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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 2
1985 3
1986 1
1989 2
1990 2
1991 4
1992 3
1993 2
1994 4
1995 4
1996 3
1997 2
1999 1
2000 4
2001 2
2002 5
2003 1
2004 1
2005 4
2006 8
2007 8
2008 5
2009 5
2010 6
2011 6
2012 5
2013 5
2014 7
2015 6
2016 8
2017 6
2018 6
2019 5
2020 4
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150 results

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Page 1
Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis.
Zhang S, Xie Y, Yan F, Zhang Y, Yang Z, Chen Z, Zhao Y, Huang Z, Cai L, Deng Z. Zhang S, et al. Autophagy. 2022 Sep;18(9):2229-2245. doi: 10.1080/15548627.2021.2016231. Epub 2021 Dec 29. Autophagy. 2022. PMID: 34964701 Free PMC article.
NPWT treatment can potentially be adopted for therapy of bone defects.Abbreviations: ADP, adenosine diphosphate; AICAR/Aic, acadesine; ALP, alkaline phosphatase; ALPL, alkaline phosphatase, biomineralization associated; AMP, adenosine monophosphate; AMPK, AMP-activa …
NPWT treatment can potentially be adopted for therapy of bone defects.Abbreviations: ADP, adenosine diphosphate; AICAR/Aic, acades …
CD137L promotes immune surveillance in melanoma via HLTF regulation.
Liang L, Zhu L, Li X, Zhou W, Zhang Y, Hung MC, Zhang G, Chen Y, Kuang X, Su J, Liu J, Chen X, Liu H. Liang L, et al. Nat Commun. 2025 Sep 26;16(1):8478. doi: 10.1038/s41467-025-63338-w. Nat Commun. 2025. PMID: 41006211 Free PMC article.
Mechanistically, helicase-like transcription factor (HLTF) is identified as a pivotal transcriptional regulator of CD137L, controlling its expression through phosphorylation of serine at position 398. Therapeutically, the AMPK agonist AICAR (acadesine) as an inducer …
Mechanistically, helicase-like transcription factor (HLTF) is identified as a pivotal transcriptional regulator of CD137L, controlling its e …
Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.
Galiñanes M, Bullough D, Mullane KM, Hearse DJ. Galiñanes M, et al. Circulation. 1992 Aug;86(2):589-97. doi: 10.1161/01.cir.86.2.589. Circulation. 1992. PMID: 1638724
BACKGROUND: We have shown that acadesine (AICAr: 5-amino-4-imidazole carboxamide riboside) improves the early recovery of function of the ischemic and reperfused rat heart. ...Two sets of four groups (n = 8 per group) were studied (one set with 30 minutes and the ot …
BACKGROUND: We have shown that acadesine (AICAr: 5-amino-4-imidazole carboxamide riboside) improves the early recovery of func …
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.
Robert G, Ben Sahra I, Puissant A, Colosetti P, Belhacene N, Gounon P, Hofman P, Bost F, Cassuto JP, Auberger P. Robert G, et al. PLoS One. 2009 Nov 18;4(11):e7889. doi: 10.1371/journal.pone.0007889. PLoS One. 2009. PMID: 19924252 Free PMC article.
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) a compound with known antileukemic effect on …
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The eff …
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.
Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T. Višnjić D, et al. Cells. 2021 May 4;10(5):1095. doi: 10.3390/cells10051095. Cells. 2021. PMID: 34064363 Free PMC article.
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. ...This review aims to give an overview of the present knowledge on AMPK-dependent and AMPK-independent effects of AICAr on meta …
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activ …
Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma.
Montraveta A, Xargay-Torrent S, López-Guerra M, Rosich L, Pérez-Galán P, Salaverria I, Beà S, Kalko SG, de Frias M, Campàs C, Roué G, Colomer D. Montraveta A, et al. Oncotarget. 2014 Feb 15;5(3):726-39. doi: 10.18632/oncotarget.1455. Oncotarget. 2014. PMID: 24519895 Free PMC article.
Here we observed that acadesine exerted a selective antitumoral activity in the majority of MCL cell lines and primary MCL samples, independently of adverse cytogenetic factors. Moreover, acadesine was highly synergistic, both in vitro and in vivo, with the anti-CD2 …
Here we observed that acadesine exerted a selective antitumoral activity in the majority of MCL cell lines and primary MCL samples, i …
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes.
Campàs C, Lopez JM, Santidrián AF, Barragán M, Bellosillo B, Colomer D, Gil J. Campàs C, et al. Blood. 2003 May 1;101(9):3674-80. doi: 10.1182/blood-2002-07-2339. Epub 2003 Jan 9. Blood. 2003. PMID: 12522004 Free article.
Incubation of B-CLL cells with acadesine induced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), indicating that it is activated by acadesine. ...Normal B lymphocytes were as sensitive as B-CLL cells to acadesine-induced apopto …
Incubation of B-CLL cells with acadesine induced the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), indi …
Acadesine extends the window of protection afforded by ischaemic preconditioning.
Tsuchida A, Yang XM, Burckhartt B, Mullane KM, Cohen MV, Downey JM. Tsuchida A, et al. Cardiovasc Res. 1994 Mar;28(3):379-83. doi: 10.1093/cvr/28.3.379. Cardiovasc Res. 1994. PMID: 8174159
OBJECTIVE: The aim was to test whether acadesine (5-amino-4-imidazolecarboxamide riboside, AICAR), an adenosine regulating agent which increases tissue adenosine during ischaemia, could prolong the window of protection from ischaemic preconditioning. ...Although SPT …
OBJECTIVE: The aim was to test whether acadesine (5-amino-4-imidazolecarboxamide riboside, AICAR), an adenosine regulating age …
Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.
Galiñanes M, Mullane KM, Bullough D, Hearse DJ. Galiñanes M, et al. Circulation. 1992 Aug;86(2):598-608. doi: 10.1161/01.cir.86.2.598. Circulation. 1992. PMID: 1638725
For these reasons, the protective properties of acadesine (AICAr: 5-amino-4-imidazole carboxamide riboside) were assessed in a rat model of myocardial ischemia and reperfusion. ...CONCLUSIONS: Acadesine improves the ability of the heart to recover from ischem …
For these reasons, the protective properties of acadesine (AICAr: 5-amino-4-imidazole carboxamide riboside) were assessed in a …
Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig.
Lasley RD, Randhawa MP Jr, Hegge JO, Mentzer RM. Lasley RD, et al. Can J Physiol Pharmacol. 1999 Apr;77(4):259-67. Can J Physiol Pharmacol. 1999. PMID: 10535674
5-Amino-4-imidazolecarboxamide riboside (AICAr) or acadesine has been proposed to exert cardioprotection by enhancing adenosine production in ischemic myocardium. However, there are conflicting reports on acadesine's effects in ischemic myocardium and few stu …
5-Amino-4-imidazolecarboxamide riboside (AICAr) or acadesine has been proposed to exert cardioprotection by enhancing adenosin …
150 results