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Year Number of Results
1996 1
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2003 31
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2005 55
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2009 117
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1,721 results

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AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells.
Yoshinaga T, Uwabe K, Naito S, Higashino K, Nakano T, Numata Y, Kihara A. Yoshinaga T, et al. PLoS One. 2016 Dec 9;11(12):e0167848. doi: 10.1371/journal.pone.0167848. eCollection 2016. PLoS One. 2016. PMID: 27936102 Free PMC article.
Though AM251 is known to act as an antagonist for the cannabinoid receptor type 1 (CB1) and an agonist for the G protein-coupled receptor 55 (GRP55), the suppression of EMT by AM251 was not mediated through either receptor. ...Activation of SMAD2/3 and p38 mitogen-a …
Though AM251 is known to act as an antagonist for the cannabinoid receptor type 1 (CB1) and an agonist for the G protein-coupled rece …
AM251, a cannabinoid receptor 1 antagonist, prevents human fibroblasts differentiation and collagen deposition induced by TGF-beta - An in vitro study.
Correia-Sá IB, Carvalho CM, Serrão PV, Machado VA, Carvalho SO, Marques M, Vieira-Coelho MA. Correia-Sá IB, et al. Eur J Pharmacol. 2021 Feb 5;892:173738. doi: 10.1016/j.ejphar.2020.173738. Epub 2020 Nov 19. Eur J Pharmacol. 2021. PMID: 33220269
AM251 shows a concentration-dependent effect over collagen deposition with a pIC50 of 5.5 (4.6-6.4). TGF-beta significantly increases CB(1) receptor expression. CB(1) inactivation with AM251 prevents fibroblasts differentiation and collagen deposition, induced by TG
AM251 shows a concentration-dependent effect over collagen deposition with a pIC50 of 5.5 (4.6-6.4). TGF-beta significantly increases
AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells.
Carpi S, Fogli S, Romanini A, Pellegrino M, Adinolfi B, Podestà A, Costa B, Da Pozzo E, Martini C, Breschi MC, Nieri P. Carpi S, et al. Anticancer Drugs. 2015 Aug;26(7):754-62. doi: 10.1097/CAD.0000000000000246. Anticancer Drugs. 2015. PMID: 25974027
The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system. ...The involvement of GPR55, TRPA1, and COX-2 in the AM251 mechanism of action was excluded. Th …
The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, …
CB(1) Ligand AM251 Induces Weight Loss and Fat Reduction in Addition to Increased Systemic Inflammation in Diet-Induced Obesity.
O'Keefe L, Vu T, Simcocks AC, Jenkin KA, Mathai ML, Hryciw DH, Hutchinson DS, McAinch AJ. O'Keefe L, et al. Int J Mol Sci. 2022 Sep 28;23(19):11447. doi: 10.3390/ijms231911447. Int J Mol Sci. 2022. PMID: 36232744 Free PMC article.
AM251 treatment had no effect on white fat UCP1 expression levels. ...The CB(1) ligand AM251 increased systemic inflammation suggesting limitations on its use in metabolic disorders....
AM251 treatment had no effect on white fat UCP1 expression levels. ...The CB(1) ligand AM251 increased systemic inflammation s
AM251, cannabinoids receptors ligand, improves recognition memory in rats.
Bialuk I, Winnicka MM. Bialuk I, et al. Pharmacol Rep. 2011;63(3):670-9. doi: 10.1016/s1734-1140(11)70578-3. Pharmacol Rep. 2011. PMID: 21857077 Free article.
While the lowest dose of AM251 (1.0 mg/kg) significantly improved recognition memory, higher doses (2.5 mg/kg and 5.0 mg/kg) did not have an influence on it. Moreover, AM251 did not affect anxiety but in the highest dose significantly attenuated psychomotor activity …
While the lowest dose of AM251 (1.0 mg/kg) significantly improved recognition memory, higher doses (2.5 mg/kg and 5.0 mg/kg) did not …
Concentration, population, and context-dependent effects of AM251 in zebrafish.
Tran S, Chatterjee D, Facciol A, Gerlai R. Tran S, et al. Psychopharmacology (Berl). 2016 Apr;233(8):1445-54. doi: 10.1007/s00213-016-4240-y. Epub 2016 Feb 16. Psychopharmacology (Berl). 2016. PMID: 26883874
We found that exposure to the highest dose of AM251 (1mg/L) for 60min increased serotonin in fish of both populations tested. In contrast, exposure to 0.1mg/L AM251 decreased, whereas to 1mg/L AM251 increased dopamine, DOPAC and 5-HIAA in fish of both populat …
We found that exposure to the highest dose of AM251 (1mg/L) for 60min increased serotonin in fish of both populations tested. In cont …
Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury.
Ueda M, Iwasaki H, Wang S, Murata E, Poon KY, Mao J, Martyn JA. Ueda M, et al. Anesthesiology. 2014 Dec;121(6):1311-9. doi: 10.1097/ALN.0000000000000422. Anesthesiology. 2014. PMID: 25188001 Free PMC article.
Astroglial activity (n=4 per time point) increased 2.90.3 fold at day 7 only. Glial activities were unaltered by AM251. CONCLUSIONS: AM251 inhibited nociceptive behaviors after burn even beyond 7-day period of administration. Although many studies have documented th …
Astroglial activity (n=4 per time point) increased 2.90.3 fold at day 7 only. Glial activities were unaltered by AM251. CONCLUSIONS: …
AM251, a selective antagonist of the CB1 receptor, inhibits the induction of long-term potentiation and induces retrograde amnesia in rats.
de Oliveira Alvares L, Genro BP, Vaz Breda R, Pedroso MF, Da Costa JC, Quillfeldt JA. de Oliveira Alvares L, et al. Brain Res. 2006 Feb 23;1075(1):60-7. doi: 10.1016/j.brainres.2005.11.101. Epub 2006 Feb 7. Brain Res. 2006. PMID: 16464439
Standard extracellular electrophysiology techniques were used to record field excitatory postsynaptic potentials from the dendritic region of CA1 neurons in response to a high frequency stimulation of Schaffer's collaterals; a micropipette ejected 0.2 microM of AM251 (in D …
Standard extracellular electrophysiology techniques were used to record field excitatory postsynaptic potentials from the dendritic region o …
The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.
Ruz-Maldonado I, Liu B, Atanes P, Pingitore A, Huang GC, Choudhary P, Persaud SJ. Ruz-Maldonado I, et al. Cell Mol Life Sci. 2020 Nov;77(22):4709-4723. doi: 10.1007/s00018-019-03433-6. Epub 2020 Jan 10. Cell Mol Life Sci. 2020. PMID: 31925452 Free PMC article.
Thus, CB(1) antagonists such as SR141716A, also known as rimonabant, and AM251 act as GPR55 agonists in some cell types. The complex pharmacological properties of cannabinoids make it difficult to fully identify the relative importance of CB(1) and GPR55 in the functional …
Thus, CB(1) antagonists such as SR141716A, also known as rimonabant, and AM251 act as GPR55 agonists in some cell types. The complex …
1,721 results