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Year Number of Results
1994 1
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2002 7
2003 4
2004 6
2005 13
2006 14
2007 11
2008 14
2009 14
2010 10
2011 37
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401 results

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Page 1
ANK3 related neurodevelopmental disorders: expanding the spectrum of heterozygous loss-of-function variants.
Kloth K, Lozic B, Tagoe J, Hoffer MJV, Van der Ven A, Thiele H, Altmüller J, Kubisch C, Au PYB, Denecke J, Bijlsma EK, Lessel D. Kloth K, et al. Neurogenetics. 2021 Oct;22(4):263-269. doi: 10.1007/s10048-021-00655-4. Epub 2021 Jul 3. Neurogenetics. 2021. PMID: 34218362 Free PMC article.
ANK3 encodes multiple isoforms of ankyrin-G, resulting in variegated tissue expression and function, especially regarding its role in neuronal development. Based on the zygosity, location, and type, ANK3 variants result in different neurodevelopmental phenotypes. .. …
ANK3 encodes multiple isoforms of ankyrin-G, resulting in variegated tissue expression and function, especially regarding its role in …
The ANK3 bipolar disorder gene regulates psychiatric-related behaviors that are modulated by lithium and stress.
Leussis MP, Berry-Scott EM, Saito M, Jhuang H, de Haan G, Alkan O, Luce CJ, Madison JM, Sklar P, Serre T, Root DE, Petryshen TL. Leussis MP, et al. Biol Psychiatry. 2013 Apr 1;73(7):683-90. doi: 10.1016/j.biopsych.2012.10.016. Epub 2012 Dec 11. Biol Psychiatry. 2013. PMID: 23237312
Ank3 expression was reduced in mouse brain either by viral-mediated RNA interference or through disruption of brain-specific Ank3 in a heterozygous knockout mouse. ...Ank3+/- mice also exhibited elevated serum corticosterone, suggesting that reduced Ank3 …
Ank3 expression was reduced in mouse brain either by viral-mediated RNA interference or through disruption of brain-specific Ank3 …
A Rare Variant of ANK3 Is Associated With Intracranial Aneurysm.
Liu J, Liao X, Zhou J, Li B, Xu L, Liu S, Li Y, Yuan D, Hu C, Jiang W, Yan J. Liu J, et al. Front Neurol. 2021 Jun 25;12:672570. doi: 10.3389/fneur.2021.672570. eCollection 2021. Front Neurol. 2021. PMID: 34248821 Free PMC article.
Amino acid R1468 in ANK3 was predicted to be located in the spectrin-binding domain of ankyrin-G and may regulate the migration of vascular endothelial cells and affect cell-cell junctions. Therefore, the variation p.R1468H may cause weakening of the artery walls, thereby …
Amino acid R1468 in ANK3 was predicted to be located in the spectrin-binding domain of ankyrin-G and may regulate the migration of va …
Clinical case report: mosaic ANK3 pathogenic variant in a patient with autism spectrum disorder and neurodevelopmental delay.
Fang X, Fee T, Davis J, Stolerman ES, Caylor RC. Fang X, et al. Cold Spring Harb Mol Case Stud. 2023 Jul 11;9(3):a006233. doi: 10.1101/mcs.a006233. Print 2023 Jun. Cold Spring Harb Mol Case Stud. 2023. PMID: 37263801 Free PMC article.
These findings have suggested genotype-phenotype correlations and even isoform-specific implications for individuals with ANK3 pathogenic variants. Here, we report a patient with speech delay, autism spectrum disorder, and a language disorder in which a de novo nonsense …
These findings have suggested genotype-phenotype correlations and even isoform-specific implications for individuals with ANK3 pathog …
ANK3 Gene Polymorphism Rs10994336 Influences Executive Functions by Modulating Methylation in Patients With Bipolar Disorder.
Tang L, Liu J, Zhu Y, Duan J, Chen Y, Wei Y, Gong X, Wang F, Tang Y. Tang L, et al. Front Neurosci. 2021 Aug 4;15:682873. doi: 10.3389/fnins.2021.682873. eCollection 2021. Front Neurosci. 2021. PMID: 34421516 Free PMC article.
The intronic single nucleotide polymorphism (SNP) rs10994336 within the ANK3 has emerged as one of the most replicated risk variants for bipolar disorder (BD) in genome-wide association studies. ...Conclusion: Our study suggests that BD-related genetic variant rs10994336 i …
The intronic single nucleotide polymorphism (SNP) rs10994336 within the ANK3 has emerged as one of the most replicated risk variants …
ANK3 gene polymorphisms and bipolar disorder: a meta-analysis.
Roby Y. Roby Y. Psychiatr Genet. 2017 Dec;27(6):225-235. doi: 10.1097/YPG.0000000000000186. Psychiatr Genet. 2017. PMID: 29068871
In the present meta-analysis, we aimed to establish whether ANK3 single nucleotide polymorphisms (SNPs) confer increased risk for BD. ...However, broader coverage is needed on less explored SNPs to further elucidate the genetic effect of other ANK3 variants that may …
In the present meta-analysis, we aimed to establish whether ANK3 single nucleotide polymorphisms (SNPs) confer increased risk for BD. …
Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders.
Aas M, Andreassen OA, Gjerstad J, Rødevand L, Hjell G, Johansen IT, Lunding SH, Ormerod MBEG, Lagerverg TV, Steen NE, Djurovic S, Akkouh I. Aas M, et al. Sci Rep. 2023 Aug 24;13(1):13845. doi: 10.1038/s41598-023-40310-6. Sci Rep. 2023. PMID: 37620394 Free PMC article.
ANK3 mRNA levels also moderated the relationship between emotional neglect and manic/hypomanic episodes. Our results suggest that ANK3 expression levels moderate the association between specific types of childhood trauma and affective traits in mental disorders....
ANK3 mRNA levels also moderated the relationship between emotional neglect and manic/hypomanic episodes. Our results suggest that …
Mood, stress and longevity: convergence on ANK3.
Rangaraju S, Levey DF, Nho K, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, Niculescu AB. Rangaraju S, et al. Mol Psychiatry. 2016 Aug;21(8):1037-49. doi: 10.1038/mp.2016.65. Epub 2016 May 24. Mol Psychiatry. 2016. PMID: 27217151 Free PMC article.
Wild-type ANK3/unc-44 increases in expression with age in C. elegans, and is maintained at lower youthful levels by mianserin treatment. ...Of note, ANK3 was previously reported to be overexpressed in fibroblasts from patients with Hutchinson-Gilford progeria syndro …
Wild-type ANK3/unc-44 increases in expression with age in C. elegans, and is maintained at lower youthful levels by mianserin treatme …
Bioinformatic analyses reveal the prognostic significance and potential role of ankyrin 3 (ANK3) in kidney renal clear cell carcinoma.
Somsuan K, Aluksanasuwan S. Somsuan K, et al. Genomics Inform. 2023 Jun;21(2):e22. doi: 10.5808/gi.23013. Epub 2023 Jun 30. Genomics Inform. 2023. PMID: 37423640 Free PMC article.
Finally, the TIMER2.0 database was used to assess correlation between ANK3 expression and immune infiltration in KIRC. We found that ANK3 expression was significantly decreased in KIRC compared to normal tissues. The KIRC patients with low ANK3 expression had …
Finally, the TIMER2.0 database was used to assess correlation between ANK3 expression and immune infiltration in KIRC. We found that …
ANK3 gene expression in bipolar disorder and schizophrenia.
Wirgenes KV, Tesli M, Inderhaug E, Athanasiu L, Agartz I, Melle I, Hughes T, Andreassen OA, Djurovic S. Wirgenes KV, et al. Br J Psychiatry. 2014 Sep;205(3):244-5. doi: 10.1192/bjp.bp.114.145433. Epub 2014 May 8. Br J Psychiatry. 2014. PMID: 24809399
ANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive. Here, we show that ANK3 gene expression in blood is …
ANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the …
401 results