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462 results

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Page 1
ANK3 gene polymorphisms and bipolar disorder: a meta-analysis.
Roby Y. Roby Y. Psychiatr Genet. 2017 Dec;27(6):225-235. doi: 10.1097/YPG.0000000000000186. Psychiatr Genet. 2017. PMID: 29068871
OBJECTIVE: Converging evidence has suggested ankyrin 3 (ANK3) as a risk gene for bipolar disorder (BD). However, association studies investigating its genetic variants and BD susceptibility have reported inconsistent results. ...CONCLUSION: The current meta-analysis provid …
OBJECTIVE: Converging evidence has suggested ankyrin 3 (ANK3) as a risk gene for bipolar disorder (BD). However, association studies …
The phenotypic and genotypic spectrum of individuals with mono- or biallelic ANK3 variants.
Furia F, Levy AM, Theunis M, Bamshad MJ, Bartos MN, Bijlsma EK, Brancati F, Cejudo L, Chong JX, De Luca C, Dean SJ, Egense A, Goel H, Guenzel AJ, Hüffmeier U, Legius E, Mancini GMS, Marcos-Alcalde I, Niclass T, Planes M, Redon S, Ros-Pardo D, Rouault K, Schot R, Schuhmann S, Shen JJ, Tao AM, Thiffault I, Van Esch H, Wentzensen IM, Barakat TS, Møller RS, Gomez-Puertas P, Chung WK, Gardella E, Tümer Z. Furia F, et al. Clin Genet. 2024 Nov;106(5):574-584. doi: 10.1111/cge.14587. Epub 2024 Jul 11. Clin Genet. 2024. PMID: 38988293 Free PMC article.
ANK3 encodes ankyrin-G, a protein involved in neuronal development and signaling. Alternative splicing gives rise to three ankyrin-G isoforms comprising different domains with distinct expression patterns. Mono- or biallelic ANK3 variants are associated with non-spe …
ANK3 encodes ankyrin-G, a protein involved in neuronal development and signaling. Alternative splicing gives rise to three ankyrin-G …
ANK3 related neurodevelopmental disorders: expanding the spectrum of heterozygous loss-of-function variants.
Kloth K, Lozic B, Tagoe J, Hoffer MJV, Van der Ven A, Thiele H, Altmüller J, Kubisch C, Au PYB, Denecke J, Bijlsma EK, Lessel D. Kloth K, et al. Neurogenetics. 2021 Oct;22(4):263-269. doi: 10.1007/s10048-021-00655-4. Epub 2021 Jul 3. Neurogenetics. 2021. PMID: 34218362 Free PMC article.
ANK3 encodes multiple isoforms of ankyrin-G, resulting in variegated tissue expression and function, especially regarding its role in neuronal development. ...Here, we present four individuals affected by a variable neurodevelopmental phenotype harboring a heterozygous fra …
ANK3 encodes multiple isoforms of ankyrin-G, resulting in variegated tissue expression and function, especially regarding its role in …
ANK3 rs10994336 and ZNF804A rs7597593 polymorphisms: genetic interaction for emotional and behavioral symptoms of alcohol withdrawal syndrome.
Shen G, Chen L, Liu Y, Zhu Q, Kang Y, Luo X, Wang F, Wang W. Shen G, et al. BMC Psychiatry. 2024 May 3;24(1):335. doi: 10.1186/s12888-024-05787-z. BMC Psychiatry. 2024. PMID: 38702695 Free PMC article.
Additionally, simple effects analysis and multiple comparisons revealed that carriers of the ANK3 rs10994336 T allele experienced more severe AWS, while the ZNF804A rs7597593 T allele appeared to provide protection against the risk associated with the ANK3 rs1099433 …
Additionally, simple effects analysis and multiple comparisons revealed that carriers of the ANK3 rs10994336 T allele experienced mor …
Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis.
Nie F, Wang X, Zhao P, Yang H, Zhu W, Zhao Y, Chen B, Valenzuela RK, Zhang R, Gallitano AL, Ma J. Nie F, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec;168(8):637-48. doi: 10.1002/ajmg.b.32348. Epub 2015 Jul 31. Am J Med Genet B Neuropsychiatr Genet. 2015. PMID: 26227746
In summary, our study provides further evidence for the positive association of CACNA1C and ANK3 with SZ. These results support the hypothesis that both SZ and BD share common genetic risk factors. Further research is needed to examine the functions of CACNA1C and ANK3 …
In summary, our study provides further evidence for the positive association of CACNA1C and ANK3 with SZ. These results support the h …
Loss of ANK3 Function Causes a Recessive Neurodevelopmental Disorder with Cerebellar Ataxia.
Maroofian R, Spoto G, Moualek D, Zaki MS, Biswas A, D'Arco F, Biglari S, Nikuei P, Gleeson JG, Tazir M, Ali Pacha L, Houlden H. Maroofian R, et al. Mov Disord. 2025 Nov;40(11):2531-2537. doi: 10.1002/mds.30324. Epub 2025 Aug 4. Mov Disord. 2025. PMID: 40879451 Free PMC article.
BACKGROUND: ANK3 encodes ankyrin-G, a key scaffolding protein essential for neuronal function. While both monoallelic and biallelic ANK3 variants have been linked to neurodevelopmental disorders (NDDs), existing evidence for their pathogenicity and clinical correlat …
BACKGROUND: ANK3 encodes ankyrin-G, a key scaffolding protein essential for neuronal function. While both monoallelic and biallelic …
ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis.
Yuan A, Yi Z, Wang Q, Sun J, Li Z, Du Y, Zhang C, Yu T, Fan J, Li H, Yu S. Yuan A, et al. Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):997-1005. doi: 10.1002/ajmg.b.32112. Epub 2012 Oct 25. Am J Med Genet B Neuropsychiatr Genet. 2012. PMID: 23109352
A genome-wide association study (GWAS) showed a single nucleotide polymorphism (SNP), rs10761482 in ankyrin 3 (ANK3), a major neuron-enriched gene, was associated with schizophrenia although inconsistent results had been reported. Two meta analyses reported another SNP rs1 …
A genome-wide association study (GWAS) showed a single nucleotide polymorphism (SNP), rs10761482 in ankyrin 3 (ANK3), a major neuron- …
Expression of ANK3 moderates the association between childhood trauma and affective traits in severe mental disorders.
Aas M, Andreassen OA, Gjerstad J, Rødevand L, Hjell G, Johansen IT, Lunding SH, Ormerod MBEG, Lagerverg TV, Steen NE, Djurovic S, Akkouh I. Aas M, et al. Sci Rep. 2023 Aug 24;13(1):13845. doi: 10.1038/s41598-023-40310-6. Sci Rep. 2023. PMID: 37620394 Free PMC article.
ANK3 mRNA levels also moderated the relationship between emotional neglect and manic/hypomanic episodes. Our results suggest that ANK3 expression levels moderate the association between specific types of childhood trauma and affective traits in mental disorders....
ANK3 mRNA levels also moderated the relationship between emotional neglect and manic/hypomanic episodes. Our results suggest that …
ANK3 as a Novel Genetic Biomarker for Liafensine in Treatment-Resistant Depression: The ENLIGHTEN Randomized Clinical Trial.
Wang G, Aguado M, Spear MA, Alphs L, Chen C, Huang H, Lu XX, Doostzadeh J, Wu S, Wang S, Patel A, Nemeroff CB, Wang Z, Li A, Luo W. Wang G, et al. JAMA Psychiatry. 2025 Dec 1;82(12):1186-1194. doi: 10.1001/jamapsychiatry.2025.2416. JAMA Psychiatry. 2025. PMID: 40928787 Free PMC article. Clinical Trial.
Investigators, patients, raters, and sponsors were blinded to ANK3 status and treatment. Data analysis was performed from March 26 to April 23, 2024. ...CONCLUSIONS AND RELEVANCE: Liafensine was efficacious and well tolerated in ANK3-positive patients with TRD, with …
Investigators, patients, raters, and sponsors were blinded to ANK3 status and treatment. Data analysis was performed from March 26 to …
Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis.
Owen N, Toms M, Young RM, Eintracht J, Sarkar H, Brooks BP, Moosajee M; Genomics England Research Consortium. Owen N, et al. Genet Med. 2022 May;24(5):1073-1084. doi: 10.1016/j.gim.2021.12.014. Epub 2022 Jan 13. Genet Med. 2022. PMID: 35034853 Free PMC article.
Expression of zebrafish ank3a, bmpr1ba/b, cdh4, and pdgfaa was localized to the OF, periocular mesenchyme cells, or ciliary marginal zone, regions traversed by the OF. Knockdown of ank3, bmpr1b, and pdgfaa revealed a coloboma and/or microphthalmia phenotype. Novel pathogen …
Expression of zebrafish ank3a, bmpr1ba/b, cdh4, and pdgfaa was localized to the OF, periocular mesenchyme cells, or ciliary marginal zone, r …
462 results