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Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends.
Lin H, Li D, Zhu J, Liu S, Li J, Yu T, Tuchin VV, Semyachkina-Glushkovskaya O, Zhu D. Lin H, et al. Neurophotonics. 2024 Jan;11(1):010601. doi: 10.1117/1.NPh.11.1.010601. Epub 2024 Feb 5. Neurophotonics. 2024. PMID: 38317779 Free PMC article. Review.
Pharmacological treatment is hampered by the blood-brain barrier, limiting drug delivery to the central nervous system (CNS). Transcranial photobiomodulation (tPBM) is a promising technology for treating brain diseases, due to its effectiveness, non-invasiveness, and affor …
Pharmacological treatment is hampered by the blood-brain barrier, limiting drug delivery to the central nervous system (CNS). Transcranial …
The emerging field of non-invasive brain stimulation in Alzheimer's disease.
Koch G, Altomare D, Benussi A, Bréchet L, Casula EP, Dodich A, Pievani M, Santarnecchi E, Frisoni GB. Koch G, et al. Brain. 2024 Dec 3;147(12):4003-4016. doi: 10.1093/brain/awae292. Brain. 2024. PMID: 39562009 Free PMC article. Review.
Amelioration has been shown in preclinical studies on behaviour of transgenic mouse models for Alzheimer's pathology and in clinical studies with variable severity of cognitive impairment. ...Here we review the most encouraging protocols based on repetitive transcra …
Amelioration has been shown in preclinical studies on behaviour of transgenic mouse models for Alzheimer's pathology and in cl …
Photobiomodulation for Hypertension and Alzheimer's Disease.
Valverde A, Mitrofanis J. Valverde A, et al. J Alzheimers Dis. 2022;90(3):1045-1055. doi: 10.3233/JAD-220632. J Alzheimers Dis. 2022. PMID: 36189597 Free PMC article. Review.
Although the cause(s) of Alzheimer's disease in the majority of cases remains elusive, it has long been associated with hypertension. ...In this review, we explore the idea that photobiomodulation, the application of specific wavelengths of light …
Although the cause(s) of Alzheimer's disease in the majority of cases remains elusive, it has long been associated with …
Photobiomodulation for Neurodegenerative Diseases: A Scoping Review.
Shen Q, Guo H, Yan Y. Shen Q, et al. Int J Mol Sci. 2024 Jan 28;25(3):1625. doi: 10.3390/ijms25031625. Int J Mol Sci. 2024. PMID: 38338901 Free PMC article.
Based on the characteristics of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), which have prolonged incubation periods and protracted courses, exploring non-invasive physical therapy methods is essentia …
Based on the characteristics of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease …
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Yang L, Wu C, Parker E, Li Y, Dong Y, Tucker L, Brann DW, Lin HW, Zhang Q. Yang L, et al. Theranostics. 2022 Feb 14;12(5):2205-2231. doi: 10.7150/thno.70756. eCollection 2022. Theranostics. 2022. PMID: 35265207 Free PMC article.
Alzheimer's disease (AD) is the most common form of dementia in the elderly, causing neuronal degeneration and cognitive deficits that significantly impair independence and quality of life for those affected and their families. ...The present work evaluated t …
Alzheimer's disease (AD) is the most common form of dementia in the elderly, causing neuronal degeneration and cognitiv …
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer's disease.
Chen H, Li N, Liu N, Zhu H, Ma C, Ye Y, Shi X, Luo G, Dong X, Tan T, Wei X, Yin H. Chen H, et al. Alzheimers Res Ther. 2025 Apr 5;17(1):72. doi: 10.1186/s13195-025-01714-w. Alzheimers Res Ther. 2025. PMID: 40188044 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease. Amyloid beta-protein (Abeta) is one of the key pathological features of AD, which is cytotoxic and can damage neurons, thereby causing cognitive dysfunction. Photobiomodulation …
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease. Amyloid beta-protein (Abeta) is one of the …
Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome.
Bicknell B, Liebert A, Borody T, Herkes G, McLachlan C, Kiat H. Bicknell B, et al. Int J Mol Sci. 2023 May 31;24(11):9577. doi: 10.3390/ijms24119577. Int J Mol Sci. 2023. PMID: 37298527 Free PMC article. Review.
This link suggests not only that the gut microbiota composition can be used to make an early diagnosis of neurodegenerative and neurodevelopmental diseases but also that modifying the gut microbiome to influence the microbiome-gut-brain axis might present a therapeutic target for …
This link suggests not only that the gut microbiota composition can be used to make an early diagnosis of neurodegenerative and neurodevelop …
Shining light on the head: Photobiomodulation for brain disorders.
Hamblin MR. Hamblin MR. BBA Clin. 2016 Oct 1;6:113-124. doi: 10.1016/j.bbacli.2016.09.002. eCollection 2016 Dec. BBA Clin. 2016. PMID: 27752476 Free PMC article. Review.
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. ...The brain suffers from many different disorders that can be cla …
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue th …
Photobiomodulation and visual stimulation against cognitive decline and Alzheimer's disease pathology: A systematic review.
Monteiro F, Carvalho Ó, Sousa N, Silva FS, Sotiropoulos I. Monteiro F, et al. Alzheimers Dement (N Y). 2022 Nov 25;8(1):e12249. doi: 10.1002/trc2.12249. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 36447479 Free PMC article. Review.
INTRODUCTION: Given the ineffectiveness of the available drug treatment against Alzheimer disease (AD), light-based therapeutic modalities have been increasingly receiving attention with photobiomodulation (PBM) and, more recently, visual stimulation ( …
INTRODUCTION: Given the ineffectiveness of the available drug treatment against Alzheimer disease (AD), light-based the …
Exosomes Derived from M2 Microglial Cells Modulated by 1070-nm Light Improve Cognition in an Alzheimer's Disease Mouse Model.
Chen C, Bao Y, Xing L, Jiang C, Guo Y, Tong S, Zhang J, Chen L, Mao Y. Chen C, et al. Adv Sci (Weinh). 2023 Nov;10(32):e2304025. doi: 10.1002/advs.202304025. Epub 2023 Sep 13. Adv Sci (Weinh). 2023. PMID: 37702115 Free PMC article.
Near-infrared photobiomodulation has been identified as a potential strategy for Alzheimer's disease (AD). ...This study highlights the critical role of exosomes derive from 1070-nm light-modulated microglia in treating AD mice, which may provid …
Near-infrared photobiomodulation has been identified as a potential strategy for Alzheimer's disease (AD). ...Th …
Recent Mechanisms of Neurodegeneration and Photobiomodulation in the Context of Alzheimer's Disease.
Su M, Nizamutdinov D, Liu H, Huang JH. Su M, et al. Int J Mol Sci. 2023 May 25;24(11):9272. doi: 10.3390/ijms24119272. Int J Mol Sci. 2023. PMID: 37298224 Free PMC article. Review.
Alzheimer's disease (AD) is a neurodegenerative disease and the world's primary cause of dementia, a condition characterized by significant progressive declines in memory and intellectual capacities. While dementia is the main symptom of Alzheimer …
Alzheimer's disease (AD) is a neurodegenerative disease and the world's primary cause of dementia, a condition c …
Photobiomodulation Therapy and the Glymphatic System: Promising Applications for Augmenting the Brain Lymphatic Drainage System.
Salehpour F, Khademi M, Bragin DE, DiDuro JO. Salehpour F, et al. Int J Mol Sci. 2022 Mar 10;23(6):2975. doi: 10.3390/ijms23062975. Int J Mol Sci. 2022. PMID: 35328396 Free PMC article. Review.
An impaired brain glymphatic system can increase the incidence of neurovascular, neuroinflammatory, and neurodegenerative diseases. Photobiomodulation (PBM) therapy can serve as a non-invasive neuroprotective strategy for maintaining and optimizing effective brain w …
An impaired brain glymphatic system can increase the incidence of neurovascular, neuroinflammatory, and neurodegenerative diseases. Photo …
Mystery of gamma wave stimulation in brain disorders.
Deng Q, Wu C, Parker E, Zhu J, Liu TC, Duan R, Yang L. Deng Q, et al. Mol Neurodegener. 2024 Dec 18;19(1):96. doi: 10.1186/s13024-024-00785-x. Mol Neurodegener. 2024. PMID: 39695746 Free PMC article. Review.
These methods include sensory stimulation, optogenetic modulation, photobiomodulation, and transcranial electrical or magnetic stimulation. Simultaneously, we explore the association between abnormal gamma oscillations and central nervous system disorders such as Alzhei …
These methods include sensory stimulation, optogenetic modulation, photobiomodulation, and transcranial electrical or magnetic stimul …
Treatment of Neurodegeneration: Integrating Photobiomodulation and Neurofeedback in Alzheimer's Dementia and Parkinson's: A Review.
Berman MH, Nichols TW. Berman MH, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):623-634. doi: 10.1089/photob.2019.4685. Photobiomodul Photomed Laser Surg. 2019. PMID: 31647776 Review.
Objective: A review of photobiomodulation (PBM) in Alzheimer's dementia is submitted. The addition of PBM in neurodegenerative diseases is a dual modality that is at present gaining traction as it is safe, antiviral, and anti-inflammatory for treating neurode …
Objective: A review of photobiomodulation (PBM) in Alzheimer's dementia is submitted. The addition of PBM in neurodegen …
Brain photobiomodulation: a potential treatment in Alzheimer's and Parkinson's diseases.
Blivet G, Touchon B, Cavadore H, Guillemin S, Pain F, Weiner M, Sabbagh M, Moro C, Touchon J. Blivet G, et al. J Prev Alzheimers Dis. 2025 Aug;12(7):100185. doi: 10.1016/j.tjpad.2025.100185. Epub 2025 Apr 25. J Prev Alzheimers Dis. 2025. PMID: 40287365 Free PMC article. Review.
Alzheimer's Disease (AD) and Parkinson's Disease (PD) are common neurodegenerative diseases, characterized by the progressive loss of synapses and neurons, leading to cognitive and motor decline. ...However, their exploratory design and inconsistent qu …
Alzheimer's Disease (AD) and Parkinson's Disease (PD) are common neurodegenerative diseases, characterized by th …
Devices used for photobiomodulation of the brain-a comprehensive and systematic review.
Fernandes F, Oliveira S, Monteiro F, Gasik M, Silva FS, Sousa N, Carvalho Ó, Catarino SO. Fernandes F, et al. J Neuroeng Rehabil. 2024 Apr 10;21(1):53. doi: 10.1186/s12984-024-01351-8. J Neuroeng Rehabil. 2024. PMID: 38600582 Free PMC article.
A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical and cadaveric approaches, in which light stimuli were applied to the head and/or neck. ...There is a la …
A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revi …
Photobiomodulation and the brain: a new paradigm.
Hennessy M, Hamblin MR. Hennessy M, et al. J Opt. 2017 Jan;19(1):013003. doi: 10.1088/2040-8986/19/1/013003. Epub 2016 Dec 14. J Opt. 2017. PMID: 28580093 Free PMC article.
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. ...Other groups have studied stroke (animal models and clinical trial …
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR …
Current application and future directions of photobiomodulation in central nervous diseases.
Yang M, Yang Z, Wang P, Sun Z. Yang M, et al. Neural Regen Res. 2021 Jun;16(6):1177-1185. doi: 10.4103/1673-5374.300486. Neural Regen Res. 2021. PMID: 33269767 Free PMC article. Review.
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions. ...We reviewed 95 papers and analyzed. Photobiomodulation has wide applicability in the treatm …
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neur …
Photobiomodulation for the aging brain.
Cardoso FDS, Gonzalez-Lima F, Gomes da Silva S. Cardoso FDS, et al. Ageing Res Rev. 2021 Sep;70:101415. doi: 10.1016/j.arr.2021.101415. Epub 2021 Jul 26. Ageing Res Rev. 2021. PMID: 34325071 Review.
As a consequence, the number of cases of age-related cognitive decline and neurological diseases associated with aging, such as Alzheimer's and Parkinson's, has been increasing. Among the non-pharmacological interventions studied for the treatment or prevention of a …
As a consequence, the number of cases of age-related cognitive decline and neurological diseases associated with aging, such as Alzheimer …
Photobiomodulation Therapy for Dementia: A Systematic Review of Pre-Clinical and Clinical Studies.
Salehpour F, Khademi M, Hamblin MR. Salehpour F, et al. J Alzheimers Dis. 2021;83(4):1431-1452. doi: 10.3233/JAD-210029. J Alzheimers Dis. 2021. PMID: 33935090
BACKGROUND: Photobiomodulation (PBM) involves the use of red and/or near-infrared light from lasers or LEDs to improve a wide range of medical disorders. ...METHODS: Literature was searched between 1967 and 2020 using a range of keywords relevant to PBM and dementia …
BACKGROUND: Photobiomodulation (PBM) involves the use of red and/or near-infrared light from lasers or LEDs to improve a wide …
Photobiomodulation in experimental models of Alzheimer's disease: state-of-the-art and translational perspectives.
Huang Z, Hamblin MR, Zhang Q. Huang Z, et al. Alzheimers Res Ther. 2024 May 21;16(1):114. doi: 10.1186/s13195-024-01484-x. Alzheimers Res Ther. 2024. PMID: 38773642 Free PMC article. Review.
Alzheimer's disease (AD) poses a significant public health problem, affecting millions of people across the world. ...In this review, we discuss the potential of photobiomodulation (PBM) for preventing and alleviating AD-associated pathologies, with a …
Alzheimer's disease (AD) poses a significant public health problem, affecting millions of people across the world. ...I …
Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases.
Semyachkina-Glushkovskaya O, Fedosov I, Penzel T, Li D, Yu T, Telnova V, Kaybeleva E, Saranceva E, Terskov A, Khorovodov A, Blokhina I, Kurths J, Zhu D. Semyachkina-Glushkovskaya O, et al. Int J Mol Sci. 2023 Feb 6;24(4):3221. doi: 10.3390/ijms24043221. Int J Mol Sci. 2023. PMID: 36834631 Free PMC article. Review.
A decrease in MLV function is associated with Alzheimer's and Parkinson's diseases, intracranial hemorrhages, brain tumors and trauma. ...This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology f …
A decrease in MLV function is associated with Alzheimer's and Parkinson's diseases, intracranial hemorrhages, brain tumors and …
Photobiomodulation in Alzheimer's Disease-A Complementary Method to State-of-the-Art Pharmaceutical Formulations and Nanomedicine?
Ailioaie LM, Ailioaie C, Litscher G. Ailioaie LM, et al. Pharmaceutics. 2023 Mar 11;15(3):916. doi: 10.3390/pharmaceutics15030916. Pharmaceutics. 2023. PMID: 36986776 Free PMC article. Review.
Alzheimer's disease (AD), as a neurodegenerative disorder, usually develops slowly but gradually worsens. ...Another goal of this review was to discover and to speed transition to completely new paradigms for the multi-target management of AD, to facilitate b …
Alzheimer's disease (AD), as a neurodegenerative disorder, usually develops slowly but gradually worsens. ...Another go …
Transcranial photobiomodulation improves functional brain networks and working memory in healthy older adults: An fNIRS study.
Yang Q, Qu X, Sheng C, Zhao X, Chen G, Wang X, Li Y, Du W, Wang X, Sun Y, Li X, Niu H, Han Y. Yang Q, et al. Neuroimage. 2025 Aug 1;316:121305. doi: 10.1016/j.neuroimage.2025.121305. Epub 2025 Jun 6. Neuroimage. 2025. PMID: 40482941 Free article. Clinical Trial.
BACKGROUND: Transcranial photobiomodulation (tPBM), as a novel non-invasive neurostimulation technique, has shown the compelling potential for improving cognitive function in aging population. ...
BACKGROUND: Transcranial photobiomodulation (tPBM), as a novel non-invasive neurostimulation technique, has shown the compelling pote …
Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.
Salehpour F, Gholipour-Khalili S, Farajdokht F, Kamari F, Walski T, Hamblin MR, DiDuro JO, Cassano P. Salehpour F, et al. Rev Neurosci. 2020 Apr 28;31(3):269-286. doi: 10.1515/revneuro-2019-0063. Rev Neurosci. 2020. PMID: 31812948 Free PMC article. Review.
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant …
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in hum …
Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends.
Hong N. Hong N. Biomed Eng Lett. 2019 Jun 12;9(3):359-366. doi: 10.1007/s13534-019-00115-x. eCollection 2019 Aug. Biomed Eng Lett. 2019. PMID: 31456895 Free PMC article. Review.
Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. ...In this review, we have introduced several previous studies showing the positive effect of PBM over neurodegenerative disorders such as …
Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. .. …
A Randomized, Double-Blind, and Sham-Controlled Trial of an Innovative Brain-Gut Photobiomodulation Therapy: Safety and Patient Compliance.
Blivet G, Relano-Gines A, Wachtel M, Touchon J. Blivet G, et al. J Alzheimers Dis. 2022;90(2):811-822. doi: 10.3233/JAD-220467. J Alzheimers Dis. 2022. PMID: 36189591 Clinical Trial.
BACKGROUND: Recent innovative non-pharmacological interventions and neurostimulation devices have shown potential for application in the treatment of Alzheimer's disease (AD). These include photobiomodulation (PBM) therapy. OBJECTIVE: This pilot …
BACKGROUND: Recent innovative non-pharmacological interventions and neurostimulation devices have shown potential for application in the tre …
[Epidural photobiomodulation accelerates the drainage of brain interstitial fluid and its mechanism].
Cai Y, Wan QQ, Cai XJ, Gao YJ, Han HB. Cai Y, et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Oct 18;54(5):1000-1005. doi: 10.19723/j.issn.1671-167X.2022.05.029. Beijing Da Xue Xue Bao Yi Xue Ban. 2022. PMID: 36241244 Free PMC article. Chinese.
OBJECTIVE: To evaluate the effect of photobiomodulation (PBM) on the drainage of brain interstitial fluid (ISF) and to investigate the possible mechanism of the positive effect of PBM on Alzheimer's disease (AD). ...The PBM group was irradiated by usin …
OBJECTIVE: To evaluate the effect of photobiomodulation (PBM) on the drainage of brain interstitial fluid (ISF) and to investigate th …
The hormetic dose-response mechanism: Nrf2 activation.
Calabrese EJ, Kozumbo WJ. Calabrese EJ, et al. Pharmacol Res. 2021 May;167:105526. doi: 10.1016/j.phrs.2021.105526. Epub 2021 Mar 2. Pharmacol Res. 2021. PMID: 33667690 Review.
Nrf2 can be activated by numerous oxidative stressors (e.g., exercise, caloric restriction/intermittent fasting) and by exposures to synthetic, naturally occurring and endogenous chemicals, to non-ionizing (e.g., low-level light) and ionizing radiation, and t …
Nrf2 can be activated by numerous oxidative stressors (e.g., exercise, caloric restriction/intermittent fasting) and by exposures to synthet …
Targeting the glymphatic system: Abeta accumulation and phototherapy strategies across different stages of Alzheimer's disease.
Zhao D, Wang J, Zhu Y, Zhang H, Ni C, Zhao Z, Dai J, He R, Liu G, Gan C, Zhang S, Tong Z. Zhao D, et al. Transl Neurodegener. 2025 Sep 24;14(1):49. doi: 10.1186/s40035-025-00510-8. Transl Neurodegener. 2025. PMID: 40993746 Free PMC article. Review.
It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer's disease (AD). Modulating cerebrospinal fluid (CSF)-based clearance and targeting key components of the glymphatic system, such as aquaporin-4, can enhance am …
It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer's disease (AD). Mod …
Transcranial photobiomodulation (laser) therapy for cognitive impairment: A review of molecular mechanisms and potential application to canine cognitive dysfunction (CCD).
Dewey CW, Brunke MW, Sakovitch K. Dewey CW, et al. Open Vet J. 2022 Mar-Apr;12(2):256-263. doi: 10.5455/OVJ.2022.v12.i2.14. Epub 2022 Apr 17. Open Vet J. 2022. PMID: 35603072 Free PMC article. Review.
Alzheimer's disease (AD) is a common degenerative brain disorder of aging people which shares many clinical and pathological features with canine cognitive dysfunction (CCD). CCD is considered a naturally occurring model of human AD. Transcranial photobiom …
Alzheimer's disease (AD) is a common degenerative brain disorder of aging people which shares many clinical and patholo …
Mechanisms and parameters of photobiomodulation for neurological and neuropsychiatric disorders: whether and how to apply?
Cao Q, Liu Z, Kang H, Wang L. Cao Q, et al. Rev Neurosci. 2025 Sep 24;37(1):77-91. doi: 10.1515/revneuro-2025-0073. Print 2026 Jan 23. Rev Neurosci. 2025. PMID: 40982764
Neurological and neuropsychiatric disorders are among the leading causes of mortality and disability worldwide, with current treatment modalities including traditional therapies, psychological and supportive interventions, and emerging therapeutic approaches. Photobiomodulatio …
Neurological and neuropsychiatric disorders are among the leading causes of mortality and disability worldwide, with current treatment modal …
Exploring the Use of Intracranial and Extracranial (Remote) Photobiomodulation Devices in Parkinson's Disease: A Comparison of Direct and Indirect Systemic Stimulations.
Johnstone DM, Hamilton C, Gordon LC, Moro C, Torres N, Nicklason F, Stone J, Benabid AL, Mitrofanis J. Johnstone DM, et al. J Alzheimers Dis. 2021;83(4):1399-1413. doi: 10.3233/JAD-210052. J Alzheimers Dis. 2021. PMID: 33843683 Review.
In recent times, photobiomodulation has been shown to be beneficial in animal models of Parkinson's disease, improving locomotive behavior and being neuroprotective. ...In relation to Parkinson's disease, given that the major zone of pathology lies deep in th …
In recent times, photobiomodulation has been shown to be beneficial in animal models of Parkinson's disease, improving locomot …
Photobiomodulation regulates astrocyte activity and ameliorates scopolamine-induced cognitive behavioral decline.
Park JO, Hong N, Lee MY, Ahn JC. Park JO, et al. Front Cell Neurosci. 2024 Sep 20;18:1448005. doi: 10.3389/fncel.2024.1448005. eCollection 2024. Front Cell Neurosci. 2024. PMID: 39371580 Free PMC article.
INTRODUCTION: The pathophysiological mechanism of Alzheimer's disease (AD) has not been clearly identified, and effective treatment methods have not yet been established. ...METHODS: In the present study, PBM was performed using light at the near-infra …
INTRODUCTION: The pathophysiological mechanism of Alzheimer's disease (AD) has not been clearly identified, and effecti …
The role of photobiomodulation in modulating neural activity and brain function: A systematic bibliometric analysis.
Zhang Z, Xue X, Liu P, Zhang C, Li J, Liu Y, Jiang Y, Lv S, Wang L, Zhou H, Shen W, Yang S, Wang F. Zhang Z, et al. Photodiagnosis Photodyn Ther. 2025 Oct;55:104712. doi: 10.1016/j.pdpdt.2025.104712. Epub 2025 Jul 10. Photodiagnosis Photodyn Ther. 2025. PMID: 40651740 Free article.
This systematic bibliometric analysis evaluates the scientific evidence, impact, and trends of photobiomodulation (PBM) for central nervous system (CNS) disorders. Analyzing 150 relevant PubMed-indexed studies (including 46 clinical trials) up to September 2024, we demonst …
This systematic bibliometric analysis evaluates the scientific evidence, impact, and trends of photobiomodulation (PBM) for central n …
Neuromodulation of brain power topography and network topology by prefrontal transcranial photobiomodulation.
Shahdadian S, Wang X, Wanniarachchi H, Chaudhari A, Truong NCD, Liu H. Shahdadian S, et al. J Neural Eng. 2022 Nov 17;19(6):066013. doi: 10.1088/1741-2552/ac9ede. J Neural Eng. 2022. PMID: 36317341 Free PMC article.
Objective.Transcranial photobiomodulation (tPBM) has shown promising benefits, including cognitive improvement, in healthy humans and in patients with Alzheimer's disease. ...In addition, in the beta band, nodal graphical analysis demonstrated signific …
Objective.Transcranial photobiomodulation (tPBM) has shown promising benefits, including cognitive improvement, in healthy humans and …
Dosimetry and Clinical Efficacy of Transcranial Photobiomodulation for Major Depression Disorder: Could they Guide Dosimetry for Alzheimer's Disease?
Caldieraro MA, Laufer-Silva T, Cassano P. Caldieraro MA, et al. J Alzheimers Dis. 2021;83(4):1453-1469. doi: 10.3233/JAD-210586. J Alzheimers Dis. 2021. PMID: 34487045 Review.
Cognitive symptoms are frequent in MDD and insufficiently treated by antidepressant medications. Transcranial photobiomodulation (t-PBM) is a novel device therapy which shows promise as an antidepressant and pro-cognitive treatment. ...One well-designed and sufficie …
Cognitive symptoms are frequent in MDD and insufficiently treated by antidepressant medications. Transcranial photobiomodulation (t-P …
"Quantum Leap" in Photobiomodulation Therapy Ushers in a New Generation of Light-Based Treatments for Cancer and Other Complex Diseases: Perspective and Mini-Review.
Santana-Blank L, Rodríguez-Santana E, Santana-Rodríguez KE, Reyes H. Santana-Blank L, et al. Photomed Laser Surg. 2016 Mar;34(3):93-101. doi: 10.1089/pho.2015.4015. Epub 2016 Feb 18. Photomed Laser Surg. 2016. PMID: 26890728 Free PMC article. Review.
OBJECTIVE: Set within the context of the 2015 International Year of Light and Light-Based Technologies,and of a growing and aging world population with ever-rising healthcare needs, this perspective and mini-review focuses on photobiomodulation (PBM) thera …
OBJECTIVE: Set within the context of the 2015 International Year of Light and Light-Based Technologies,and of a growing and ag …
Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy.
Cardoso FDS, de Souza Oliveira Tavares C, Araujo BHS, Mansur F, Lopes-Martins RÁB, Gomes da Silva S. Cardoso FDS, et al. Cell Mol Neurobiol. 2022 Aug;42(6):1875-1886. doi: 10.1007/s10571-021-01069-4. Epub 2021 Mar 11. Cell Mol Neurobiol. 2022. PMID: 33704604 Free PMC article.
Recent evidences have shown the therapeutic potential of transcranial photobiomodulation on traumatic brain injury and Alzheimer's disease. Despite the promising benefits in the brain, little is known about the laser's effects in the absence of patholo …
Recent evidences have shown the therapeutic potential of transcranial photobiomodulation on traumatic brain injury and Alzheimer …
Abdominal Photobiomodulation and the Gut-Brain Axis: A Systematic Review of Mechanistic and Translational Evidence.
N F Guimarães G, Dos Santos Cardoso F, Gamboa L, W Barrett D, Gonzalez-Lima F. N F Guimarães G, et al. Biomedicines. 2025 Dec 11;13(12):3042. doi: 10.3390/biomedicines13123042. Biomedicines. 2025. PMID: 41463053 Free PMC article. Review.
Background/Objectives: Bidirectional communication between the gut and brain is central to neurological and psychiatric health, and abdominal photobiomodulation (PBM) has emerged as a promising non-invasive way to modulate this axis by targeting intestinal mitochondria, ep …
Background/Objectives: Bidirectional communication between the gut and brain is central to neurological and psychiatric health, and abdomina …
Efficacy of Transcranial Direct Current Stimulation and Photobiomodulation in Improving Cognitive Abilities for Alzheimer's Disease: A Systematic Review.
Cornea M, Vintilă BI, Bucuța M, Ștef L, Anghel CE, Grama AM, Lomnasan A, Stetiu AA, Boicean A, Sava M, Paziuc LC, Manea MC, Tîbîrnă A, Băcilă CI. Cornea M, et al. J Clin Med. 2025 Mar 6;14(5):1766. doi: 10.3390/jcm14051766. J Clin Med. 2025. PMID: 40095881 Free PMC article. Review.
Background: Due to the increasing global prevalence of Alzheimer's dementia (AD), neuromodulation techniques such as transcranial direct current stimulation (tDCS) and photobiomodulation (PBM) are considered potential complementary therapies. ...
Background: Due to the increasing global prevalence of Alzheimer's dementia (AD), neuromodulation techniques such as transcran …
Photobiomodulation Therapy: A Novel Therapeutic Approach to Alzheimer's Disease Made Possible by the Evidence of a Brain-Gut Interconnection.
Blivet G, Roman FJ, Lelouvier B, Ribière C, Touchon J. Blivet G, et al. J Integr Neurosci. 2024 Apr 30;23(5):92. doi: 10.31083/j.jin2305092. J Integr Neurosci. 2024. PMID: 38812393 Free article. Review.
The evidence of brain-gut interconnections in Alzheimer's disease (AD) opens novel avenues for the treatment of a pathology for which no definitive treatment exists. ...PBM is a safe, non-invasive, non-ionizing, and non-thermal therapy that uses red or …
The evidence of brain-gut interconnections in Alzheimer's disease (AD) opens novel avenues for the treatment of a patho …
Modifying Alzheimer's disease pathophysiology with photobiomodulation: model, evidence, and future with EEG-guided intervention.
Lim L. Lim L. Front Neurol. 2024 Aug 23;15:1407785. doi: 10.3389/fneur.2024.1407785. eCollection 2024. Front Neurol. 2024. PMID: 39246604 Free PMC article. Review.
This manuscript outlines a model of Alzheimer's Disease (AD) pathophysiology in progressive layers, from its genesis to the development of biomarkers and then to symptom expression. ...Extending beyond these accumulations, we explore a broader spectrum of pat …
This manuscript outlines a model of Alzheimer's Disease (AD) pathophysiology in progressive layers, from its genesis to …
Therapeutic Potentials of Near-Infrared II Photobiomodulation to Treat Cerebrovascular Diseases via Nitric Oxide Signalling.
Kashiwagi S, Yokomizo S, Bragin DE, Perle SJ, Kastanenka KV, Gerashchenko D, Atochin DN. Kashiwagi S, et al. Adv Exp Med Biol. 2024;1463:195-200. doi: 10.1007/978-3-031-67458-7_33. Adv Exp Med Biol. 2024. PMID: 39400823 Free PMC article. Review.
Restoring endothelial NO represents a promising approach to treating cerebrovascular diseases, including stroke. Low-power near-infrared (NIR) light shows diverse beneficial effects, broadly defined as photobiomodulation (PBM). The literature reports that PBM increa …
Restoring endothelial NO represents a promising approach to treating cerebrovascular diseases, including stroke. Low-power near-infrared (NI …
Photobiomodulation as a Potential Treatment for Alzheimer's Disease: A Review Paper.
Wang M, Dinarvand D, Chan CTY, Bragin A, Li L. Wang M, et al. Brain Sci. 2024 Oct 26;14(11):1064. doi: 10.3390/brainsci14111064. Brain Sci. 2024. PMID: 39595827 Free PMC article. Review.
BACKGROUND: Alzheimer's disease (AD), the most prevalent form of dementia, is a leading neurodegenerative disorder currently affecting approximately 55 million individuals globally, a number projected to escalate to 139 million by 2050. ...CONCLUSIONS: The fi …
BACKGROUND: Alzheimer's disease (AD), the most prevalent form of dementia, is a leading neurodegenerative disorder curr …
Does photobiomodulation alter mitochondrial dynamics?
Trajano LADSN, Siqueira PB, Rodrigues MMS, Pires BRB, da Fonseca AS, Mencalha AL. Trajano LADSN, et al. Photochem Photobiol. 2025 Jan-Feb;101(1):21-37. doi: 10.1111/php.13963. Epub 2024 May 22. Photochem Photobiol. 2025. PMID: 38774941 Review.
This review focuses on the mitochondrial dynamic's role in various diseases, evaluating the possible therapeutic role of low-power lasers (LPL) and light-emitting diodes (LED). Studies increasingly support that mitochondrial dysfunction is correlated with severe neurodegen …
This review focuses on the mitochondrial dynamic's role in various diseases, evaluating the possible therapeutic role of low-power lasers (L …
Self-assembly and 3D Bioprinting of Neurospheres and Evaluation of Caffeine and Photobiomodulation Effects in an Alzheimer's Disease In Vitro Model.
Rodrigues Salles G, Granato AEC, Viero FT, Pacheco-Soares C, Ferreira ST, Porcionatto M, Ulrich H. Rodrigues Salles G, et al. Stem Cell Rev Rep. 2025 May;21(4):988-1000. doi: 10.1007/s12015-025-10850-7. Epub 2025 Apr 8. Stem Cell Rev Rep. 2025. PMID: 40198478
Several in vitro models of Alzheimer's disease (AD) rely on 2D cell culture, and, more recently, 3D cultures represented by free-floating neurospheres have been used as models for the disease. The advantage of 3D over 2D cell culture is that cell-extra …
Several in vitro models of Alzheimer's disease (AD) rely on 2D cell culture, and, more recently, 3D cultures represente …
Exploring the effect of photobiomodulation and gamma visual stimulation induced by 808 nm and visible LED in Alzheimer's disease mouse model.
Xu H, Luo Z, Zhang R, Golovynska I, Huang Y, Samanta S, Zhou T, Li S, Guo B, Liu L, Weng X, He J, Liao C, Wang Y, Ohulchanskyy TY, Qu J. Xu H, et al. J Photochem Photobiol B. 2024 Jan;250:112816. doi: 10.1016/j.jphotobiol.2023.112816. Epub 2023 Nov 23. J Photochem Photobiol B. 2024. PMID: 38029664
Although photobiomodulation (PBM) and gamma visual stimulatqion (GVS) have been overwhelmingly explored in the recent time as a possible light stimulation (LS) means of Alzheimer's disease (AD) therapy, their effects have not been assesse …
Although photobiomodulation (PBM) and gamma visual stimulatqion (GVS) have been overwhelmingly explored in the recent time as a possi …
"Photobiomics": Can Light, Including Photobiomodulation, Alter the Microbiome?
Liebert A, Bicknell B, Johnstone DM, Gordon LC, Kiat H, Hamblin MR. Liebert A, et al. Photobiomodul Photomed Laser Surg. 2019 Nov;37(11):681-693. doi: 10.1089/photob.2019.4628. Epub 2019 Oct 9. Photobiomodul Photomed Laser Surg. 2019. PMID: 31596658 Free PMC article. Review.
Background: PBM describes the use of low levels of visible or near-infrared (NIR) light to heal and stimulate tissue, and to relieve pain and inflammation. In recent years, PBM has been applied to the head as an investigative approach to treat diverse brain diseases such a …
Background: PBM describes the use of low levels of visible or near-infrared (NIR) light to heal and stimulate tissue, and to relieve …
Synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the beta-amyloid neurotoxicity in the in vitro Alzheimer's disease models.
Zhang R, Zhou T, Samanta S, Luo Z, Li S, Xu H, Qu J. Zhang R, et al. Front Neuroimaging. 2022 Jul 22;1:903531. doi: 10.3389/fnimg.2022.903531. eCollection 2022. Front Neuroimaging. 2022. PMID: 37555169 Free PMC article.
BACKGROUND: In Alzheimer's disease (AD), the deposition of beta-amyloid (Abeta) plaques is closely associated with the neuronal apoptosis and activation of microglia, which may result in the functional impairment of neurons through pro-inflammation and over-p …
BACKGROUND: In Alzheimer's disease (AD), the deposition of beta-amyloid (Abeta) plaques is closely associated with the …
Effects of Home Photobiomodulation Treatments on Cognitive and Behavioral Function, Cerebral Perfusion, and Resting-State Functional Connectivity in Patients with Dementia: A Pilot Trial.
Chao LL. Chao LL. Photobiomodul Photomed Laser Surg. 2019 Mar;37(3):133-141. doi: 10.1089/photob.2018.4555. Epub 2019 Feb 13. Photobiomodul Photomed Laser Surg. 2019. PMID: 31050950 Clinical Trial.
Objective: To examine the effects of transcranial and intranasal photobiomodulation (PBM) therapy, administered at home, in patients with dementia. Background: This study sought to replicate and build upon a previously published case series report describing improve …
Objective: To examine the effects of transcranial and intranasal photobiomodulation (PBM) therapy, administered at home, in pa …
Exploring the Effect of Combined Transcranial and Intra-Oral Photobiomodulation Therapy Over a Four-Week Period on Physical and Cognitive Outcome Measures for People with Parkinson's Disease: A Randomized Double-Blind Placebo-Controlled Pilot Study.
Bullock-Saxton J, Lehn A, Laakso EL. Bullock-Saxton J, et al. J Alzheimers Dis. 2021;83(4):1499-1512. doi: 10.3233/JAD-210170. J Alzheimers Dis. 2021. PMID: 34092640 Clinical Trial.
BACKGROUND: Neuroprotection against Parkinson's disease degeneration by photobiomodulation has been reported in animal models but no true placebo-controlled human studies have been published. OBJECTIVE: To understand if photobiomodulation therapy can p …
BACKGROUND: Neuroprotection against Parkinson's disease degeneration by photobiomodulation has been reported in animal models …
Photobiomodulation for Alzheimer's Disease: Translating Basic Research to Clinical Application.
Enengl J, Hamblin MR, Dungel P. Enengl J, et al. J Alzheimers Dis. 2020;75(4):1073-1082. doi: 10.3233/JAD-191210. J Alzheimers Dis. 2020. PMID: 32390621 Free PMC article. Review.
This review covers the literature on photobiomodulation therapy as a novel approach to prevent and treat Alzheimer's disease, aiming to bridge that gap by gathering together the terms and technical specifications into a single concise suggestion …
This review covers the literature on photobiomodulation therapy as a novel approach to prevent and treat Alzheimer's …
Transcranial photobiomodulation in the management of brain disorders.
Montazeri K, Farhadi M, Fekrazad R, Akbarnejad Z, Chaibakhsh S, Mahmoudian S. Montazeri K, et al. J Photochem Photobiol B. 2021 Aug;221:112207. doi: 10.1016/j.jphotobiol.2021.112207. Epub 2021 May 5. J Photochem Photobiol B. 2021. PMID: 34119804
No RCTs were performed in the fields of Alzheimer's and Parkinson's diseases. The human RCTs and animal studies reported no adverse events resulted from the use of tPBM. ...Search keywords were the followings: transcranial photobiomodulation" OR "transcranial …
No RCTs were performed in the fields of Alzheimer's and Parkinson's diseases. The human RCTs and animal studies reported no ad …
Transcranial photobiomodulation therapy with 808 nm light changes expression of genes and proteins associated with neuroprotection, neuroinflammation, oxidative stress, and Alzheimer's disease: Whole RNA sequencing of mouse cortex and hippocampus.
Li B, Golovynska I, Stepanov YV, Golovynskyi S, Golovynskyi A, Kolesnik D, Stepanova LI, Lai P, Lin F, Qu J. Li B, et al. PLoS One. 2025 Jul 18;20(7):e0326881. doi: 10.1371/journal.pone.0326881. eCollection 2025. PLoS One. 2025. PMID: 40679987 Free PMC article.
Light therapy, using red and near-infrared (NIR) irradiation, is currently applied for the treatment of various neurodegenerative diseases, such as Alzheimer's disease (AD). Transcranial photobiomodulation therapy (tPBMT) can allev …
Light therapy, using red and near-infrared (NIR) irradiation, is currently applied for the treatment of various neurodegenerat …
The Beneficial Role of Photobiomodulation in Neurodegenerative Diseases.
Abijo A, Lee CY, Huang CY, Ho PC, Tsai KJ. Abijo A, et al. Biomedicines. 2023 Jun 26;11(7):1828. doi: 10.3390/biomedicines11071828. Biomedicines. 2023. PMID: 37509468 Free PMC article. Review.
Photobiomodulation (PBM), also known as Low-level Laser Therapy (LLLT), involves the use of light from a laser or light-emitting diode (LED) in the treatment of various disorders and it has recently gained increasing interest. ...Here, we …
Photobiomodulation (PBM), also known as Low-level Laser Therapy (LLLT), involves the use of light from a …
Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer's Disease.
Ning S, Jorfi M, Patel SR, Kim DY, Tanzi RE. Ning S, et al. Front Neurosci. 2022 Mar 24;16:854992. doi: 10.3389/fnins.2022.854992. eCollection 2022. Front Neurosci. 2022. PMID: 35401082 Free PMC article. Review.
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, clinically defined by progressive cognitive decline and pathologically, by brain atrophy, neuroinflammation, and accumulation of extracellular amyloid plaques and intracellular neur …
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, clinically defined by progressive cogniti …
A randomized sham-controlled trial of transcranial and intranasal photobiomodulation in Japanese patients with mild cognitive impairment and mild dementia due to Alzheimer's disease: a protocol.
Yokoi Y, Inagawa T, Yamada Y, Matsui M, Tomizawa A, Noda T. Yokoi Y, et al. Front Neurol. 2024 Jul 5;15:1371284. doi: 10.3389/fneur.2024.1371284. eCollection 2024. Front Neurol. 2024. PMID: 39036627 Free PMC article.
It is potentially beneficial for patients with Alzheimer's disease (AD). We present a study protocol for a randomised controlled trial designed to evaluate the efficacy and safety of PBM. ...The primary outcome will be the mean change in the Alzheimer …
It is potentially beneficial for patients with Alzheimer's disease (AD). We present a study protocol for a randomised c …
Therapeutic Potential of Photobiomodulation In Alzheimer's Disease: A Systematic Review.
Cardoso FDS, Lopes Martins RÁB, Gomes da Silva S. Cardoso FDS, et al. J Lasers Med Sci. 2020 Fall;11(Suppl 1):S16-S22. doi: 10.34172/jlms.2020.S3. Epub 2020 Dec 30. J Lasers Med Sci. 2020. PMID: 33995964 Free PMC article. Review.
Introduction: Alzheimer disease (AD) is characterized by the decline of cognitive functions such as learning and memory. ...A systematic search was conducted on the bibliographic databases (PubMed and ScienceDirect) with the keywords based on MeSH terms: "photobi …
Introduction: Alzheimer disease (AD) is characterized by the decline of cognitive functions such as learning and memory. ...A …
Photobiomodulation's potential as a non-invasive therapy for alzheimer's disease and minimal cognitive impairment: A 12-week investigation.
Razzaghi M, Sheibani F, Kimia N, Razzaghi Z, Chenari Z, Ashrafi F, Barati M, Advani S. Razzaghi M, et al. Photodiagnosis Photodyn Ther. 2024 Apr;46:103991. doi: 10.1016/j.pdpdt.2024.103991. Epub 2024 Feb 16. Photodiagnosis Photodyn Ther. 2024. PMID: 38367922 Free article.
BACKGROUND: Alzheimer's Disease (AD), undergoing a faster increase in occurrence than any other type of dementia, lacks a curative remedy despite advanced discoveries. ...CONCLUSION: In general, PBM appears to hold promise as a potentially safe method for enh …
BACKGROUND: Alzheimer's Disease (AD), undergoing a faster increase in occurrence than any other type of dementia, lacks …
Quantification and stimulation of human glymphatic dynamics: New features of Alzheimer's disease and effects of brain photobiomodulation.
Saeed F, Siepker KL, Jang S, Shahdadian S, Liu H. Saeed F, et al. Res Sq [Preprint]. 2025 Mar 5:rs.3.rs-6115809. doi: 10.21203/rs.3.rs-6115809/v1. Res Sq. 2025. PMID: 40092434 Free PMC article. Preprint.
This study employed a multi-color optical method to quantify prefrontal CSF dynamics in two groups: (1) older adults with (n = 16) and without (n = 27) Alzheimer's disease and (2) young adults (n = 26) before and after prefrontal light stimulation. The …
This study employed a multi-color optical method to quantify prefrontal CSF dynamics in two groups: (1) older adults with (n = 16) and witho …
Light Modulation of Brain and Development of Relevant Equipment.
Li X, Liu C, Wang R. Li X, et al. J Alzheimers Dis. 2020;74(1):29-41. doi: 10.3233/JAD-191240. J Alzheimers Dis. 2020. PMID: 32039856 Review.
Optogenetic techniques can activate or silence targeted neurons with high temporal and spatial accuracy and provide precise control, and have recently become a method for quick manipulation of genetically identified types of neurons. Photobiomodulation (PBM) is light …
Optogenetic techniques can activate or silence targeted neurons with high temporal and spatial accuracy and provide precise control, and hav …
Transcranial photobiomodulation therapy in older women regarding cognitive functions: a systematic review.
García-Castro P, Conejo NM, González-Pardo H. García-Castro P, et al. Lasers Med Sci. 2025 Nov 15;40(1):480. doi: 10.1007/s10103-025-04742-y. Lasers Med Sci. 2025. PMID: 41240183
Transcranial photobiomodulation therapy (tPBM) is a promising non-invasive treatment that uses red or near-infrared light to modulate biological functions and elicit therapeutic effects. ...Studies have shown that tPBM significantly improves cognitive impairm …
Transcranial photobiomodulation therapy (tPBM) is a promising non-invasive treatment that uses red or near-infrared light …
Neuroprotective Potential of Photobiomodulation Therapy: Mitigating Amyloid-Beta Accumulation and Modulating Acetylcholine Levels in an In Vitro Model of Alzheimer's Disease.
Thammasart S, Namchaiw P, Pasuwat K, Tonsomboon K, Khantachawana A. Thammasart S, et al. Photobiomodul Photomed Laser Surg. 2024 Aug;42(8):524-533. doi: 10.1089/pho.2024.0042. Epub 2024 Jul 26. Photobiomodul Photomed Laser Surg. 2024. PMID: 39058735
Background: Alzheimer's disease (AD) is characterized by the accumulation of Abeta peptides, leading to neurodegeneration, cholinergic deficit, and cognitive decline. ...Conclusions: PBMT at 810 nm effectively reduces Abeta42-induced toxicity and supports neu …
Background: Alzheimer's disease (AD) is characterized by the accumulation of Abeta peptides, leading to neurodegenerati …
[Transcranial photobiomodulation in therapy of neurodegenerative diseases of the brain: theoretical background and clinical effectiveness].
Belova AN, Israelyan YA, Sushin VO, Shabanova MA, Rezenova AM. Belova AN, et al. Vopr Kurortol Fizioter Lech Fiz Kult. 2021;98(6):61-67. doi: 10.17116/kurort20219806161. Vopr Kurortol Fizioter Lech Fiz Kult. 2021. PMID: 34965698 Russian.
Transcranial photobiomodulation (tPBM) is a form of light therapy that uses monochromatic visible and infrared light from non-ionizing radiation sources (lasers, LEDs) placed on the scalp, forehead, or intranasally to project light directly to t …
Transcranial photobiomodulation (tPBM) is a form of light therapy that uses monochromatic visible and infrared light …
Therapeutic non-invasive brain treatments in Alzheimer's disease: recent advances and challenges.
Wu C, Yang L, Feng S, Zhu L, Yang L, Liu TC, Duan R. Wu C, et al. Inflamm Regen. 2022 Oct 3;42(1):31. doi: 10.1186/s41232-022-00216-8. Inflamm Regen. 2022. PMID: 36184623 Free PMC article. Review.
Alzheimer's disease (AD) is one of the major neurodegenerative diseases and the most common form of dementia. ...In this paper, we reviewed the advances of the most widely studied non-invasive therapies, including photobiomodulation (PBM), transcranial …
Alzheimer's disease (AD) is one of the major neurodegenerative diseases and the most common form of dementia. ...In thi …
Effects of Photobiomodulation on Changes in Cognitive Function and Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment: A Pilot Uncontrolled Trial.
Baik JS, Lee TY, Kim NG, Pak K, Ko SH, Min JH, Shin YI. Baik JS, et al. J Alzheimers Dis. 2021;83(4):1513-1519. doi: 10.3233/JAD-210386. J Alzheimers Dis. 2021. PMID: 34420956 Clinical Trial.
BACKGROUND: Photobiomodulation (PBM) affects local blood flow regulation through nitric oxide generation, and various studies have reported on its effect on improving cognitive function in neurodegenerative diseases. ...
BACKGROUND: Photobiomodulation (PBM) affects local blood flow regulation through nitric oxide generation, and various studies have re …
Photobiomodulation for Alzheimer's disease: photoelectric coupling effect on attenuating Abeta neurotoxicity.
Tian Z, Wang P, Huang K, Yu J, Zhang M, Liu Y, Zhao H, Zhu B, Huang X, Tong Z. Tian Z, et al. Lasers Med Sci. 2023 Jan 12;38(1):39. doi: 10.1007/s10103-022-03692-z. Lasers Med Sci. 2023. PMID: 36633696 Free PMC article. Review.
Alzheimer's disease (AD) and dementia are the most worrying health problems faced by people globally today. Although the pathological features of AD consisting of amyloid-beta (Abeta) plaques in the extracellular space (ECS) and intracellular tau tangles are …
Alzheimer's disease (AD) and dementia are the most worrying health problems faced by people globally today. Although th …
Light, Water, and Melatonin: The Synergistic Regulation of Phase Separation in Dementia.
Loh D, Reiter RJ. Loh D, et al. Int J Mol Sci. 2023 Mar 19;24(6):5835. doi: 10.3390/ijms24065835. Int J Mol Sci. 2023. PMID: 36982909 Free PMC article. Review.
The swift rise in acceptance of molecular principles defining phase separation by a broad array of scientific disciplines is shadowed by increasing discoveries linking phase separation to pathological aggregations associated with numerous neurodegenerative disorders, including …
The swift rise in acceptance of molecular principles defining phase separation by a broad array of scientific disciplines is shadowed by inc …
Mitochondrial respiration as a target for neuroprotection and cognitive enhancement.
Gonzalez-Lima F, Barksdale BR, Rojas JC. Gonzalez-Lima F, et al. Biochem Pharmacol. 2014 Apr 15;88(4):584-93. doi: 10.1016/j.bcp.2013.11.010. Epub 2013 Dec 4. Biochem Pharmacol. 2014. PMID: 24316434 Review.
We propose that improving brain mitochondrial respiration is an important future direction in research and treatment of Alzheimer's disease (AD) and other conditions associated with cognitive impairment and neurodegeneration. ...First, low-dose USP methylene …
We propose that improving brain mitochondrial respiration is an important future direction in research and treatment of Alzheimer' …
A Brief Review of Low-Level Light Therapy in Depression Disorder.
Shirkavand A, Akhavan Tavakoli M, Ebrahimpour Z. Shirkavand A, et al. J Lasers Med Sci. 2023 Nov 11;14:e55. doi: 10.34172/jlms.2023.55. eCollection 2023. J Lasers Med Sci. 2023. PMID: 38028864 Free PMC article. Review.
Introduction: Low-level laser therapy (LLLT), also called Photobiomodulation, has gained widespread acceptance as a mainstream modality, particularly in the form of photobiostimulation (PBM). ...Preclinical studies using animal models have shown promis …
Introduction: Low-level laser therapy (LLLT), also called Photobiomodulation, has gained widespread acceptance a …
Promoted CD4(+) T cell-derived IFN-gamma/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice.
Wu X, Shen Q, Chang H, Li J, Xing D. Wu X, et al. J Neuroinflammation. 2022 Oct 10;19(1):253. doi: 10.1186/s12974-022-02617-5. J Neuroinflammation. 2022. PMID: 36217178 Free PMC article.
BACKGROUND: The immune system has been implicated in synaptic plasticity, inflammation, and the progression of Alzheimer's disease (AD). However, there were few studies on improving the niche microenvironment of neural stem cells (NSCs) in the brain of AD to …
BACKGROUND: The immune system has been implicated in synaptic plasticity, inflammation, and the progression of Alzheimer's …
Neuromodulation in the Treatment of Alzheimer's Disease: Current and Emerging Approaches.
Pople CB, Meng Y, Li DZ, Bigioni L, Davidson B, Vecchio LM, Hamani C, Rabin JS, Lipsman N. Pople CB, et al. J Alzheimers Dis. 2020;78(4):1299-1313. doi: 10.3233/JAD-200913. J Alzheimers Dis. 2020. PMID: 33164935 Review.
Here we review work in animal models and humans with Alzheimer's disease exploring emerging neuromodulation modalities. Approaches reviewed include deep brain stimulation, transcranial magnetic stimulation, transcranial electrical stimulation, ultrasound stim …
Here we review work in animal models and humans with Alzheimer's disease exploring emerging neuromodulation modalities. …
Photobiomodulation mitigates blood-brain barrier disruption in APP/PS1 mouse model of Alzheimer's disease by activating the AMPK pathway.
Ma C, Ye Y, Shi X, Li N, Mu Z, Tan T, Yin H, Dai J, Liu Y, Chen H. Ma C, et al. Alzheimers Res Ther. 2025 Jun 23;17(1):141. doi: 10.1186/s13195-025-01787-7. Alzheimers Res Ther. 2025. PMID: 40551167 Free PMC article.
BACKGROUND: Photobiomodulation (PBM), which utilizes specific light wavelengths to regulate cellular metabolism, signal transduction, and gene expression, has emerged as a promising intervention for enhancing cognitive function in Alzheimer's diseas …
BACKGROUND: Photobiomodulation (PBM), which utilizes specific light wavelengths to regulate cellular metabolism, signal transd …
The Efficacy and Safety of Transcranial Photobiomodulation for Mild Cognitive Impairment Due to Alzheimer's Disease: A Randomized, Double-Blind, Sham-Controlled Study.
Chun H, Yoon ML, Lee HW, Lee JY, Hong SB, Ha SS, Yoon KJ. Chun H, et al. Photobiomodul Photomed Laser Surg. 2025 Sep;43(9):411-416. doi: 10.1177/15578550251369575. Photobiomodul Photomed Laser Surg. 2025. PMID: 40939031 Clinical Trial.
Objective: This study investigated the efficacy and safety of a self-administered, at-home, wearable tPBM device for improving cognitive function in individuals with mild cognitive impairment (MCI) due to Alzheimer's disease (AD). Methods: Individuals with MC …
Objective: This study investigated the efficacy and safety of a self-administered, at-home, wearable tPBM device for improving cognitive fun …
Photobiomodulation by LED 660 nm and Taurine against H(2)O(2) oxidative stress in SH-SY5Y cells.
Rossato RC, Salles GR, Albuquerque AL, Porcionatto MA, Granato AEC, Ulrich H, Dos Santos MIB, Pacheco-Soares C. Rossato RC, et al. Lasers Med Sci. 2025 Apr 24;40(1):211. doi: 10.1007/s10103-025-04467-y. Lasers Med Sci. 2025. PMID: 40274660
Alzheimer's Disease (AD) is a progressive uncurable neurodegenerative pathology affecting millions worldwide. Photobiomodulation and Taurine are promising alternatives for preventing and reducing the rapid progression of neurodegeneration, stimulating …
Alzheimer's Disease (AD) is a progressive uncurable neurodegenerative pathology affecting millions worldwide. Photob …
Deciphering Alzheimer's disease: predicting new therapeutic strategies via improved understanding of biology and pathogenesis.
Khoury R, Grossberg GT. Khoury R, et al. Expert Opin Ther Targets. 2020 Sep;24(9):859-868. doi: 10.1080/14728222.2020.1790530. Epub 2020 Jul 13. Expert Opin Ther Targets. 2020. PMID: 32603232 Review.
INTRODUCTION: There is no cure for Alzheimer's disease (AD). One explanation may pertain to the need to intervene as early as possible upstream from the accumulation of beta-amyloid plaques and tau tangles. ...Going forward, innovative treatment strategies in …
INTRODUCTION: There is no cure for Alzheimer's disease (AD). One explanation may pertain to the need to intervene as ea …
Phototherapy of Alzheimer's Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review.
Semyachkina-Glushkovskaya O, Penzel T, Poluektov M, Fedosov I, Tzoy M, Terskov A, Blokhina I, Sidorov V, Kurths J. Semyachkina-Glushkovskaya O, et al. Int J Mol Sci. 2023 Jun 30;24(13):10946. doi: 10.3390/ijms241310946. Int J Mol Sci. 2023. PMID: 37446135 Free PMC article.
The global number of people with Alzheimer's disease (AD) doubles every 5 years. It has been established that unless an effective treatment for AD is found, the incidence of AD will triple by 2060. ...The development of methods for augmentation of the LDRSB f …
The global number of people with Alzheimer's disease (AD) doubles every 5 years. It has been established that unless an …
Mind the Gap: Unraveling the Intricate Dance Between Alzheimer's Disease and Related Dementias and Bone Health.
Karnik SJ, Margetts TJ, Wang HS, Movila A, Oblak AL, Fehrenbacher JC, Kacena MA, Plotkin LI. Karnik SJ, et al. Curr Osteoporos Rep. 2024 Feb;22(1):165-176. doi: 10.1007/s11914-023-00847-x. Epub 2024 Jan 29. Curr Osteoporos Rep. 2024. PMID: 38285083 Free PMC article. Review.
PURPOSE OF REVIEW: This review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis is on "inflammaging"-a low-level inflammation common to both, and its implica …
PURPOSE OF REVIEW: This review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) an …
Improved cognitive function, efficiency, saccadic eye movement, and depressive symptoms in mild cognitive impairment with transcranial photobiomodulation.
Lee TL, Kwok TC, Lam LC, Fung HH, Cheung MC, Han YMY, Chan AS. Lee TL, et al. J Alzheimers Dis. 2025 Sep;107(2):529-541. doi: 10.1177/13872877251361033. Epub 2025 Sep 1. J Alzheimers Dis. 2025. PMID: 40702818
BackgroundMild cognitive impairment (MCI) is a critical stage with higher progression to Alzheimer's disease, yet effective interventions are still lacking.ObjectiveSome empirical studies have shown that transcranial photobiomodulation (tPBM) may be ef …
BackgroundMild cognitive impairment (MCI) is a critical stage with higher progression to Alzheimer's disease, yet effec …
Photobiomodulation in the aging brain: a systematic review from animal models to humans.
Rodríguez-Fernández L, Zorzo C, Arias JL. Rodríguez-Fernández L, et al. Geroscience. 2024 Dec;46(6):6583-6623. doi: 10.1007/s11357-024-01231-y. Epub 2024 Jun 11. Geroscience. 2024. PMID: 38861125 Free PMC article.
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmacological therapy that shows promising results in the treatment or prevention of age-related cognitive impairments. ...Locomotor activ …
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmac …
Unleashing light's healing power: an overview of photobiomodulation for Alzheimer's treatment.
Ramanishankar A, S AS, Begum RF, Jayasankar N, Nayeem A, Prajapati BG, Nirenjen S. Ramanishankar A, et al. Future Sci OA. 2024 May 24;10(1):FSO922. doi: 10.2144/fsoa-2023-0155. eCollection 2024. Future Sci OA. 2024. PMID: 38841181 Free PMC article. Review.
Aim: Photobiomodulation involves the use of low-level light therapy or near-infrared light therapy found to be useful in the treatment of a wide range of neurological diseases. ...Alzheimer's disease (AD) is an …
Aim: Photobiomodulation involves the use of low-level light therapy or near-infrared light ther …
Nutritional Ketosis and photobiomodulation remediate mitochondria warding off Alzheimer's disease in a diabetic, ApoE4+ patient with mild cognitive impairment: A case report.
Horner S, Berger L, Gibas K. Horner S, et al. Photodiagnosis Photodyn Ther. 2020 Jun;30:101777. doi: 10.1016/j.pdpdt.2020.101777. Epub 2020 Apr 16. Photodiagnosis Photodyn Ther. 2020. PMID: 32305654
Alzheimer's Disease (AD) is a neurodegenerative progressive disorder for which there is currently no cure. ...Further, visible red or near-infrared (NIR) light has been shown to heal and stimulate damaged tissue by interacting with the mitochondria to …
Alzheimer's Disease (AD) is a neurodegenerative progressive disorder for which there is currently no cure. ...Further, …
Insights Into the Therapeutic Potential of SIRT1-modifying Compounds for Alzheimer's Disease: A Focus on Molecular Mechanisms.
AlHayani DA, Kubaev A, Uthirapathy S, Mandaliya V, Ballal S, Kalia R, Arya R, Gabble BC, Alasheqi MQ, Kadhim AJ. AlHayani DA, et al. J Mol Neurosci. 2025 Feb 25;75(1):29. doi: 10.1007/s12031-025-02324-9. J Mol Neurosci. 2025. PMID: 40000535 Review.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, significantly impacting patients' quality of life. ...Additionally, we discuss emerging innovative therapies, including pharmacological ag …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss …
Can transcranial photobiomodulation improve cognitive function in TBI patients? A systematic review.
Zeng J, Wang C, Chai Y, Lei D, Wang Q. Zeng J, et al. Front Psychol. 2024 Jun 17;15:1378570. doi: 10.3389/fpsyg.2024.1378570. eCollection 2024. Front Psychol. 2024. PMID: 38952831 Free PMC article.
INTRODUCTION: Transcranial photobiomodulation (tPBM) is a non-invasive neuromodulation technology which has become a promising therapy for treating many brain diseases. Although it has been confirmed in studies targeting neurological diseases including Alzheimer …
INTRODUCTION: Transcranial photobiomodulation (tPBM) is a non-invasive neuromodulation technology which has become a promising the …
Non-Pharmacological Therapeutic Options for the Treatment of Alzheimer's Disease.
Huynh QS, Elangovan S, Holsinger RMD. Huynh QS, et al. Int J Mol Sci. 2022 Sep 20;23(19):11037. doi: 10.3390/ijms231911037. Int J Mol Sci. 2022. PMID: 36232336 Free PMC article. Review.
Alzheimer's disease is a growing global crisis in need of urgent diagnostic and therapeutic strategies. The current treatment strategy mostly involves immunotherapeutic medications that have had little success in halting disease progress. Hypotheses fo …
Alzheimer's disease is a growing global crisis in need of urgent diagnostic and therapeutic strategies. The current tre …
Non-invasive transcranial brain modulation for neurological disorders treatment: A narrative review.
Mosilhy EA, Alshial EE, Eltaras MM, Rahman MMA, Helmy HI, Elazoul AH, Hamdy O, Mohammed HS. Mosilhy EA, et al. Life Sci. 2022 Oct 15;307:120869. doi: 10.1016/j.lfs.2022.120869. Epub 2022 Aug 6. Life Sci. 2022. PMID: 35940222 Review.
The commonly noninvasive techniques used in neurological manipulations include photobiomodulation (PBM), transcranial electrical stimulation (TES), transcranial magnetic stimulation (TMS), and ultrasound stimulation (USS). ...Neurological disorders such as epilepsy, Parkin …
The commonly noninvasive techniques used in neurological manipulations include photobiomodulation (PBM), transcranial electrical stim …
Neuroprotective Effects Against POCD by Photobiomodulation: Evidence from Assembly/Disassembly of the Cytoskeleton.
Liebert AD, Chow RT, Bicknell BT, Varigos E. Liebert AD, et al. J Exp Neurosci. 2016 Feb 1;10:1-19. doi: 10.4137/JEN.S33444. eCollection 2016. J Exp Neurosci. 2016. PMID: 26848276 Free PMC article. Review.
While often reversible, it consumes medical resources, compromises patient well-being, and possibly accelerates progression into Alzheimer's disease. Anesthetics have been implicated in POCD, as has neuroinflammation, as indicated by cytokine inflammatory mar …
While often reversible, it consumes medical resources, compromises patient well-being, and possibly accelerates progression into Alzheime …
Treating cognitive impairment with transcranial low level laser therapy.
de la Torre JC. de la Torre JC. J Photochem Photobiol B. 2017 Mar;168:149-155. doi: 10.1016/j.jphotobiol.2017.02.008. Epub 2017 Feb 13. J Photochem Photobiol B. 2017. PMID: 28219828 Review.
This report examines the potential of low level laser therapy (LLLT) to alter brain cell function and neurometabolic pathways using red or near infrared (NIR) wavelengths transcranially for the prevention and treatment of cognitive impairment. ...We have prev …
This report examines the potential of low level laser therapy (LLLT) to alter brain cell function and neurometabolic pa …
Bibliometric Analysis to Global Research Status Quo on Photobiomodulation.
Liu J, Xia D, Wei M, Zhou S, Li J, Weng Y. Liu J, et al. Photobiomodul Photomed Laser Surg. 2023 Dec;41(12):683-693. doi: 10.1089/photob.2023.0058. Epub 2023 Nov 27. Photobiomodul Photomed Laser Surg. 2023. PMID: 38011736
Background: Photobiomodulation (PBM) becomes a remedial technology with growing popularity. The primary goal of this article is to conduct a PBM literature review, providing an overall systematic understanding of current and future trends. ...Current trends were characteri …
Background: Photobiomodulation (PBM) becomes a remedial technology with growing popularity. The primary goal of this article is to co …
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model.
Yang L, Wu C, Tucker L, Dong Y, Li Y, Xu P, Zhang Q. Yang L, et al. J Alzheimers Dis. 2021;83(4):1415-1429. doi: 10.3233/JAD-201616. J Alzheimers Dis. 2021. PMID: 34219711
BACKGROUND: Anxious-depressive-like behavior has been recognized as an early endophenotype in Alzheimer's disease (AD). Recent studies support early treatment of anxious-depressive-like behavior as a potential target to alleviate memory loss and reduce the ri …
BACKGROUND: Anxious-depressive-like behavior has been recognized as an early endophenotype in Alzheimer's disease (AD). …
Can mild cognitive impairment be stabilized by showering brain mitochondria with laser photons?
de la Torre JC, Olmo AD, Valles S. de la Torre JC, et al. Neuropharmacology. 2020 Jul;171:107841. doi: 10.1016/j.neuropharm.2019.107841. Epub 2019 Nov 5. Neuropharmacology. 2020. PMID: 31704275 Review.
Reduced ATP production from mitochondrial loss or damage in the wear-and-tear of aging worsens when vascular risk factors (VRF) to Alzheimer's disease develop that can accelerate both age-decline CBF and mitochondrial deficiency to a level where mild cognitiv …
Reduced ATP production from mitochondrial loss or damage in the wear-and-tear of aging worsens when vascular risk factors (VRF) to Alzhei …
The role of low-level laser therapy in Alzheimer's disease: a review of the potential benefits of vitamin D enhancement.
Firoozi A, Shadi M, Rezagholizadeh A. Firoozi A, et al. Lasers Med Sci. 2025 Mar 25;40(1):159. doi: 10.1007/s10103-025-04407-w. Lasers Med Sci. 2025. PMID: 40131549 Review.
As the global population ages, neurodegenerative diseases, particularly Alzheimer's disease (AD), have become a major public health concern. AD is the most prevalent neurodegenerative disorder, accounting for 60-80% of cases, and is characterized by progressi …
As the global population ages, neurodegenerative diseases, particularly Alzheimer's disease (AD), have become a major p …
Protocol Report on the Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD) Study.
Iosifescu DV, Song X, Gersten MB, Adib A, Cho Y, Collins KM, Yates KF, Hurtado-Puerto AM, McEachern KM, Osorio RS, Cassano P. Iosifescu DV, et al. Healthcare (Basel). 2023 Jul 13;11(14):2017. doi: 10.3390/healthcare11142017. Healthcare (Basel). 2023. PMID: 37510458 Free PMC article.
BACKGROUND: Alzheimer's disease's (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into the cerebral …
BACKGROUND: Alzheimer's disease's (AD) prevalence is projected to increase as the population ages and current treatment …
Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia.
de la Torre JC. de la Torre JC. Brain Pathol. 2016 Sep;26(5):618-31. doi: 10.1111/bpa.12405. Brain Pathol. 2016. PMID: 27324946 Free PMC article. Review.
Cardiovascular and cerebrovascular diseases are major risk factors in the development of cognitive impairment and Alzheimer's disease (AD). These cardio-cerebral disorders promote a variety of vascular risk factors which in the presence of advancing age are p …
Cardiovascular and cerebrovascular diseases are major risk factors in the development of cognitive impairment and Alzheimer's …
Light therapy for sleep disturbances in older adults with dementia: a systematic review, meta-analysis and meta-regression.
Tan JSI, Cheng LJ, Chan EY, Lau Y, Lau ST. Tan JSI, et al. Sleep Med. 2022 Feb;90:153-166. doi: 10.1016/j.sleep.2022.01.013. Epub 2022 Feb 3. Sleep Med. 2022. PMID: 35180479
BACKGROUND: Sleep disturbances in older adults with dementia are common. Light therapy may help in regulating their sleep or wake cycle. However, data in the literature on the effectiveness of light therapy for the people with the said condition remain …
BACKGROUND: Sleep disturbances in older adults with dementia are common. Light therapy may help in regulating their sleep or w …
Accelerated Molecular Transportation in the Brain Extracellular Space with 755-nm Light Attenuates Post-Stroke Cognitive Impairment in Rats.
Yang L, Gao Y, Lopes LS, Lian J, Fu W, Tan H, Yang S, Xie Z, Huang Y, Zhang J, Lu Y, Tang H, Xiong B, Wei X, Xie L, Peng Y, Liu X, Han H. Yang L, et al. Cyborg Bionic Syst. 2025 May 6;6:0262. doi: 10.34133/cbsystems.0262. eCollection 2025. Cyborg Bionic Syst. 2025. PMID: 40330544 Free PMC article.
After ischemic stroke, the accumulation of pathobiomolecules in the brain extracellular space (ECS) will exacerbate neurological damage and cognitive impairment. Photobiomodulation (PBM) has been demonstrated to improve cognitive function in Alzheimer's di …
After ischemic stroke, the accumulation of pathobiomolecules in the brain extracellular space (ECS) will exacerbate neurological damage and …
Brain Photobiomodulation Improves Sleep Quality in Subjective Cognitive Decline: A Randomized, Sham-Controlled Study.
Zhao X, Du W, Jiang J, Han Y. Zhao X, et al. J Alzheimers Dis. 2022;87(4):1581-1589. doi: 10.3233/JAD-215715. J Alzheimers Dis. 2022. PMID: 35491787 Clinical Trial.
BACKGROUND: Sleep appears to be a sensitive biomarker that facilitates early detection and effective intervention for Alzheimer's disease, while subjective cognitive decline (SCD) is a risk factor for Alzheimer's disease. ...METHODS: Fift …
BACKGROUND: Sleep appears to be a sensitive biomarker that facilitates early detection and effective intervention for Alzheimer's …
Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Lymphatic Drainage and Blood Oxygen Saturation of the Brain.
Semyachkina-Glushkovskaya O, Klimova M, Iskra T, Bragin D, Abdurashitov A, Dubrovsky A, Khorovodov A, Terskov A, Blokhina I, Lezhnev N, Vinnik V, Agranovich I, Mamedova A, Shirokov A, Navolokin N, Khlebsov B, Tuchin V, Kurths J. Semyachkina-Glushkovskaya O, et al. Adv Exp Med Biol. 2021;1269:57-61. doi: 10.1007/978-3-030-48238-1_9. Adv Exp Med Biol. 2021. PMID: 33966195 Free PMC article.
Here, we demonstrate the therapeutic effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm(2), a 9-day course) in mice with the injected model of Alzheimer's disease (AD) associated with accumulation of beta-amyloid (Abeta) in the brain re …
Here, we demonstrate the therapeutic effects of transcranial photobiomodulation (tPBM, 1267 nm, 32 J/cm(2), a 9-day course) in mice w …
Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition.
Berman MH, Halper JP, Nichols TW, Jarrett H, Lundy A, Huang JH. Berman MH, et al. J Neurol Neurosci. 2017;8(1):176. doi: 10.21767/2171-6625.1000176. Epub 2017 Feb 28. J Neurol Neurosci. 2017. PMID: 28593105 Free PMC article.
Alzheimer's disease (AD) is a common, chronic expensive debilitating neurodegenerative disease with no current treatments to prevent the physical deterioration of the brain and the consequent cognitive deficits. The current pathophysiology of Alzhei …
Alzheimer's disease (AD) is a common, chronic expensive debilitating neurodegenerative disease with no current t …
Promising Strategies to Reduce the SARS-CoV-2 Amyloid Deposition in the Brain and Prevent COVID-19-Exacerbated Dementia and Alzheimer's Disease.
Navolokin N, Adushkina V, Zlatogorskaya D, Telnova V, Evsiukova A, Vodovozova E, Eroshova A, Dosadina E, Diduk S, Semyachkina-Glushkovskaya O. Navolokin N, et al. Pharmaceuticals (Basel). 2024 Jun 16;17(6):788. doi: 10.3390/ph17060788. Pharmaceuticals (Basel). 2024. PMID: 38931455 Free PMC article. Review.
The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with cognitive impairment and Alzheimer's disease (AD) progression. Once it enters the brain, the SARS-CoV-2 virus stimulates accumulation of amyloids in the brain that are hi …
The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with cognitive impairment and Alzheimer's …
Attenuation Abeta1-42-induced neurotoxicity in neuronal cell by 660nm and 810nm LED light irradiation.
Thammasart S, Namchaiw P, Pasuwat K, Tonsomboon K, Khantachawana A. Thammasart S, et al. PLoS One. 2023 Jul 21;18(7):e0283976. doi: 10.1371/journal.pone.0283976. eCollection 2023. PLoS One. 2023. PMID: 37478089 Free PMC article.
Oligomeric amyloid-beta 1-42 (Abeta1-42) has a close correlation with neurodegenerative disorder especially Alzheimer's disease (AD). It induces oxidative stress and mitochondrial damage in neurons. Therefore, it is used to generate AD-like in vitro model for …
Oligomeric amyloid-beta 1-42 (Abeta1-42) has a close correlation with neurodegenerative disorder especially Alzheimer's dis …
Photobiomodulation Using a Low-Level Light-Emitting Diode Improves Cognitive Dysfunction in the 5XFAD Mouse Model of Alzheimer's Disease.
Cho GM, Lee SY, Park JH, Kim MJ, Park KJ, Choi BT, Shin YI, Kim NG, Shin HK. Cho GM, et al. J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):631-639. doi: 10.1093/gerona/gly240. J Gerontol A Biol Sci Med Sci. 2020. PMID: 30346494
Here we investigated the effects of photobiomodulation using light-emitting diode on amyloid plaques, gliosis, and neuronal loss to prevent and/or recover cognitive impairment, and optimal timing of photobiomodulation initiation for recovering cognitive funct …
Here we investigated the effects of photobiomodulation using light-emitting diode on amyloid plaques, gliosis, and neuronal lo …
Raman Spectroscopy Reveals Photobiomodulation-Induced alpha-Helix to beta-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases.
Di Gregorio E, Staelens M, Hosseinkhah N, Karimpoor M, Liburd J, Lim L, Shankar K, Tuszyński JA. Di Gregorio E, et al. Nanomaterials (Basel). 2024 Jun 26;14(13):1093. doi: 10.3390/nano14131093. Nanomaterials (Basel). 2024. PMID: 38998698 Free PMC article.
Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the u …
Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and …
Photobiomodulation for Alzheimer's Disease: Has the Light Dawned?
Hamblin MR. Hamblin MR. Photonics. 2019 Sep;6(3):77. doi: 10.3390/photonics6030077. Epub 2019 Jul 4. Photonics. 2019. PMID: 31363464 Free PMC article.
Next to cancer, Alzheimer's disease (AD) and dementia is probably the most worrying health problem facing the Western world today. ...Although the pathological features of AD consisting of beta-amyloid plaques and tau tangles are well established, considerabl …
Next to cancer, Alzheimer's disease (AD) and dementia is probably the most worrying health problem facing the Western w …
Near-infrared light therapy normalizes amyloid load, neuronal lipid membrane order, rafts and cholesterol level in Alzheimer's disease.
Golovynska I, Golovynskyi S, Stepanov YV, Qu J, Zhang R, Qu J. Golovynska I, et al. J Photochem Photobiol B. 2025 Jan;262:113086. doi: 10.1016/j.jphotobiol.2024.113086. Epub 2024 Dec 21. J Photochem Photobiol B. 2025. PMID: 39724841
Cholesterol dysregulation, disorder of neuronal membrane lipid packing, and lipid rafts lead to the synthesis and accumulation of toxic amyloid-beta (Abeta), contributing to the development of Alzheimer's disease (AD). Our study shows that near-infrared (NIR) …
Cholesterol dysregulation, disorder of neuronal membrane lipid packing, and lipid rafts lead to the synthesis and accumulation of toxic amyl …
Rapid Reversal of Cognitive Decline, Olfactory Dysfunction, and Quality of Life Using Multi-Modality Photobiomodulation Therapy: Case Report.
Salehpour F, Hamblin MR, DiDuro JO. Salehpour F, et al. Photobiomodul Photomed Laser Surg. 2019 Mar;37(3):159-167. doi: 10.1089/photob.2018.4569. Photobiomodul Photomed Laser Surg. 2019. PMID: 31050946
Objective: We present a case report of reversal of cognitive impairment, olfactory dysfunction, and quality of life measures in a patient with cognitive decline after multi-modality photobiomodulation (PBM) therapy. Background: Transcranial and intranasal PBM has be …
Objective: We present a case report of reversal of cognitive impairment, olfactory dysfunction, and quality of life measures in a patient wi …
Effects of Morning Blue-Green 500 nm Light Therapy on Cognition and Biomarkers in Middle-Aged and Older Adults with Subjective Cognitive Decline and Mild Cognitive Impairment: Study Protocol for a Randomized Controlled Trial.
Wang Z, Zhang Y, Dong L, Zheng Z, Zhong D, Long X, Cai Q, Jian W, Zhang S, Wu W, Yao D. Wang Z, et al. J Alzheimers Dis. 2021;83(4):1521-1536. doi: 10.3233/JAD-201560. J Alzheimers Dis. 2021. PMID: 33843675
BACKGROUND: Given that there is no specific drug to treat Alzheimer's disease, non-pharmacologic interventions in people with subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are one of the most important treatment strategies. …
BACKGROUND: Given that there is no specific drug to treat Alzheimer's disease, non-pharmacologic interventions in peopl …
[Alterations of physiological rhythms in neurodegenerative disorders: problems and prospects of light therapy].
Zueva MV, Tsapenko IV, Manko OM, Smoleevsky AE. Zueva MV, et al. Klin Med (Mosk). 2016;94(6):427-32. Klin Med (Mosk). 2016. PMID: 30289659 Review. Russian.
This review provides an outline of circadian disorders associated with neurodegenerative diseases of the brain in the elderly, including Alzheimer's (AD) and Parkinson's diseases (PD). Since light is one of the most powerful environmental cues synchronizing p …
This review provides an outline of circadian disorders associated with neurodegenerative diseases of the brain in the elderly, including …
Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease.
Johnstone DM, Moro C, Stone J, Benabid AL, Mitrofanis J. Johnstone DM, et al. Front Neurosci. 2016 Jan 11;9:500. doi: 10.3389/fnins.2015.00500. eCollection 2015. Front Neurosci. 2016. PMID: 26793049 Free PMC article. Review.
Alzheimer's and Parkinson's disease are the two most common neurodegenerative disorders. ...Previous studies have used NIr to treat tissue stressed by hypoxia, toxic insult, genetic mutation and mitochondrial dysfunction with much success. Here we propose NIr …
Alzheimer's and Parkinson's disease are the two most common neurodegenerative disorders. ...Previous studies have used …
Transcranial Photobiomodulation Treatment: Significant Improvements in Four Ex-Football Players with Possible Chronic Traumatic Encephalopathy.
Naeser MA, Martin PI, Ho MD, Krengel MH, Bogdanova Y, Knight JA, Hamblin MR, Fedoruk AE, Poole LG, Cheng C, Koo B. Naeser MA, et al. J Alzheimers Dis Rep. 2023 Jan 31;7(1):77-105. doi: 10.3233/ADR-220022. eCollection 2023. J Alzheimers Dis Rep. 2023. PMID: 36777329 Free PMC article.
BACKGROUND: Chronic traumatic encephalopathy, diagnosed postmortem (hyperphosphorylated tau), is preceded by traumatic encephalopathy syndrome with worsening cognition and behavior/mood disturbances, over years. Transcranial photobiomodulation (tPBM) may promote improvemen …
BACKGROUND: Chronic traumatic encephalopathy, diagnosed postmortem (hyperphosphorylated tau), is preceded by traumatic encephalopathy syndro …
Translation from Preclinical Research to Clinical Trials: Brain-Gut Photobiomodulation Therapy for Alzheimer's Disease.
Blivet G, Roman FJ, Delrieu J, Touchon J. Blivet G, et al. J Integr Neurosci. 2024 Mar 11;23(3):57. doi: 10.31083/j.jin2303057. J Integr Neurosci. 2024. PMID: 38538226 Free article.
Recently, novel non-pharmacological interventions, such as photobiomodulation (PBM) therapy, have shown promise for the treatment of Alzheimer's disease (AD). ...Compared to the sham patients, the PBM-treated patients had lower Alzheimer' …
Recently, novel non-pharmacological interventions, such as photobiomodulation (PBM) therapy, have shown promise for the treatm …
Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Abeta levels in Alzheimer's disease models.
Zhang Z, Shen Q, Wu X, Zhang D, Xing D. Zhang Z, et al. Aging Cell. 2020 Jan;19(1):e13054. doi: 10.1111/acel.13054. Epub 2019 Oct 30. Aging Cell. 2020. PMID: 31663252 Free PMC article.
A hallmark of Alzheimer's disease (AD) is the accumulation of amyloid-beta (Abeta), which correlates significantly with progressive cognitive deficits. Although photobiomodulation therapy (PBMT), as a novel noninvasive physiotherapy strategy, ha …
A hallmark of Alzheimer's disease (AD) is the accumulation of amyloid-beta (Abeta), which correlates significantly with …
Photobiomodulation at 660 nm Alleviates Alzheimer's Disease Pathology Through Amyloid-beta Reduction and SIRT1 Upregulation in the Hippocampus of 5xFAD Mice.
Nairuz T, Heo JC, Park HJ, Lee JH. Nairuz T, et al. Int J Mol Sci. 2025 Sep 30;26(19):9569. doi: 10.3390/ijms26199569. Int J Mol Sci. 2025. PMID: 41096835 Free PMC article.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Abeta) accumulation, synaptic dysfunction, and cognitive decline. Current pharmacological treatments provide only symptomatic relief without altering diseas …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Abeta) accumulation …
Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness: the role of the meningeal lymphatics.
Oxana SG, Alexander S, Inna B, Ivan F, Andrey T, Alexander D, Maria T, Daria E, Viktoria A, Arina E, Valeria T, Anna T, Valeria K, Maria M, Alexander D, Thomas P, Jürgen K. Oxana SG, et al. Front Optoelectron. 2023 Sep 18;16(1):22. doi: 10.1007/s12200-023-00080-5. Front Optoelectron. 2023. PMID: 37721564 Free PMC article.
With the increase in the aging population, the global number of people with Alzheimer's disease (AD) progressively increased worldwide. The situation is aggravated by the fact that there is no the effective pharmacological therapy of AD. Photobiomod …
With the increase in the aging population, the global number of people with Alzheimer's disease (AD) progressively incr …
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease.
Shen Q, Liu L, Gu X, Xing D. Shen Q, et al. Aging Cell. 2021 Jan;20(1):e13289. doi: 10.1111/acel.13289. Epub 2020 Dec 18. Aging Cell. 2021. PMID: 33336891 Free PMC article.
Alzheimer's disease (AD), a severe age-related neurodegenerative disorder, lacks effective therapeutic methods at present. Physical approaches such as gamma frequency light flicker that can effectively reduce amyloid load have been reported recently. O …
Alzheimer's disease (AD), a severe age-related neurodegenerative disorder, lacks effective therapeutic methods at prese …
Low-Level Laser Therapy to the Bone Marrow Ameliorates Neurodegenerative Disease Progression in a Mouse Model of Alzheimer's Disease: A Minireview.
Oron A, Oron U. Oron A, et al. Photomed Laser Surg. 2016 Dec;34(12):627-630. doi: 10.1089/pho.2015.4072. Epub 2016 Jun 13. Photomed Laser Surg. 2016. PMID: 27294393 Review.
OBJECTIVE: This communication reviews the ability of low-level laser therapy (LLLT) to stimulate mesenchymal stem cells (MSCs) in autologous bone marrow (BM) to enhance the capacity of MSCs to infiltrate the brain, clear beta-amyloid, and improve cognition. . …
OBJECTIVE: This communication reviews the ability of low-level laser therapy (LLLT) to stimulate mesenchymal stem cells …
Near-infrared light reduces beta-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer's disease.
Stepanov YV, Golovynska I, Zhang R, Golovynskyi S, Stepanova LI, Gorbach O, Dovbynchuk T, Garmanchuk LV, Ohulchanskyy TY, Qu J. Stepanov YV, et al. Alzheimers Res Ther. 2022 Jun 18;14(1):84. doi: 10.1186/s13195-022-01022-7. Alzheimers Res Ther. 2022. PMID: 35717405 Free PMC article.
Microglia cells play a key role in the pathology of Alzheimer's disease by causing chronic inflammation. We present new results concerning the PBM of both oxidative stress and microglia metabolism associated with the activation of metabolic processes by 808 n …
Microglia cells play a key role in the pathology of Alzheimer's disease by causing chronic inflammation. We present new …
Near-infrared laser diode mitigates Aβ1-42-induced neurodegeneration in cortical neurons.
Kim MJ, Kim MH, Kim S, Lee JJ, Kim HJ. Kim MJ, et al. J Photochem Photobiol B. 2024 Oct;259:113021. doi: 10.1016/j.jphotobiol.2024.113021. Epub 2024 Aug 30. J Photochem Photobiol B. 2024. PMID: 39222549
Alzheimer's disease, a prevalent neurodegenerative condition primarily affecting older adults, remains incurable. ...Thus, near-infrared LD treatment emerges as a promising approach for slowing or treating Alzheimer's disease, offering ne …
Alzheimer's disease, a prevalent neurodegenerative condition primarily affecting older adults, remains incurable. ...Th …
Gender Differences of Dementia in Response to Intensive Self-Administered Transcranial and Intraocular Near-Infrared Stimulation.
Qi X, Nizamutdinov D, Berman MH, Dougal G, Chazot PL, Wu E, Stevens AB, Yi SS, Huang JH. Qi X, et al. Cureus. 2021 Jul 5;13(7):e16188. doi: 10.7759/cureus.16188. eCollection 2021 Jul. Cureus. 2021. PMID: 34262831 Free PMC article.
Methods A total of 60 patient-caregiver dyads were enrolled and randomized to this double-blind, sham-controlled clinical trial. The tNIR light has a wavelength of 1,060 nm to 1,080 nm and was delivered via a photobiomodulation (PBM) unit. The active PBM unit emits …
Methods A total of 60 patient-caregiver dyads were enrolled and randomized to this double-blind, sham-controlled clinical trial. The tNIR …
Gut flora-targeted photobiomodulation therapy improves senile dementia in an Ass-induced Alzheimer's disease animal model.
Chen Q, Wu J, Dong X, Yin H, Shi X, Su S, Che B, Li Y, Yang J. Chen Q, et al. J Photochem Photobiol B. 2021 Mar;216:112152. doi: 10.1016/j.jphotobiol.2021.112152. Epub 2021 Feb 10. J Photochem Photobiol B. 2021. PMID: 33610085
BACKGROUND: Emerging evidence suggests that the gut microbiota plays an important role in the pathological progression of Alzheimer's disease (AD). Photobiomodulation (PBM) therapy is believed to have a positive regulatory effect on the imbalanc …
BACKGROUND: Emerging evidence suggests that the gut microbiota plays an important role in the pathological progression of Alzheimer' …
Effects of whole-head 810 nm near-infrared therapy on cognitive and neuropsychiatric symptoms in Alzheimer's disease: A pilot study.
Guo R, Li D, Li F, Ji L, Liu H, Qiao H, Lv Z, Tang Y, Wang D. Guo R, et al. J Alzheimers Dis. 2025 Mar;104(1):52-60. doi: 10.1177/13872877251313819. Epub 2025 Feb 5. J Alzheimers Dis. 2025. PMID: 39910867 Clinical Trial.
Near-infrared (NIR) light treatment has shown potential in cognitive improvement in previous studies. However, clinical trials of NIR for AD remain limited.ObjectiveThis study investigated the safety and effects of whole-head 810 nm NIR therapy in AD patients, inclu …
Near-infrared (NIR) light treatment has shown potential in cognitive improvement in previous studies. However, clinical trials of NIR …
The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model.
Buendía D, Guncay T, Oyanedel M, Lemus M, Weinstein A, Ardiles ÁO, Marcos J, Fernandes A, Zângaro R, Muñoz P. Buendía D, et al. Brain Sci. 2022 Sep 21;12(10):1272. doi: 10.3390/brainsci12101272. Brain Sci. 2022. PMID: 36291206 Free PMC article.
Alzheimer's disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carr …
Alzheimer's disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiom …
Dose response of transcranial near infrared light stimulation on brain functional connectivity and cognition in older adults-A randomized comparison.
Joshi H, Sinha P, Bowers D, John JP. Joshi H, et al. J Biophotonics. 2024 Feb;17(2):e202300215. doi: 10.1002/jbio.202300215. Epub 2023 Oct 31. J Biophotonics. 2024. PMID: 37776079 Clinical Trial.
Photobiomodulation, also called low-level light therapy, has been reported in animal studies to have an effect on brain activity and cognition. ...Replication of these findings in an adequately powered randomized sham-controlled study in healthy …
Photobiomodulation, also called low-level light therapy, has been reported in animal studies to have an e …
A randomized, blinded study of photobiomodulation in a mouse model of Alzheimer's disease showed no preventive effect.
Sipion M, Ferreira FM, Scholler J, Brana C, Gora M, Kouvas G, Barthet G, Sobolewski A. Sipion M, et al. Sci Rep. 2023 Nov 14;13(1):19828. doi: 10.1038/s41598-023-47039-2. Sci Rep. 2023. PMID: 37963979 Free PMC article.
Photobiomodulation (PBM), the process of exposing tissue to red or near-infrared light, has become a topic of great interest as a therapy for diverse pathologies, including neurodegenerative disorders. Here, we aimed to evaluate the potential beneficial effec …
Photobiomodulation (PBM), the process of exposing tissue to red or near-infrared light, has become a topic of great interest a …
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed ME, Zhu L, Liu TC, Cohen RM, Zhang Q. Lu Y, et al. Neurobiol Aging. 2017 Jan;49:165-182. doi: 10.1016/j.neurobiolaging.2016.10.003. Epub 2016 Oct 11. Neurobiol Aging. 2017. PMID: 27815990 Free PMC article.
Beta amyloid (Abeta) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Abeta-induced neurotoxicity in rat hippocamp …
Beta amyloid (Abeta) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The prese …
Repeated transcranial photobiomodulation improves working memory of healthy older adults: behavioral outcomes of poststimulation including a three-week follow-up.
Qu X, Li L, Zhou X, Dong Q, Liu H, Liu H, Yang Q, Han Y, Niu H. Qu X, et al. Neurophotonics. 2022 Jul;9(3):035005. doi: 10.1117/1.NPh.9.3.035005. Epub 2022 Sep 27. Neurophotonics. 2022. PMID: 36177151 Free PMC article.
SIGNIFICANCE: Decline in cognitive ability is a significant issue associated with healthy aging. Transcranial photobiomodulation (tPBM) is an emerging non-invasive neuromodulation technique and has shown promise to overcome this challenge. ...
SIGNIFICANCE: Decline in cognitive ability is a significant issue associated with healthy aging. Transcranial photobiomodulation (tPB …
Reversal of Acquired Prosopagnosia Using Quantitative Electroencephalography-Guided Laser Therapy.
Hedaya R, Lubar J. Hedaya R, et al. Photobiomodul Photomed Laser Surg. 2022 Mar;40(3):205-210. doi: 10.1089/photob.2021.0048. Epub 2022 Jan 4. Photobiomodul Photomed Laser Surg. 2022. PMID: 34981964
Methods: We report the reversal of acquired associative-type prosopagnosia (AAP) using quantitative electroencephalography (qEEG)-guided transcranial laser therapy (qGLT) in a subject with temporal lobe epilepsy (TLE) and mild cognitive impairment (MCI). ...
Methods: We report the reversal of acquired associative-type prosopagnosia (AAP) using quantitative electroencephalography (qEEG)-guided tra …
Modulating cerebrospinal fluid dynamics using pulsed photobiomodulation.
Motsenyat A, Zhong XZ, Van Lankveld H, Chen JX, Mathew A, Chen JJ. Motsenyat A, et al. Brain Stimul. 2025 Nov 26;19(1):102988. doi: 10.1016/j.brs.2025.102988. Online ahead of print. Brain Stimul. 2025. PMID: 41314512 Free article.
INTRODUCTION: The use of photobiomodulation (PBM) to enhance brain health, specifically glymphatic drainage and thus neurotoxic waste clearance, may make it a promising therapeutic tool against neurodegenerative diseases such as Alzheimer's disease. .. …
INTRODUCTION: The use of photobiomodulation (PBM) to enhance brain health, specifically glymphatic drainage and thus neurotoxic waste …
Pilot Study on Dose-Dependent Effects of Transcranial Photobiomodulation on Brain Electrical Oscillations: A Potential Therapeutic Target in Alzheimer's Disease.
Spera V, Sitnikova T, Ward MJ, Farzam P, Hughes J, Gazecki S, Bui E, Maiello M, De Taboada L, Hamblin MR, Franceschini MA, Cassano P. Spera V, et al. J Alzheimers Dis. 2021;83(4):1481-1498. doi: 10.3233/JAD-210058. J Alzheimers Dis. 2021. PMID: 34092636
BACKGROUND: Transcranial photobiomodulation (tPBM) has recently emerged as a potential cognitive enhancement technique and clinical treatment for various neuropsychiatric and neurodegenerative disorders by delivering invisible near-infrared light to the scalp and in …
BACKGROUND: Transcranial photobiomodulation (tPBM) has recently emerged as a potential cognitive enhancement technique and clinical t …
Photoactivation of TGFbeta/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer's disease model.
Wu X, Shen Q, Zhang Z, Zhang D, Gu Y, Xing D. Wu X, et al. Stem Cell Res Ther. 2021 Jun 11;12(1):345. doi: 10.1186/s13287-021-02399-2. Stem Cell Res Ther. 2021. PMID: 34116709 Free PMC article.
METHODS: Amyloid precursor protein/presenilin 1 (APP/PS1) mice were treated with photobiomodulation therapy (PBMT) for 0.1 mW/mm(2) per day in the dark for 1 month (10 min for each day). ...CONCLUSION: Our study demonstrates that PBMT, as a viable therapeutic strate …
METHODS: Amyloid precursor protein/presenilin 1 (APP/PS1) mice were treated with photobiomodulation therapy (PBMT) for 0.1 mW/ …
Near-infrared light stimulation regulates neural oscillation and memory behavior of mice with Alzheimer's disease.
Zhang S, Wang X, Jiao H. Zhang S, et al. Front Neurosci. 2024 Oct 21;18:1417178. doi: 10.3389/fnins.2024.1417178. eCollection 2024. Front Neurosci. 2024. PMID: 39498394 Free PMC article.
Photobiomodulation (PBM) is a non-invasive neuromodulation technique for the brain. Low-intensity near-infrared light (1-500 mw) has demonstrated the ability to improve memory in Alzheimer's disease (AD) model mice, suggesting its potential for …
Photobiomodulation (PBM) is a non-invasive neuromodulation technique for the brain. Low-intensity near-infrared light (1-500 m …
Non-Amyloid Approaches to Disease Modification for Alzheimer's Disease: An EU/US CTAD Task Force Report.
Gauthier S, Aisen PS, Cummings J, Detke MJ, Longo FM, Raman R, Sabbagh M, Schneider L, Tanzi R, Tariot P, Weiner M, Touchon J, Vellas B; EU/US CTAD Task Force. Gauthier S, et al. J Prev Alzheimers Dis. 2020;7(3):152-157. doi: 10.14283/jpad.2020.18. Epub 2020 Apr 6. J Prev Alzheimers Dis. 2020. PMID: 32420298 Free PMC article.
While amyloid-targeting therapies continue to predominate in the Alzheimer's disease (AD) drug development pipeline, there is increasing recognition that to effectively treat the disease it may be necessary to target other mechanisms and pathways as we …
While amyloid-targeting therapies continue to predominate in the Alzheimer's disease (AD) drug development pipeline, th …
Mid infrared light treatment attenuates cognitive decline and alters the gut microbiota community in APP/PS1 mouse model.
Wang M, Cao J, Amakye WK, Gong C, Li Q, Ren J. Wang M, et al. Biochem Biophys Res Commun. 2020 Feb 26;523(1):60-65. doi: 10.1016/j.bbrc.2019.12.015. Epub 2019 Dec 9. Biochem Biophys Res Commun. 2020. PMID: 31831179
Alzheimer's disease (AD) as the first most neurodegenerative disease in the elderly still has no effective therapy, suggesting that the intervention toolbox for AD should be expanded. One newly developed strategy involves the use of photobiom …
Alzheimer's disease (AD) as the first most neurodegenerative disease in the elderly still has no effective th …
Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
Arrant AE, Onyilo VC, Unger DE, Roberson ED. Arrant AE, et al. J Neurosci. 2018 Feb 28;38(9):2341-2358. doi: 10.1523/JNEUROSCI.3081-17.2018. Epub 2018 Jan 29. J Neurosci. 2018. PMID: 29378861 Free PMC article.
Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause neurodegenerative disease. Progranulin haploinsufficiency causes frontotemporal dementia (FTD) and complete progranulin deficiency causes CLN11 neuronal ceroid lipofuscinosis (NCL). ...Even areas wi …
Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause neurodegenerative disease. Progranulin haploinsufficiency …
Executive Summary of 2025 International Conference of the Korean Dementia Association and International Congress of the Asian Society Against Dementia (IC-KDA/ASAD 2025): A Report From the Academic Committee of the Korean Dementia Association.
Kim J, Kim GH, Kang K, Kim HJ, Suh J, Yoon B, Cho H, Pyun JM, Park YH, Choe HK, Kim YK, Lee KH, Kim JG, Yang SJ, Baek MJ, Chin J, Jang H, Moon SY; Academic Committee of the Korean Dementia Association. Kim J, et al. Dement Neurocogn Disord. 2025 Oct;24(4):209-232. doi: 10.12779/dnd.2025.24.4.209. Epub 2025 Oct 20. Dement Neurocogn Disord. 2025. PMID: 41220866 Free PMC article. Review.
Scientific highlights spanned the continuum from discovery to implementation: plasma and imaging biomarkers, retinal and electroencephalogram/voice-based digital biomarkers, and multimodal neuroimaging for risk stratification and outcome prediction; updates on anti-amyloid monocl …
Scientific highlights spanned the continuum from discovery to implementation: plasma and imaging biomarkers, retinal and electroencephalogra …
Photobiomodulation Enhances Memory Processing in Older Adults with Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy Study.
Chan AS, Lee TL, Hamblin MR, Cheung MC. Chan AS, et al. J Alzheimers Dis. 2021;83(4):1471-1480. doi: 10.3233/JAD-201600. J Alzheimers Dis. 2021. PMID: 33998541
BACKGROUND: Recent studies of photobiomodulation (PBM) in patients with cognitive or psychological disorders (including traumatic brain injury, stroke, and dementia) have yielded some encouraging results. ...
BACKGROUND: Recent studies of photobiomodulation (PBM) in patients with cognitive or psychological disorders (including traumatic bra …
Photostimulation of lymphatic clearance of beta-amyloid from mouse brain: a new strategy for the therapy of Alzheimer's disease.
Li D, Lin H, Sun S, Liu S, Liu Z, He Y, Zhu J, Xu J, Semyachkina-Glushkovskaya O, Yu T, Zhu D. Li D, et al. Front Optoelectron. 2023 Dec 14;16(1):45. doi: 10.1007/s12200-023-00099-8. Front Optoelectron. 2023. PMID: 38095816 Free PMC article.
Alzheimer's disease (AD) is an age-related neurodegenerative disorder that poses a significant burden on socio-economic and healthcare systems worldwide. ...Photobiomodulation (PBM) is a non-invasive and effective therapeutic method that has shown prom …
Alzheimer's disease (AD) is an age-related neurodegenerative disorder that poses a significant burden on socio-economic …
Dose Response of Transcranial Photobiomodulation on Cognitive Efficiency in Healthy Older Adults: A Task-Related Functional Near-Infrared Spectroscopy Study.
Lee TL, Chan AS. Lee TL, et al. J Alzheimers Dis. 2024;101(1):321-335. doi: 10.3233/JAD-240473. J Alzheimers Dis. 2024. PMID: 39177599 Clinical Trial.
BACKGROUND: Alzheimer's disease has become increasingly prevalent among the older population, leading to significant social and economic burdens. Transcranial photobiomodulation (tPBM) has shown promise as a cognitive intervention for enhancing cogniti …
BACKGROUND: Alzheimer's disease has become increasingly prevalent among the older population, leading to significant so …
Effect of low-level laser therapy (LLLT) on cognitive impairment among patients with chronic schizophrenia: a double-blind randomized placebo-controlled clinical trial.
Kheradmand A, Tabeie F, Seif P, Rezaei O, Yasamy MT. Kheradmand A, et al. Lasers Med Sci. 2022 Aug;37(6):2717-2725. doi: 10.1007/s10103-022-03545-9. Epub 2022 Mar 22. Lasers Med Sci. 2022. PMID: 35314926 Clinical Trial.
Low-level laser therapy (LLLT) is a noninvasive technique used in different medical fields. It has been applied in different medical areas such as wound healing, traumatic brain injuries, neurological disorders, cognitive disorders, Alzheimer's …
Low-level laser therapy (LLLT) is a noninvasive technique used in different medical fields. It has been applied in diff …
Photobiomodulation under Electroencephalographic Controls of Sleep for Stimulation of Lymphatic Removal of Toxins from Mouse Brain.
Blokina I, Iluykov E, Myagkov D, Tuktarov D, Popov S, Inozemzev T, Fedosov I, Shirokov A, Terskov A, Dmitrenko A, Evsyukova A, Zlatogorskaya D, Adushkina V, Tuzhilkin M, Manzhaeva M, Krupnova V, Dubrovsky A, Elizarova I, Tzoy M, Semyachkina-Glushkovskaya O. Blokina I, et al. J Vis Exp. 2024 Jun 28;(208). doi: 10.3791/67035. J Vis Exp. 2024. PMID: 39007605
The development of innovative technologies for the stimulation of MLV functions is a promising direction in the progress of the treatment of various brain diseases associated with MLV abnormalities, including Alzheimer's and Parkinson's diseases, brain tumors, traum …
The development of innovative technologies for the stimulation of MLV functions is a promising direction in the progress of the treatment of …
Transcranial photobiomodulation therapy improves cognitive test scores in dogs with presumptive canine cognitive dysfunction: A case series of five dogs.
Dewey CW, Rishniw M, Brunke MW, Gerardi J, Sakovitch K. Dewey CW, et al. Open Vet J. 2024 May;14(5):1167-1171. doi: 10.5455/OVJ.2024.v14.i5.11. Epub 2024 May 31. Open Vet J. 2024. PMID: 38938435 Free PMC article.
BACKGROUND: Canine cognitive dysfunction (CCD) is considered the canine version of human Alzheimer's disease (AD). As with AD, CCD is a multifactorial and progressive neurodegenerative disorder for which effective treatment options are continuously being soug …
BACKGROUND: Canine cognitive dysfunction (CCD) is considered the canine version of human Alzheimer's disease (AD). As w …
Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer's disease and related dementia living in long-term care facilities.
Figueiro MG, Plitnick BA, Lok A, Jones GE, Higgins P, Hornick TR, Rea MS. Figueiro MG, et al. Clin Interv Aging. 2014 Sep 12;9:1527-37. doi: 10.2147/CIA.S68557. eCollection 2014. Clin Interv Aging. 2014. PMID: 25246779 Free PMC article.
BACKGROUND: Light therapy has shown great promise as a nonpharmacological method to improve symptoms associated with Alzheimer's disease and related dementias (ADRD), with preliminary studies demonstrating that appropriately timed light e …
BACKGROUND: Light therapy has shown great promise as a nonpharmacological method to improve symptoms associated with Alzhei …
Impact of Combined Photo-Biomodulation and Aerobic Exercise on Cognitive Function and Quality-of-Life in Elderly Alzheimer Patients with Anemia: A Randomized Clinical Trial.
Nagy EN, Ali AY, Behiry ME, Naguib MM, Elsayed MM. Nagy EN, et al. Int J Gen Med. 2021 Jan 14;14:141-152. doi: 10.2147/IJGM.S280559. eCollection 2021. Int J Gen Med. 2021. PMID: 33469351 Free PMC article.
The present study aimed to evaluate a new, safe, and easy therapeutic approach to improve Alzheimer's disease-related symptoms that interfere with the whole life activities and social interaction of elderly patients. ...CONCLUSION: Combined low-leve …
The present study aimed to evaluate a new, safe, and easy therapeutic approach to improve Alzheimer's disease-related s …
Transcranial LED therapy on amyloid-beta toxin 25-35 in the hippocampal region of rats.
da Luz Eltchechem C, Salgado ASI, Zângaro RA, da Silva Pereira MC, Kerppers II, da Silva LA, Parreira RB. da Luz Eltchechem C, et al. Lasers Med Sci. 2017 May;32(4):749-756. doi: 10.1007/s10103-017-2156-3. Epub 2017 Mar 2. Lasers Med Sci. 2017. PMID: 28255783
Excessive Abeta deposition in the brain is associated with the formation of senile plaques, and their diffuse distribution is related to Alzheimer's disease. Thirty rats (EG) were irradiated with light-emitting diode (photobiomodulation (PBM)) i …
Excessive Abeta deposition in the brain is associated with the formation of senile plaques, and their diffuse distribution is related to …
Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer's disease.
Farfara D, Tuby H, Trudler D, Doron-Mandel E, Maltz L, Vassar RJ, Frenkel D, Oron U. Farfara D, et al. J Mol Neurosci. 2015 Feb;55(2):430-6. doi: 10.1007/s12031-014-0354-z. Epub 2014 Jul 4. J Mol Neurosci. 2015. PMID: 24994540
Low-level laser therapy (LLLT) has been used to treat inflammation, tissue healing, and repair processes. ...The aim of the present study was to investigate the ability of LLLT to stimulate MSCs of autologous BM in order to affect neurological behavior and be …
Low-level laser therapy (LLLT) has been used to treat inflammation, tissue healing, and repair processes. ...The aim of …
Low energy laser light (632.8 nm) suppresses amyloid-beta peptide-induced oxidative and inflammatory responses in astrocytes.
Yang X, Askarova S, Sheng W, Chen JK, Sun AY, Sun GY, Yao G, Lee JC. Yang X, et al. Neuroscience. 2010 Dec 15;171(3):859-68. doi: 10.1016/j.neuroscience.2010.09.025. Epub 2010 Sep 25. Neuroscience. 2010. PMID: 20884337 Free PMC article.
Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid beta-peptides (Abeta) in mediating these processes. ...This study should prove to provide the groundwo …
Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studie …
Low-level light therapy improves cortical metabolic capacity and memory retention.
Rojas JC, Bruchey AK, Gonzalez-Lima F. Rojas JC, et al. J Alzheimers Dis. 2012;32(3):741-52. doi: 10.3233/JAD-2012-120817. J Alzheimers Dis. 2012. PMID: 22850314
Cerebral hypometabolism characterizes mild cognitive impairment and Alzheimer's disease. Low-level light therapy (LLLT) enhances the metabolic capacity of neurons in culture through photostimulation of cytochrome oxidase, the mitoc …
Cerebral hypometabolism characterizes mild cognitive impairment and Alzheimer's disease. Low-level lig …
Nanoparticle-emitted light attenuates amyloid-beta-induced superoxide and inflammation in astrocytes.
Bungart BL, Dong L, Sobek D, Sun GY, Yao G, Lee JC. Bungart BL, et al. Nanomedicine. 2014 Jan;10(1):15-7. doi: 10.1016/j.nano.2013.10.007. Epub 2013 Nov 4. Nanomedicine. 2014. PMID: 24200521 Free PMC article.
Alzheimer's disease (AD) is the sixth leading cause of age-related death with no effective intervention yet available. ...These data provide a proof of concept for a nanomedicine platform for LLLT. FROM THE CLINICAL EDITOR: Low Level Laser Th …
Alzheimer's disease (AD) is the sixth leading cause of age-related death with no effective intervention yet available. …
Exploring the Effects of Near Infrared Light on Resting and Evoked Brain Activity in Humans Using Magnetic Resonance Imaging.
El Khoury H, Mitrofanis J, Henderson LA. El Khoury H, et al. Neuroscience. 2019 Dec 1;422:161-171. doi: 10.1016/j.neuroscience.2019.10.037. Epub 2019 Nov 1. Neuroscience. 2019. PMID: 31682952
To this end, we used a vielight transcranial device (810 nm) and compared the scans in subjects after active- and sham-light sessions. Our fMRI results showed that, while light had no effect on cerebral blood flow and global resting state brain activity (task-negati …
To this end, we used a vielight transcranial device (810 nm) and compared the scans in subjects after active- and sham-light sessions …
Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.
Meng C, He Z, Xing D. Meng C, et al. J Neurosci. 2013 Aug 14;33(33):13505-17. doi: 10.1523/JNEUROSCI.0918-13.2013. J Neurosci. 2013. PMID: 23946409 Free PMC article.
Downregulation of brain-derived neurotrophic factor (BDNF) in the hippocampus occurs early in the progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal survival and dendrite growth, BDNF upregulation may contribute to rescue de …
Downregulation of brain-derived neurotrophic factor (BDNF) in the hippocampus occurs early in the progression of Alzheimer's …
Microglia modulation with 1070-nm light attenuates Abeta burden and cognitive impairment in Alzheimer's disease mouse model.
Tao L, Liu Q, Zhang F, Fu Y, Zhu X, Weng X, Han H, Huang Y, Suo Y, Chen L, Gao X, Wei X. Tao L, et al. Light Sci Appl. 2021 Sep 8;10(1):179. doi: 10.1038/s41377-021-00617-3. Light Sci Appl. 2021. PMID: 34493703 Free PMC article.
Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues, has been considered as a possible therapeutic strategy for Alzheimer's disease (AD), while its specif …
Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in c …
Amelioration of Alzheimer's Disease Pathology in Zebrafish by Photobiomodulation.
Eroglu B, Velez D, Jones K, Deak F, Eroglu A. Eroglu B, et al. Biomedicines. 2025 Dec 18;13(12):3121. doi: 10.3390/biomedicines13123121. Biomedicines. 2025. PMID: 41463129 Free PMC article.
While affecting approximately 15% of the world population, neurodegenerative diseases, such as Alzheimer's disease (AD), are currently incurable, requiring testing of alternative treatment strategies. Hence, this study was conducted to test the hypothesis tha …
While affecting approximately 15% of the world population, neurodegenerative diseases, such as Alzheimer's disease (AD) …
Photobiomodulation therapy increases neural stem cell pool in aged 3xTg-AD mice.
Johnson KJ, Johnson K, Grant A, Taglialatela G, Micci MA. Johnson KJ, et al. PLoS One. 2025 Apr 22;20(4):e0321668. doi: 10.1371/journal.pone.0321668. eCollection 2025. PLoS One. 2025. PMID: 40261888 Free PMC article.
Presently approved Alzheimer's Disease (AD) therapeutics are designed for targeted removal of the AD-related toxic protein aggregate amyloid-beta (Abeta) and have only shown moderate efficacy at slowing disease progression. ...Therefore, targeted thera …
Presently approved Alzheimer's Disease (AD) therapeutics are designed for targeted removal of the AD-related toxic prot …
Long-term safety of single and multiple infrared transcranial laser treatments in Sprague-Dawley rats.
McCarthy TJ, De Taboada L, Hildebrandt PK, Ziemer EL, Richieri SP, Streeter J. McCarthy TJ, et al. Photomed Laser Surg. 2010 Oct;28(5):663-7. doi: 10.1089/pho.2009.2581. Photomed Laser Surg. 2010. PMID: 20961232
BACKGROUND AND OBJECTIVE: Growing interest exists in the use of near-infrared laser therapies for the treatment of numerous neurologic conditions, including acute ischemic stroke, traumatic brain injury, Parkinson's disease, and Alzheimer's disease. In …
BACKGROUND AND OBJECTIVE: Growing interest exists in the use of near-infrared laser therapies for the treatment of numerous neurologic condi …
The Effect of 40-Hz White LED Therapy on Structure-Function of Brain Mitochondrial ATP-Sensitive Ca-Activated Large-Conductance Potassium Channel in Amyloid Beta Toxicity.
Nazari M, Jafari A, Torabi N, Vajed-Samiei T, Ghasemi R, Fahanik-Babaei J, Eliassi A. Nazari M, et al. Neurotox Res. 2022 Oct;40(5):1380-1392. doi: 10.1007/s12640-022-00565-9. Epub 2022 Sep 3. Neurotox Res. 2022. PMID: 36057039
Photobiomodulation therapy has become the focus of medical research in many areas such as Alzheimer's disease (AD), because of its modulatory effect on cellular processes through light energy absorption via photoreceptors/chromophores loc …
Photobiomodulation therapy has become the focus of medical research in many areas such as Alzheimer's disease …
Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington's disease.
Nedosekin DA, Chen T, Ayyadevara S, Zharov VP, Shmookler Reis RJ. Nedosekin DA, et al. Sci Rep. 2021 Oct 5;11(1):19732. doi: 10.1038/s41598-021-98661-x. Sci Rep. 2021. PMID: 34611196 Free PMC article.
Aggregation of proteins is a prominent hallmark of virtually all neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's diseases. Little progress has been made in their treatment to slow or prevent the formation of aggregates by post-transla …
Aggregation of proteins is a prominent hallmark of virtually all neurodegenerative disorders including Alzheimer's, Parkinson' …
The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women.
Salgado AS, Zângaro RA, Parreira RB, Kerppers II. Salgado AS, et al. Lasers Med Sci. 2015 Jan;30(1):339-46. doi: 10.1007/s10103-014-1669-2. Epub 2014 Oct 3. Lasers Med Sci. 2015. PMID: 25277249
During aging processes, there is a range of functional changes, where we can highlight the disease related to the central nervous system, such as Alzheimer disease and others forms of dementia. This study investigated the effects of transcranial light …
During aging processes, there is a range of functional changes, where we can highlight the disease related to the central nervous sys …
Effect of Incidence Sites on Light Distribution at Different Wavelengths During Transcranial Photobiomodulation.
Zhang B, Yang S, Piao M, Chang P, Li T. Zhang B, et al. Acad Radiol. 2025 May 22:S1076-6332(25)00429-5. doi: 10.1016/j.acra.2025.04.076. Online ahead of print. Acad Radiol. 2025. PMID: 40410107
RATIONALE AND OBJECTIVES: Transcranial photobiomodulation (tPBM) has emerged as a promising noninvasive therapeutic technique for neurological diseases, such as Alzheimer's Disease and Stroke. ...To achieve similar photon fluence reaching brain parench …
RATIONALE AND OBJECTIVES: Transcranial photobiomodulation (tPBM) has emerged as a promising noninvasive therapeutic technique for neu …
Neuroprotective effect of a new photobiomodulation technique against Abeta(25-35) peptide-induced toxicity in mice: Novel hypothesis for therapeutic approach of Alzheimer's disease suggested.
Blivet G, Meunier J, Roman FJ, Touchon J. Blivet G, et al. Alzheimers Dement (N Y). 2018 Feb 2;4:54-63. doi: 10.1016/j.trci.2017.12.003. eCollection 2018. Alzheimers Dement (N Y). 2018. PMID: 29955652 Free PMC article.
INTRODUCTION: Photobiomodulation was assessed as a novel treatment of Alzheimer's disease (AD) by the use of a new device RGn500 combining photonic and magnetic emissions in a mouse model of AD. ...RESULTS: RGn500 daily application for 10 min produced …
INTRODUCTION: Photobiomodulation was assessed as a novel treatment of Alzheimer's disease (AD) by the use of a n …
Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia.
Purushothuman S, Johnstone DM, Nandasena C, van Eersel J, Ittner LM, Mitrofanis J, Stone J. Purushothuman S, et al. Neurosci Lett. 2015 Mar 30;591:155-159. doi: 10.1016/j.neulet.2015.02.037. Epub 2015 Feb 19. Neurosci Lett. 2015. PMID: 25703226
We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). ...
We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigate …
Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report.
Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Saltmarche AE, et al. Photomed Laser Surg. 2017 Aug;35(8):432-441. doi: 10.1089/pho.2016.4227. Epub 2017 Feb 10. Photomed Laser Surg. 2017. PMID: 28186867 Free PMC article.
OBJECTIVE: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10-24 would improve when treated with near-infrared photobiomodulation …
OBJECTIVE: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease …
Use of Mitochondrial Delayed Luminescence Measurements From Brain Tissue to Optimize Photobiomodulation Prarameters in Alzheimer's Disease Mice.
Kim HB, Sung CK. Kim HB, et al. J Biophotonics. 2025 Oct;18(10):e202500151. doi: 10.1002/jbio.202500151. Epub 2025 Jun 23. J Biophotonics. 2025. PMID: 40551353 Free PMC article.
The therapeutic potential of photobiomodulation (PBM) for Alzheimer's disease (AD) was evaluated by examining beta-amyloid accumulation, microglial activation, and memory function. Mitochondrial delayed luminescence (m-DL), an indirect mitochondrial ma …
The therapeutic potential of photobiomodulation (PBM) for Alzheimer's disease (AD) was evaluated by examining be …
Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.
Purushothuman S, Johnstone DM, Nandasena C, Mitrofanis J, Stone J. Purushothuman S, et al. Alzheimers Res Ther. 2014 Jan 3;6(1):2. doi: 10.1186/alzrt232. eCollection 2014. Alzheimers Res Ther. 2014. PMID: 24387311 Free PMC article.
INTRODUCTION: Previous work has demonstrated the efficacy of irradiating tissue with red to infrared light in mitigating cerebral pathology and degeneration in animal models of stroke, traumatic brain injury, parkinsonism and Alzheimer's disease (AD). …
INTRODUCTION: Previous work has demonstrated the efficacy of irradiating tissue with red to infrared light in mitigating cerebral pat …
Photobiomodulation by low-power laser irradiation attenuates Abeta-induced cell apoptosis through the Akt/GSK3beta/beta-catenin pathway.
Liang J, Liu L, Xing D. Liang J, et al. Free Radic Biol Med. 2012 Oct 1;53(7):1459-67. doi: 10.1016/j.freeradbiomed.2012.08.003. Epub 2012 Aug 11. Free Radic Biol Med. 2012. PMID: 22917976
Apoptosis induced by amyloid beta peptide (Abeta) is thought to associate with the pathogenesis of Alzheimer disease (AD). Accumulating evidence shows that low-power laser irradiation (LPLI) is capable of reducing Abeta-induced apoptosis. ...
Apoptosis induced by amyloid beta peptide (Abeta) is thought to associate with the pathogenesis of Alzheimer disease (AD). Acc …
Neuro-lymphaphotonics opens new horizons of the future technologies for the therapy of brain diseases.
Liu S, Semyachkina-Glushkovskaya O, Yu T, Ilukov E, Rafailov E, Sokolovski S, Kurths J, Zhu D. Liu S, et al. Theranostics. 2026 Jan 1;16(2):776-793. doi: 10.7150/thno.120374. eCollection 2026. Theranostics. 2026. PMID: 41346709 Free PMC article. Review.
Since MLVs are located on the brain surface, light penetrating the skull easily reaches MLVs and affects their functions. Therefore, MLVs are an ideal target for photobiomodulation (PBM). The pioneering studies have shown that PBM of MLVs is a promising strategy for …
Since MLVs are located on the brain surface, light penetrating the skull easily reaches MLVs and affects their functions. Therefore, …
Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast Injury.
Perez Garcia G, Perez GM, Otero-Pagan A, Abutarboush R, Kawoos U, De Gasperi R, Gama Sosa MA, Pryor D, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Perez Garcia G, et al. Neurotrauma Rep. 2021 Dec 2;2(1):548-563. doi: 10.1089/neur.2021.0005. eCollection 2021. Neurotrauma Rep. 2021. PMID: 34901948 Free PMC article.
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from chronic cognitive and mental health problems, including post-traumatic stress disorder (PTSD). Transcranial laser therapy (TLT) uses lo …
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from ch …
Inhibition of Aβ(25-35)-induced cell apoptosis by low-power-laser-irradiation (LPLI) through promoting Akt-dependent YAP cytoplasmic translocation.
Zhang H, Wu S, Xing D. Zhang H, et al. Cell Signal. 2012 Jan;24(1):224-32. doi: 10.1016/j.cellsig.2011.09.004. Epub 2011 Sep 14. Cell Signal. 2012. PMID: 21945154
Deposition of amyloid-beta-peptide (Abeta) in the brain is considered a pathological hallmark of Alzheimer's disease (AD). Our previous studies show that Yes-associated protein (YAP) is involved in the regulation of apoptosis induced by Abeta(25-35) through Y …
Deposition of amyloid-beta-peptide (Abeta) in the brain is considered a pathological hallmark of Alzheimer's disease (A …
Gut Microbiota-Targeted Photobiomodulation Ameliorates Alzheimer's Pathology via the Gut-Brain Axis: Comparable Efficacy to Transcranial Irradiation.
Cao S, Shi X, Chen Y, Liu T, Hu J, Dong X, Chen H, Dai J, Yin H. Cao S, et al. Microorganisms. 2025 Nov 22;13(12):2659. doi: 10.3390/microorganisms13122659. Microorganisms. 2025. PMID: 41471864 Free PMC article.
Alzheimer's disease (AD) is a major neurodegenerative disorder with limited effective and affordable therapies. Photobiomodulation (PBM) offers a safe, non-invasive treatment strategy, yet conventional transcranial PBM (tc-PBM) is restricted by low sku …
Alzheimer's disease (AD) is a major neurodegenerative disorder with limited effective and affordable therapies. Phot …
Transcranial Near-Infrared Laser Therapy for Stroke: How to Recover from Futility in the NEST-3 Clinical Trial.
Lapchak PA, Boitano PD. Lapchak PA, et al. Acta Neurochir Suppl. 2016;121:7-12. doi: 10.1007/978-3-319-18497-5_2. Acta Neurochir Suppl. 2016. PMID: 26463915
Because NILT remains a promising therapeutic approach to treat stroke, we designed a systematic study to determine laser light penetration profiles across the skull of four different species with increasing skull thickness: mouse, rat, rabbit, and human.Our study demonstra …
Because NILT remains a promising therapeutic approach to treat stroke, we designed a systematic study to determine laser light penetr …
Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer's disease.
Zinchenko E, Navolokin N, Shirokov A, Khlebtsov B, Dubrovsky A, Saranceva E, Abdurashitov A, Khorovodov A, Terskov A, Mamedova A, Klimova M, Agranovich I, Martinov D, Tuchin V, Semyachkina-Glushkovskaya O, Kurts J. Zinchenko E, et al. Biomed Opt Express. 2019 Jul 15;10(8):4003-4017. doi: 10.1364/BOE.10.004003. eCollection 2019 Aug 1. Biomed Opt Express. 2019. PMID: 31452991 Free PMC article.
The behavior tests showed that tPBM improved the cognitive, memory and neurological status of mice with Alzheimer's disease (AD). Using of our original method based on optical coherence tomography (OCT) analysis of clearance of gold nanorods (GNRs) from the b …
The behavior tests showed that tPBM improved the cognitive, memory and neurological status of mice with Alzheimer's disease …
Monitoring photobiomodulation of amyloid-beta aggregation in 3D cultured cells using label-free nonlinear optical imaging.
Zhou T, Zhang R, Ohulchanskyy TY, Qu J. Zhou T, et al. Biomed Opt Express. 2025 Feb 24;16(3):1143-1155. doi: 10.1364/BOE.549594. eCollection 2025 Mar 1. Biomed Opt Express. 2025. PMID: 40109529 Free PMC article.
The accumulation of beta-amyloid (Abeta) peptide aggregates, commonly known as plaques, is considered a key hallmark in the development of Alzheimer's disease (AD). Recently, low-level light therapy (LLLT), also referred to as p …
The accumulation of beta-amyloid (Abeta) peptide aggregates, commonly known as plaques, is considered a key hallmark in the development of …
670 nm laser light and EGCG complementarily reduce amyloid-beta aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease?
Sommer AP, Bieschke J, Friedrich RP, Zhu D, Wanker EE, Fecht HJ, Mereles D, Hunstein W. Sommer AP, et al. Photomed Laser Surg. 2012 Jan;30(1):54-60. doi: 10.1089/pho.2011.3073. Epub 2011 Oct 26. Photomed Laser Surg. 2012. PMID: 22029866
OBJECTIVE: The aim of the present study is to present the results of in vitro experiments with possible relevance in the treatment of Alzheimer's disease (AD). BACKGROUND DATA: Despite intensive research efforts, there is no treatment for AD. ...We hope that …
OBJECTIVE: The aim of the present study is to present the results of in vitro experiments with possible relevance in the treatment of Alz …
White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans.
Park Y, Yoon E, Park J, Kim JS, Han JW, Bae JB, Kim SS, Kim DW, Woo SJ, Park J, Lee W, Yoo S, Kim KW. Park Y, et al. Geroscience. 2025 Feb;47(1):1019-1037. doi: 10.1007/s11357-024-01281-2. Epub 2024 Jul 15. Geroscience. 2025. PMID: 39004653 Free PMC article.
Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer's disease in mouse models. However, clinical trials in Alzheimer's disease (AD) patients have yielded inconsistent results, necessitating …
Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer's disease in mouse …
Low-power laser irradiation inhibiting Abeta25-35-induced PC12 cell apoptosis via PKC activation.
Zhang L, Xing D, Zhu D, Chen Q. Zhang L, et al. Cell Physiol Biochem. 2008;22(1-4):215-22. doi: 10.1159/000149799. Epub 2008 Jul 25. Cell Physiol Biochem. 2008. PMID: 18769048
Apoptosis is a contributing pathophysiological mechanism of Alzheimer's disease (AD). Recently, low-power laser irradiation (LPLI) has been applied to moderate AD, but the underlying mechanism remains unknown. ...
Apoptosis is a contributing pathophysiological mechanism of Alzheimer's disease (AD). Recently, low-power laser irradia …