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192 results

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Page 1
AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway.
Mak HY, Ouyang Q, Tumanov S, Xu J, Rong P, Dong F, Lam SM, Wang X, Lukmantara I, Du X, Gao M, Brown AJ, Gong X, Shui G, Stocker R, Huang X, Chen S, Yang H. Mak HY, et al. Nat Commun. 2021 Nov 25;12(1):6877. doi: 10.1038/s41467-021-27279-4. Nat Commun. 2021. PMID: 34824276 Free PMC article.
Paradoxically, AGPAT2 deficiency is known to dramatically increase the level of its product, PA. Here, we find that AGPAT2 deficiency impairs the biogenesis and growth of lipid droplets. We show that AGPAT2 deficiency compromises the stability of CDP-diacylgl …
Paradoxically, AGPAT2 deficiency is known to dramatically increase the level of its product, PA. Here, we find that AGPAT2 def …
Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr(-/-) mice.
Peng K, Chen X, Pei K, Wang X, Ma X, Liang C, Dong Q, Liu Z, Han M, Liu G, Yang H, Zheng M, Liu G, Gao M. Peng K, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166850. doi: 10.1016/j.bbadis.2023.166850. Epub 2023 Aug 15. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37591406 Free article.
This study will investigate the effect of Agpat2 on hyperlipidemia and atherosclerosis. METHODS AND RESULTS: In this study, Agpat2 knockout (Agpat2(-/-)) mice were generated using CRISPR/Cas system, which showed severe loss of adipose tissue and fatty liver, …
This study will investigate the effect of Agpat2 on hyperlipidemia and atherosclerosis. METHODS AND RESULTS: In this study, Agpat2 …
Transcriptional Inhibition of AGPAT2 Induces Abnormal Lipid Metabolism and Oxidative Stress in the Liver of Nile Tilapia Oreochromis niloticus.
Feng T, Tao Y, Yan Y, Lu S, Li Y, Zhang X, Qiang J. Feng T, et al. Antioxidants (Basel). 2023 Mar 12;12(3):700. doi: 10.3390/antiox12030700. Antioxidants (Basel). 2023. PMID: 36978948 Free PMC article.
The enzyme 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) is an intermediate enzyme in triglyceride synthesis. The aim was to study the regulatory mechanism of AGPAT2 on Nile tilapia, Oreochromis niloticus. ...The liver cells became severely vacuolated and …
The enzyme 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) is an intermediate enzyme in triglyceride synthesis. The aim was t …
Absence of AGPAT2 impairs brown adipogenesis, increases IFN stimulated gene expression and alters mitochondrial morphology.
Tapia PJ, Figueroa AM, Eisner V, González-Hódar L, Robledo F, Agarwal AK, Garg A, Cortés V. Tapia PJ, et al. Metabolism. 2020 Oct;111:154341. doi: 10.1016/j.metabol.2020.154341. Epub 2020 Aug 15. Metabolism. 2020. PMID: 32810486
Agpat2 deficient (Agpat2(-/-)) mice completely lacks both white and interscapular brown adipose tissue (iBAT). The objective of the present study was to characterize the effects of AGPAT2 deficiency in brown adipocyte differentiation. METHODS: Preadipocytes o …
Agpat2 deficient (Agpat2(-/-)) mice completely lacks both white and interscapular brown adipose tissue (iBAT). The objective o …
AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue.
Cautivo KM, Lizama CO, Tapia PJ, Agarwal AK, Garg A, Horton JD, Cortés VA. Cautivo KM, et al. Mol Metab. 2016 May 13;5(7):491-505. doi: 10.1016/j.molmet.2016.05.004. eCollection 2016 Jul. Mol Metab. 2016. PMID: 27408775 Free PMC article.
Phospholipid profiling was determined by electrospray ionization tandem mass spectrometry (ESI-MS/MS). RESULTS: In contrast to adult Agpat2 (-/-) mice, fetuses and newborn Agpat2 (-/-) mice have normal mass of white and brown adipose tissue. ...Furthermore, differen …
Phospholipid profiling was determined by electrospray ionization tandem mass spectrometry (ESI-MS/MS). RESULTS: In contrast to adult Agpa …
Decreased caveolae in AGPAT2 lacking adipocytes is independent of changes in cholesterol or sphingolipid levels: A whole cell and plasma membrane lipidomic analysis of adipogenesis.
González-Hódar L, McDonald JG, Vale G, Thompson BM, Figueroa AM, Tapia PJ, Robledo F, Agarwal AK, Garg A, Horton JD, Cortés V. González-Hódar L, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Sep 1;1867(9):166167. doi: 10.1016/j.bbadis.2021.166167. Epub 2021 May 12. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 33989739 Free article.
Lipidome changes were quantified in differentiated Agpat2(-/-) adipocytes to identify lipids with potential adipogenic roles. METHODS: Agpat2(-/-) and wild type brown preadipocytes were differentiated in vitro. ...Abnormal lipid composition is associated with the ad …
Lipidome changes were quantified in differentiated Agpat2(-/-) adipocytes to identify lipids with potential adipogenic roles. METHODS …
AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism.
Fernández-Galilea M, Tapia P, Cautivo K, Morselli E, Cortés VA. Fernández-Galilea M, et al. Biochem Biophys Res Commun. 2015 Nov 6;467(1):39-45. doi: 10.1016/j.bbrc.2015.09.128. Epub 2015 Sep 28. Biochem Biophys Res Commun. 2015. PMID: 26417690
The aim of this study was to determine whether impaired autophagy or excessive cell death underlie the adipogenic inability of Agpat2(-/-) mice preadipocytes. METHODS: Preadipocytes were isolated from interscapular brown adipose tissue (BAT) of Agpat2(-/-) and Ag …
The aim of this study was to determine whether impaired autophagy or excessive cell death underlie the adipogenic inability of Agpat2 …
Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue.
Agarwal AK, Tunison K, Vale G, McDonald JG, Li X, Scherer PE, Horton JD, Garg A. Agarwal AK, et al. iScience. 2023 Sep 1;26(10):107806. doi: 10.1016/j.isci.2023.107806. eCollection 2023 Oct 20. iScience. 2023. PMID: 37752957 Free PMC article.
The mechanism by which Agpat2 deficiency results in loss of adipose tissue remains unknown. We studied this by re-expressing human AGPAT2 (hAGPAT2) in Agpat2-null mice, regulated by doxycycline. ...Furthermore, the stromal vascular fraction cells of regenerat …
The mechanism by which Agpat2 deficiency results in loss of adipose tissue remains unknown. We studied this by re-expressing human …
Leu124Serfs*26, a novel AGPAT2 mutation in congenital generalized lipodystrophy with early cardiovascular complications.
Montenegro Junior RM, Lima GEDCP, Fernandes VO, Montenegro APDR, Ponte CMM, Martins LV, Pinheiro DP, de Moraes MEA, de Moraes Filho MO, d'Alva CB. Montenegro Junior RM, et al. Diabetol Metab Syndr. 2020 Apr 6;12:28. doi: 10.1186/s13098-020-00538-y. eCollection 2020. Diabetol Metab Syndr. 2020. PMID: 32280377 Free PMC article.
BACKGROUND: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by the near-total loss of subcutaneous adipose tissue soon after birth, resulting in ectopic fat deposition and severe metabolic disturbances. Most cases are caused by A …
BACKGROUND: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by the near-total loss of subcut …
Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations.
Subauste AR, Das AK, Li X, Elliott BG, Evans C, El Azzouny M, Treutelaar M, Oral E, Leff T, Burant CF. Subauste AR, et al. Diabetes. 2012 Nov;61(11):2922-31. doi: 10.2337/db12-0004. Epub 2012 Aug 7. Diabetes. 2012. PMID: 22872237 Free PMC article.
In the current study, we investigated the adipogenic defect associated with AGPAT2 mutations. Adipogenesis was studied in muscle-derived multipotent cells (MDMCs) isolated from vastus lateralis biopsies obtained from controls and subjects harboring AGPAT2 mutations …
In the current study, we investigated the adipogenic defect associated with AGPAT2 mutations. Adipogenesis was studied in muscle-deri …
192 results