associated data
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GENBANK/AF028029
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GENBANK/AF028030
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GENBANK/AF028031
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GENBANK/AF028032
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GENBANK/AF028033
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GENBANK/AF028058