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Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.

Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, Kitazawa M, Matusow B, Nguyen H, West BL, Green KN. Elmore MR, et al. Neuron. 2014 Apr 16;82(2):380-97. doi: 10.1016/j.neuron.2014.02.040. Neuron. 2014. PMID: 24742461 Free PMC article.

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Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MR, Blurton-Jones M, West BL, Green KN. Spangenberg EE, et al. Brain. 2016 Apr;139(Pt 4):1265-81. doi: 10.1093/brain/aww016. Epub 2016 Feb 26. Brain. 2016. PMID: 26921617 Free PMC article.

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.

Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Kayed R, et al. Science. 2003 Apr 18;300(5618):486-9. doi: 10.1126/science.1079469. Science. 2003. PMID: 12702875 Free article.

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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.

Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. Sosna J, et al. Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. Mol Neurodegener. 2018. PMID: 29490706 Free PMC article.

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Exercise builds brain health: key roles of growth factor cascades and inflammation.

Cotman CW, Berchtold NC, Christie LA. Cotman CW, et al. Trends Neurosci. 2007 Sep;30(9):464-72. doi: 10.1016/j.tins.2007.06.011. Epub 2007 Aug 31. Trends Neurosci. 2007. PMID: 17765329 Review.

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Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.

Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P; Alzheimer’s Disease Cooperative Study. Galasko DR, et al. Arch Neurol. 2012 Jul;69(7):836-41. doi: 10.1001/archneurol.2012.85. Arch Neurol. 2012. PMID: 22431837 Free PMC article. Clinical Trial.

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A dramatic increase of C1q protein in the CNS during normal aging.

Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L, Tsai HH, Huang EJ, Rowitch DH, Berns DS, Tenner AJ, Shamloo M, Barres BA. Stephan AH, et al. J Neurosci. 2013 Aug 14;33(33):13460-74. doi: 10.1523/JNEUROSCI.1333-13.2013. J Neurosci. 2013. PMID: 23946404 Free PMC article.

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Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice.

Dagher NN, Najafi AR, Kayala KM, Elmore MR, White TE, Medeiros R, West BL, Green KN. Dagher NN, et al. J Neuroinflammation. 2015 Aug 1;12:139. doi: 10.1186/s12974-015-0366-9. J Neuroinflammation. 2015. PMID: 26232154 Free PMC article.

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Structural classification of toxic amyloid oligomers.

Glabe CG. Glabe CG. J Biol Chem. 2008 Oct 31;283(44):29639-43. doi: 10.1074/jbc.R800016200. Epub 2008 Aug 22. J Biol Chem. 2008. PMID: 18723507 Free PMC article. Review.

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Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy.

Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. Vasilevko V, et al. Ann N Y Acad Sci. 2010 Oct;1207:58-70. doi: 10.1111/j.1749-6632.2010.05786.x. Ann N Y Acad Sci. 2010. PMID: 20955427 Free PMC article. Review.

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