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circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth.
Ou R, Lv J, Zhang Q, Lin F, Zhu L, Huang F, Li X, Li T, Zhao L, Ren Y, Xu Y. Ou R, et al. Mol Ther Nucleic Acids. 2020 Mar 6;19:50-60. doi: 10.1016/j.omtn.2019.09.022. Epub 2019 Sep 30. Mol Ther Nucleic Acids. 2020. PMID: 31812104 Free PMC article.
Using a bioinformatics analysis, we found circ_0004214 was a circular form of AMOTL1. Through qRT-PCR analysis, circAMOTL1 and its host gene AMOTL1 were both upregulated in cervical cancer tissues and closely correlated with poor prognosis of cervical canc …
Using a bioinformatics analysis, we found circ_0004214 was a circular form of AMOTL1. Through qRT-PCR analysis, circAMOTL1 and its ho …
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin.
Couderc C, Boin A, Fuhrmann L, Vincent-Salomon A, Mandati V, Kieffer Y, Mechta-Grigoriou F, Del Maestro L, Chavrier P, Vallerand D, Brito I, Dubois T, De Koning L, Bouvard D, Louvard D, Gautreau A, Lallemand D. Couderc C, et al. Neoplasia. 2016 Jan;18(1):10-24. doi: 10.1016/j.neo.2015.11.010. Neoplasia. 2016. PMID: 26806348 Free PMC article.
Here we show that the motin family member AMOTL1 is an important effector of Hippo signaling in breast cancer. AMOTL1 connects Hippo signaling to tumor cell aggressiveness. ...In parallel, YAP stimulates AMOTL1 expression. The loss of Merlin expression …
Here we show that the motin family member AMOTL1 is an important effector of Hippo signaling in breast cancer. AMOTL1 c …
Harnessing machine learning and multi-omics to explore tumor evolutionary characteristics and the role of AMOTL1 in prostate cancer.
Zhu W, Wu J, Lai W, Li F, Zeng H, Li X, Su H, Liu B, Zhao X, Zou C, Xiao H, Luo Y. Zhu W, et al. Int J Biol Macromol. 2025 Jan;286:138402. doi: 10.1016/j.ijbiomac.2024.138402. Epub 2024 Dec 4. Int J Biol Macromol. 2025. PMID: 39643184
Furthermore, we experimentally validated the critical role of AMOTL1 in PCa pharmacodynamics through its interaction with AR, pivotal for modulating the sensitivity to AR antagonist. Additionally, we demonstrated the generalizability and applicability of TECPI across pan- …
Furthermore, we experimentally validated the critical role of AMOTL1 in PCa pharmacodynamics through its interaction with AR, pivotal …
CircAMOTL1 RNA and AMOTL1 Protein: Complex Functions of AMOTL1 Gene Products.
Sadlak J, Joshi I, Prószyński TJ, Kischel A. Sadlak J, et al. Int J Mol Sci. 2023 Jan 20;24(3):2103. doi: 10.3390/ijms24032103. Int J Mol Sci. 2023. PMID: 36768425 Free PMC article. Review.
This review summarizes current knowledge about circRNAs and focuses on the functions of AMOTL1 circRNAs and AMOTL1 protein. Both products from the AMOTL1 gene have well-known functions in physiology, cancer, and other disorders. Using AMOTL1 as …
This review summarizes current knowledge about circRNAs and focuses on the functions of AMOTL1 circRNAs and AMOTL1 protein. Bo …
MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells.
Wan HY, Li QQ, Zhang Y, Tian W, Li YN, Liu M, Li X, Tang H. Wan HY, et al. Cancer Lett. 2014 Dec 1;355(1):148-58. doi: 10.1016/j.canlet.2014.09.005. Epub 2014 Sep 11. Cancer Lett. 2014. PMID: 25218344
In previous studies, miR-124 was found to repress proliferation and metastasis in different types of cancers, but whether it functions in cervical cancer remained unknown. Here, we demonstrate that miR-124 can repress vasculogenic mimicry, migration and invasion in …
In previous studies, miR-124 was found to repress proliferation and metastasis in different types of cancers, but whether it function …
Hsa_circ_0001278 Facilitates Colorectal Cancer Progression via Sponging miR-338-5p and Regulating AMOTL1 Expression.
Ge H, Yan Y, Wang H, Bian J, Deng Z, Su X, Yang Z, Song J. Ge H, et al. Comb Chem High Throughput Screen. 2025;28(1):99-109. doi: 10.2174/0113862073265207231108052536. Comb Chem High Throughput Screen. 2025. PMID: 38018210
BACKGROUND: Colorectal cancer (CRC) ranks as the third most common cancer and is second in terms of mortality worldwide. ...Further mechanistic studies revealed that hsa_circ_0001278 sponges miR-338-5p to regulate angiomotin-like 1 (AMOTL1), thereby facilitat …
BACKGROUND: Colorectal cancer (CRC) ranks as the third most common cancer and is second in terms of mortality worldwide. ...Fu …
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis.
Zhou Y, Zhang J, Li H, Huang T, Wong CC, Wu F, Wu M, Weng N, Liu L, Cheng ASL, Yu J, Wong N, Lo KW, Tang PMK, Kang W, To KF. Zhou Y, et al. Oncogene. 2020 May;39(22):4375-4389. doi: 10.1038/s41388-020-1293-5. Epub 2020 Apr 20. Oncogene. 2020. PMID: 32313226 Free PMC article.
The interaction between YAP1 and AMOTL1 was suggested by co-immunoprecipitation and immunofluorescent staining. The clinical significance of the AMOTL1-YAP1-CTGF axis in gastric cancer (GC) was analyzed by multiple clinical cohorts. ...The cytoplasmic interac …
The interaction between YAP1 and AMOTL1 was suggested by co-immunoprecipitation and immunofluorescent staining. The clinical signific …
SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.
Xu XC, Jiang JX, Zhou YQ, He S, Liu Y, Li YQ, Wei PP, Bei JX, Sun J, Luo CL. Xu XC, et al. Cell Death Dis. 2023 Aug 9;14(8):511. doi: 10.1038/s41419-023-06034-1. Cell Death Dis. 2023. PMID: 37558679 Free PMC article.
Among these events, we verify the generation of a long isoform of AMOTL1 (AMOTL1-L) through a direct bond of the SRSF3 RRM domain with the exon 12 of AMOTL1 to promote exon inclusion. Functional studies also reveal that AMOTL1-L promotes the proliferat …
Among these events, we verify the generation of a long isoform of AMOTL1 (AMOTL1-L) through a direct bond of the SRSF3 RRM dom …
Angiomotin family proteins in the Hippo signaling pathway.
Wang Y, Yu FX. Wang Y, et al. Bioessays. 2024 Aug;46(8):e2400076. doi: 10.1002/bies.202400076. Epub 2024 May 17. Bioessays. 2024. PMID: 38760875 Review.
The Motin family proteins (Motins) are a class of scaffolding proteins consisting of Angiomotin (AMOT), AMOT-like protein 1 (AMOTL1), and AMOT-like protein 2 (AMOTL2). Motins play a pivotal role in angiogenesis, tumorigenesis, and neurogenesis by modulating multiple cellul …
The Motin family proteins (Motins) are a class of scaffolding proteins consisting of Angiomotin (AMOT), AMOT-like protein 1 (AMOTL1), …
41 results