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Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression.
Guo B, Zhang M, Hao W, Wang Y, Zhang T, Liu C. Guo B, et al. Transl Psychiatry. 2023 Jan 9;13(1):5. doi: 10.1038/s41398-022-02297-y. Transl Psychiatry. 2023. PMID: 36624089 Free PMC article. Review.
This review summarizes clinical and animal studies on inflammation in neural circuits related to anxiety and depression and the evidence that neuromodulation therapies regulate neuroinflammation in the treatment of neurological diseases. ...This review provides a be …
This review summarizes clinical and animal studies on inflammation in neural circuits related to anxiety and depression and th …
Brain Photobiomodulation Therapy: a Narrative Review.
Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH, Hamblin MR. Salehpour F, et al. Mol Neurobiol. 2018 Aug;55(8):6601-6636. doi: 10.1007/s12035-017-0852-4. Epub 2018 Jan 11. Mol Neurobiol. 2018. PMID: 29327206 Free PMC article. Review.
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. ...Its therapeutic role in disorders such as dementia and Parkinson's disease, as we …
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide ran …
Low-intensity LASER and LED (photobiomodulation therapy) for pain control of the most common musculoskeletal conditions.
DE Oliveira MF, Johnson DS, Demchak T, Tomazoni SS, Leal-Junior EC. DE Oliveira MF, et al. Eur J Phys Rehabil Med. 2022 Apr;58(2):282-289. doi: 10.23736/S1973-9087.21.07236-1. Epub 2021 Dec 16. Eur J Phys Rehabil Med. 2022. PMID: 34913330 Free PMC article.
Photobiomodulation therapy applied in the form of low-intensity Light Amplification by Stimulated Emission of Radiation (LASER) and light-emitting diode (LED) has been shown to reduce inflammation and swelling, promote healing, and reduce pain for an a …
Photobiomodulation therapy applied in the form of low-intensity Light Amplification by Stimulated Emission of Radiation …
Photobiomodulation: shining a light on depression.
Wang L, Mao L, Huang Z, Switzer JA, Hess DC, Zhang Q. Wang L, et al. Theranostics. 2025 Jan 1;15(2):362-383. doi: 10.7150/thno.104502. eCollection 2025. Theranostics. 2025. PMID: 39744683 Free PMC article. Review.
Depression is a prevalent public health issue, characterized by persistent low mood, impaired concentration, and diminished motivation. Photobiomodulation (PBM), which involves the application of red or near-infrared light, modulates physiological processes b …
Depression is a prevalent public health issue, characterized by persistent low mood, impaired concentration, and diminished motivatio …
Post-stroke fatigue: a scoping review.
Aali G, Drummond A, das Nair R, Shokraneh F. Aali G, et al. F1000Res. 2020 Apr 7;9:242. doi: 10.12688/f1000research.22880.2. eCollection 2020. F1000Res. 2020. PMID: 32934800 Free PMC article.
They investigated exercise, pharmacotherapy, psychotherapy, education, and light therapy. Observational studies mainly reported the factors related to PSF including co-morbidities, depression and anxiety, quality of life, activities of daily living, st …
They investigated exercise, pharmacotherapy, psychotherapy, education, and light therapy. Observational studies mainly reporte …
Pharmacological and non-pharmacological management of burning mouth syndrome: A systematic review.
Reyad AA, Mishriky R, Girgis E. Reyad AA, et al. Dent Med Probl. 2020 Jul-Sep;57(3):295-304. doi: 10.17219/dmp/120991. Dent Med Probl. 2020. PMID: 33113291 Free article.
As many BMS patients suffer from psychiatric comorbidities, several psychotropic drugs are included in the management of BMS, reducing the complaint, while managing anxiety, depression and pain disorders. In this review, a search of the published literature r …
As many BMS patients suffer from psychiatric comorbidities, several psychotropic drugs are included in the management of BMS, reducing the c …
Shining light on the head: Photobiomodulation for brain disorders.
Hamblin MR. Hamblin MR. BBA Clin. 2016 Oct 1;6:113-124. doi: 10.1016/j.bbacli.2016.09.002. eCollection 2016 Dec. BBA Clin. 2016. PMID: 27752476 Free PMC article. Review.
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. ...The brain suffers from many different disorders that can …
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue th …
Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis.
Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YC. Yeh SW, et al. Pain Physician. 2019 May;22(3):241-254. Pain Physician. 2019. PMID: 31151332 Free article.
BACKGROUND: Fibromyalgia is a chronic disorder characterized by widespread pain and tenderness. Low-level laser therapy (LLLT), an emerging nonpharmacological treatment, has been used for relieving musculoskeletal or neuropathic pain. ...LLLT is an eff …
BACKGROUND: Fibromyalgia is a chronic disorder characterized by widespread pain and tenderness. Low-level laser ther …
Photobiomodulation Therapy on Brain: Pioneering an Innovative Approach to Revolutionize Cognitive Dynamics.
Nairuz T, Sangwoo-Cho, Lee JH. Nairuz T, et al. Cells. 2024 Jun 3;13(11):966. doi: 10.3390/cells13110966. Cells. 2024. PMID: 38891098 Free PMC article. Review.
Photobiomodulation (PBM) therapy on the brain employs red to near-infrared (NIR) light to treat various neurological and psychological disorders. ...It shows promise for treating conditions like dementia, stroke, brain trauma, Parkinson's disease, and …
Photobiomodulation (PBM) therapy on the brain employs red to near-infrared (NIR) light to treat various neurological an …
The clinical efficacy of intravascular laser irradiation of blood (ILIB): A narrative review of randomized controlled trial.
Díaz L, Gil AC, Marttens AV, Basualdo J, Sotomayor C, Becerra AV, Beltrán V, Jorquera G, Caviedes R, Fernández E. Díaz L, et al. Photodiagnosis Photodyn Ther. 2025 Jun;53:104618. doi: 10.1016/j.pdpdt.2025.104618. Epub 2025 May 3. Photodiagnosis Photodyn Ther. 2025. PMID: 40324571 Free article. Review.
BACKGROUND: Intravascular Laser Irradiation of Blood (ILIB) is a systemic application of photobiomodulation therapy (PBMT), proposed to modulate oxidative stress, inflammation, and mitochondrial function. ...RESULTS: Eight RCTs comprising 340 participants wer …
BACKGROUND: Intravascular Laser Irradiation of Blood (ILIB) is a systemic application of photobiomodulation therapy (PBMT), pr …
Transcranial photobiomodulation as an adjunctive therapy for persistent anxiety and depression in patients undergoing psychotherapy, EMDR, and/or SSRI treatment: A case series.
Jamail J, Fuller L. Jamail J, et al. Explore (NY). 2025 Sep-Oct;21(5):103228. doi: 10.1016/j.explore.2025.103228. Epub 2025 Jul 18. Explore (NY). 2025. PMID: 40743705 Free article.
Transcranial photobiomodulation (TPBM), a non-invasive neuromodulation therapy that uses near-infrared light, has shown antidepressant effects in animal studies and randomized clinical trials. ...CONCLUSION: TPBM may serve as an effective adjunctive therap …
Transcranial photobiomodulation (TPBM), a non-invasive neuromodulation therapy that uses near-infrared light, has shown …
Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials.
Ji Q, Yan S, Ding J, Zeng X, Liu Z, Zhou T, Wu Z, Wei W, Li H, Liu S, Ai S. Ji Q, et al. Front Psychiatry. 2024 Jan 31;14:1267415. doi: 10.3389/fpsyt.2023.1267415. eCollection 2023. Front Psychiatry. 2024. PMID: 38356614 Free PMC article.
Photobiomodulation (PBM) is a non-invasive neuromodulation technique that could treat patients with mood disorders such as depression. METHODS: A systematic search of ten databases, including randomized controlled trials (RCTs) for depression, was cond …
Photobiomodulation (PBM) is a non-invasive neuromodulation technique that could treat patients with mood disorders such as …
Study of transcranial photobiomodulation at 945-nm wavelength: anxiety and depression.
Kerppers FK, Dos Santos KMMG, Cordeiro MER, da Silva Pereira MC, Barbosa D, Pezzini AA, Cunha LF, Fonseca M, Bragnholo K, Salgado ASI, Kerppers II. Kerppers FK, et al. Lasers Med Sci. 2020 Dec;35(9):1945-1954. doi: 10.1007/s10103-020-02983-7. Epub 2020 Mar 7. Lasers Med Sci. 2020. PMID: 32144511 Clinical Trial.
Transcranial photobiomodulation is an innovative method for the stimulation of neural activity which consists of the exposure of neural tissue to low-level light irradiance. ...The objective was to analyze the effects of transcranial photobiomodulat …
Transcranial photobiomodulation is an innovative method for the stimulation of neural activity which consists of the exposure of neur …
Transcranial Photobiomodulation Improves Cognitive Function, Post-Concussion, and PTSD Symptoms in Mild Traumatic Brain Injury.
Lee TL, Chan DY, Chan DT, Cheung MC, Shum DH, Chan AS. Lee TL, et al. J Neurotrauma. 2025 Oct;42(19-20):1695-1707. doi: 10.1089/neu.2025.0048. Epub 2025 Jun 9. J Neurotrauma. 2025. PMID: 40485299 Clinical Trial.
Despite the common assumption of full recovery, significant disturbances persist in many patients with mTBI, including cognitive deficit, headache, dizziness, sleep problems, and symptoms of post-traumatic stress disorder (PTSD). Given that effe …
Despite the common assumption of full recovery, significant disturbances persist in many patients with mTBI, including cognitive deficit, he …
Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC. Alvarenga-Brant R, et al. J Dent Res. 2023 Feb;102(2):135-145. doi: 10.1177/00220345221130025. Epub 2022 Oct 8. J Dent Res. 2023. PMID: 36214096
Four comparable interventions were grouped into different network geometries to ensure the transitivity assumption for pain: photobiomodulation therapy, alpha-lipoic acid, phytotherapics, and anxiolytics/antidepressants. ...The anxiolytic (clonazepam) probably reduc …
Four comparable interventions were grouped into different network geometries to ensure the transitivity assumption for pain: photobiomodu …
The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioid craving in patients undergoing methadone maintenance treatment: a double-blind, randomized, controlled trial.
Helali H, Samani N, Tabeie F, Eiliaei S, Kheradmand A. Helali H, et al. BMC Psychiatry. 2025 Feb 3;25(1):94. doi: 10.1186/s12888-025-06555-3. BMC Psychiatry. 2025. PMID: 39901090 Free PMC article. Clinical Trial.
The levels of anxiety, depression, and opioid craving were compared between the two groups before and after the intervention, as well as at one-month and three-month follow-up assessments. ...CONCLUSION: tPBMT led to significant improvements in anxiety, de …
The levels of anxiety, depression, and opioid craving were compared between the two groups before and after the intervention, …
Light Therapy in Chronic Migraine.
Hou TW, Yang CC, Lai TH, Wu YH, Yang CP. Hou TW, et al. Curr Pain Headache Rep. 2024 Jul;28(7):621-626. doi: 10.1007/s11916-024-01258-y. Epub 2024 Jun 12. Curr Pain Headache Rep. 2024. PMID: 38865075 Review.
PURPOSE OF REVIEW: This review assesses the effectiveness and safety of light therapy, particularly green light therapy, as an emerging non-pharmacological treatment for chronic migraine (CM). ...In addition to green light, other forms of lig …
PURPOSE OF REVIEW: This review assesses the effectiveness and safety of light therapy, particularly green light ther …
User Personas for eHealth Regarding the Self-Management of Depressive Symptoms in People Living With HIV: Mixed Methods Study.
Zhao T, Tang C, Ma J, Yan H, Su X, Zhong X, Wang H. Zhao T, et al. J Med Internet Res. 2025 Feb 17;27:e56289. doi: 10.2196/56289. J Med Internet Res. 2025. PMID: 39960763 Free PMC article.
Low-level self-managers had relatively low levels of self-efficacy, self-management abilities of depressive symptoms, and eHealth literacy. Low-level self-managers had an acceptable attitude toward using eHealth for the self-management of dep …
Low-level self-managers had relatively low levels of self-efficacy, self-management abilities of depressive symptoms, a …
Mitochondrial dysfunction in depression: Mechanisms and targeted therapy strategies.
Xia X, Li K, Jiang B, Zou W, Wang L. Xia X, et al. Asian J Psychiatr. 2025 Oct;112:104694. doi: 10.1016/j.ajp.2025.104694. Epub 2025 Sep 5. Asian J Psychiatr. 2025. PMID: 40934745 Review.
Major depressive disorder (MDD) is a severe mental illness with complex pathophysiology. Growing evidence highlights mitochondrial dysfunction as a key player in MDD, influencing neuroinflammation, synaptic plasticity, and energy metabolism. ...This review underscor …
Major depressive disorder (MDD) is a severe mental illness with complex pathophysiology. Growing evidence highlights mitochond …
Effects of photobiomodulation on auriculotherapy points for sleep disorders, anxiety, and temporomandibular dysfunctions.
Fernandes MP, Vidal CL, de Oliveira TT, Botelho AL, Valente MLDC, Dos Reis AC. Fernandes MP, et al. Cranio. 2023 Jul;41(4):362-367. doi: 10.1080/08869634.2020.1853896. Epub 2020 Dec 7. Cranio. 2023. PMID: 33287687
OBJECTIVE: The purpose of this study was to evaluatephotobiomodulation applied at auriculotherapy points forsleep disorder (SD) and anxiety related to temporomandibulardysfunction (TMD). METHODS: The study consisted of two groups of 20 participants: Auriculotherapy …
OBJECTIVE: The purpose of this study was to evaluatephotobiomodulation applied at auriculotherapy points forsleep disorder (SD) and …
Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser.
Eshaghi E, Sadigh-Eteghad S, Mohaddes G, Rasta SH. Eshaghi E, et al. Lasers Surg Med. 2019 Sep;51(7):634-642. doi: 10.1002/lsm.23082. Epub 2019 Mar 18. Lasers Surg Med. 2019. PMID: 30883832
OBJECTIVES: The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders is a demonstrated and identified issue. ...MATERIALS AND METHODS: CRS procedure (3 hours/day, over 3 weeks) was performed as a typical …
OBJECTIVES: The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders …
Dosimetry and Clinical Efficacy of Transcranial Photobiomodulation for Major Depression Disorder: Could they Guide Dosimetry for Alzheimer's Disease?
Caldieraro MA, Laufer-Silva T, Cassano P. Caldieraro MA, et al. J Alzheimers Dis. 2021;83(4):1453-1469. doi: 10.3233/JAD-210586. J Alzheimers Dis. 2021. PMID: 34487045 Review.
BACKGROUND: Major depressive disorder (MDD) is prevalent and has significant impact on individuals and society. Cognitive symptoms are frequent in MDD and insufficiently treated by antidepressant medications. Transcranial photobiomodulation (t-PBM) is a novel …
BACKGROUND: Major depressive disorder (MDD) is prevalent and has significant impact on individuals and society. Cognitive symp …
Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial.
Noda Y, Taniguchi K, Takano M, Mimura Y, Yanagisawa N, Hayano M, Kitahata R, Ogawa Y, Mimura M, Tsubota K. Noda Y, et al. J Affect Disord. 2025 May 1;376:325-332. doi: 10.1016/j.jad.2025.02.031. Epub 2025 Feb 15. J Affect Disord. 2025. PMID: 39961441 Clinical Trial.
BACKGROUND: Medication-supplemented psychotherapy is the primary treatment for mild major depressive disorder (MDD). However, limited resources and patient non-adherence present challenges, necessitating innovative and less burdensome interventions. ...Neuromodulati …
BACKGROUND: Medication-supplemented psychotherapy is the primary treatment for mild major depressive disorder (MDD). However, …
PBM alleviates depression and anxiety like behaviors in mice: insight from local field potential.
Tan Y, Liu J, Qiu Y, Ruan H, Qin Q, Li X, Xu Z, Qiao X, Jiang X. Tan Y, et al. Behav Brain Funct. 2025 Nov 14;21(1):38. doi: 10.1186/s12993-025-00308-8. Behav Brain Funct. 2025. PMID: 41239492 Free PMC article.
BACKGROUND: Depression involves abnormal neural oscillations. Photobiomodulation (PBM) modulates such oscillations but lacks behavioral electrophysiological mechanistic studies. ...No significant PAC changes was observed during depression tasks. CONCLUSION: P …
BACKGROUND: Depression involves abnormal neural oscillations. Photobiomodulation (PBM) modulates such oscillations but lacks b …
Local and systemic photobiomodulation using a 650 nm LED on skin temperature and hyperalgesia in cellulite: a randomized, placebo-controlled and double-blinded clinical trial.
Lopes-Martins RAB, Bueno F, Ferreira HODC, Faria LA, Sousa MMB, Lobo AB, Freitas VFDS, Lopes-Martins PSL, Aimbire F, Leonardo PS. Lopes-Martins RAB, et al. Lasers Med Sci. 2024 Nov 13;39(1):275. doi: 10.1007/s10103-024-04232-7. Lasers Med Sci. 2024. PMID: 39535674 Clinical Trial.
Cellulite is a skin condition that significantly affects women, characterized by "holes" or depressions in the skin, affecting approximately 95% of women at some point in their lives. ...This study investigates the effects of local and systemic photobiomodulation on …
Cellulite is a skin condition that significantly affects women, characterized by "holes" or depressions in the skin, affecting approx …
Mechanisms and parameters of photobiomodulation for neurological and neuropsychiatric disorders: whether and how to apply?
Cao Q, Liu Z, Kang H, Wang L. Cao Q, et al. Rev Neurosci. 2025 Sep 24;37(1):77-91. doi: 10.1515/revneuro-2025-0073. Print 2026 Jan 23. Rev Neurosci. 2025. PMID: 40982764
Photobiomodulation (PBM), a neuromodulatory technique using lasers and light-emitting diodes (LEDs), has emerged as a promising intervention for enhancing brain function by stimulating neural activity, thereby protecting brain tissue and restoring function. ...This …
Photobiomodulation (PBM), a neuromodulatory technique using lasers and light-emitting diodes (LEDs), has emerged as a promisin …
Comparative effectiveness of photobiomodulation and manual therapy alone or combined in TMD patients: a randomized clinical trial.
Brochado FT, Jesus LH, Carrard VC, Freddo AL, Chaves KD, Martins MD. Brochado FT, et al. Braz Oral Res. 2018 Jul 10;32:e50. doi: 10.1590/1807-3107bor-2018.vol32.0050. Braz Oral Res. 2018. PMID: 29995062 Free article. Clinical Trial.
The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensity, mandibular movements, psychosocial aspects, and anxiety symptoms of temporomandibular disorder (TMD) patients. ...Seven eva …
The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensit …
Transcranial Photobiomodulation Therapy as an Intervention for Opioid Cravings and Depression: A Pilot Cohort Study.
Flora J, Watson Huffer K. Flora J, et al. Photobiomodul Photomed Laser Surg. 2024 Aug;42(8):509-513. doi: 10.1089/photob.2024.0032. Epub 2024 Aug 7. Photobiomodul Photomed Laser Surg. 2024. PMID: 39110620
Introduction: The opioid crisis, a declared national health emergency, has prompted the exploration of innovative treatments to address the pervasive issues of opioid cravings and associated depression. Aims: This pilot cohort study investigated the efficacy of transcrania …
Introduction: The opioid crisis, a declared national health emergency, has prompted the exploration of innovative treatments to address the …
Protocol for a Single-Arm Feasibility Study of Photobiomodulation for Fatigue, Depression, and Pain in Inflammatory Bowel Disease.
Ewais T, Begun J, Laakso EL. Ewais T, et al. Biomedicines. 2023 Aug 2;11(8):2179. doi: 10.3390/biomedicines11082179. Biomedicines. 2023. PMID: 37626676 Free PMC article.
BACKGROUND: There are limited treatment options for mental health comorbidities associated with Inflammatory Bowel Disease (IBD), although they have been shown to negatively affect the course of IBD and multiple important areas of functioning. Photobiomodulation (PBM) is a …
BACKGROUND: There are limited treatment options for mental health comorbidities associated with Inflammatory Bowel Disease (IBD), although t …
Brain photobiomodulation therapy on neurological and psychological diseases.
Chamkouri H, Liu Q, Zhang Y, Chen C, Chen L. Chamkouri H, et al. J Biophotonics. 2024 Jan;17(1):e202300145. doi: 10.1002/jbio.202300145. Epub 2023 Oct 1. J Biophotonics. 2024. PMID: 37403428 Review.
Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the mitochondrial respiratory chain can be stimulated by red light, which increases ATP synthesis. In addition, the ion channels' light …
Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the m …
Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization.
Khoodoruth MAS, Estudillo-Guerra MA, Pacheco-Barrios K, Nyundo A, Chapa-Koloffon G, Ouanes S. Khoodoruth MAS, et al. Front Psychiatry. 2022 Apr 14;13:886918. doi: 10.3389/fpsyt.2022.886918. eCollection 2022. Front Psychiatry. 2022. PMID: 35492692 Free PMC article. Review.
Depressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the use of antidepressants revolutionized the management of depression and had a tremendous positive impact on the patient's outcome, a …
Depressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the …
Transcranial photobiomodulation increases cognition and serum BDNF levels in adults over 50 years: A randomized, double-blind, placebo-controlled trial.
de Oliveira BH, Lins EF, Kunde NF, Salgado ASI, Martins LM, Bobinski F, Vieira WF, Cassano P, Quialheiro A, Martins DF. de Oliveira BH, et al. J Photochem Photobiol B. 2024 Nov;260:113041. doi: 10.1016/j.jphotobiol.2024.113041. Epub 2024 Oct 5. J Photochem Photobiol B. 2024. PMID: 39423445 Clinical Trial.
NIR t-PBM has recently emerged as a potential therapy for various neurodegenerative conditions, including memory issues. AIMS: This study aimed to evaluate cognition scores (primary outcome), depression, anxiety, resilience scores, neuroplasticity, and neurod …
NIR t-PBM has recently emerged as a potential therapy for various neurodegenerative conditions, including memory issues. AIMS: This s …
Photobiomodulation: An Emerging Treatment Modality for Depression.
Vieira WF, Iosifescu DV, McEachern KM, Gersten M, Cassano P. Vieira WF, et al. Psychiatr Clin North Am. 2023 Jun;46(2):331-348. doi: 10.1016/j.psc.2023.02.013. Epub 2023 Mar 25. Psychiatr Clin North Am. 2023. PMID: 37149348 Review.
Major depressive disorder (MDD) is considered a global crisis. Conventional treatments for MDD consist of pharmacotherapy and psychotherapy, although a significant number of patients with depression respond poorly to conventional treatments and are diagnosed …
Major depressive disorder (MDD) is considered a global crisis. Conventional treatments for MDD consist of pharmacotherapy and …
Molecular Mechanisms of Emerging Antidepressant Strategies: From Ketamine to Neuromodulation.
Kowalczyk M, Aebisher D, Szpara J, Czech S, Bartusik-Aebisher D, Henrykowska G. Kowalczyk M, et al. Int J Mol Sci. 2025 Dec 28;27(1):344. doi: 10.3390/ijms27010344. Int J Mol Sci. 2025. PMID: 41516220 Free PMC article. Review.
Depression is a common, debilitating, and potentially life-threatening mental disorder affecting individuals across all age groups and populations. ...It is estimated that more than 300 million people worldwide are affected, and patients with major depressive …
Depression is a common, debilitating, and potentially life-threatening mental disorder affecting individuals across all age gr …
Effects of Photobiomodulation on Burning Mouth Syndrome: A Systematic Review and Meta-Analysis.
Okuhara MR, Trevisani VFM, Macedo CR. Okuhara MR, et al. J Oral Rehabil. 2025 Apr;52(4):540-553. doi: 10.1111/joor.13931. Epub 2025 Jan 28. J Oral Rehabil. 2025. PMID: 39871648
OBJECTIVE: The objective of this research is to evaluate the effectiveness and safety of photobiomodulation or low-level laser therapy on burning mouth syndrome compared to placebo, no-laser, clonazepam and alpha-lipoic acid. ...Likewise, the compariso …
OBJECTIVE: The objective of this research is to evaluate the effectiveness and safety of photobiomodulation or low-level …
Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stress.
Farazi N, Mahmoudi J, Sadigh-Eteghad S, Farajdokht F, Rasta SH. Farazi N, et al. Lasers Med Sci. 2022 Mar;37(2):1181-1191. doi: 10.1007/s10103-021-03370-6. Epub 2021 Aug 25. Lasers Med Sci. 2022. PMID: 34432186
The development of anxiety and depression due to chronic exposure to noise stress has remained as an unsolved health problem so far. ...Also, there is no available data on the relationship between the application of tPBM and hippocampal brain-derived neurotro …
The development of anxiety and depression due to chronic exposure to noise stress has remained as an unsolved health pr …
A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms.
Laakso EL, Ewais T. Laakso EL, et al. Biomedicines. 2023 May 22;11(5):1497. doi: 10.3390/biomedicines11051497. Biomedicines. 2023. PMID: 37239169 Free PMC article.
To add quality to life, alternate methods of symptom management need to be identified. OBJECTIVE: To demonstrate how photobiomodulation, through its numerous mechanisms, may offer an adjunctive therapy in inflammatory bowel disease. ...MAIN FINDINGS: In this paper, …
To add quality to life, alternate methods of symptom management need to be identified. OBJECTIVE: To demonstrate how photobiomodulation …
Photobiomodulation mitigates blood-brain barrier disruption in APP/PS1 mouse model of Alzheimer's disease by activating the AMPK pathway.
Ma C, Ye Y, Shi X, Li N, Mu Z, Tan T, Yin H, Dai J, Liu Y, Chen H. Ma C, et al. Alzheimers Res Ther. 2025 Jun 23;17(1):141. doi: 10.1186/s13195-025-01787-7. Alzheimers Res Ther. 2025. PMID: 40551167 Free PMC article.
BACKGROUND: Photobiomodulation (PBM), which utilizes specific light wavelengths to regulate cellular metabolism, signal transduction, and gene expression, has emerged as a promising intervention for enhancing cognitive function in Alzheimer's disease (AD). ...Mechan …
BACKGROUND: Photobiomodulation (PBM), which utilizes specific light wavelengths to regulate cellular metabolism, signal transd …
Low Energy Ultrapulse CO2 Fractional Laser Combined with Autologous Platelet-Rich Plasma in Periorbital Rejuvenation Treatment.
Qi Y, Sun C, Zhou Y, Luo L, Wang C. Qi Y, et al. J Invest Surg. 2025 Dec;38(1):2484543. doi: 10.1080/08941939.2025.2484543. Epub 2025 Apr 20. J Invest Surg. 2025. PMID: 40254943 Free article. Clinical Trial.
VISIA (wrinkles, texture), SOFT (skin elasticity, moisture), upper eyelid depression, and infraorbital hollowing were evaluated before and at 1, 3, and 6 months post-treatment. ...RESULTS: The combination group exhibited higher overall effective rate of GAIS, greater impro …
VISIA (wrinkles, texture), SOFT (skin elasticity, moisture), upper eyelid depression, and infraorbital hollowing were evaluated befor …
Efficacy and Safety of Photobiomodulation in MELAS: Protocol for a Series of N-of-1 Trials.
Laakso EL, Ewais T, McMahon K, Forbes J, Phillips L. Laakso EL, et al. J Clin Med. 2025 Mar 17;14(6):2047. doi: 10.3390/jcm14062047. J Clin Med. 2025. PMID: 40142856 Free PMC article.
Medical treatment varies and focuses on managing symptoms. Photobiomodulation (PBM) can decrease mitochondrial damage thereby increasing energy production and decreasing cell death. ...The primary outcome is patient-reported fatigue assessed using the Checklist of Individu …
Medical treatment varies and focuses on managing symptoms. Photobiomodulation (PBM) can decrease mitochondrial damage thereby increas …
Photobiomodulation as part of multimodal analgesia to improve pain relief and wound healing after elective caesarean section: A protocol for randomized controlled trial.
Khaled M, Baranov A, Diaz A, Patel M, Clements S, Farsinejad P, Khatana K, Gnanapragasam A, Selvanayagam S, Muhsen Z, Chan J, Hunjan S, Kazi A, Sharma S, Luketic L, Ewusie JE, Cordovani D, Shanthanna H. Khaled M, et al. PLoS One. 2024 Dec 26;19(12):e0314010. doi: 10.1371/journal.pone.0314010. eCollection 2024. PLoS One. 2024. PMID: 39724020 Free PMC article.
Photobiomodulation therapy (PBMT) uses light-emitting diode (LED) and laser and has suggested potential for improving pain control and wound healing. ...Patients will receive a maximum of 5 post-surgical treatment sessions of active PBMT (intervention: LED …
Photobiomodulation therapy (PBMT) uses light-emitting diode (LED) and laser and has suggested potential for improving p …
Effects of low-level laser therapy on burning pain and quality of life in patients with burning mouth syndrome: a systematic review and meta-analysis.
Lu C, Yang C, Li X, Du G, Zhou X, Luo W, Du Q, Tang G. Lu C, et al. BMC Oral Health. 2023 Oct 9;23(1):734. doi: 10.1186/s12903-023-03441-w. BMC Oral Health. 2023. PMID: 37814265 Free PMC article.
BACKGROUND: Burning mouth syndrome (BMS) is a complex chronic pain disorder that significantly impairs patients' quality of life. Low-level laser therapy (LLLT) uses infrared or near-infrared light to produce analgesic, anti-inflammatory, and bi …
BACKGROUND: Burning mouth syndrome (BMS) is a complex chronic pain disorder that significantly impairs patients' quality of life. …
Light Modulation of Brain and Development of Relevant Equipment.
Li X, Liu C, Wang R. Li X, et al. J Alzheimers Dis. 2020;74(1):29-41. doi: 10.3233/JAD-191240. J Alzheimers Dis. 2020. PMID: 32039856 Review.
Light modulation plays an important role in understanding the pathology of brain disorders and improving brain function. Optogenetic techniques can activate or silence targeted neurons with high temporal and spatial accuracy and provide precise control, and have rec …
Light modulation plays an important role in understanding the pathology of brain disorders and improving brain function. Optog …
Transcranial Photobiomodulation For The Management Of Depression: Current Perspectives.
Askalsky P, Iosifescu DV. Askalsky P, et al. Neuropsychiatr Dis Treat. 2019 Nov 22;15:3255-3272. doi: 10.2147/NDT.S188906. eCollection 2019. Neuropsychiatr Dis Treat. 2019. PMID: 31819453 Free PMC article. Review.
Major depressive disorder (MDD) is a prevalent condition associated with high rates of disability, as well as suicidal ideation and behavior. ...In this paper, we review a novel neuromodulation strategy, transcranial photobiomodulation (t-PBM) with near-infra …
Major depressive disorder (MDD) is a prevalent condition associated with high rates of disability, as well as suicidal ideatio …
Photobiomodulation and the brain: a new paradigm.
Hennessy M, Hamblin MR. Hennessy M, et al. J Opt. 2017 Jan;19(1):013003. doi: 10.1088/2040-8986/19/1/013003. Epub 2016 Dec 14. J Opt. 2017. PMID: 28580093 Free PMC article.
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. ...Other groups have studied stroke (animal models and clinical trial …
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR …
Current application and future directions of photobiomodulation in central nervous diseases.
Yang M, Yang Z, Wang P, Sun Z. Yang M, et al. Neural Regen Res. 2021 Jun;16(6):1177-1185. doi: 10.4103/1673-5374.300486. Neural Regen Res. 2021. PMID: 33269767 Free PMC article. Review.
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions. ...We reviewed 95 papers and analyzed. Photobiomodulation has wide applicability in the treatm …
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neur …
Treating neuropathic pain and comorbid affective disorders: Preclinical and clinical evidence.
Coelho DRA, Gersten M, Jimenez AS, Fregni F, Cassano P, Vieira WF. Coelho DRA, et al. Pain Pract. 2024 Sep;24(7):937-955. doi: 10.1111/papr.13370. Epub 2024 Apr 4. Pain Pract. 2024. PMID: 38572653 Review.
INTRODUCTION: Neuropathic pain (NP) significantly impacts quality of life and often coexists with affective disorders such as anxiety and depression. Addressing both NP and its psychiatric manifestations requires a comprehensive understanding of therapeutic o …
INTRODUCTION: Neuropathic pain (NP) significantly impacts quality of life and often coexists with affective disorders such as anxi …
Efficacy and safety of photobiomodulation combined with oral cryotherapy on oral mucosa pain in patients with burning mouth syndrome: a multi-institutional, randomized, controlled trial.
Lu C, Zhou X, Yang C, Jiang X, Li X, Huang Z, Du Q, Tang G. Lu C, et al. BMC Med. 2025 Apr 7;23(1):196. doi: 10.1186/s12916-025-04015-z. BMC Med. 2025. PMID: 40189502 Free PMC article. Clinical Trial.
BACKGROUND: The prevalence of burning mouth syndrome (BMS) is approximately 8% in clinical patients; thus, BMS remains a therapeutic challenge. Photobiomodulation (PBM) and oral cryotherapy (OCT) have been evaluated for the treatment of burning pain, but no confirmatory tr …
BACKGROUND: The prevalence of burning mouth syndrome (BMS) is approximately 8% in clinical patients; thus, BMS remains a therapeutic challen …
Red-light photobiomodulation improves cognition and neuropsychiatric symptoms in post-stroke cognitive impairment: a randomized trial.
Huang X, Sun Z, Wu W, Lou L, Wang P, Wang Q, Fu Y, Xu L, Song M, Zhu L, Huang J, Ni S, Chen G, Liu X, Tong Z. Huang X, et al. Front Neurol. 2025 Nov 26;16:1634701. doi: 10.3389/fneur.2025.1634701. eCollection 2025. Front Neurol. 2025. PMID: 41383236 Free PMC article. Clinical Trial.
INTRODUCTION: Acute stroke patients often develop post-stroke cognitive impairment (PSCI) and dysthymic disorders. Formaldehyde (FA) induces cognitive decline and depression; while red light (RL) at 630 nm can degrade FA by activating FA-dehydrogenase (FDH). …
INTRODUCTION: Acute stroke patients often develop post-stroke cognitive impairment (PSCI) and dysthymic disorders. Formaldehyde (FA) …
Dose-dependent tolerability and safety of transcranial photobiomodulation: a randomized controlled trial.
Coelho DRA, Fernando Vieira W, Hurtado Puerto AM, B Gersten M, Anne Collins K, Peterson A, Siu K, Tural Ü, Vlad Iosifescu D, Cassano P. Coelho DRA, et al. Lasers Med Sci. 2025 May 29;40(1):248. doi: 10.1007/s10103-025-04501-z. Lasers Med Sci. 2025. PMID: 40437278 Clinical Trial.
Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light has emerged as a promising therapy for major depressive disorder (MDD). ...
Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light has emerged as a promising therapy for major …
Photobiomodulation prevents PTSD-like memory impairments in rats.
Li Y, Dong Y, Yang L, Tucker L, Zong X, Brann D, Hamblin MR, Vazdarjanova A, Zhang Q. Li Y, et al. Mol Psychiatry. 2021 Nov;26(11):6666-6679. doi: 10.1038/s41380-021-01088-z. Epub 2021 Apr 15. Mol Psychiatry. 2021. PMID: 33859360 Free PMC article.
An impaired fear memory (contextual amnesia), however, puts the individual at risk of developing posttraumatic stress disorder (PTSD) due to the inability to identify a safe context when encountering trauma-associated cues later in life. Although it is gainin …
An impaired fear memory (contextual amnesia), however, puts the individual at risk of developing posttraumatic stress disorder …
Transcranial and systemic photobiomodulation for major depressive disorder: A systematic review of efficacy, tolerability and biological mechanisms.
Caldieraro MA, Cassano P. Caldieraro MA, et al. J Affect Disord. 2019 Jan 15;243:262-273. doi: 10.1016/j.jad.2018.09.048. Epub 2018 Sep 17. J Affect Disord. 2019. PMID: 30248638
BACKGROUND: Photobiomodulation (PBM) with red and near-infrared light (NIR) -also known as Low-Level Light Therapy-is a low risk, inexpensive treatment-based on non-retinal exposure-under study for several neuropsychiatric conditions. The …
BACKGROUND: Photobiomodulation (PBM) with red and near-infrared light (NIR) -also known as Low-Level Light …
The Efficacy of Photobiomodulation Therapy in Improving Cognitive Function and Reducing Depression and Anxiety in Patients with Mild-to-Moderate Dementia: A Double-Blinded Randomized Clinical Trial.
Jarrahi S, Samani N, Tanjani PT, Tabeie F, Kordmir T, Kheradmand A. Jarrahi S, et al. Photobiomodul Photomed Laser Surg. 2025 Dec;43(12):585-591. doi: 10.1177/25785478251376443. Epub 2025 Sep 10. Photobiomodul Photomed Laser Surg. 2025. PMID: 40930542 Clinical Trial.
Background: There is strong evidence supporting the effectiveness of photobiomodulation therapy (PBMT) in improving neuronal damage and enhancing neuropsychological activities. ...Similarly, the two groups had similar mean scores for depression and anxiety …
Background: There is strong evidence supporting the effectiveness of photobiomodulation therapy (PBMT) in improving neuronal d …
Low-level laser therapy in knee osteoarthritis: a narrative review.
Zhao X, Lou X, Wu B, Du H, Li L, Zheng Q, Guo X, Xiao W, Xue S, Zhang X. Zhao X, et al. Clin Exp Rheumatol. 2025 Nov;43(11):1971-1983. doi: 10.55563/clinexprheumatol/muqrbi. Epub 2025 May 8. Clin Exp Rheumatol. 2025. PMID: 40371537 Free article. Review.
Its main symptoms include pain, swelling, stiffness, and limited mobility; besides, severe cases can lead to disability and complete loss of function.KOA can also lead to psychological issues such as depression and anxiety, posing substantial burdens on patients, fa …
Its main symptoms include pain, swelling, stiffness, and limited mobility; besides, severe cases can lead to disability and complete loss of …
Photobiomodulation as a promising new tool in the management of psychological disorders: A systematic review.
Gutiérrez-Menéndez A, Marcos-Nistal M, Méndez M, Arias JL. Gutiérrez-Menéndez A, et al. Neurosci Biobehav Rev. 2020 Dec;119:242-254. doi: 10.1016/j.neubiorev.2020.10.002. Epub 2020 Oct 15. Neurosci Biobehav Rev. 2020. PMID: 33069687
This systematic review collects studies up to 2019 about the beneficial effects of photobiomodulation as a therapy for treating psychological disorders and a tool for modulating cognitive processes. This technique is mostly used for the treatment of depres …
This systematic review collects studies up to 2019 about the beneficial effects of photobiomodulation as a therapy for treatin …
Mood Disorders in Youth: Complementary and Integrative Medicine.
Saxena K, Kurian S, Kumar R, Arnold LE, Simkin DR. Saxena K, et al. Child Adolesc Psychiatr Clin N Am. 2023 Apr;32(2):367-394. doi: 10.1016/j.chc.2022.08.012. Child Adolesc Psychiatr Clin N Am. 2023. PMID: 37147043 Review.
Omega-3 polyunsaturated fatty acids, probiotics, vitamin C, vitamin D, folic acid and L-methyl folate, broad-spectrum micronutrients, N-acetylcysteine, physical activity, herbs, bright light therapy, melatonin, saffron, meditation, school-based interventions, and tr …
Omega-3 polyunsaturated fatty acids, probiotics, vitamin C, vitamin D, folic acid and L-methyl folate, broad-spectrum micronutrients, N-acet …
Photobiomodulation therapy in mood disorders: a systematic review.
Montazeri K, Farhadi M, Fekrazad R, Chaibakhsh S, Mahmoudian S. Montazeri K, et al. Lasers Med Sci. 2022 Dec;37(9):3343-3351. doi: 10.1007/s10103-022-03641-w. Epub 2022 Nov 21. Lasers Med Sci. 2022. PMID: 36404359
Photobiomodulation therapy (PBMT) uses photons of light to repair, modulate and improve the function of target tissue. ...Based on grade practice recommendations, PBMT can be classified as strongly recommended for moderate grade of major depressive …
Photobiomodulation therapy (PBMT) uses photons of light to repair, modulate and improve the function of target tissue. …
Experimental, controversial, and futuristic treatments for chronic tinnitus.
Folmer RL, Theodoroff SM, Martin WH, Shi Y. Folmer RL, et al. J Am Acad Audiol. 2014 Jan;25(1):106-25. doi: 10.3766/jaaa.25.1.7. J Am Acad Audiol. 2014. PMID: 24622863 Review.
Effective and noninvasive treatments for tinnitus include acoustic therapy (which includes hearing aids and other types of environmental sound enrichment); cognitive-behavioral therapy; psychological counseling; hypnosis; biofeedback; and relaxation training. Over-t …
Effective and noninvasive treatments for tinnitus include acoustic therapy (which includes hearing aids and other types of environmen …
Brain-gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation.
Sancho-Balsells A, Borràs-Pernas S, Flotta F, Chen W, Del Toro D, Rodríguez MJ, Alberch J, Blivet G, Touchon J, Xifró X, Giralt A. Sancho-Balsells A, et al. J Affect Disord. 2024 Jun 1;354:574-588. doi: 10.1016/j.jad.2024.03.075. Epub 2024 Mar 14. J Affect Disord. 2024. PMID: 38490587 Free article.
BACKGROUND: Chronic stress is an important risk factor for the development of major depressive disorder (MDD). ...CONCLUSIONS: Our results suggest that non-invasive photobiomodulation of both the brain and the gut microbiome could be beneficial in the …
BACKGROUND: Chronic stress is an important risk factor for the development of major depressive disorder (MDD). ...CONCL …
Wearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: A randomized, double blind, sham-controlled trial.
Guu TW, Cassano P, Li WJ, Tseng YH, Ho WY, Lin YT, Lin SY, Chang JP, Mischoulon D, Su KP. Guu TW, et al. J Affect Disord. 2025 Mar 1;372:635-642. doi: 10.1016/j.jad.2024.12.065. Epub 2024 Dec 18. J Affect Disord. 2025. PMID: 39706483 Free article. Clinical Trial.
METHODS: We randomized 48 outpatients with major depressive disorder (MDD) into tPBM or sham with 1:1 ratio. All participants were advised to receive the device-based intervention for at least 20 min daily at their preferred time and place for 8 weeks. The complianc …
METHODS: We randomized 48 outpatients with major depressive disorder (MDD) into tPBM or sham with 1:1 ratio. All participants …
Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.
Salehpour F, Gholipour-Khalili S, Farajdokht F, Kamari F, Walski T, Hamblin MR, DiDuro JO, Cassano P. Salehpour F, et al. Rev Neurosci. 2020 Apr 28;31(3):269-286. doi: 10.1515/revneuro-2019-0063. Rev Neurosci. 2020. PMID: 31812948 Free PMC article. Review.
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant …
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in hum …
Recent advances in light energy biotherapeutic strategies with photobiomodulation on central nervous system disorders.
Ma H, Du Y, Xie D, Wei ZZ, Pan Y, Zhang Y. Ma H, et al. Brain Res. 2024 Jan 1;1822:148615. doi: 10.1016/j.brainres.2023.148615. Epub 2023 Oct 14. Brain Res. 2024. PMID: 37783261 Review.
Transcranial photobiomodulation refers to irradiation of the brain through the skull using low-intensity red or near-infrared light, which is the most commonly studied method of light energy biotherapy for central nervous system disorders. ...Multiple …
Transcranial photobiomodulation refers to irradiation of the brain through the skull using low-intensity red or near-infrared ligh …
A case control series for the effect of photobiomodulation in patients with low back pain and concurrent depression.
Gabel CP, Petrie SR, Mischoulon D, Hamblin MR, Yeung A, Sangermano L, Cassano P. Gabel CP, et al. Laser Ther. 2018 Sep 30;27(3):167-173. doi: 10.5978/islsm.27_18-OR-18. Laser Ther. 2018. PMID: 32158062 Free PMC article.
BACKGROUND AND AIMS: To present incidental findings in patients with low back pain (LBP) who received photobiomodulation (PBM) administered to the back and thighs as an adjunct to physical therapy (PT) and then experienced improvement in concurrent depression …
BACKGROUND AND AIMS: To present incidental findings in patients with low back pain (LBP) who received photobiomodulation (PBM) admini …
Near-infrared photobiomodulation combined with coenzyme Q(10) for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis.
Salehpour F, Farajdokht F, Cassano P, Sadigh-Eteghad S, Erfani M, Hamblin MR, Salimi MM, Karimi P, Rasta SH, Mahmoudi J. Salehpour F, et al. Brain Res Bull. 2019 Jan;144:213-222. doi: 10.1016/j.brainresbull.2018.10.010. Epub 2018 Oct 29. Brain Res Bull. 2019. PMID: 30385146 Free PMC article.
This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q(10) (CoQ(10)) on depressive-like behavior, cerebral oxidative stress, inflammation, and apoptosis markers in mice. To induce a depressive …
This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q(10) (CoQ(10)) o …
Synergy Between Neurofeedback and Biofeedback Enhances Therapeutic Outcomes.
Thompson L. Thompson L. Appl Psychophysiol Biofeedback. 2025 Jun;50(2):305-314. doi: 10.1007/s10484-025-09706-0. Appl Psychophysiol Biofeedback. 2025. PMID: 40293646 Review.
Then comes discussion of the history of combining modalities along with discussion of which combinations of treatments should be considered for different disorders. Attention-Deficit/Hyperactivity Disorder (ADHD), for example, requires more than one intervention bec …
Then comes discussion of the history of combining modalities along with discussion of which combinations of treatments should be considered …
Laser acupuncture improves post-dialysis fatigue and sleep quality independent of time-varying dialysis and depression symptoms: a double-blind, randomized, placebo-controlled trial.
Sung RY, Yeh ML, Chen FP, Lo MY, Yu J. Sung RY, et al. BMC Complement Med Ther. 2025 Dec 13;26(1):19. doi: 10.1186/s12906-025-05203-3. BMC Complement Med Ther. 2025. PMID: 41390393 Free PMC article. Clinical Trial.
The study also considered time-varying dialysis and depressive symptoms. METHODS: Seventy-two patients were randomly assigned to either the laser acupuncture (LA) group or the control group. The LA group received acupuncture with a low-level laser at specific …
The study also considered time-varying dialysis and depressive symptoms. METHODS: Seventy-two patients were randomly assigned to eith …
Poly-L-Lactic Acid Combined With CO2 Fractional Laser for the Treatment of Acne Scars.
Zhou C, Chen W, Zhang L, Luo X, Zhu L, Zhang E, Li K, Qin X. Zhou C, et al. J Cosmet Dermatol. 2025 Jun;24(6):e70271. doi: 10.1111/jocd.70271. J Cosmet Dermatol. 2025. PMID: 40476635 Free PMC article. Clinical Trial.
CONCLUSIONS: The combination of CO(2) fractional laser and PLLA can safely and effectively treat acne scars, especially rolling and boxcar depressed scars....
CONCLUSIONS: The combination of CO(2) fractional laser and PLLA can safely and effectively treat acne scars, especially rolling and boxcar …
Photobiomodulation therapy for the treatment of vulvar pain among those with provoked vestibulodynia: a randomized controlled trial.
I Antonio F, Pukall C, McLean L. I Antonio F, et al. J Sex Med. 2025 Apr 15;22(4):579-587. doi: 10.1093/jsxmed/qdaf011. J Sex Med. 2025. PMID: 39940084 Clinical Trial.
OBJECTIVE: To determine whether a 15-session photobiomodulation (PBM) intervention is more effective than sham-PBM for reducing vulvar pain. ...Secondary outcomes: pain-related domains reported on the VPAQ, sexual function, depression, anxiety and stress …
OBJECTIVE: To determine whether a 15-session photobiomodulation (PBM) intervention is more effective than sham-PBM for reducing vulva …
A high-power near-infrared photobiomodulation device: design, fabrication, and primary impact on treatment-resistant depression.
Hosseini SH, Zamani SA, Baleghi Y, Ahmadi Noubar H, Rezapour M, Hasannezhad Reskati M. Hosseini SH, et al. Lasers Med Sci. 2025 Nov 25;40(1):495. doi: 10.1007/s10103-025-04732-0. Lasers Med Sci. 2025. PMID: 41288780
Depression is a prevalent psychiatric disorder, affecting a significant portion of the population. ...Photobiomodulation represents an emerging therapeutic approach for depression, utilizing an enhanced near-infrared therapy device. ...
Depression is a prevalent psychiatric disorder, affecting a significant portion of the population. ...Photobiomodulation …
Efficacy of Photobiomodulation in Reducing Symptomatology and Improving the Quality of Life in Patients with Xerostomia and Hyposalivation: A Randomized Controlled Trial.
Ferrandez-Pujante A, Pons-Fuster E, López-Jornet P. Ferrandez-Pujante A, et al. J Clin Med. 2022 Jun 14;11(12):3414. doi: 10.3390/jcm11123414. J Clin Med. 2022. PMID: 35743485 Free PMC article.
Xerostomia was assessed using a salivary flow visual analog scale (VAS) and the Xerostomia Inventory (XI). The Hospital Anxiety and Depression (HAD) scale, Oral Health Impact Profile (OHIP-14), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) …
Xerostomia was assessed using a salivary flow visual analog scale (VAS) and the Xerostomia Inventory (XI). The Hospital Anxiety and …
Transcranial photobiomodulation prevents PTSD-like comorbidities in rats experiencing underwater trauma.
Li Y, Dong Y, Yang L, Tucker L, Yang B, Zong X, Hamblin MR, Zhang Q. Li Y, et al. Transl Psychiatry. 2021 May 5;11(1):270. doi: 10.1038/s41398-021-01389-5. Transl Psychiatry. 2021. PMID: 33953158 Free PMC article.
Maladaptive fear memory processing after a traumatic event is a major contributor to the development of the comorbidities related to posttraumatic stress disorder (PTSD). An intervention to normalize this process could be a first-line treatment to prevent …
Maladaptive fear memory processing after a traumatic event is a major contributor to the development of the comorbidities related to posttra …
Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies.
Cardoso FDS, Salehpour F, Coimbra NC, Gonzalez-Lima F, Gomes da Silva S. Cardoso FDS, et al. Front Neurosci. 2022 Sep 20;16:1006031. doi: 10.3389/fnins.2022.1006031. eCollection 2022. Front Neurosci. 2022. PMID: 36203812 Free PMC article.
We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficient anti-inflammatory therapy. METHODS: We conducted a systematic search on the bibliographic databases (PubMed and ScienceDirect) with …
We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficien …
Dose-dependent effects of transcranial photobiomodulation on brain temperature in patients with major depressive disorder: a spectroscopy study.
Weerasekera A, Coelho DRA, Ratai EM, Collins KA, Puerto AMH, De Taboada L, Gersten MB, Clancy JA, Hoptman MJ, Irvin MK, Sparpana AM, Sullivan EF, Song X, Adib A, Cassano P, Iosifescu DV. Weerasekera A, et al. Lasers Med Sci. 2024 Oct 7;39(1):249. doi: 10.1007/s10103-024-04198-6. Lasers Med Sci. 2024. PMID: 39370461 Clinical Trial.
This study aimed to evaluate the dose-dependent brain temperature effects of transcranial photobiomodulation (t-PBM). Thirty adult subjects with major depressive disorder were randomized to three t-PBM sessions with different doses (low: 50 mW/cm(2), medium: …
This study aimed to evaluate the dose-dependent brain temperature effects of transcranial photobiomodulation (t-PBM). Thirty adult su …
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3.
Hong N, Kim HJ, Kang K, Park JO, Mun S, Kim HG, Kang BH, Chung PS, Lee MY, Ahn JC. Hong N, et al. Cell Biosci. 2023 Jan 12;13(1):8. doi: 10.1186/s13578-022-00949-6. Cell Biosci. 2023. PMID: 36635704 Free PMC article.
Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to represent a pathogen that characterizes the neurobiology of TLE. Photobiomodulation (PBM) is a rapidly growing therapy for the attenuation of neurona …
Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to represent a pathogen th …
Effects of transcranial photobiomodulation on anxiety-like behavior and spatial learning in adult and old female rats.
García-Castro P, Sal-Sarria S, González-Pardo H, Arias JL, Martínez JA, Conejo NM. García-Castro P, et al. Physiol Behav. 2026 Feb 26;310:115293. doi: 10.1016/j.physbeh.2026.115293. Online ahead of print. Physiol Behav. 2026. PMID: 41763463 Free article.
This study evaluated the effects of tPBM on anxiety-like behavior, spatial learning, and regional brain oxidative metabolism in adult and old female Wistar rats. ...Behavioral performance was assessed using the Elevated Zero Maze (EZM) and Morris Water Maze (MWM), followed …
This study evaluated the effects of tPBM on anxiety-like behavior, spatial learning, and regional brain oxidative metabolism in adult …
Potential application of PBM use in hair follicle organoid culture for the treatment of androgenic alopecia.
Roets B. Roets B. Mater Today Bio. 2023 Nov 3;23:100851. doi: 10.1016/j.mtbio.2023.100851. eCollection 2023 Dec. Mater Today Bio. 2023. PMID: 38024838 Free PMC article. Review.
However, the main challenges are to maintain the cell populations within the organoid in a proliferative and inductive state, as well as to promote the maturation of organoids. Photobiomodulation is a form of light therapy that stimulates endogenous chromopho …
However, the main challenges are to maintain the cell populations within the organoid in a proliferative and inductive state, as well as to …
Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy.
Morries LD, Cassano P, Henderson TA. Morries LD, et al. Neuropsychiatr Dis Treat. 2015 Aug 20;11:2159-75. doi: 10.2147/NDT.S65809. eCollection 2015. Neuropsychiatr Dis Treat. 2015. PMID: 26347062 Free PMC article. Review.
In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, and hyperbaric oxygen therapy. All available literature suggests a marginal benefit with prolonged treatment courses. ...The extant li …
In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, a …
Whole-Body Photobiomodulation Therapy for Fibromyalgia: A Feasibility Trial.
Fitzmaurice BC, Heneghan NR, Rayen ATA, Grenfell RL, Soundy AA. Fitzmaurice BC, et al. Behav Sci (Basel). 2023 Aug 29;13(9):717. doi: 10.3390/bs13090717. Behav Sci (Basel). 2023. PMID: 37753995 Free PMC article.
Effective treatment for fibromyalgia (FM) is lacking and further treatment options are needed. Photobiomodulation therapy (PBMT) represents one potential treatment option. Whilst favourable findings have been reported using localised PBMT, no investigations have est …
Effective treatment for fibromyalgia (FM) is lacking and further treatment options are needed. Photobiomodulation therapy (PBM …
Photobiomodulation therapy mitigates depressive-like behaviors by remodeling synaptic links and mitochondrial function.
Chen H, Shi X, Liu N, Jiang Z, Ma C, Luo G, Liu S, Wei X, Liu Y, Ming D. Chen H, et al. J Photochem Photobiol B. 2024 Sep;258:112998. doi: 10.1016/j.jphotobiol.2024.112998. Epub 2024 Jul 31. J Photochem Photobiol B. 2024. PMID: 39096719
Depression, a multifactorial mental disorder, characterized by cognitive slowing, anxiety, and impaired cognitive function, imposes a significant burden on public health. ...It is recognized for its therapeutic efficacy in treating depression, yet its …
Depression, a multifactorial mental disorder, characterized by cognitive slowing, anxiety, and impaired cognitive funct …
Photobiomodulation as a Therapeutic Strategy for Major Depressive Disorder: Mechanisms and Prospects.
Hu S, Li X, Guo B, Xu W, Liu TC, Yang L. Hu S, et al. Photobiomodul Photomed Laser Surg. 2025 Oct;43(10):441-456. doi: 10.1177/25785478251371716. Epub 2025 Sep 1. Photobiomodul Photomed Laser Surg. 2025. PMID: 40888424 Review.
Background: Depression is a prevalent mental disorder characterized by mental suffering and emotional distress. ...Photobiomodulation (PBM), a noninvasive therapeutic approach, has shown potential in treating mood disorders such as depression an …
Background: Depression is a prevalent mental disorder characterized by mental suffering and emotional distress. ...Photobio …
Photobiomodulation for Major Depressive Disorder: Linking Transcranial Infrared Light, Biophotons and Oxidative Stress.
Vieira WF, Gersten M, Caldieraro MAK, Cassano P. Vieira WF, et al. Harv Rev Psychiatry. 2023 May-Jun 01;31(3):124-141. doi: 10.1097/HRP.0000000000000363. Harv Rev Psychiatry. 2023. PMID: 37171473 Review.
Incompletely treated major depressive disorder (MDD) poses an enormous global health burden. Conventional treatment for MDD consists of pharmacotherapy and psychotherapy, though a significant number of patients do not achieve remission with such treatments. Transcra …
Incompletely treated major depressive disorder (MDD) poses an enormous global health burden. Conventional treatment for MDD co …
Low-level light therapy for sleep quality, fatigue, depression, and cold limbs in older adults in nursing homes: A feasibility trial.
Lai IH, Tai CJ, Chien LY. Lai IH, et al. Geriatr Nurs. 2025 Sep-Oct;65:103498. doi: 10.1016/j.gerinurse.2025.103498. Epub 2025 Jul 8. Geriatr Nurs. 2025. PMID: 40633237
OBJECTIVES: To examine the feasibility and effectiveness of low-level light therapy (LLLT) on head acupoints for improving geriatric symptoms (poor sleep, fatigue, depression, cold limbs), meridian energy, energy balance, and autonomic nervous s …
OBJECTIVES: To examine the feasibility and effectiveness of low-level light therapy (LLLT) on head acupoints for …
Effects of transcranial photobiomodulation and methylene blue on biochemical and behavioral profiles in mice stress model.
Meynaghizadeh-Zargar R, Sadigh-Eteghad S, Mohaddes G, Salehpour F, Rasta SH. Meynaghizadeh-Zargar R, et al. Lasers Med Sci. 2020 Apr;35(3):573-584. doi: 10.1007/s10103-019-02851-z. Epub 2019 Aug 1. Lasers Med Sci. 2020. PMID: 31372913
The effectiveness of transcranial photobiomodulation (tPBM) and methylene Blue (MB) in treating learning and memory impairments is previously reported. ...Elevated plus maze (EPM) was used to evaluate anxiety-like behaviors. Novel object recognition (NOR) test and B …
The effectiveness of transcranial photobiomodulation (tPBM) and methylene Blue (MB) in treating learning and memory impairments is pr …
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety.
Schiffer F, Johnston AL, Ravichandran C, Polcari A, Teicher MH, Webb RH, Hamblin MR. Schiffer F, et al. Behav Brain Funct. 2009 Dec 8;5:46. doi: 10.1186/1744-9081-5-46. Behav Brain Funct. 2009. PMID: 19995444 Free PMC article.
BACKGROUND: Many studies have reported beneficial effects from the application of near-infrared (NIR) light photobiomodulation (PBM) to the body, and one group has reported beneficial effects applying it to the brain in stroke patients. ...METHODS: We gave 10 patien …
BACKGROUND: Many studies have reported beneficial effects from the application of near-infrared (NIR) light photobiomodulation …
Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review.
Orliaguet M, Misery L. Orliaguet M, et al. Biomolecules. 2021 Aug 18;11(8):1237. doi: 10.3390/biom11081237. Biomolecules. 2021. PMID: 34439903 Free PMC article.
On the other hand, the role of psychological factors in BMS has also been the focus of several studies and has shown a link with psychiatric disorders such as anxiety and/or depression symptoms. Depending on the patient, the neuropathic and psychogenic compon …
On the other hand, the role of psychological factors in BMS has also been the focus of several studies and has shown a link with psychiatric …
Effect of photobiomodulation intervention for depressive symptoms: A systematic review and meta-analysis.
Seok JW, Kim K, Kim JU, Kim JD. Seok JW, et al. J Affect Disord. 2026 Jan 15;393(Pt B):120413. doi: 10.1016/j.jad.2025.120413. Epub 2025 Oct 14. J Affect Disord. 2026. PMID: 41101469 Free article.
BACKGROUND: Although photobiomodulation (PBM) has been investigated as a non-invasive treatment for reducing depressive symptoms, its effectiveness and optimal treatment settings remain unknown. This meta-analysis assessed the overall impact of PBM on depressive …
BACKGROUND: Although photobiomodulation (PBM) has been investigated as a non-invasive treatment for reducing depressive sympto …
Near-Infrared Stimulation in Psychiatry Disorders: A Systematic Review of Efficacy and Biological Mechanisms.
Woźniak J, Pazdrak M, Domanasiewicz A, Kaźmierski J. Woźniak J, et al. NeuroSci. 2025 Mar 17;6(1):26. doi: 10.3390/neurosci6010026. NeuroSci. 2025. PMID: 40137870 Free PMC article. Review.
BACKGROUND: Photobiomodulation (PBM), also referred to as low-level light therapy (LLLT), is an emerging non-pharmacological approach. ...Publications focused on PBM treatment in psychiatric disorders such as major depressive di …
BACKGROUND: Photobiomodulation (PBM), also referred to as low-level light therapy (LLLT), is an emerging …
Can mild cognitive impairment be stabilized by showering brain mitochondria with laser photons?
de la Torre JC, Olmo AD, Valles S. de la Torre JC, et al. Neuropharmacology. 2020 Jul;171:107841. doi: 10.1016/j.neuropharm.2019.107841. Epub 2019 Nov 5. Neuropharmacology. 2020. PMID: 31704275 Review.
This intervention uses transcranial infrared brain stimulation (TIBS), a form of photobiomodulation (PBM). PBM is a bioenergetic non-ionizing, therapeutic approach using low level light emission from laser or light emitting diodes. ...This artic …
This intervention uses transcranial infrared brain stimulation (TIBS), a form of photobiomodulation (PBM). PBM is a bioenergetic non- …
Photobiomodulation therapy alleviates repeated closed head injury-induced anxiety-like behaviors.
Chen Z, Li M, Wu C, Su Y, Feng S, Deng Q, Zou P, Liu TC, Duan R, Yang L. Chen Z, et al. J Biophotonics. 2024 Feb;17(2):e202300343. doi: 10.1002/jbio.202300343. Epub 2023 Nov 1. J Biophotonics. 2024. PMID: 37909411
Although extensive studies have focused on how to treat rCHI-induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI-induced anxiety has received little research attention. The current study was designed to assess the effects o …
Although extensive studies have focused on how to treat rCHI-induced brain injury and reduce the possibility of developing memory deficits, …
Comparative efficacy of pharmaceutical (Ibuprofen) and non-pharmaceutical (photobiomodulation, and chewing gum) interventions for pain reduction after elastomeric separator placement in orthodontic patients: a randomized clinical trial.
Azizi F, Zaseh MMS, Golshah A, Imani MM, Safari-Faramani R. Azizi F, et al. Lasers Med Sci. 2024 Sep 25;39(1):239. doi: 10.1007/s10103-024-04186-w. Lasers Med Sci. 2024. PMID: 39317795 Clinical Trial.
This study compared the efficacy of pharmaceutical (ibuprofen) and non-pharmaceutical (photobiomodulation and chewing gum) interventions for pain reduction after elastomeric separator placement in orthodontic patients. This 3-arm, parallel-group randomized clinical trial w …
This study compared the efficacy of pharmaceutical (ibuprofen) and non-pharmaceutical (photobiomodulation and chewing gum) interventi …
Transcranial Photobiomodulation and Firefighter Health and Wellness: A Single-Arm, Open-Label Pilot Study.
Tate DF, Lindsey HM, Wilde EA. Tate DF, et al. Photobiomodul Photomed Laser Surg. 2025 Aug;43(8):337-345. doi: 10.1177/15578550251362096. Epub 2025 Jul 28. Photobiomodul Photomed Laser Surg. 2025. PMID: 40719008
Background: First responders are often exposed to many physically and mentally stressful events throughout their careers, and common complaints include poor sleep quality, chronic pain, post-traumatic stress symptoms, mood dysregulation, and cognitive impairm …
Background: First responders are often exposed to many physically and mentally stressful events throughout their careers, and common complai …
Efficiency of Early Sequential Laser Treatment for Facial Linear Scars in Cross-Sectional Regions.
Guo L, Xue P, Fan X, Yin Y, Dou W, Li T, Yang Q. Guo L, et al. J Cosmet Dermatol. 2025 Feb;24(2):e70053. doi: 10.1111/jocd.70053. J Cosmet Dermatol. 2025. PMID: 39943911 Free PMC article.
Antera 3D analysis revealed substantial improvements in average roughness, depression depth, and elevation depth across facial regions. The significance of improvements in color variation, texture elevation span, melanin hyperconcentration, and hemoglobin hyperconcentratio …
Antera 3D analysis revealed substantial improvements in average roughness, depression depth, and elevation depth across facial region …
Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity.
Huang Z, Zhang Y, Ma X, Feng Y, Zong X, Jordan JD, Zhang Q. Huang Z, et al. Theranostics. 2023 Jan 16;13(3):913-930. doi: 10.7150/thno.78777. eCollection 2023. Theranostics. 2023. PMID: 36793860 Free PMC article.
Furthermore, there is no available treatment that prevents or alleviates the neurologic sequelae of ELA, especially traumatic stress. Hence, the present study aims to investigate the mechanisms for these associations and evaluate whether photobiomodulation (PBM), a …
Furthermore, there is no available treatment that prevents or alleviates the neurologic sequelae of ELA, especially traumatic stress. …
Emerging lasers and light-based therapies in the management of acne: a review.
Jean-Pierre P, Tordjman L, Ghodasara A, Nwosu C, Nouri K. Jean-Pierre P, et al. Lasers Med Sci. 2024 Sep 28;39(1):245. doi: 10.1007/s10103-024-04196-8. Lasers Med Sci. 2024. PMID: 39340675 Free PMC article. Review.
All these pharmacologic treatments have a risk of side effects ranging from mild ones, like skin irritation and dryness, to severe ones, like depression. Thus, there is a demand for exploring other treatment modalities in treating acne, and laser and light-based the …
All these pharmacologic treatments have a risk of side effects ranging from mild ones, like skin irritation and dryness, to severe ones, lik …
A Brief Review of Low-Level Light Therapy in Depression Disorder.
Shirkavand A, Akhavan Tavakoli M, Ebrahimpour Z. Shirkavand A, et al. J Lasers Med Sci. 2023 Nov 11;14:e55. doi: 10.34172/jlms.2023.55. eCollection 2023. J Lasers Med Sci. 2023. PMID: 38028864 Free PMC article. Review.
Introduction: Low-level laser therapy (LLLT), also called Photobiomodulation, has gained widespread acceptance as a mainstream modality, particularly in the form of photobiostimulation (PBM). ...In addition, it helps Parkinson's patients with their mov …
Introduction: Low-level laser therapy (LLLT), also called Photobiomodulation, has gained widespread acceptance a …
Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.
Cho Y, Tural U, Iosifescu DV. Cho Y, et al. Photobiomodul Photomed Laser Surg. 2023 Sep;41(9):460-466. doi: 10.1089/photob.2023.0041. Epub 2023 Aug 31. Photobiomodul Photomed Laser Surg. 2023. PMID: 37651208 Free PMC article.
Background: Transcranial photobiomodulation (tPBM) is a novel, noninvasive, device-based intervention, which has been tested as a possible treatment for various neurological and psychiatric conditions. Recently, it has been investigated as an innovative treatment for major …
Background: Transcranial photobiomodulation (tPBM) is a novel, noninvasive, device-based intervention, which has been tested as a pos …
Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis.
Cassano P, Petrie SR, Hamblin MR, Henderson TA, Iosifescu DV. Cassano P, et al. Neurophotonics. 2016 Jul;3(3):031404. doi: 10.1117/1.NPh.3.3.031404. Epub 2016 Mar 4. Neurophotonics. 2016. PMID: 26989758 Free PMC article. Review.
We examined the use of near-infrared and red radiation (photobiomodulation, PBM) for treating major depressive disorder (MDD). While still experimental, preliminary data on the use of PBM for brain disorders are promising. ...We found clinical and prec …
We examined the use of near-infrared and red radiation (photobiomodulation, PBM) for treating major depressive disorder …
The efficacy of photobiomodulation on dental injection pain: a systematic review of randomized clinical trials.
Altuhafy M, Baig V, Jabr L, Khan J. Altuhafy M, et al. J Dent Anesth Pain Med. 2024 Jun;24(3):145-159. doi: 10.17245/jdapm.2024.24.3.145. Epub 2024 May 27. J Dent Anesth Pain Med. 2024. PMID: 38840646 Free PMC article. Review.
Dental injections are routinely performed and can result in pain and anxiety in patients. This systematic review aimed to evaluate the efficacy of photobiomodulation therapy (PBMT) in dental injections for pain management in patients undergoing dental treatme …
Dental injections are routinely performed and can result in pain and anxiety in patients. This systematic review aimed to evaluate th …
Exploring photobiomodulation as a complementary approach for mental health: an integrative review.
Cidral-Filho FJ, Hewitson A, Vitorino VL, Donatello N. Cidral-Filho FJ, et al. Lasers Med Sci. 2025 Nov 29;40(1):502. doi: 10.1007/s10103-025-04738-8. Lasers Med Sci. 2025. PMID: 41315118 Review.
Fourteen studies published through July 2025 were included, addressing conditions such as anxiety, depression, and seasonal affective disorder (SAD). PBM showed therapeutic potential, with reported improvements in brain activity, reduced anxiety, and a …
Fourteen studies published through July 2025 were included, addressing conditions such as anxiety, depression, and seasonal af …
Transcranial Photobiomodulation Treatment: Significant Improvements in Four Ex-Football Players with Possible Chronic Traumatic Encephalopathy.
Naeser MA, Martin PI, Ho MD, Krengel MH, Bogdanova Y, Knight JA, Hamblin MR, Fedoruk AE, Poole LG, Cheng C, Koo B. Naeser MA, et al. J Alzheimers Dis Rep. 2023 Jan 31;7(1):77-105. doi: 10.3233/ADR-220022. eCollection 2023. J Alzheimers Dis Rep. 2023. PMID: 36777329 Free PMC article.
There was significant improvement at 1 month on post-traumatic stress disorder (PTSD), depression, pain, and sleep. One case discontinued narcotic pain medications and had reduced tinnitus. ...Significant correlations for increased SN fun …
There was significant improvement at 1 month on post-traumatic stress disorder (PTSD), depression, …
Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury.
Wu C, Li M, Chen Z, Feng S, Deng Q, Duan R, Liu TC, Yang L. Wu C, et al. Transl Psychiatry. 2025 Jan 11;15(1):8. doi: 10.1038/s41398-025-03228-3. Transl Psychiatry. 2025. PMID: 39799140 Free PMC article.
This study assessed the prophylactic efficacy of remote photobiomodulation (PBM) targeted at the lungs against rCHI-induced brain injury and associated behavioral deficits. ...Results demonstrated that remote PBM significantly improved depressive-like behaviors, mot …
This study assessed the prophylactic efficacy of remote photobiomodulation (PBM) targeted at the lungs against rCHI-induced brain inj …
LAight Therapy is an Effective and Gentle Treatment in Adolescents Suffering from Hidradenitis Suppurative: Results from 96 Patients Using Real-world Data.
Strobel A, Schultheis M, Staubach P, Grabbe S, Hennig K, Szepietowski J, Matusiak Ł, Von Stebut E, Kirschner U, Bayer H, Nikolakis G, Garcovich S. Strobel A, et al. Acta Derm Venereol. 2025 Sep 22;105:adv43543. doi: 10.2340/actadv.v105.43543. Acta Derm Venereol. 2025. PMID: 40981520 Free PMC article.
Physicians prefer to avoid the use of systemic medications and surgery in children due to the potential side effects, psychological burden, and long-term consequences. The device-based LAight therapy combines intense pulsed light and radiofrequency and received EU- …
Physicians prefer to avoid the use of systemic medications and surgery in children due to the potential side effects, psychological burden, …
From Numbness to Comfort: Pioneering Pediatric Anesthesia Reversal with Photobiomodulation.
Meharwade P, Mothi P, Honakeri KS, Sanjeev A, Baby HR, Tavargeri A. Meharwade P, et al. Int J Clin Pediatr Dent. 2025 Dec;18(12):1526-1529. doi: 10.5005/jp-journals-10005-3336. Epub 2025 Dec 16. Int J Clin Pediatr Dent. 2025. PMID: 41552024 Free PMC article. Review.
This review highlights pediatric anesthesia management by investigating the application of photobiomodulation (PBM) for the efficient and safe reversal of LA effects. PBM, a low-level laser therapy (LLLT), has gained momentum of late for its therapeuti …
This review highlights pediatric anesthesia management by investigating the application of photobiomodulation (PBM) for the efficient …
Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.
Xu Z, Guo X, Yang Y, Tucker D, Lu Y, Xin N, Zhang G, Yang L, Li J, Du X, Zhang Q, Xu X. Xu Z, et al. Mol Neurobiol. 2017 Aug;54(6):4551-4559. doi: 10.1007/s12035-016-9983-2. Epub 2016 Jul 5. Mol Neurobiol. 2017. PMID: 27379735 Free PMC article.
Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobility, neurotransmitter deficiency, and energy metabolic decline. Low-level laser therapy (LLLT) has been investigated i …
Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobi …
Low-Fluence Q-Switch 1064 Nm Laser Combined With Oral Tranexamic Acid: A Quicker Treatment for Laser-Induced Postinflammatory Hyperpigmentation.
Feng W, Yang L. Feng W, et al. J Cosmet Dermatol. 2025 Feb;24(2):e70018. doi: 10.1111/jocd.70018. J Cosmet Dermatol. 2025. PMID: 39927593 Free PMC article.
Obvious hyperpigmentation can lead to an ugly appearance and severe anxiety. Therefore, a fast and effective treatment for laser-induced PIH is necessary. ...
Obvious hyperpigmentation can lead to an ugly appearance and severe anxiety. Therefore, a fast and effective treatment for laser-indu …
Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury.
Naeser MA, Martin PI, Ho MD, Krengel MH, Bogdanova Y, Knight JA, Yee MK, Zafonte R, Frazier J, Hamblin MR, Koo BB. Naeser MA, et al. Photomed Laser Surg. 2016 Dec;34(12):610-626. doi: 10.1089/pho.2015.4037. Photomed Laser Surg. 2016. PMID: 28001756 Review.
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM imp …
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to impr …
Photobiomodulation therapy for repeated closed head injury in rats.
Yang B, Xu J, Li Y, Dong Y, Li Y, Tucker L, Yang L, Zong X, Wu C, Xu T, Hu S, Zhang Q, Yan X. Yang B, et al. J Biophotonics. 2020 Feb;13(2):e201960117. doi: 10.1002/jbio.201960117. Epub 2019 Nov 25. J Biophotonics. 2020. PMID: 31657525
Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here, we examined PBM in a repeated closed head injury (rCHI) rat model. ...We found that PBM-treated rCHI rats had a significant reduction in m …
Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here …
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model.
Yang L, Wu C, Tucker L, Dong Y, Li Y, Xu P, Zhang Q. Yang L, et al. J Alzheimers Dis. 2021;83(4):1415-1429. doi: 10.3233/JAD-201616. J Alzheimers Dis. 2021. PMID: 34219711
We hypothesize that photobiomodulation (PBM) could be an effective method to alleviate depression and anxiety at the early stage of AD pathogenesis. ...CONCLUSION: Our findings support our hypothesis that PBM could be an effective method to alleviate depre …
We hypothesize that photobiomodulation (PBM) could be an effective method to alleviate depression and anxiety at the ea …
Neuromodulation in the Treatment of Alzheimer's Disease: Current and Emerging Approaches.
Pople CB, Meng Y, Li DZ, Bigioni L, Davidson B, Vecchio LM, Hamani C, Rabin JS, Lipsman N. Pople CB, et al. J Alzheimers Dis. 2020;78(4):1299-1313. doi: 10.3233/JAD-200913. J Alzheimers Dis. 2020. PMID: 33164935 Review.
Neuromodulation as a treatment strategy for psychiatric and neurological diseases has grown in popularity in recent years, with the approval of repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression being one such example. These approaches offe …
Neuromodulation as a treatment strategy for psychiatric and neurological diseases has grown in popularity in recent years, with the approval …
Photobiomodulation improves frontal lobe cognitive functions and mental health of older adults with non-amnestic mild cognitive impairment: Case studies.
Cheung MC, Lee TL, Sze SL, Chan AS. Cheung MC, et al. Front Psychol. 2023 Jan 10;13:1095111. doi: 10.3389/fpsyg.2022.1095111. eCollection 2022. Front Psychol. 2023. PMID: 36704674 Free PMC article.
METHODS: Three older adults with mild cognitive impairment (MCI) of the non-amnestic type received 18-session tPBM stimulation for 9 weeks and were assessed with neuropsychological tests of memory and executive functions and standardized questionnaires on depressive and …
METHODS: Three older adults with mild cognitive impairment (MCI) of the non-amnestic type received 18-session tPBM stimulation for 9 weeks a …
The Effectiveness of Low-Level LED Light Therapy for Sleep Problems, Psychological Symptoms, and Heart Rate Variability in Shift-Work Nurses: A Randomized Controlled Trial.
Liao YH, Tai CJ, Ming JL, Lin LH, Chien LY. Liao YH, et al. J Nurs Manag. 2025 Jun 17;2025:6478834. doi: 10.1155/jonm/6478834. eCollection 2025. J Nurs Manag. 2025. PMID: 40557249 Free PMC article. Clinical Trial.
The Depression Anxiety Stress Scale-21 and Insomnia Severity Index were used to measure psychological symptoms and sleep problems, respectively. ...No significant differences were observed in heart rate variability between the two groups. Conclusion: Low …
The Depression Anxiety Stress Scale-21 and Insomnia Severity Index were used to measure psychological symptoms and slee …
Non-invasive transcranial brain modulation for neurological disorders treatment: A narrative review.
Mosilhy EA, Alshial EE, Eltaras MM, Rahman MMA, Helmy HI, Elazoul AH, Hamdy O, Mohammed HS. Mosilhy EA, et al. Life Sci. 2022 Oct 15;307:120869. doi: 10.1016/j.lfs.2022.120869. Epub 2022 Aug 6. Life Sci. 2022. PMID: 35940222 Review.
The commonly noninvasive techniques used in neurological manipulations include photobiomodulation (PBM), transcranial electrical stimulation (TES), transcranial magnetic stimulation (TMS), and ultrasound stimulation (USS). ...However, each technique owns its unique mechani …
The commonly noninvasive techniques used in neurological manipulations include photobiomodulation (PBM), transcranial electrical stim …
Long-term efficacy of photobiomodulation in burning mouth syndrome: A secondary analysis of a randomized controlled trial.
Lu C, Zhang X, Jiang X, Jiang M, Li X, Du Q, Tang G. Lu C, et al. J Dent. 2026 Feb;165:106275. doi: 10.1016/j.jdent.2025.106275. Epub 2025 Dec 1. J Dent. 2026. PMID: 41338367 Clinical Trial.

The recurrence group had relatively higher pain intensity, poorer oral health-related quality of life, and more severe anxiety and depressive symptoms compared to non-recurrence patients (p < 0.05). PBM + OCT combination therapy showed a lower recurrence r

…
The recurrence group had relatively higher pain intensity, poorer oral health-related quality of life, and more severe anxiety and …
Photodynamic Therapy, Photobiomodulation and Acetonide Triamcinolone 0.1% in the Treatment of Oral Lichen Planus: A Randomized Clinical Trial.
Salinas-Gilabert C, Gómez García F, Galera Molero F, Pons-Fuster E, Vander Beken S, Lopez Jornet P. Salinas-Gilabert C, et al. Pharmaceutics. 2022 Dec 22;15(1):30. doi: 10.3390/pharmaceutics15010030. Pharmaceutics. 2022. PMID: 36678659 Free PMC article.
Objective: To evaluate the efficacy of photodynamic therapy (PDT) and photobiomodulation (PBM) in the treatment of oral lichen planus (OLP) in comparison with the use of topical corticosteroids. ...Patient pain was evaluated, and the Thongprasom severity score, the …
Objective: To evaluate the efficacy of photodynamic therapy (PDT) and photobiomodulation (PBM) in the treatment of oral lichen …
Efficacy and safety of the 589/1319 nm solid-state dual-wavelength laser combined with topical benzoyl peroxide for inflammatory acne vulgaris: a split-face randomized controlled trial.
Boonpethkaew S, Ratanapokasatit Y, Chirasuthat S, Wattanakrai P. Boonpethkaew S, et al. Arch Dermatol Res. 2025 Mar 26;317(1):635. doi: 10.1007/s00403-025-04146-6. Arch Dermatol Res. 2025. PMID: 40140055 Free PMC article. Clinical Trial.
Inflammatory lesion count (ILC) and acne-related skin parameters, including hemoglobin level, melanin level, skin depression, and skin roughness were measured. Adverse events (AEs) and patients' satisfaction were assessed. ...On the adjunctive laser side, the change in ILC …
Inflammatory lesion count (ILC) and acne-related skin parameters, including hemoglobin level, melanin level, skin depression, and ski …
The Efficacy and Safety of Transcranial Photobiomodulation for Mild Cognitive Impairment Due to Alzheimer's Disease: A Randomized, Double-Blind, Sham-Controlled Study.
Chun H, Yoon ML, Lee HW, Lee JY, Hong SB, Ha SS, Yoon KJ. Chun H, et al. Photobiomodul Photomed Laser Surg. 2025 Sep;43(9):411-416. doi: 10.1177/15578550251369575. Photobiomodul Photomed Laser Surg. 2025. PMID: 40939031 Clinical Trial.
Background: Transcranial photobiomodulation (tPBM) is a promising noninvasive neuromodulation modality with potential therapeutic benefits for neurodegenerative diseases. Infrared light delivered by a tPBM device penetrates the cortex, stimulating neuronal activity …
Background: Transcranial photobiomodulation (tPBM) is a promising noninvasive neuromodulation modality with potential therapeutic ben …
Neurometabolite Changes After Transcranial Photobiomodulation in Major Depressive Disorder: A Randomized Controlled Trial Investigating Dose-Dependent Effects.
Coelho DRA, Tural Ü, Hurtado Puerto AM, Collins KA, Gersten MB, Parincu Z, Siu K, Iosifescu DV, Ratai EM, Cassano P, Weerasekera A. Coelho DRA, et al. J Clin Med. 2025 May 13;14(10):3402. doi: 10.3390/jcm14103402. J Clin Med. 2025. PMID: 40429396 Free PMC article.
Background: Transcranial photobiomodulation (t-PBM) is a promising non-invasive therapy for Major Depressive Disorder (MDD). ...Clinical outcomes were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS) and the Symptoms of De …
Background: Transcranial photobiomodulation (t-PBM) is a promising non-invasive therapy for Major Depressive Disorde …
Effect of laser biostimulation and a low-calorie diet vs. a low-calorie diet alone on insulin resistance, inflammatory biomarkers, and depression among obese postmenopausal women: a randomized controlled trial.
Elsayed MM, Rakha M, Elsheimy HA, Abdelaziz NE, Nagy EN. Elsayed MM, et al. Eur Rev Med Pharmacol Sci. 2022 May;26(9):3269-3277. doi: 10.26355/eurrev_202205_28745. Eur Rev Med Pharmacol Sci. 2022. PMID: 35587078 Free article. Clinical Trial.
OBJECTIVE: Postmenopausal women are significantly predisposed to a multitude of disorders. Laser biostimulation (LB) and a healthy diet have been linked to multiple health benefits. ...Before and after the intervention, IR [measured by the Homeostatic Model Assessment of I …
OBJECTIVE: Postmenopausal women are significantly predisposed to a multitude of disorders. Laser biostimulation (LB) and a healthy di …
Comparison of efficacy of photobiomodulation and topical anesthetic spray in reducing the injection pain in children aged 6-12 years - A randomized clinical trial.
Bollepalli B, Penmetsa A, Peddi R, Mannam H, Koruprolu R, Penmetsa GS. Bollepalli B, et al. J Indian Soc Pedod Prev Dent. 2025 Apr 1;43(2):269-275. doi: 10.4103/jisppd.jisppd_154_25. Epub 2025 Jun 30. J Indian Soc Pedod Prev Dent. 2025. PMID: 40586469 Free article. Clinical Trial.
BACKGROUND: Local anesthesia administration is associated with pain, resulting in dental anxiety in children. Various techniques have been tried to minimize this discomfort such as topical anesthetic gel, spray, Vibration of tissue, and distraction techniques. Literature h …
BACKGROUND: Local anesthesia administration is associated with pain, resulting in dental anxiety in children. Various techniques have …
Transcranial photobiomodulation promotes traumatic brain injury recovery via modulating glial cell polarization and neuroinflammation: a study of 1064 nm light-emitting diodes.
Chen G, Xu Z, Ma H, Qin Q, Li X, Yang A, Chen Y, Tan Y, Qiu Y, Wang Y, Ruan H, Jiang X, Zhang J. Chen G, et al. J Transl Med. 2025 Nov 7;23(1):1245. doi: 10.1186/s12967-025-07170-2. J Transl Med. 2025. PMID: 41204266 Free PMC article.
BACKGROUND: Photobiomodulation (PBM) utilizing 1064 nm near-infrared light, renowned for its deep tissue penetration capabilities, has demonstrated significant therapeutic potential in addressing brain disorders; however, its specific effects and underlying m …
BACKGROUND: Photobiomodulation (PBM) utilizing 1064 nm near-infrared light, renowned for its deep tissue penetration capabilit …
[Low Level Laser Therapy in Nursing Care].
Wu JH. Wu JH. Hu Li Za Zhi. 2024 Feb;71(1):15-21. doi: 10.6224/JN.202402_71(1).03. Hu Li Za Zhi. 2024. PMID: 38253849 Chinese.
The high pressure nature of their work makes nursing staffs relatively susceptible to high levels of anxiety and insomnia and to poor mental health. Low level laser therapy (photobiomodulation therapy, PBMT) is an alternative approach to …
The high pressure nature of their work makes nursing staffs relatively susceptible to high levels of anxiety and insomnia and to poor …
Photobiomodulation in the aging brain: a systematic review from animal models to humans.
Rodríguez-Fernández L, Zorzo C, Arias JL. Rodríguez-Fernández L, et al. Geroscience. 2024 Dec;46(6):6583-6623. doi: 10.1007/s11357-024-01231-y. Epub 2024 Jun 11. Geroscience. 2024. PMID: 38861125 Free PMC article.
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmacological therapy that shows promising results in the treatment or prevention of age-related cognitive impairments. ...In healthy aged …
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmac …
The potential of transcranial photobiomodulation therapy for treatment of major depressive disorder.
Salehpour F, Rasta SH. Salehpour F, et al. Rev Neurosci. 2017 May 24;28(4):441-453. doi: 10.1515/revneuro-2016-0087. Rev Neurosci. 2017. PMID: 28231069 Review.
Major depressive disorder is a common debilitating mood disorder that affects quality of life. ...In this review, we focus on some issue relating to the application of photobiomodulation therapy for major depressive disorder. There …
Major depressive disorder is a common debilitating mood disorder that affects quality of life. ...In this review, we fo …
Evaluation of the Photobiomodulation Treatment With the TINI Laser Device for Managing Chronic High-Frequency Tinnitus: A Randomised Controlled Trial.
Choi JE, Lee MY, Jung JY. Choi JE, et al. Clin Otolaryngol. 2025 May;50(3):544-554. doi: 10.1111/coa.14291. Epub 2025 Feb 12. Clin Otolaryngol. 2025. PMID: 39943716 Clinical Trial.
INTRODUCTION: To evaluate the efficacy of the TINI laser device, a photobiomodulation (PBM) therapy, for managing chronic high-frequency tinnitus in patients with unilateral or bilateral tinnitus. ...Psychological assessments were also conducted to measure levels of …
INTRODUCTION: To evaluate the efficacy of the TINI laser device, a photobiomodulation (PBM) therapy, for managing chronic high …
UC-USP collaborative exercise on photobiomodulation therapy in neurological orofacial disturbances.
Nunes T, Caetano C, Pimenta M, Saraiva J, Rocha S, Freitas P, Figueiredo J, Pereira SA, Corte-Real A. Nunes T, et al. J Clin Exp Dent. 2020 Jul 1;12(7):e650-e655. doi: 10.4317/jced.56839. eCollection 2020 Jul. J Clin Exp Dent. 2020. PMID: 32904953 Free PMC article.
BACKGROUND: Neurosensory peripheral disorders are one of the most common risks associated with iatrogenic and/or post-traumatic injuries. ...CONCLUSIONS: Our results supported the improvement of quality of life and impairment reduction in the individuals subm …
BACKGROUND: Neurosensory peripheral disorders are one of the most common risks associated with iatrogenic and/or post-traum …
Transcranial Photobiomodulation Improves Cognitive Performance in Young Healthy Adults: A Systematic Review and Meta-Analysis.
Salehpour F, Majdi A, Pazhuhi M, Ghasemi F, Khademi M, Pashazadeh F, Hamblin MR, Cassano P. Salehpour F, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):635-643. doi: 10.1089/photob.2019.4673. Epub 2019 Sep 24. Photobiomodul Photomed Laser Surg. 2019. PMID: 31549906 Free PMC article.
Background: Transcranial photobiomodulation (t-PBM) is a noninvasive modality that may improve cognitive function in both healthy and diseased subjects. ...
Background: Transcranial photobiomodulation (t-PBM) is a noninvasive modality that may improve cognitive function in both healthy and …
Effect of low-level laser stimulation of acupuncture points in pediatric dentistry: a systematic review.
Mira PCDS, Vilela LD, Corona SAM, Borsatto MC. Mira PCDS, et al. Lasers Med Sci. 2023 Jan 24;38(1):52. doi: 10.1007/s10103-023-03720-6. Lasers Med Sci. 2023. PMID: 36690781
The biomodulatory potential of low-level laser therapy (LLLT) has prompted investigations of different outcomes in health. ...A total of four studies using LLLT for photobiomodulation were included (n = 4). The most common wavelengths used were in the …
The biomodulatory potential of low-level laser therapy (LLLT) has prompted investigations of different outcomes in heal …
Penetration Profiles of Visible and Near-Infrared Lasers and Light-Emitting Diode Light Through the Head Tissues in Animal and Human Species: A Review of Literature.
Salehpour F, Cassano P, Rouhi N, Hamblin MR, De Taboada L, Farajdokht F, Mahmoudi J. Salehpour F, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):581-595. doi: 10.1089/photob.2019.4676. Epub 2019 Sep 25. Photobiomodul Photomed Laser Surg. 2019. PMID: 31553265 Review.
Background and objective: Photobiomodulation (PBM) therapy is a promising and noninvasive approach to stimulate neuronal function and improve brain repair. ...Conclusions: In conclusion, it is worthwhile mentioning that since the effectiveness of brain PBM is closel …
Background and objective: Photobiomodulation (PBM) therapy is a promising and noninvasive approach to stimulate neuronal funct …
Auxillary aids for pain and anxiety reduction during dental local anesthesia in pediatric patients: a systematic review.
Saxena B, Goswami M, Saxena A, Padha S, Sharma A, Garg Y, Singhal P. Saxena B, et al. Evid Based Dent. 2025 Jun;26(2):114-115. doi: 10.1038/s41432-024-01094-4. Epub 2025 Jan 8. Evid Based Dent. 2025. PMID: 39775158
AIMS/OBJECTIVES: This systematic review aimed to evaluate the effectiveness of auxiliary aids-Transcutaneous Electrical Nerve Stimulation (TENS), vibrotactile devices, and Low-Level Laser Therapy (LLLT) in reducing pain and anxiety during dental local …
AIMS/OBJECTIVES: This systematic review aimed to evaluate the effectiveness of auxiliary aids-Transcutaneous Electrical Nerve Stimulation (T …
A Protocol for Transcranial Photobiomodulation Therapy in Mice.
Salehpour F, De Taboada L, Cassano P, Kamari F, Mahmoudi J, Ahmadi-Kandjani S, Rasta SH, Sadigh-Eteghad S. Salehpour F, et al. J Vis Exp. 2018 Nov 18;(141). doi: 10.3791/59076. J Vis Exp. 2018. PMID: 30507909
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain function in a wide range of neurological and psychiatric disorders, and memory enhancement in age-related cognitive decline and neurod …
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain f …
Protocol for a randomized clinical trial on the efficacy of blue light emitting diode in the treatment of recurrent vulvovaginal candidiasis.
Ramos JDGDS, da Costa MO, Dos Santos JLP, Micussi MTABC, Gouveia GPM. Ramos JDGDS, et al. Lasers Med Sci. 2025 Jun 5;40(1):255. doi: 10.1007/s10103-025-04515-7. Lasers Med Sci. 2025. PMID: 40471351
INTRODUCTION: Blue light (BL) induces reactive oxygen species (ROS), exerting an antimicrobial effect. This study will assess its effectiveness in women with recurrent vulvovaginal candidiasis (RVVC). ...The primary outcome will be the absence of Candida Albicans (CA), whi …
INTRODUCTION: Blue light (BL) induces reactive oxygen species (ROS), exerting an antimicrobial effect. This study will assess its eff …
Advanced Intervention Effects of Pulsed and Steady Transcranial Photobiomodulation on Sleep, Mood, and EEG Signal Regulation.
Zhang X, Miao X, Jiang H, Ren Y, Huo L, Liu M, Chen H. Zhang X, et al. J Biophotonics. 2025 Jun;18(6):e70004. doi: 10.1002/jbio.70004. Epub 2025 Mar 18. J Biophotonics. 2025. PMID: 40101768
Outcomes were assessed using the Karolinska Sleepiness Scale (KSS) (for measuring sleepiness), State-Trait Anxiety Inventory (STAI) (for assessing anxiety), Visual Analog Scale (VAS) (for measuring stress), and Beck Depression Inventory-II (BDI-II) (fo …
Outcomes were assessed using the Karolinska Sleepiness Scale (KSS) (for measuring sleepiness), State-Trait Anxiety Inventory (STAI) ( …
Central nervous system abnormalities in fibromyalgia and chronic fatigue syndrome: new concepts in treatment.
Gur A, Oktayoglu P. Gur A, et al. Curr Pharm Des. 2008;14(13):1274-94. doi: 10.2174/138161208799316348. Curr Pharm Des. 2008. PMID: 18537652 Review.
Because of the similarities between both disorders it was suggested that they share a common pathophysiological mechanisms, namely, central nervous system (CNS) dysfunction. ...Researches suggest that the (CNS) is primarily involved in both disorders in regard to th …
Because of the similarities between both disorders it was suggested that they share a common pathophysiological mechanisms, namely, c …
Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice.
Lepicard EM, Joubert C, Hagneau I, Perez-Diaz F, Chapouthier G. Lepicard EM, et al. Pharmacol Biochem Behav. 2000 Dec;67(4):739-48. doi: 10.1016/s0091-3057(00)00419-6. Pharmacol Biochem Behav. 2000. PMID: 11166064
The study in an ethological perspective of inbred strains of mice offers a more accurate description of anxiety-related behavior. In this context, behavioral performances of the BALB/cByJ and C57BL/6J strains were systematically compared in the staircase test, the light …
The study in an ethological perspective of inbred strains of mice offers a more accurate description of anxiety-related behavior. In …
Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment.
Baumgartner J, Šimaljaková M. Baumgartner J, et al. J Cosmet Laser Ther. 2017 Dec;19(8):459-464. doi: 10.1080/14764172.2017.1343953. Epub 2017 Jun 30. J Cosmet Laser Ther. 2017. PMID: 28665237
The treatment, usually asked from patients as the result of anxiety and social embarrassment, should be performed in a non-aggressive manner. OBJECTIVES: To determine the safety and effectiveness of 595-nm variable-pulse pulsed dye laser (VPPDL) with a Dynamic Cooling Devi …
The treatment, usually asked from patients as the result of anxiety and social embarrassment, should be performed in a non-aggressive …
Nonpharmacological interventions for acute pain management in patients with opioid abuse or opioid tolerance: a scoping review.
Hargett J, Criswell A, Palokas M. Hargett J, et al. JBI Evid Synth. 2022 Nov 1;20(11):2697-2720. doi: 10.11124/JBIES-21-00169. JBI Evid Synth. 2022. PMID: 36065876
Nonpharmacological techniques have shown potential in reducing postoperative pain, opioid consumption, stress, and anxiety. INCLUSION CRITERIA: Eligible studies included participants in either inpatient or outpatient health care settings who were experiencing acute …
Nonpharmacological techniques have shown potential in reducing postoperative pain, opioid consumption, stress, and anxiety. IN …
Effect of modified intravascular laser irradiation of blood in the oral and systemic conditions during dental treatment-A systematic review.
Oliveira MC, Silva DFB, de Oliveira Andrade A, Pita de Melo D, de Sousa YAB, da Silva LOP, de Castro Gomes DQ. Oliveira MC, et al. Lasers Med Sci. 2024 Dec 20;39(1):300. doi: 10.1007/s10103-024-04264-z. Lasers Med Sci. 2024. PMID: 39704836
This systematic literature review study aimed to answer the question, "Is modified-ILIB an effective adjuvant therapy in the control of systemic conditions and/or oral changes in children and adults during dental treatment?". ...The outcomes were periodontal parameters and …
This systematic literature review study aimed to answer the question, "Is modified-ILIB an effective adjuvant therapy in the control …
Transcranial Photobiomodulation for Neuromodulation of Brain Disorders: A Perspective.
De Ridder D, Hamblin MR, Vanneste S. De Ridder D, et al. Neuromodulation. 2026 Feb 5:S1094-7159(25)01203-6. doi: 10.1016/j.neurom.2025.12.006. Online ahead of print. Neuromodulation. 2026. PMID: 41642156 Review.
INTRODUCTION: Photobiomodulation (PBM) uses light to modulate biological activity. Because red and near-infrared wavelengths penetrate the skin and skull, PBM can be applied transcranially (tPBM) to noninvasively modulate brain activity, offering therapeutic potenti …
INTRODUCTION: Photobiomodulation (PBM) uses light to modulate biological activity. Because red and near-infrared wavelengths p …
Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy.
Cardoso FDS, de Souza Oliveira Tavares C, Araujo BHS, Mansur F, Lopes-Martins RÁB, Gomes da Silva S. Cardoso FDS, et al. Cell Mol Neurobiol. 2022 Aug;42(6):1875-1886. doi: 10.1007/s10571-021-01069-4. Epub 2021 Mar 11. Cell Mol Neurobiol. 2022. PMID: 33704604 Free PMC article.
We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their exploratory activity and habituation in open field, anxiety in elevated plus maze, spatial memory in Barnes maze, and aversive memory in a step …
We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their explorator …
Effect of Femtosecond Laser Radiation on Cognitive Abilities in Mice.
Ivanitskii GR, Sorokina SS, Dyukina AR, Yusupov VI. Ivanitskii GR, et al. Dokl Biochem Biophys. 2025 Oct;524(1):514-518. doi: 10.1134/S1607672925601234. Epub 2025 Nov 20. Dokl Biochem Biophys. 2025. PMID: 41264153
Open field and Barnes maze tests were performed 5 months after a single irradiation to assess general activity, anxiety level, and spatial learning ability. Irradiated animals retained normal motor skills, did not show anxiety, and demonstrated stable long-term memo …
Open field and Barnes maze tests were performed 5 months after a single irradiation to assess general activity, anxiety level, and sp …
Role of Photobiomodulation Therapy in Neurological Primary Burning Mouth Syndrome. A Systematic Review and Meta-Analysis of Human Randomised Controlled Clinical Trials.
Hanna R, Dalvi S, Bensadoun RJ, Raber-Durlacher JE, Benedicenti S. Hanna R, et al. Pharmaceutics. 2021 Nov 2;13(11):1838. doi: 10.3390/pharmaceutics13111838. Pharmaceutics. 2021. PMID: 34834253 Free PMC article. Review.
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). Photobiomodulation therapy (PBMT) has been utilised in npBMS management, however, its role of intervention remains controversial. …
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). …
Improved cognitive function, efficiency, saccadic eye movement, and depressive symptoms in mild cognitive impairment with transcranial photobiomodulation.
Lee TL, Kwok TC, Lam LC, Fung HH, Cheung MC, Han YMY, Chan AS. Lee TL, et al. J Alzheimers Dis. 2025 Sep;107(2):529-541. doi: 10.1177/13872877251361033. Epub 2025 Sep 1. J Alzheimers Dis. 2025. PMID: 40702818
Participants underwent comprehensive assessments before and after the intervention, including neuropsychological tests, measurements of oxygenated hemoglobin (HbO) using function near-infrared spectroscopy during a visual working memory task, saccadic movement measurement using a …
Participants underwent comprehensive assessments before and after the intervention, including neuropsychological tests, measurements of oxyg …
Long-Term Benefits of Photobiomodulation Therapy on Health-Related Quality of Life in Burning Mouth Syndrome Patients: A Prospective Study.
de Abreu JM, Nunes T, Almiro PA, Figueiredo J, Corte-Real A. de Abreu JM, et al. J Clin Med. 2024 Jul 22;13(14):4272. doi: 10.3390/jcm13144272. J Clin Med. 2024. PMID: 39064312 Free PMC article.
This study aimed to evaluate the impact of prolonged Photobiomodulation with low-level laser therapy on BMS patients by examining the efficacy of an outpatient protocol in a real-world setting. ...Conclusions: Therefore, Photobiomodulation with …
This study aimed to evaluate the impact of prolonged Photobiomodulation with low-level laser therapy on BMS pati …
Dual-Brain Psychology: A novel theory and treatment based on cerebral laterality and psychopathology.
Schiffer F. Schiffer F. Front Psychol. 2022 Oct 19;13:986374. doi: 10.3389/fpsyg.2022.986374. eCollection 2022. Front Psychol. 2022. PMID: 36337511 Free PMC article.
Stimulating the positive hemisphere in most therapy patients rapidly relieves symptoms such as anxiety, depression, or substance cravings. Two randomized controlled trials used unilateral transcranial photobiomodulation to the positive hemisphere as a …
Stimulating the positive hemisphere in most therapy patients rapidly relieves symptoms such as anxiety, depression, or …
Sensory-motor and cardiorespiratory sensory rehabilitation associated with transcranial photobiomodulation in patients with central nervous system injury: Trial protocol for a single-center, randomized, double-blind, and controlled clinical trial.
Pinto AP, Guimarães CL, Souza GADS, Leonardo PS, Neves MFD, Lima FPS, Lima MO, Lopes-Martins RAB. Pinto AP, et al. Medicine (Baltimore). 2019 Jun;98(25):e15851. doi: 10.1097/MD.0000000000015851. Medicine (Baltimore). 2019. PMID: 31232920 Free PMC article.
Aerobic exercises bring benefits in terms of fatigue retardation, gait improvement, regulation of the autonomic nervous system, neuroprotection of the brain, stimulation of the production of endogenous neutrotransmitters related to general well-being, and a favoring of neuroplast …
Aerobic exercises bring benefits in terms of fatigue retardation, gait improvement, regulation of the autonomic nervous system, neuroprotect …
The 2910-nm Fiber Laser Is Safe and Effective for Improving Acne Scarring.
Bernstein E, Alajmi A, Wang J, Hochman E, Biesman B, Sanzo JF. Bernstein E, et al. Lasers Surg Med. 2024 Nov;56(9):755-761. doi: 10.1002/lsm.23845. Epub 2024 Sep 22. Lasers Surg Med. 2024. PMID: 39308036 Clinical Trial.
BACKGROUND: Acne scarring results from the inflammation associated with acne papules, which alters dermal collagen, typically producing depressed scars. Lasers have been used to remodel skin improving the texture and appearance of acne scars. ...
BACKGROUND: Acne scarring results from the inflammation associated with acne papules, which alters dermal collagen, typically producing d …
Analysis of the psychopathological profile, quality of life, and cost-effectiveness of oral lichen planus patients treated with photobiomodulation.
Sobral SS, da Silva Brandão EH, de Barros Gallo C, Molon A, Sobral APT, de Fátima Teixeira da Silva D, Motta LJ, Dos Santos Franco AL, Rodrigues MFSD. Sobral SS, et al. Clin Oral Investig. 2022 Jan;26(1):719-728. doi: 10.1007/s00784-021-04050-z. Epub 2021 Jul 12. Clin Oral Investig. 2022. PMID: 34251533 Clinical Trial.
MATERIALS AND METHODS: Patients were randomized into two groups: Control (clobetasol propionate 0.05%) and Photobiomodulation (660 nm, 100mW, 177 J/cm(2), 5 s, 0.5 J) twice a week for 30 days. The Hospital Anxiety and Depression Scale (HADS) and OHIP-14 were …
MATERIALS AND METHODS: Patients were randomized into two groups: Control (clobetasol propionate 0.05%) and Photobiomodulation (660 nm …
Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer's disease and related dementia living in long-term care facilities.
Figueiro MG, Plitnick BA, Lok A, Jones GE, Higgins P, Hornick TR, Rea MS. Figueiro MG, et al. Clin Interv Aging. 2014 Sep 12;9:1527-37. doi: 10.2147/CIA.S68557. eCollection 2014. Clin Interv Aging. 2014. PMID: 25246779 Free PMC article.
BACKGROUND: Light therapy has shown great promise as a nonpharmacological method to improve symptoms associated with Alzheimer's disease and related dementias (ADRD), with preliminary studies demonstrating that appropriately timed light exposure can improve n …
BACKGROUND: Light therapy has shown great promise as a nonpharmacological method to improve symptoms associated with Alzheimer …
Transcranial Photobiomodulation to Improve Cognition in Gulf War Illness.
Martin PI, Chao L, Krengel MH, Ho MD, Yee M, Lew R, Knight J, Hamblin MR, Naeser MA. Martin PI, et al. Front Neurol. 2021 Jan 21;11:574386. doi: 10.3389/fneur.2020.574386. eCollection 2020. Front Neurol. 2021. PMID: 33551948 Free PMC article.
Introduction: Approximately 25-30% of veterans deployed to Kuwait, 1990-91, report persistent multi-symptom Gulf War Illness (GWI) likely from neurotoxicant exposures. Photobiomodulation (PBM) in red/near-infrared (NIR) wavelengths is a safe, non-invasive modality shown to …
Introduction: Approximately 25-30% of veterans deployed to Kuwait, 1990-91, report persistent multi-symptom Gulf War Illness (GWI) likely fr …
Photobiomodulation enhances cognitive function in aging rats and modulates cytochrome c oxidase activity and c-Fos expression in memory-related circuits.
Rodríguez-Fernández L, Zorzo C, Gutiérrez-Menéndez A, Lobo JC, Valle DFD, Castillo-Escalona EG, Martínez JA, Arias JL. Rodríguez-Fernández L, et al. Physiol Behav. 2026 Jan 1;303:115135. doi: 10.1016/j.physbeh.2025.115135. Epub 2025 Oct 17. Physiol Behav. 2026. PMID: 41110494 Free article.
Aging is marked by a progressive decline in cognitive and behavioral functions, underscoring the need for innovative therapeutic strategies. Photobiomodulation (PBM) therapy has emerged as a non-invasive technique that enhances mitochondrial function and supports ne …
Aging is marked by a progressive decline in cognitive and behavioral functions, underscoring the need for innovative therapeutic strategies. …
Photobiomodulation therapy and transcutaneous electrical nerve stimulation on chronic neck pain patients: Study protocol clinical trial (SPIRIT Compliant).
Rampazo ÉP, de Andrade ALM, da Silva VR, Back CGN, Liebano RE. Rampazo ÉP, et al. Medicine (Baltimore). 2020 Feb;99(8):e19191. doi: 10.1097/MD.0000000000019191. Medicine (Baltimore). 2020. PMID: 32080103 Free PMC article.
This study will be performed in Department of Physical Therapy at Federal University of Sao Carlos, Sao Carlos/SP, Brazil. One hundred and forty-four patients with chronic neck pain will be randomized into 4 groups: active photobiomodulation therapy with acti …
This study will be performed in Department of Physical Therapy at Federal University of Sao Carlos, Sao Carlos/SP, Brazil. One hundre …
The history of light therapy in hospital physiotherapy and medicine with emphasis on Australia: Evolution into novel areas of practice.
Liebert A, Kiat H. Liebert A, et al. Physiother Theory Pract. 2021 Mar;37(3):389-400. doi: 10.1080/09593985.2021.1887060. Epub 2021 Mar 7. Physiother Theory Pract. 2021. PMID: 33678141 Review.
Objective: The objective of this narrative review was to investigate the history of light therapy in hospital settings, with reference to physiotherapy and particularly in an Australian context.Types of articles and search method:a review of available literature was …
Objective: The objective of this narrative review was to investigate the history of light therapy in hospital settings, with r …
Evaluation of the effectiveness of photobiomodulation therapy as an alternative method to local anesthesia injection in pediatric dentistry.
Diab HM, El-Malt MA, Mourad YO. Diab HM, et al. J Indian Soc Pedod Prev Dent. 2023 Jul-Sep;41(3):222-227. doi: 10.4103/jisppd.jisppd_305_23. J Indian Soc Pedod Prev Dent. 2023. PMID: 37861636 Free article. Clinical Trial.
BACKGROUND: The idea of receiving local anesthesia (LA) via an injection is a major source of dental fear and anxiety. In children, dental anxiety is considered the main reason for avoiding dental treatments. ...AIM: This study was performed to evaluate the effectiv …
BACKGROUND: The idea of receiving local anesthesia (LA) via an injection is a major source of dental fear and anxiety. In children, d …
Photobiomodulation for modulation of neuropathic pain and improvement of scar tissue.
Santiago R, Gomes S, Ozsarfati J, Zitney M. Santiago R, et al. Scars Burn Heal. 2022 Oct 26;8:20595131221134052. doi: 10.1177/20595131221134052. eCollection 2022 Jan-Dec. Scars Burn Heal. 2022. PMID: 36310679 Free PMC article.
BACKGROUND: This case-report explores the effects of photobiomodulation therapy (PBMT) on the healing of scar tissue. The patient was a 32-year old female two years post cholecystectomy resulting in a 15 cm linear scar that was causing severe pain. ...LAY SUMMARY: D …
BACKGROUND: This case-report explores the effects of photobiomodulation therapy (PBMT) on the healing of scar tissue. The pati …
Photobiomodulation therapy in diabetes: Benefits for pain relief, quality of life, and wound healing.
da Silva Oliveira VR, de Paula Oliveira I, Alonso-Matielo H, Oliveira VT, Kremer JL, Casalverini MCD, Ribeiro FQ, Maria-Engler SS, Assis SR, Teixeira MJ, Lotfi CFP, Otoch JP, Dale CS. da Silva Oliveira VR, et al. Photochem Photobiol. 2025 Jul-Aug;101(4):913-924. doi: 10.1111/php.14053. Epub 2025 Jan 20. Photochem Photobiol. 2025. PMID: 39829285
A 5 mm skin biopsy was taken for fibroblast culture. PBM therapy, using 660 nm red light, was administered twice weekly for 7 weeks on lower limb wounds. Results indicated that DM patients faced significant sensory impairments, impacting their quality of life. PBM …
A 5 mm skin biopsy was taken for fibroblast culture. PBM therapy, using 660 nm red light, was administered twice weekly for 7 …
Very Low-Level Transcranial Photobiomodulation for Major Depressive Disorder: The ELATED-3 Multicenter, Randomized, Sham-Controlled Trial.
Iosifescu DV, Norton RJ, Tural U, Mischoulon D, Collins K, McDonald E, De Taboada L, Foster S, Cusin C, Yeung A, Clain A, Schoenfeld D, Hamblin MR, Cassano P. Iosifescu DV, et al. J Clin Psychiatry. 2022 Aug 8;83(5):21m14226. doi: 10.4088/JCP.21m14226. J Clin Psychiatry. 2022. PMID: 35950904 Clinical Trial.
Background: Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light might represent a treatment for major depressive disorder (MDD). ...The primary outcome was reduction in depression severity (Hamilton Depression Rating Sc …
Background: Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light might represent a treatment for major de …
Treatment of chronic symptoms following mild traumatic brain injury with transcranial LED: a sham run-in pilot study of photobiomodulation therapy.
Karr JE, Iverson GL, Boudreau N, Zafonte R. Karr JE, et al. Brain Inj. 2024 May 11;38(6):425-435. doi: 10.1080/02699052.2024.2309258. Epub 2024 Feb 8. Brain Inj. 2024. PMID: 38329020
PRIMARY OBJECTIVE: We evaluated whether photobiomodulation with red/near infrared light applied transcranially via light emitting diodes (LED) was associated with reduced symptoms and improved cognitive functioning in patients with chronic symptoms following …
PRIMARY OBJECTIVE: We evaluated whether photobiomodulation with red/near infrared light applied transcranially via light …
Antidepressant and antioxidant effects of transcranial irradiation with 830-nm low-power laser in an animal model of depression.
Mohammed HS, Khadrawy YA. Mohammed HS, et al. Lasers Med Sci. 2022 Apr;37(3):1615-1623. doi: 10.1007/s10103-021-03410-1. Epub 2021 Sep 6. Lasers Med Sci. 2022. PMID: 34487275
The present study aimed at investigating the antidepressant and antioxidant actions of near-infrared (NIR) laser at a wavelength of 830 nm and power of 100 mW which applied transcranially on an animal model of depression induced by repeated doses of reserpine (0.2 mg/kg). …
The present study aimed at investigating the antidepressant and antioxidant actions of near-infrared (NIR) laser at a wavelength of 830 nm a …
Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS( )) Coupled with Transcranial Photobiomodulation (tPBM) For Co-Occurring Traumatic Brain Injury (TBI) and Post-Traumatic Stress Disorder (PTSD).
Mahajan S, Bodahanapati A, Katta A, Aydemir E, Mendoza A, Vigilia C, Blum K, Baron D, Lewandrowski KU, Badgaiyan RD, Sunder K. Mahajan S, et al. Acta Sci Neurol. 2025 Mar;8(3):20-27. doi: 10.31080/asne.2025.08.0809. Epub 2025 Feb 24. Acta Sci Neurol. 2025. PMID: 41018541 Free PMC article.
This study provides further evidence demonstrating the beneficial effects of PrTMS( ) treatment in co-occurring disorders. Furthermore, this study illustrates the benefit of augmenting PrTMS( ) with tPBM for superior outcomes. ...Further, large-scale, randomized and blinde …
This study provides further evidence demonstrating the beneficial effects of PrTMS( ) treatment in co-occurring disorders. Furthermor …
[Burning mouth syndrome: pathogenic and therapeutic concepts].
Ferensztajn E, Łojko D, Rybakowski J. Ferensztajn E, et al. Psychiatr Pol. 2013 Nov-Dec;47(6):973-88. Psychiatr Pol. 2013. PMID: 25007531 Review. Polish.
The psychiatric aspect of BMS is significant: the most frequent co-morbidities are depression and anxiety disorders, and a number of psychotropic drugs play an essential role in its treatment. ...
The psychiatric aspect of BMS is significant: the most frequent co-morbidities are depression and anxiety disorders, an …
Clinical Efficacy of 830 nm LED Photobiomodulation Therapy on Postoperative Blepharoplasty Complications.
Ye H, Xiang Y. Ye H, et al. Aesthetic Plast Surg. 2025 Feb;49(3):655-663. doi: 10.1007/s00266-024-04374-7. Epub 2024 Oct 23. Aesthetic Plast Surg. 2025. PMID: 39443322 Clinical Trial.
In this research, the authors introduce a photobiomodulation therapy and to investigate the efficacy and safety of 830 nm light-emitting diode (LED) phototherapy in improving complications after incisional blepharoplasty. ...CONCLUSION: Photobiomodulation …
In this research, the authors introduce a photobiomodulation therapy and to investigate the efficacy and safety of 830 nm l …
Evaluation of photobiomodulation effects on pain, edema, paresthesia, and bone regeneration after surgically assisted rapid maxillary expansion: Study protocol for a randomized, controlled, and double blind clinical trial.
da Fonseca EV, Bussadori SK, da Silva Martinho LFC, de Sousa Melo MC, de Andrade FL, Gonçalves MLL, Mesquita-Ferrari RA, Horliana ACRT, Fernandes KPS. da Fonseca EV, et al. Medicine (Baltimore). 2019 Nov;98(48):e17756. doi: 10.1097/MD.0000000000017756. Medicine (Baltimore). 2019. PMID: 31770194 Free PMC article.
There are few studies on the effect of photobiomodulation (PBM) after SARME and it was not possible to find studies on the efficacy of light emitted by diode (LED) after this type of intervention. ...Secondarily, data regarding the occurrence of headache; otalgia; n …
There are few studies on the effect of photobiomodulation (PBM) after SARME and it was not possible to find studies on the efficacy o …
Transcranial photobiomodulation in children aged 2-6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology.
Fradkin Y, De Taboada L, Naeser M, Saltmarche A, Snyder W, Steingold E. Fradkin Y, et al. Front Neurol. 2024 Apr 26;15:1221193. doi: 10.3389/fneur.2024.1221193. eCollection 2024. Front Neurol. 2024. PMID: 38737349 Free PMC article.
BACKGROUND: Small pilot studies have suggested that transcranial photobiomodulation (tPBM) could help reduce symptoms of neurological conditions, such as depression, traumatic brain injury, and autism spectrum disorder (ASD). ...METHOD: We conducted a randomi …
BACKGROUND: Small pilot studies have suggested that transcranial photobiomodulation (tPBM) could help reduce symptoms of neurological …
Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review.
Chow R, Armati P, Laakso EL, Bjordal JM, Baxter GD. Chow R, et al. Photomed Laser Surg. 2011 Jun;29(6):365-81. doi: 10.1089/pho.2010.2928. Epub 2011 Apr 1. Photomed Laser Surg. 2011. PMID: 21456946
The findings were then evaluated with special reference to the neurophysiology of pain and implications for the analgesic effects of low-level laser therapy (LLLT). BACKGROUND: LLLT is used in the treatment of pain, and laser-induced neural inhibition has bee …
The findings were then evaluated with special reference to the neurophysiology of pain and implications for the analgesic effects of low …
The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model.
Buendía D, Guncay T, Oyanedel M, Lemus M, Weinstein A, Ardiles ÁO, Marcos J, Fernandes A, Zângaro R, Muñoz P. Buendía D, et al. Brain Sci. 2022 Sep 21;12(10):1272. doi: 10.3390/brainsci12101272. Brain Sci. 2022. PMID: 36291206 Free PMC article.
Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial light therapy (TLTC) on sy …
Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive fun …
Effect of low-level laser therapy (LLLT) on cognitive impairment among patients with chronic schizophrenia: a double-blind randomized placebo-controlled clinical trial.
Kheradmand A, Tabeie F, Seif P, Rezaei O, Yasamy MT. Kheradmand A, et al. Lasers Med Sci. 2022 Aug;37(6):2717-2725. doi: 10.1007/s10103-022-03545-9. Epub 2022 Mar 22. Lasers Med Sci. 2022. PMID: 35314926 Clinical Trial.
Low-level laser therapy (LLLT) is a noninvasive technique used in different medical fields. ...Nevertheless, the depression/anxiety subscale in the PANSS test showed a significant reduction after 6 sessions but did not persist after 2 months. .. …
Low-level laser therapy (LLLT) is a noninvasive technique used in different medical fields. ...Nevertheless, the dep …
Photobiomodulation's potential as a non-invasive therapy for alzheimer's disease and minimal cognitive impairment: A 12-week investigation.
Razzaghi M, Sheibani F, Kimia N, Razzaghi Z, Chenari Z, Ashrafi F, Barati M, Advani S. Razzaghi M, et al. Photodiagnosis Photodyn Ther. 2024 Apr;46:103991. doi: 10.1016/j.pdpdt.2024.103991. Epub 2024 Feb 16. Photodiagnosis Photodyn Ther. 2024. PMID: 38367922 Free article.
RESULTS: The mean reduction of Hamilton's anxiety questionnaire score was 3.33 6.08 in the intervention group and 2.00 3.46 in the control group (p-value=0.836). The mean score reduction of the Hamilton depression questionnaire was 3.16 3.86 in the intervention grou …
RESULTS: The mean reduction of Hamilton's anxiety questionnaire score was 3.33 6.08 in the intervention group and 2.00 3.46 in the co …
Effects of transcranial photobiomodulation with near-infrared light on sexual dysfunction.
Cassano P, Dording C, Thomas G, Foster S, Yeung A, Uchida M, Hamblin MR, Bui E, Fava M, Mischoulon D, Iosifescu DV. Cassano P, et al. Lasers Surg Med. 2019 Feb;51(2):127-135. doi: 10.1002/lsm.23011. Epub 2018 Sep 17. Lasers Surg Med. 2019. PMID: 30221776 Free PMC article. Clinical Trial.
NIR t-PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessions of NIR t-PBM on sexual dysfunction. METHODS: We performed a secondary analysis of a double-blind clinical trial on t-PBM for major dep …
NIR t-PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessio …
Selective photobiomodulation for emotion regulation: model-based dosimetry study.
Cassano P, Tran AP, Katnani H, Bleier BS, Hamblin MR, Yuan Y, Fang Q. Cassano P, et al. Neurophotonics. 2019 Jan;6(1):015004. doi: 10.1117/1.NPh.6.1.015004. Epub 2019 Feb 7. Neurophotonics. 2019. PMID: 30796882 Free PMC article.
The transcranial photobiomodulation (t-PBM) technique is a promising approach for the treatment of a wide range of neuropsychiatric disorders, including disorders characterized by poor regulation of emotion such as major depressive disorder (MDD …
The transcranial photobiomodulation (t-PBM) technique is a promising approach for the treatment of a wide range of neuropsychiatric …
Health challenges and importance of using photobiomodulation therapy in patients with epidermolysis bullosa: a cross-sectional study.
Silveira Souza M, Cascão Lopes L, Grossmann de Almeida L, Cintra Dantas MT, Dutra Gontijo Moura M, Borges de Almeida R, de Mattos Camargo Grossmann S. Silveira Souza M, et al. Lasers Med Sci. 2025 Jun 17;40(1):285. doi: 10.1007/s10103-025-04533-5. Lasers Med Sci. 2025. PMID: 40523961
Epidermolysis bullosa (EB) is a rare genetic disorder affecting connective tissue that causes painful ulcerations and oral disorders. ...Pain was significantly associated with mucosal lesions (p =.024), and photobiomodulation therapy using a low …
Epidermolysis bullosa (EB) is a rare genetic disorder affecting connective tissue that causes painful ulcerations and oral disorde …
Long-pulsed nd: YAG laser treatment of nail psoriasis: clinical and ultrasonographic assessment.
El-Basiony MAS, El-Komy MHM, Samy NA, Aly DG, El-Gendy H, Hassan MFAS, El Sayed H, Soliman MM. El-Basiony MAS, et al. Arch Dermatol Res. 2024 Jun 8;316(7):365. doi: 10.1007/s00403-024-03036-7. Arch Dermatol Res. 2024. PMID: 38850336 Free PMC article. Clinical Trial.
Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associated with anxiety and significant functional impairment of the quality of life. The 1064 nm Nd: YAG laser was reported to yield satisfa …
Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associat …
Transcranial Photobiomodulation with Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study.
Maiello M, Losiewicz OM, Bui E, Spera V, Hamblin MR, Marques L, Cassano P. Maiello M, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):644-650. doi: 10.1089/photob.2019.4677. Photobiomodul Photomed Laser Surg. 2019. PMID: 31647775 Free PMC article. Clinical Trial.
Objective: Our aim was to test the anxiolytic effect of transcranial photobiomodulation (t-PBM) with near-infrared light (NIR) in subjects suffering from generalized anxiety disorder (GAD). Background: t-PBM with NIR is an experimental, noninvasive tre …
Objective: Our aim was to test the anxiolytic effect of transcranial photobiomodulation (t-PBM) with near-infrared light (NIR) …
Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.
Li Q, Zhang X, Yang X, Pan N, Li X, Kemp GJ, Wang S, Gong Q. Li Q, et al. Neurobiol Stress. 2023 Oct 1;27:100578. doi: 10.1016/j.ynstr.2023.100578. eCollection 2023 Nov. Neurobiol Stress. 2023. PMID: 37842018 Free PMC article.
BACKGROUND: Social anxiety (SA) is a negative emotional response that can lead to mental health issues, which some have experienced during the coronavirus disease 2019 (COVID-19) pandemic. ...In terms of nodal network parameters, SA alterations were positively linked to a …
BACKGROUND: Social anxiety (SA) is a negative emotional response that can lead to mental health issues, which some have experienced d …
The effectiveness of transmeatal low-power laser stimulation in treating tinnitus.
Ngao CF, Tan TS, Narayanan P, Raman R. Ngao CF, et al. Eur Arch Otorhinolaryngol. 2014 May;271(5):975-80. doi: 10.1007/s00405-013-2491-3. Epub 2013 Apr 19. Eur Arch Otorhinolaryngol. 2014. PMID: 23605244 Clinical Trial.
In term of VAS scores, there seems to be no statistically significant improvement in patients' annoyance, sleep disruption, depression, concentration and tinnitus loudness and pitch heard between the two groups. Transmeatal low-power laser stimulation did not demonstrate s …
In term of VAS scores, there seems to be no statistically significant improvement in patients' annoyance, sleep disruption, depression …
Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study.
Henderson TA, Morries LD. Henderson TA, et al. Front Psychiatry. 2017 Sep 29;8:187. doi: 10.3389/fpsyt.2017.00187. eCollection 2017. Front Psychiatry. 2017. PMID: 29033859 Free PMC article.
Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain injury (TBI). The current objective is to explore multi-Watt NILT efficacy in a proof-of-concept study as a treatment for depression …
Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain …
Efficacy of photobiomodulation on oral lichen planus: a protocol study for a double-blind, randomised controlled clinical trial.
Ferri EP, Gallo CB, Abboud CS, Yanaguizawa WH, Horliana ACRT, Silva DFTD, Pavani C, Bussadori SK, Nunes FD, Mesquita-Ferrari RA, Fernandes KPS, Rodrigues MFSD. Ferri EP, et al. BMJ Open. 2018 Oct 8;8(10):e024083. doi: 10.1136/bmjopen-2018-024083. BMJ Open. 2018. PMID: 30297352 Free PMC article.
Photobiomodulation (PBM) has been shown to be a potential therapeutic tool to treat inflammatory disorders, including OLP. ...Pain will be evaluated using visual analogue scale and clinical characteristics will be scored using the Thongprasom Index. The quality of l …
Photobiomodulation (PBM) has been shown to be a potential therapeutic tool to treat inflammatory disorders, including OLP. ... …
An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation.
Schiffer F, Khan A, Bolger E, Flynn E, Seltzer WP, Teicher MH. Schiffer F, et al. Front Psychiatry. 2021 Aug 10;12:713686. doi: 10.3389/fpsyt.2021.713686. eCollection 2021. Front Psychiatry. 2021. PMID: 34447323 Free PMC article.
We report here our findings from our second randomized controlled trial to evaluate unilateral transcranial photobiomodulation as a treatment for opioid use disorder. Methods: We enrolled 39 participants with active opioid cravings at 2 sites, 19 received the active …
We report here our findings from our second randomized controlled trial to evaluate unilateral transcranial photobiomodulation as a t …
Acne Treatment With 3-Step Broadband Light Protocol.
Bitter P Jr. Bitter P Jr. J Drugs Dermatol. 2016 Nov 1;15(11):1382-1388. J Drugs Dermatol. 2016. PMID: 28095551
BACKGROUND AND OBJECTIVE: A new 3-step protocol using broadband light allows patients with moderate to severe in ammatory acne to avoid potential side effects of systemic acne treatments and the risks and uncertainties associated with laser and light treatments to d …
BACKGROUND AND OBJECTIVE: A new 3-step protocol using broadband light allows patients with moderate to severe in ammatory acne to avo …
The effects of music and muscle relaxation on patient anxiety in a coronary care unit.
Elliott D. Elliott D. Heart Lung. 1994 Jan-Feb;23(1):27-35. Heart Lung. 1994. PMID: 8150641 Clinical Trial.
OUTCOME MEASURES: Psychologic (State Trait Anxiety Inventory, Hospital Anxiety and Depression Scale, Linear Analogue Anxiety Scale) and physiologic (systolic and diastolic blood pressure and heart rate) variables were measured as indicators of anxie …
OUTCOME MEASURES: Psychologic (State Trait Anxiety Inventory, Hospital Anxiety and Depression Scale, Linear Analogue …
Low-level Laser Therapy to Alleviate Pain of Local Anesthesia Injection in Children: A Randomized Control Trial.
Khan BS, Setty JV, Srinivasan I, Kibriya S, Anu S, Radhakrishna S, Milit Y. Khan BS, et al. Int J Clin Pediatr Dent. 2023 Nov;16(Suppl 3):283-287. doi: 10.5005/jp-journals-10005-2699. Int J Clin Pediatr Dent. 2023. PMID: 38268643 Free PMC article.
RESULTS: The study showed PBM exhibited the lowest mean scores of anxiety/pain using VAS, Wong-Baker Faces Pain Rating Scale, FLACC scale and pulse rate as compared to precooling, vibration, and topical anesthesia. ...HOW TO CITE THIS ARTICLE: Khan BS, Setty JV, Srinivasan …
RESULTS: The study showed PBM exhibited the lowest mean scores of anxiety/pain using VAS, Wong-Baker Faces Pain Rating Scale, FLACC s …
Dose-response and efficacy of 830-nanometer photobiomodulation in healing diabetic foot ulcers: randomized, double-blind, clinical trial protocol.
Bezerra Miranda M, Silva Barros AC, Barbosa da Rocha R, Ahmed Hazime F, Saura Cardoso V. Bezerra Miranda M, et al. Lasers Med Sci. 2025 Sep 29;40(1):395. doi: 10.1007/s10103-025-04632-3. Lasers Med Sci. 2025. PMID: 41021046
Diabetic foot ulcers (DFUs) cause limitations in physical functioning and performance of activities of daily living (ADLs), accompanied by high emotional burden, anxiety, and depression. Furthermore, persistent and recurrent ulcers, severe amputations, and limitatio …
Diabetic foot ulcers (DFUs) cause limitations in physical functioning and performance of activities of daily living (ADLs), accompanied by h …
Non-specific effects and clusters of women with painful TMD responders and non-responders to LLLT: double-blind randomized clinical trial.
Magri LV, Carvalho VA, Rodrigues FCC, Bataglion C, Leite-Panissi CRA. Magri LV, et al. Lasers Med Sci. 2018 Feb;33(2):385-392. doi: 10.1007/s10103-017-2406-4. Epub 2017 Dec 5. Lasers Med Sci. 2018. PMID: 29209867 Clinical Trial.
The aim was to analyze the non-specific effects (placebo, spontaneous remission, and regression to the mean) of the low-level laser therapy (LLLT) in women with myofascial pain (painful temporomandibular disorder (TMD)), as well as to differentiate bet …
The aim was to analyze the non-specific effects (placebo, spontaneous remission, and regression to the mean) of the low-level …
Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser Stimulation.
Barrett DW, Beevers CG, Gonzalez-Lima F. Barrett DW, et al. Biol Psychiatry Glob Open Sci. 2025 Jan 9;5(2):100449. doi: 10.1016/j.bpsgos.2025.100449. eCollection 2025 Mar. Biol Psychiatry Glob Open Sci. 2025. PMID: 39990627 Free PMC article.
Cognitive behavioral therapy is a mainstream treatment for major depressive disorder. This is the first study to investigate whether TILS would augment the antidepressant effects of internet-based cognitive behavioral therapy. METHODS: Sixty participan …
Cognitive behavioral therapy is a mainstream treatment for major depressive disorder. This is the first study to invest …
Effectiveness of Photobiomodulation to Treat Motor and Non-Motor Symptoms of Parkinson's Disease: A Randomised Clinical Trial with Extended Treatment.
Saltmarche AE, Hares O, Bicknell B, Liebert A, Naeser M, Ramachandran S, Sykes J, Togeretz K, Namini A, Heller GZ, Herkes G. Saltmarche AE, et al. J Clin Med. 2025 Oct 22;14(21):7463. doi: 10.3390/jcm14217463. J Clin Med. 2025. PMID: 41226860 Free PMC article.
This study examined the effectiveness of photobiomodulation therapy (PBMt) combined with exercise to improve PD symptoms and quality of life. ...Conclusions: As the largest study to date, results add increasing weight to previous clinical trials and highlight potent …
This study examined the effectiveness of photobiomodulation therapy (PBMt) combined with exercise to improve PD symptoms and q …
Effects of ILIB on anxiety and physiological parameters during third molar surgery: a pilot randomized trial.
Santos CMM, Mattos NM, Silva RAP, Mariano-Junior WJ, Ferreira MS, Santos-Silva MAG, Mendonça EF, Martins AFL. Santos CMM, et al. Lasers Med Sci. 2025 Dec 29;41(1):4. doi: 10.1007/s10103-025-04797-x. Lasers Med Sci. 2025. PMID: 41460388 Clinical Trial.
ILIB was applied via transcutaneous over the radial artery for 30 min before the surgical procedure. Anxiety levels were assessed using the State-Trait Anxiety Inventory (STAI-Y, state subscale) at baseline and four minutes after local anesthesia. ...Further researc …
ILIB was applied via transcutaneous over the radial artery for 30 min before the surgical procedure. Anxiety levels were assessed usi …
Effect of photobiomodulation on pain perception during local anesthesia in children: a systematic review and meta-analysis.
Zanchetta Peron F, Ribeiro MC, da Costa VPP, Leão Goettems M. Zanchetta Peron F, et al. J Dent Anesth Pain Med. 2026 Feb;26(1):1-18. doi: 10.17245/jdapm.2026.26.1.1. Epub 2026 Jan 26. J Dent Anesth Pain Med. 2026. PMID: 41640722 Free PMC article. Review.
Pain associated with anesthetic injections is a significant concern in pediatric dentistry and is often linked to dental fear and anxiety. Photobiomodulation (PBMT) may reduce pain symptoms in children during local anesthesia administration. ...
Pain associated with anesthetic injections is a significant concern in pediatric dentistry and is often linked to dental fear and anxiety …
Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia.
Nizamutdinov D, Qi X, Berman MH, Dougal G, Dayawansa S, Wu E, Yi SS, Stevens AB, Huang JH. Nizamutdinov D, et al. Aging Dis. 2021 Jul 1;12(4):954-963. doi: 10.14336/AD.2021.0229. eCollection 2021 Jul. Aging Dis. 2021. PMID: 34221541 Free PMC article.
Low emission of transcranial near-infrared (tNIR) light can reach human brain parenchyma and be beneficial to a number of neurological and neurodegenerative disorders. ...Active treatment consisted of low power tNIR light stimulations with an active photob …
Low emission of transcranial near-infrared (tNIR) light can reach human brain parenchyma and be beneficial to a number of neurologica …
Investigating factors associated with depression of older women in Macau.
Chan MF, Zeng W. Chan MF, et al. J Clin Nurs. 2009 Nov;18(21):2969-77. doi: 10.1111/j.1365-2702.2009.02867.x. Epub 2009 Sep 3. J Clin Nurs. 2009. PMID: 19732244

The results showed that variables like having hypertension (p = 0.010), a poor social network (p < 0.001), low self-perceived scores on health status (p < 0.001) and ability to meet living costs (p < 0.001), and a low level of ability to do housework (p &lt

…

The results showed that variables like having hypertension (p = 0.010), a poor social network (p < 0.001), low self-perceived scores on h

…
Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress-Induced Depression.
Zhang D, Shen Q, Wu X, Xing D. Zhang D, et al. Oxid Med Cell Longev. 2021 Mar 29;2021:6678276. doi: 10.1155/2021/6678276. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33859781 Free PMC article.
Accumulating evidence indicates that dysfunction of the glutamatergic neurotransmission has been widely involved in the pathophysiology and treatment of depression. Photobiomodulation therapy (PBMT) has been demonstrated to regulate neuronal function both in …
Accumulating evidence indicates that dysfunction of the glutamatergic neurotransmission has been widely involved in the pathophysiology and …
Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial.
Germano Maciel D, Trajano da Silva M, Rodrigues JA, Viana Neto JB, de França IM, Melo ABM, Barros da Silva TYP, de Brito Vieira WH. Germano Maciel D, et al. Lasers Med Sci. 2018 Dec;33(9):1949-1959. doi: 10.1007/s10103-018-2561-2. Epub 2018 Jun 21. Lasers Med Sci. 2018. PMID: 29931588 Clinical Trial.
This study aims to investigate the effects of low-level laser therapy (LLLT) combined to a functional exercise program on treatment of FM. ...Pre- and post-intervention evaluations regarding pain (sites, intensity, and threshold), functional performance (bala …
This study aims to investigate the effects of low-level laser therapy (LLLT) combined to a functional exercise program …
Botulinum toxin A (BT-A) versus low-level laser therapy (LLLT) in chronic migraine treatment: a comparison.
Loeb LM, Amorim RP, Mazzacoratti MDGN, Scorza FA, Peres MFP. Loeb LM, et al. Arq Neuropsiquiatr. 2018 Oct;76(10):663-667. doi: 10.1590/0004-282X20180109. Arq Neuropsiquiatr. 2018. PMID: 30427505 Free article. Clinical Trial.
OBJECTIVE: The aim of this work was to evaluate patients with chronic migraine treated with botulinum toxin A (BT-A) and compare this with low level laser therapy (LLLT), referencing: pain days, pain intensity, intake of drugs/self-medication, anxiety …
OBJECTIVE: The aim of this work was to evaluate patients with chronic migraine treated with botulinum toxin A (BT-A) and compare this with …
Illuminating Cognitive Performance: Assessing the Role of Transcranial Photobiomodulation in Augmenting Cognition.
Lundie M, Koch M, Villanueva A, Nguyen T, Garner C, Satsangi M, Advani P, Krawczyk D. Lundie M, et al. Mil Med. 2025 Sep 1;190(Supplement_2):456-463. doi: 10.1093/milmed/usaf227. Mil Med. 2025. PMID: 40984141
INTRODUCTION: Transcranial photobiomodulation (tPBM) is an innovative, noninvasive neuromodulation modality that utilizes near-infrared light to modulate neural activity and improve cognition. ...N = 3 out of 4 participants who received tPBM stimulation demonstrated …
INTRODUCTION: Transcranial photobiomodulation (tPBM) is an innovative, noninvasive neuromodulation modality that utilizes near-infrar …
Transcranial Photobiomodulation Modulates Oxidative Stress Biomarkers and Complex IV Activity in Anhedonic-Like Behavior.
Bortoluzzi L, Colombo R, da Motta Pinto KB, Viscardi LH, Missiaggia R, Turella DJ, Schwantess L, Salvador M, Branco CS, Rigotti M, Scotton E, Schons T, Ribeiro SB, Caldieraro MA, Rosa AR. Bortoluzzi L, et al. Neurochem Res. 2026 Feb 21;51(2):83. doi: 10.1007/s11064-026-04681-2. Neurochem Res. 2026. PMID: 41721935 Free PMC article.
Major depressive disorder (MDD) is a prevalent and complex condition with limited treatment success in many patients. Photobiomodulation (PBM), particularly transcranial PBM (tPBM) using red to near-infrared light, has emerged as a promising non-invasi …
Major depressive disorder (MDD) is a prevalent and complex condition with limited treatment success in many patients. Photo …
Effect of Low-level LASER Therapy on P6 Acupoint to Control Gag Reflex in Children: A Clinical Trial.
Goel H, Mathur S, Sandhu M, Jhingan P, Sachdev V. Goel H, et al. J Acupunct Meridian Stud. 2017 Oct;10(5):317-323. doi: 10.1016/j.jams.2017.07.002. Epub 2017 Jul 28. J Acupunct Meridian Stud. 2017. PMID: 29078966 Free article. Clinical Trial.
OBJECTIVE: To investigate the effect of low level laser therapy (LLLT) on PC6 acupuncture point in suppressing gag reflex, regulating pulse rates and oxygen saturation, thereby reducing the anxiety levels. ...In group B (20 patients), steps were revers …
OBJECTIVE: To investigate the effect of low level laser therapy (LLLT) on PC6 acupuncture point in suppressing gag refl …
Near-infrared laser transcranial photobiomodulation for the treatment of chronic stress-induced low sexual desire in male mice.
Liu G, Su X, Li F, Hu H, He D, Yang L. Liu G, et al. Lasers Med Sci. 2025 Nov 15;40(1):479. doi: 10.1007/s10103-025-04731-1. Lasers Med Sci. 2025. PMID: 41240116
Chronic stress can induce both depression and low sexual desire (LSD); however, selective serotonin reuptake inhibitors (SSRIs) may exacerbate LSD while being used to treat depression. It's known that sunlight could improve sexual desire, therefore we want to …
Chronic stress can induce both depression and low sexual desire (LSD); however, selective serotonin reuptake inhibitors (SSRIs …
High energy density LED-based photobiomodulation inhibits squamous cell carcinoma progression in co-cultures in vitro.
Takemoto MM, Garcez AS, Sperandio M. Takemoto MM, et al. J Photochem Photobiol B. 2019 Oct;199:111592. doi: 10.1016/j.jphotobiol.2019.111592. Epub 2019 Aug 14. J Photochem Photobiol B. 2019. PMID: 31479916
Current management of oral potentially malignant disorders is careful monitoring. Unfortunately, the 'watch and wait' approach only generates anxiety and a feeling of powerlessness, especially to those caring for patients. Photobiomodulation (PBM) has emerged …
Current management of oral potentially malignant disorders is careful monitoring. Unfortunately, the 'watch and wait' approach only g …
Integrated Cooling-Vacuum-Assisted Non-Fractional 1540 nm Erbium:Glass Laser is Effective in Treating Acne Scars.
Politi Y, Levi A, Lapidoth M. Politi Y, et al. J Drugs Dermatol. 2016 Nov 1;15(11):1359-1363. J Drugs Dermatol. 2016. PMID: 28095548
Among which, atrophic scars are the most prevalent form, presenting as dermal depressions caused by inflammatory degeneration of dermal collagen. Mid-infrared laser skin interaction is characterized by its modest absorption in water and nite penetration to the mid-dermis. …
Among which, atrophic scars are the most prevalent form, presenting as dermal depressions caused by inflammatory degeneration of derm …
Study of transcranial therapy 904 nm in experimental model of stroke.
de Jesus Fonseca EG, Pedroso A, Neuls D, Barbosa D, Cidral-Filho FJ, Salgado ASI, Dubiela A, Carraro E, Kerppers II. de Jesus Fonseca EG, et al. Lasers Med Sci. 2019 Oct;34(8):1619-1625. doi: 10.1007/s10103-019-02758-9. Epub 2019 Mar 2. Lasers Med Sci. 2019. PMID: 30826952
The objective of the present study was to evaluate the effects of photobiomodulation with a light-emitting diode (LED) device (904 nm, 110 mW, 7 J/cm(2)) on neurogenesis, muscle resistance, and motor behavior in animals submitted to an experimental model of hemipleg …
The objective of the present study was to evaluate the effects of photobiomodulation with a light-emitting diode (LED) device …
Photobiomodulation therapy on puncture-associated pain: A controlled randomized double-blind clinical trial.
Ferreira GF, Machado GGA, Roncolato VL, Ramalho KM, Motta LJ, Bussadori SK, Duran CCG, Fernandes KPS, Mesquita Ferrari RA, Chiniforush N, Horliana ACRT. Ferreira GF, et al. Photochem Photobiol. 2025 May-Jun;101(3):771-781. doi: 10.1111/php.14027. Epub 2024 Oct 14. Photochem Photobiol. 2025. PMID: 39400883 Clinical Trial.
This study aimed to determine whether photobiomodulation therapy (PBMT), used as a pre-anesthetic, could modulate puncture pain and enhance the effectiveness of local anesthesia. ...Pain levels were measured using the visual analog scale, and anesthetic efficacy was …
This study aimed to determine whether photobiomodulation therapy (PBMT), used as a pre-anesthetic, could modulate puncture pai …
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