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1996 3
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211 results

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Page 1
DEK::AFF2 Fusion Carcinomas of Head and Neck.
Ruangritchankul K, Sandison A. Ruangritchankul K, et al. Adv Anat Pathol. 2023 Mar 1;30(2):86-94. doi: 10.1097/PAP.0000000000000376. Epub 2022 Oct 12. Adv Anat Pathol. 2023. PMID: 36221219 Review.
A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. ...This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and patte …
A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkerati …
DEK::AFF2 Fusion-Associated Squamous Cell Carcinoma: A Case Series with Literature Review on an Emerging and Challenging Entity.
Amin SE, Lewis JS Jr, Bridge JA, Hang JF, Naik U, Bishop JA, Saluja K. Amin SE, et al. Head Neck Pathol. 2024 Sep 23;18(1):86. doi: 10.1007/s12105-024-01690-x. Head Neck Pathol. 2024. PMID: 39312022 Free PMC article. Review.
On morphologic review of these 30 cases, 6 were worrisome for DEK::AFF2 SCC and were selected for AFF2 immunohistochemical stain (IHC), of which 3 cases were positive. All 3 AFF2 IHC positive cases were also positive for DEK::AFF2 fusion by fluorescenc …
On morphologic review of these 30 cases, 6 were worrisome for DEK::AFF2 SCC and were selected for AFF2 immunohistochemical sta …
DEK::AFF2 Carcinoma of the Sinonasal Tract and Skull Base: A Comprehensive Review.
Rivera JP, Kuo YJ, Hang JF. Rivera JP, et al. Surg Pathol Clin. 2024 Dec;17(4):587-597. doi: 10.1016/j.path.2024.07.008. Epub 2024 Aug 17. Surg Pathol Clin. 2024. PMID: 39489551 Review.
An accurate diagnosis requires the recognition of these key histologic features, followed by molecular confirmation. Recently, AFF2 immunohistochemistry has been demonstrated to be a sensitive and specific ancillary marker. This comprehensive review summarizes the current …
An accurate diagnosis requires the recognition of these key histologic features, followed by molecular confirmation. Recently, AFF2 i …
An intragenic duplication in the AFF2 gene associated with Cornelia de Lange syndrome phenotype.
Lucia-Campos C, Parenti I, Latorre-Pellicer A, Gil-Salvador M, Bestetti I, Finelli P, Larizza L, Arnedo M, Ayerza-Casas A, Del Rincón J, Trujillano L, Morte B, Pérez-Jurado LA, Lapunzina P, Leitão E, Beygo J, Lich C, Kilpert F, Kaya S, Depienne C, Kaiser FJ, Ramos FJ, Puisac B, Pié J. Lucia-Campos C, et al. Front Genet. 2024 Nov 1;15:1472543. doi: 10.3389/fgene.2024.1472543. eCollection 2024. Front Genet. 2024. PMID: 39553472 Free PMC article.
Consistent with the phenotypical differences observed between the mother and the aunt, there is a marked difference in X-inactivation patterns skewing. Given the crucial role of AFF2 in transcriptional regulation, it is not surprising that AFF2 variants can give ris …
Consistent with the phenotypical differences observed between the mother and the aunt, there is a marked difference in X-inactivation patter …
AFF2 Is Associated With X-Linked Partial (Focal) Epilepsy With Antecedent Febrile Seizures.
Zou D, Qin B, Wang J, Shi Y, Zhou P, Yi Y, Liao J, Lu X. Zou D, et al. Front Mol Neurosci. 2022 Mar 30;15:795840. doi: 10.3389/fnmol.2022.795840. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35431806 Free PMC article.
OBJECTIVE: AFF2 mutations were associated with X-linked intellectual developmental disorder-109 and in males with autism spectrum disorder (ASD). ...CONCLUSION: AFF2 is potentially a candidate causative gene of X-link partial epilepsy with antecedent febrile seizure …
OBJECTIVE: AFF2 mutations were associated with X-linked intellectual developmental disorder-109 and in males with autism spectrum dis …
DEK::AFF2 Squamous Cell Carcinomas of the Sinonasal Region and Temporal Bone Diagnosed After Recurrences: A Report of Two Patients.
Owosho AA, Gleysteen JP, Wood CB, Franklin A, Angel J, Jain R. Owosho AA, et al. Int J Surg Pathol. 2025 Aug;33(5):1258-1266. doi: 10.1177/10668969241301061. Epub 2025 Jan 17. Int J Surg Pathol. 2025. PMID: 39819065 Review.
DEK::AFF2 squamous cell carcinoma is a recently recognized entity characterized by a non-viral-related non-keratinizing squamous cell carcinoma with chromosomal rearrangement between DEK on 6p22.3 and AFF2 on Xq28. ...In this article, we report on 2 patients with DE …
DEK::AFF2 squamous cell carcinoma is a recently recognized entity characterized by a non-viral-related non-keratinizing squamous cell …
DEK::AFF2-Associated Papillary Squamous Cell Carcinoma of the Sinonasal Tract: Clinicopathologic Characterization of 9 Cases.
Zhao Y, Fu Y, Wang W, Peng H, Wang S. Zhao Y, et al. Head Neck Pathol. 2025 May 20;19(1):66. doi: 10.1007/s12105-025-01799-7. Head Neck Pathol. 2025. PMID: 40392381 Free PMC article.
PURPOSE: To delineate the clinicopathological and molecular characteristics of DEK::AFF2 fusion-associated carcinomas to elucidate their biological drivers and refine therapeutic strategies. ...All cases demonstrated nuclear positivity for p40/p63 and AFF2 (30% ~90% …
PURPOSE: To delineate the clinicopathological and molecular characteristics of DEK::AFF2 fusion-associated carcinomas to elucidate th …
Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375/TAB2 axis.
Zhi L, Liang J, Huang W, Ma J, Qing Z, Wang X. Zhi L, et al. Exp Mol Pathol. 2021 Apr;119:104617. doi: 10.1016/j.yexmp.2021.104617. Epub 2021 Jan 31. Exp Mol Pathol. 2021. PMID: 33535081
RNA pull-down assay was used to select the miRNA target of circ_AFF2. The interaction between miR-375 and circ_AFF2 or TAB2 was analyzed using the dual-luciferase reporter assay. ...In addition, circ_AFF2 could interact with miR-375 and the function of circ_ …
RNA pull-down assay was used to select the miRNA target of circ_AFF2. The interaction between miR-375 and circ_AFF2 or TAB2 wa …
DEK :: AFF2 Fusion Sinonasal and Skull Base Nonkeratinizing Squamous Cell Carcinoma : A Clinical Outcome Study Compared With Conventional Sinonasal Squamous Cell Carcinoma.
Hart SA, Hang JF, Chernock RD, Mikula MW, Rooper L, Amin SE, Saluja K, Bishop JA, Chen YH, Cipriani NA, David SN, Dupont WD, Plummer WD, Ferrer KT, Geromes A, Hsieh MS, Hernandez-Prera JC, Kuo YJ, Sasaki E, Shi Q, Truong T, Velez Torres JM, Lewis JS Jr. Hart SA, et al. Am J Surg Pathol. 2025 Feb 1;49(2):130-137. doi: 10.1097/PAS.0000000000002335. Epub 2024 Dec 25. Am J Surg Pathol. 2025. PMID: 39719672
We solicited cases of molecularly or AFF2 immunohistochemistry (IHC) proven DEK :: AFF2 SCC from surgical pathologists to collect patient demographic, clinical, and outcome data. ...Ki-67 immunohistochemistry was performed. We also compared the DEK :: AFF2 su …
We solicited cases of molecularly or AFF2 immunohistochemistry (IHC) proven DEK :: AFF2 SCC from surgical pathologists to coll …
Case Report: "DEK::AFF2 fusion associated sinonasal carcinomas: a novel oncogenic driver and emerging therapeutic strategies".
Knebel M, Agaimy A, Kühn JP, Körner S, Braun F, Brust L, Flockerzi V, Wemmert S, Balensiefer B, Schick B, Yilmaz U, Zaito M, Bozzato A, Linxweiler M. Knebel M, et al. Front Immunol. 2025 Jul 4;16:1611790. doi: 10.3389/fimmu.2025.1611790. eCollection 2025. Front Immunol. 2025. PMID: 40688086 Free PMC article.
BACKGROUND: DEK::AFF2 fusion-associated carcinomas of the sinonasal tract are exceedingly rare, with fewer than 100 cases reported worldwide, but probably underrecognized. ...CONCLUSION: These cases highlight the aggressive nature of DEK::AFF2 fusion-associated carc …
BACKGROUND: DEK::AFF2 fusion-associated carcinomas of the sinonasal tract are exceedingly rare, with fewer than 100 cases reported wo …
211 results