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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
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2,716 results

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Page 1
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.
Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T. Višnjić D, et al. Cells. 2021 May 4;10(5):1095. doi: 10.3390/cells10051095. Cells. 2021. PMID: 34064363 Free PMC article.
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. ...This review aims to give an overview of the present knowledge on AMPK-dependent and AMPK-independent effects of AICAr on meta …
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activ …
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Fu Y, Hou J, Yang Q, Lin Y, Rui N, Wang J, Wu H, Yu B. Fu Y, et al. J Nanobiotechnology. 2025 Jul 5;23(1):486. doi: 10.1186/s12951-025-03543-3. J Nanobiotechnology. 2025. PMID: 40616103 Free PMC article.
A novel nanoliposome composite hydrogel, Gel@Lipo@AICAR, has been successfully developed for the targeted delivery of AICAR. The intra-articular administration of Gel@Lipo@AICAR demonstrated excellent biosafety and therapeutic potential in mitigating the prog …
A novel nanoliposome composite hydrogel, Gel@Lipo@AICAR, has been successfully developed for the targeted delivery of AICAR. T …
Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating Mitophagy.
Chandrasekaran K, Choi J, Salimian M, Hedayat AF, Russell JW. Chandrasekaran K, et al. Int J Mol Sci. 2024 Dec 25;26(1):80. doi: 10.3390/ijms26010080. Int J Mol Sci. 2024. PMID: 39795939 Free PMC article.
We investigated the impact of an exercise mimetic, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), on DPN. AICAR treatment prevented or reversed experimental DPN in mouse models of both T2D and T1D. ...However, AICAR's protection in DPN in T2D m …
We investigated the impact of an exercise mimetic, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), on DPN. AICAR treatm …
AICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats.
Choksey A, Carter RD, Thackray BD, Ball V, Kennedy BWC, Ha LHT, Sharma E, Broxholme J, Castro-Guarda M, Murphy MP, Heather LC, Tyler DJ, Timm KN. Choksey A, et al. J Mol Cell Cardiol. 2024 Jun;191:12-22. doi: 10.1016/j.yjmcc.2024.04.011. Epub 2024 Apr 21. J Mol Cell Cardiol. 2024. PMID: 38643934 Free article.
In line with our hypothesis, AICAR improved cardiac systolic function. AICAR furthermore improved cardiac mitochondrial fatty acid oxidation, independent of mitochondrial number, and in the absence of observable AMPK-activation. ...Though it is unclear whether AI …
In line with our hypothesis, AICAR improved cardiac systolic function. AICAR furthermore improved cardiac mitochondrial fatty …
AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity.
Fassett EK, Mayer B, Fassett JT. Fassett EK, et al. Cell Mol Life Sci. 2025 Nov 13;82(1):395. doi: 10.1007/s00018-025-05905-4. Cell Mol Life Sci. 2025. PMID: 41231272 Free PMC article.
Here, we identified a novel mechanism by which pretreatment with AICAr protects neonatal rat cardiomyocytes against doxorubicin toxicity. Despite increasing AMPKThr172 and ULK1Ser555 phosphorylation, AICAr suppressed cardiomyocyte LC3 lipidation and caused accumulat …
Here, we identified a novel mechanism by which pretreatment with AICAr protects neonatal rat cardiomyocytes against doxorubicin toxic …
AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative stress and promoting mesothelial cell repair.
Wu Y, Duan X, Gao Z, Yang N, Xue F. Wu Y, et al. PLoS One. 2022 Sep 1;17(9):e0272928. doi: 10.1371/journal.pone.0272928. eCollection 2022. PLoS One. 2022. PMID: 36048820 Free PMC article.
RESULTS: The rats in the AICAR-treated group had fewer adhesion formation incidences and a reduced Nair's score. ...The ROS, SOD, Catalase, Gpx, MDA levels and fiber thickness were decreased by AICAR treatments compared to the control. However, the NO production, Nr …
RESULTS: The rats in the AICAR-treated group had fewer adhesion formation incidences and a reduced Nair's score. ...The ROS, SOD, Cat …
AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes.
Hinkle JS, Rivera CN, Vaughan RA. Hinkle JS, et al. Biochimie. 2022 Apr;195:77-85. doi: 10.1016/j.biochi.2021.11.004. Epub 2021 Nov 16. Biochimie. 2022. PMID: 34798200
Interestingly, branched-chain alpha-keto acid dehydrogenase a (BCKDHa) protein was significantly increased following AICAR-treatment suggesting increased overall BCAA catabolic capacity in AICAR-treated cells. Together, these experiments demonstrate AICAR/AMP …
Interestingly, branched-chain alpha-keto acid dehydrogenase a (BCKDHa) protein was significantly increased following AICAR-treatment …
AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.
Ahmad I, Molyvdas A, Jian MY, Zhou T, Traylor AM, Cui H, Liu G, Song W, Agarwal A, Jilling T, Aggarwal S, Matalon S. Ahmad I, et al. Eur Respir J. 2021 Dec 23;58(6):2003694. doi: 10.1183/13993003.03694-2020. Print 2021 Dec. Eur Respir J. 2021. PMID: 34049949 Free PMC article.
RESULTS: There was a marked downregulation of phosphorylated AMPK and LKB1 in lung tissues and in L2 and H441 cells post exposure. AICAR increased survival in C57BL/6 but not in HO-1(-/-) mice. In WT mice, AICAR decreased lung injury and restored phosphorylated AMPK …
RESULTS: There was a marked downregulation of phosphorylated AMPK and LKB1 in lung tissues and in L2 and H441 cells post exposure. AICAR …
An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.
Aftab F, Rodriguez-Fuguet A, Silva L, Kobayashi IS, Sun J, Politi K, Levantini E, Zhang W, Kobayashi SS, Zhang WC. Aftab F, et al. Br J Cancer. 2023 May;128(9):1647-1664. doi: 10.1038/s41416-023-02196-z. Epub 2023 Feb 21. Br J Cancer. 2023. PMID: 36810913 Free PMC article.
RESULTS: AICAR reduced EGFR-mutant tumour cell growth by inducing DNA damage and apoptosis. MUC1 was one of the leading AICAR-binding and degrading proteins. ...AICAR reduced EGFR-mutant cell line-derived tumour formation in vivo. Co-treating patient and tran …
RESULTS: AICAR reduced EGFR-mutant tumour cell growth by inducing DNA damage and apoptosis. MUC1 was one of the leading AICAR- …
AMPK activation by AICAR reduces diet induced fatty liver in C57BL/6 mice.
Krishnan U A, Viswanathan P, Venkataraman AC. Krishnan U A, et al. Tissue Cell. 2023 Jun;82:102054. doi: 10.1016/j.tice.2023.102054. Epub 2023 Mar 2. Tissue Cell. 2023. PMID: 36913846
We aimed to study the effect of AICAR on lipid levels, oxidant-antioxidant balance, AMPK and mTOR activation and FOXO3 gene expression in liver of mice model. ...For the last two weeks, groups 3 and 4 were administered AICAR (150 mg/kg bw/day, i.p.) while groups 1 a …
We aimed to study the effect of AICAR on lipid levels, oxidant-antioxidant balance, AMPK and mTOR activation and FOXO3 gene expressio …
2,716 results