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188 results

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Page 1
DEK::AFF2 Fusion Carcinomas of Head and Neck.
Ruangritchankul K, Sandison A. Ruangritchankul K, et al. Adv Anat Pathol. 2023 Mar 1;30(2):86-94. doi: 10.1097/PAP.0000000000000376. Epub 2022 Oct 12. Adv Anat Pathol. 2023. PMID: 36221219 Review.
A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. ...This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and patte …
A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkerati …
DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA. Rooper LM, et al. Am J Surg Pathol. 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. Am J Surg Pathol. 2021. PMID: 34049316
This study aims to characterize a larger cohort of carcinomas with DEK-AFF2 fusions to assess whether they truly constitute a distinctive entity. Among 27 sinonasal and skull base nonkeratinizing squamous cell carcinoma that were negative for human papillomavirus and Epste …
This study aims to characterize a larger cohort of carcinomas with DEK-AFF2 fusions to assess whether they truly constitute a distinc …
DEK::AFF2 Fusion-Associated Squamous Cell Carcinoma: A Case Series with Literature Review on an Emerging and Challenging Entity.
Amin SE, Lewis JS Jr, Bridge JA, Hang JF, Naik U, Bishop JA, Saluja K. Amin SE, et al. Head Neck Pathol. 2024 Sep 23;18(1):86. doi: 10.1007/s12105-024-01690-x. Head Neck Pathol. 2024. PMID: 39312022 Review.
On morphologic review of these 30 cases, 6 were worrisome for DEK::AFF2 SCC and were selected for AFF2 immunohistochemical stain (IHC), of which 3 cases were positive. All 3 AFF2 IHC positive cases were also positive for DEK::AFF2 fusion by fluorescenc …
On morphologic review of these 30 cases, 6 were worrisome for DEK::AFF2 SCC and were selected for AFF2 immunohistochemical sta …
DEK::AFF2 Carcinoma of the Sinonasal Tract and Skull Base: A Comprehensive Review.
Rivera JP, Kuo YJ, Hang JF. Rivera JP, et al. Surg Pathol Clin. 2024 Dec;17(4):587-597. doi: 10.1016/j.path.2024.07.008. Epub 2024 Aug 17. Surg Pathol Clin. 2024. PMID: 39489551 Review.
An accurate diagnosis requires the recognition of these key histologic features, followed by molecular confirmation. Recently, AFF2 immunohistochemistry has been demonstrated to be a sensitive and specific ancillary marker. This comprehensive review summarizes the current …
An accurate diagnosis requires the recognition of these key histologic features, followed by molecular confirmation. Recently, AFF2 i …
AFF2 Is Associated With X-Linked Partial (Focal) Epilepsy With Antecedent Febrile Seizures.
Zou D, Qin B, Wang J, Shi Y, Zhou P, Yi Y, Liao J, Lu X. Zou D, et al. Front Mol Neurosci. 2022 Mar 30;15:795840. doi: 10.3389/fnmol.2022.795840. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35431806 Free PMC article.
OBJECTIVE: AFF2 mutations were associated with X-linked intellectual developmental disorder-109 and in males with autism spectrum disorder (ASD). ...CONCLUSION: AFF2 is potentially a candidate causative gene of X-link partial epilepsy with antecedent febrile seizure …
OBJECTIVE: AFF2 mutations were associated with X-linked intellectual developmental disorder-109 and in males with autism spectrum dis …
Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts.
Qu W, Jiang L, Hou G. Qu W, et al. J Orthop Surg Res. 2021 Mar 2;16(1):165. doi: 10.1186/s13018-021-02306-8. J Orthop Surg Res. 2021. PMID: 33653372 Free PMC article.
Circ-AFF2 downregulation played an opposite role. Circ-AFF2 targeted miR-650, and miR-650 downregulation reversed the effect of circ-AFF2 interference on RAFLS processes. ...CONCLUSION: Circ-AFF2 promoted proliferation, inflammatory response, migration …
Circ-AFF2 downregulation played an opposite role. Circ-AFF2 targeted miR-650, and miR-650 downregulation reversed the effect o …
Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375/TAB2 axis.
Zhi L, Liang J, Huang W, Ma J, Qing Z, Wang X. Zhi L, et al. Exp Mol Pathol. 2021 Apr;119:104617. doi: 10.1016/j.yexmp.2021.104617. Epub 2021 Jan 31. Exp Mol Pathol. 2021. PMID: 33535081
RNA pull-down assay was used to select the miRNA target of circ_AFF2. The interaction between miR-375 and circ_AFF2 or TAB2 was analyzed using the dual-luciferase reporter assay. ...In addition, circ_AFF2 could interact with miR-375 and the function of circ_ …
RNA pull-down assay was used to select the miRNA target of circ_AFF2. The interaction between miR-375 and circ_AFF2 or TAB2 wa …
DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology.
Kuo YJ, Lewis JS Jr, Zhai C, Chen YA, Chernock RD, Hsieh MS, Lan MY, Lee CK, Weinreb I, Hang JF. Kuo YJ, et al. Mod Pathol. 2021 Oct;34(10):1820-1830. doi: 10.1038/s41379-021-00846-2. Epub 2021 Jun 9. Mod Pathol. 2021. PMID: 34108636 Free article.
A novel DEK-AFF2 fusion has been recently identified in four cases of basaloid to nonkeratinizing squamous cell carcinoma (SCC) in the sinonasal tract and middle ear with high-grade morphology. ...Therefore, we propose the new terminology "DEK-AFF2 fusion-associated …
A novel DEK-AFF2 fusion has been recently identified in four cases of basaloid to nonkeratinizing squamous cell carcinoma (SCC) in th …
DEK :: AFF2 Fusion Sinonasal and Skull Base Nonkeratinizing Squamous Cell Carcinoma : A Clinical Outcome Study Compared With Conventional Sinonasal Squamous Cell Carcinoma.
Hart SA, Hang JF, Chernock RD, Mikula MW, Rooper L, Amin SE, Saluja K, Bishop JA, Chen YH, Cipriani NA, David SN, Dupont WD, Plummer WD, Ferrer KT, Geromes A, Hsieh MS, Hernandez-Prera JC, Kuo YJ, Sasaki E, Shi Q, Truong T, Velez Torres JM, Lewis JS Jr. Hart SA, et al. Am J Surg Pathol. 2025 Feb 1;49(2):130-137. doi: 10.1097/PAS.0000000000002335. Epub 2024 Dec 25. Am J Surg Pathol. 2025. PMID: 39719672
We solicited cases of molecularly or AFF2 immunohistochemistry (IHC) proven DEK :: AFF2 SCC from surgical pathologists to collect patient demographic, clinical, and outcome data. ...Ki-67 immunohistochemistry was performed. We also compared the DEK :: AFF2 su …
We solicited cases of molecularly or AFF2 immunohistochemistry (IHC) proven DEK :: AFF2 SCC from surgical pathologists to coll …
Sinonasal Adenosquamous Carcinoma - Morphology and Genetic Drivers Including Low- and High-Risk Human Papillomavirus mRNA, DEK::AFF2 Fusion, and MAML2 Rearrangement.
Holliday D Jr, Mehrad M, Ely KA, Tong F, Wang X, Hang JF, Kuo YJ, Velez-Torres JM, Lott-Limbach A, Lewis JS Jr. Holliday D Jr, et al. Head Neck Pathol. 2023 Jun;17(2):487-497. doi: 10.1007/s12105-023-01538-w. Epub 2023 Feb 28. Head Neck Pathol. 2023. PMID: 36849671 Free PMC article.
They were tested for p16 expression by immunohistochemistry (70% cut-off), DEK::AFF2 fusion by fluorescence in situ hybridization (FISH) and AFF2 immunohistochemistry, MAML2 rearrangement by FISH, and low- and high-risk HPV by RNA ISH and reverse transcription PCR, …
They were tested for p16 expression by immunohistochemistry (70% cut-off), DEK::AFF2 fusion by fluorescence in situ hybridization (FI …
188 results