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ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A.
Wang Y, Wu J, Luo W, Zhang H, Shi G, Shen Y, Zhu Y, Ma C, Dai B, Ye D, Zhu Y. Wang Y, et al. Cell Death Dis. 2021 Jul 1;12(7):661. doi: 10.1038/s41419-021-03947-7. Cell Death Dis. 2021. PMID: 34210956 Free PMC article.
Our results showed the upregulation of ALPK2 in bladder cancer, and data mining of TCGA database showed the association between ALPK2 and pathological parameters of patients with bladder cancer. ...Moreover, the overexpression of DEPDC1A can rescue the …
Our results showed the upregulation of ALPK2 in bladder cancer, and data mining of TCGA database showed the association betwee …
Knockdown of ALPK2 inhibits the development and progression of Ovarian Cancer.
Zhu X, Yan S, Xiao S, Xue M. Zhu X, et al. Cancer Cell Int. 2020 Jun 24;20:267. doi: 10.1186/s12935-020-01347-z. eCollection 2020. Cancer Cell Int. 2020. PMID: 32595416 Free PMC article.
BACKGROUND: Alpha protein kinase 2 (ALPK2) was known to play a vital role in cancer by regulating cell cycle and DNA repair. Ovarian cancer (OC) is one of the most lethal malignancies in the female reproductive system. The emphasis of this study is to explore …
BACKGROUND: Alpha protein kinase 2 (ALPK2) was known to play a vital role in cancer by regulating cell cycle and DNA repair. O …
Hsa_circ_0065217 promotes growth and metastasis of renal cancer through regulating the miR-214-3p-ALPK2 axis.
Yan JS, Chen Q, Li YL, Gao YQ. Yan JS, et al. Cell Cycle. 2021 Dec;20(23):2519-2530. doi: 10.1080/15384101.2021.1991123. Epub 2021 Oct 27. Cell Cycle. 2021. PMID: 34705617 Free PMC article.
Moreover, ALPK2 overexpression reversed hsa_circ_0065217 knockdown effects on RCC cell-line malignancy. Thus, hsa_circ_0065217/miR-214-3p/ALPK2 signaling putatively promotes RCC tumorigenesis and is a putative RCC treatment target....
Moreover, ALPK2 overexpression reversed hsa_circ_0065217 knockdown effects on RCC cell-line malignancy. Thus, hsa_circ_0065217/miR-21 …
Alpha Protein Kinase 2 Promotes Esophageal Cancer via Integrin Alpha 11.
Ainiwaer J, Zhang L, Niyazi M, Awut E, Zheng S, Sheyhidin I, Dai J. Ainiwaer J, et al. Biomed Res Int. 2022 Jun 29;2022:7676582. doi: 10.1155/2022/7676582. eCollection 2022. Biomed Res Int. 2022. Retraction in: Biomed Res Int. 2023 Dec 29;2023:9831830. doi: 10.1155/2023/9831830. PMID: 35813220 Free PMC article. Retracted.
Among the alpha protein kinases, alpha protein kinase 2 (ALPK2) presumably has a connection with EC, but it has never been revealed before. METHODS: In this study, IHC analysis was used for ALPK2 expression quantification in ES tissues. ...CONCLUSIONS: ALPK2 …
Among the alpha protein kinases, alpha protein kinase 2 (ALPK2) presumably has a connection with EC, but it has never been revealed b …
Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer.
Liu H, Zhou L, Cheng H, Wang S, Luan W, Cai E, Ye X, Zhu H, Cui H, Li Y, Chang X. Liu H, et al. Chin Med J (Engl). 2023 Dec 20;136(24):2974-2982. doi: 10.1097/CM9.0000000000002328. Epub 2023 Jun 8. Chin Med J (Engl). 2023. PMID: 37284741 Free PMC article.
BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the biggest cause of gynecological cancer-related mortality because of its extremely metastatic nature. ...Differentially expressed genes (DEGs) were selected to evaluate the effects on the prognosis and progre …
BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the biggest cause of gynecological cancer-related mortality because of …
An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.
Nishi K, Luo H, Nakabayashi K, Doi K, Ishikura S, Iwaihara Y, Yoshida Y, Tanisawa K, Arai T, Mori S, Sawabe M, Muramatsu M, Tanaka M, Sakata T, Shirasawa S, Tsunoda T. Nishi K, et al. Anticancer Res. 2017 Jul;37(7):3855-3862. doi: 10.21873/anticanres.11765. Anticancer Res. 2017. PMID: 28668886
The aim of this study was to determine the association between ALPK2 germline variants and colorectal cancer. MATERIALS AND METHODS: Missense single nucleotide variants in the exons of the ALPK2 gene in 2,343 consecutive autopsy cases (1,446 cases with can …
The aim of this study was to determine the association between ALPK2 germline variants and colorectal cancer. MATERIALS AND ME …
Knockdown of ALPK2 blocks development and progression of renal cell carcinoma.
Jiang J, Han P, Qian J, Zhang S, Wang S, Cao Q, Shao P. Jiang J, et al. Exp Cell Res. 2020 Jul 15;392(2):112029. doi: 10.1016/j.yexcr.2020.112029. Epub 2020 Apr 21. Exp Cell Res. 2020. PMID: 32330508
The influence of ALPK2 knockdown on tumor growth in vivo was evaluated by mice xenograft models. The results demonstrated that ALPK2 was upregulated in tumor tissues of RCC and its high expression was significantly associated with advanced stage and poor prognosis. …
The influence of ALPK2 knockdown on tumor growth in vivo was evaluated by mice xenograft models. The results demonstrated that ALP …
ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model.
Yoshida Y, Tsunoda T, Doi K, Fujimoto T, Tanaka Y, Ota T, Ogawa M, Matsuzaki H, Kuroki M, Iwasaki A, Shirasawa S. Yoshida Y, et al. Anticancer Res. 2012 Jun;32(6):2301-8. Anticancer Res. 2012. PMID: 22641666
MATERIALS AND METHODS: We established a specific anti-alpha-kinase 2 (ALPK2) antibody and addressed the ALPK2 function in HKe3 cells, which are HCT116 cells with a disruption in oncogenic KRAS, in a 3D colonic-crypt model. ...Furthermore, ALPK2 siRNA reduced …
MATERIALS AND METHODS: We established a specific anti-alpha-kinase 2 (ALPK2) antibody and addressed the ALPK2 function in HKe3 …
Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer.
Győrffy B. Győrffy B. Geroscience. 2023 Jun;45(3):1889-1898. doi: 10.1007/s11357-023-00742-4. Epub 2023 Mar 1. Geroscience. 2023. PMID: 36856946 Free PMC article.
Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually at an advanced stage, there is a high demand for reliable prognostic biomarkers capable of the selection of effective chemo- and targeted therapies. ...Our results help to prioritize …
Progress in ovarian cancer treatment lags behind other tumor types. With diagnosis usually at an advanced stage, there is a high dema …
Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines.
Junnila S, Kokkola A, Karjalainen-Lindsberg ML, Puolakkainen P, Monni O. Junnila S, et al. BMC Cancer. 2010 Mar 1;10:73. doi: 10.1186/1471-2407-10-73. BMC Cancer. 2010. PMID: 20187983 Free PMC article.
BACKGROUND: Gastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer related death. Gene copy number alterations play an important role in the development of gastric cancer and a change in gene copy number is …
BACKGROUND: Gastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer related …
20 results