Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1998 1
2000 2
2002 1
2003 1
2004 4
2005 1
2006 2
2007 2
2008 4
2009 4
2010 2
2011 3
2013 8
2014 5
2015 8
2016 15
2017 13
2018 18
2019 21
2020 20
2021 24
2022 23
2023 28
2024 32
2025 24

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

231 results

Results by year

Filters applied: . Clear all
Page 1
Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression.
Guo B, Zhang M, Hao W, Wang Y, Zhang T, Liu C. Guo B, et al. Transl Psychiatry. 2023 Jan 9;13(1):5. doi: 10.1038/s41398-022-02297-y. Transl Psychiatry. 2023. PMID: 36624089 Free PMC article. Review.
This review summarizes clinical and animal studies on inflammation in neural circuits related to anxiety and depression and the evidence that neuromodulation therapies regulate neuroinflammation in the treatment of neurological diseases. ...This review provides a be …
This review summarizes clinical and animal studies on inflammation in neural circuits related to anxiety and depression and th …
Low-intensity LASER and LED (photobiomodulation therapy) for pain control of the most common musculoskeletal conditions.
DE Oliveira MF, Johnson DS, Demchak T, Tomazoni SS, Leal-Junior EC. DE Oliveira MF, et al. Eur J Phys Rehabil Med. 2022 Apr;58(2):282-289. doi: 10.23736/S1973-9087.21.07236-1. Epub 2021 Dec 16. Eur J Phys Rehabil Med. 2022. PMID: 34913330 Free PMC article.
Photobiomodulation therapy applied in the form of low-intensity Light Amplification by Stimulated Emission of Radiation (LASER) and light-emitting diode (LED) has been shown to reduce inflammation and swelling, promote healing, and reduce pain for an a …
Photobiomodulation therapy applied in the form of low-intensity Light Amplification by Stimulated Emission of Radiation …
Brain Photobiomodulation Therapy: a Narrative Review.
Salehpour F, Mahmoudi J, Kamari F, Sadigh-Eteghad S, Rasta SH, Hamblin MR. Salehpour F, et al. Mol Neurobiol. 2018 Aug;55(8):6601-6636. doi: 10.1007/s12035-017-0852-4. Epub 2018 Jan 11. Mol Neurobiol. 2018. PMID: 29327206 Free PMC article. Review.
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. ...Its therapeutic role in disorders such as dementia and Parkinson's disease, as we …
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide ran …
Post-stroke fatigue: a scoping review.
Aali G, Drummond A, das Nair R, Shokraneh F. Aali G, et al. F1000Res. 2020 Apr 7;9:242. doi: 10.12688/f1000research.22880.2. eCollection 2020. F1000Res. 2020. PMID: 32934800 Free PMC article.
They investigated exercise, pharmacotherapy, psychotherapy, education, and light therapy. Observational studies mainly reported the factors related to PSF including co-morbidities, depression and anxiety, quality of life, activities of daily living, st …
They investigated exercise, pharmacotherapy, psychotherapy, education, and light therapy. Observational studies mainly reporte …
Pharmacological and non-pharmacological management of burning mouth syndrome: A systematic review.
Reyad AA, Mishriky R, Girgis E. Reyad AA, et al. Dent Med Probl. 2020 Jul-Sep;57(3):295-304. doi: 10.17219/dmp/120991. Dent Med Probl. 2020. PMID: 33113291 Free article.
As many BMS patients suffer from psychiatric comorbidities, several psychotropic drugs are included in the management of BMS, reducing the complaint, while managing anxiety, depression and pain disorders. In this review, a search of the published literature r …
As many BMS patients suffer from psychiatric comorbidities, several psychotropic drugs are included in the management of BMS, reducing the c …
Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Alvarenga-Brant R, Costa FO, Mattos-Pereira G, Esteves-Lima RP, Belém FV, Lai H, Ge L, Gomez RS, Martins CC. Alvarenga-Brant R, et al. J Dent Res. 2023 Feb;102(2):135-145. doi: 10.1177/00220345221130025. Epub 2022 Oct 8. J Dent Res. 2023. PMID: 36214096 Review.
Four comparable interventions were grouped into different network geometries to ensure the transitivity assumption for pain: photobiomodulation therapy, alpha-lipoic acid, phytotherapics, and anxiolytics/antidepressants. ...The anxiolytic (clonazepam) probably reduc …
Four comparable interventions were grouped into different network geometries to ensure the transitivity assumption for pain: photobiomodu …
Shining light on the head: Photobiomodulation for brain disorders.
Hamblin MR. Hamblin MR. BBA Clin. 2016 Oct 1;6:113-124. doi: 10.1016/j.bbacli.2016.09.002. eCollection 2016 Dec. BBA Clin. 2016. PMID: 27752476 Free PMC article. Review.
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. ...The brain suffers from many different disorders that can …
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue th …
Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis.
Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YC. Yeh SW, et al. Pain Physician. 2019 May;22(3):241-254. Pain Physician. 2019. PMID: 31151332 Free article.
BACKGROUND: Fibromyalgia is a chronic disorder characterized by widespread pain and tenderness. Low-level laser therapy (LLLT), an emerging nonpharmacological treatment, has been used for relieving musculoskeletal or neuropathic pain. ...LLLT is an eff …
BACKGROUND: Fibromyalgia is a chronic disorder characterized by widespread pain and tenderness. Low-level laser ther …
Photobiomodulation Therapy on Brain: Pioneering an Innovative Approach to Revolutionize Cognitive Dynamics.
Nairuz T, Sangwoo-Cho, Lee JH. Nairuz T, et al. Cells. 2024 Jun 3;13(11):966. doi: 10.3390/cells13110966. Cells. 2024. PMID: 38891098 Free PMC article. Review.
Photobiomodulation (PBM) therapy on the brain employs red to near-infrared (NIR) light to treat various neurological and psychological disorders. ...It shows promise for treating conditions like dementia, stroke, brain trauma, Parkinson's disease, and …
Photobiomodulation (PBM) therapy on the brain employs red to near-infrared (NIR) light to treat various neurological an …
Effect of low-level laser stimulation of acupuncture points in pediatric dentistry: a systematic review.
Mira PCDS, Vilela LD, Corona SAM, Borsatto MC. Mira PCDS, et al. Lasers Med Sci. 2023 Jan 24;38(1):52. doi: 10.1007/s10103-023-03720-6. Lasers Med Sci. 2023. PMID: 36690781 Review.
The biomodulatory potential of low-level laser therapy (LLLT) has prompted investigations of different outcomes in health. ...A total of four studies using LLLT for photobiomodulation were included (n = 4). The most common wavelengths used were in the …
The biomodulatory potential of low-level laser therapy (LLLT) has prompted investigations of different outcomes in heal …
Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials.
Ji Q, Yan S, Ding J, Zeng X, Liu Z, Zhou T, Wu Z, Wei W, Li H, Liu S, Ai S. Ji Q, et al. Front Psychiatry. 2024 Jan 31;14:1267415. doi: 10.3389/fpsyt.2023.1267415. eCollection 2023. Front Psychiatry. 2024. PMID: 38356614 Free PMC article.
Photobiomodulation (PBM) is a non-invasive neuromodulation technique that could treat patients with mood disorders such as depression. METHODS: A systematic search of ten databases, including randomized controlled trials (RCTs) for depression, was cond …
Photobiomodulation (PBM) is a non-invasive neuromodulation technique that could treat patients with mood disorders such as …
Study of transcranial photobiomodulation at 945-nm wavelength: anxiety and depression.
Kerppers FK, Dos Santos KMMG, Cordeiro MER, da Silva Pereira MC, Barbosa D, Pezzini AA, Cunha LF, Fonseca M, Bragnholo K, Salgado ASI, Kerppers II. Kerppers FK, et al. Lasers Med Sci. 2020 Dec;35(9):1945-1954. doi: 10.1007/s10103-020-02983-7. Epub 2020 Mar 7. Lasers Med Sci. 2020. PMID: 32144511 Clinical Trial.
Transcranial photobiomodulation is an innovative method for the stimulation of neural activity which consists of the exposure of neural tissue to low-level light irradiance. ...The objective was to analyze the effects of transcranial photobiomodulat …
Transcranial photobiomodulation is an innovative method for the stimulation of neural activity which consists of the exposure of neur …
Effects of photobiomodulation on auriculotherapy points for sleep disorders, anxiety, and temporomandibular dysfunctions.
Fernandes MP, Vidal CL, de Oliveira TT, Botelho AL, Valente MLDC, Dos Reis AC. Fernandes MP, et al. Cranio. 2023 Jul;41(4):362-367. doi: 10.1080/08869634.2020.1853896. Epub 2020 Dec 7. Cranio. 2023. PMID: 33287687
OBJECTIVE: The purpose of this study was to evaluatephotobiomodulation applied at auriculotherapy points forsleep disorder (SD) and anxiety related to temporomandibulardysfunction (TMD). METHODS: The study consisted of two groups of 20 participants: Auriculotherapy …
OBJECTIVE: The purpose of this study was to evaluatephotobiomodulation applied at auriculotherapy points forsleep disorder (SD) and …
Dosimetry and Clinical Efficacy of Transcranial Photobiomodulation for Major Depression Disorder: Could they Guide Dosimetry for Alzheimer's Disease?
Caldieraro MA, Laufer-Silva T, Cassano P. Caldieraro MA, et al. J Alzheimers Dis. 2021;83(4):1453-1469. doi: 10.3233/JAD-210586. J Alzheimers Dis. 2021. PMID: 34487045 Review.
BACKGROUND: Major depressive disorder (MDD) is prevalent and has significant impact on individuals and society. Cognitive symptoms are frequent in MDD and insufficiently treated by antidepressant medications. Transcranial photobiomodulation (t-PBM) is a novel …
BACKGROUND: Major depressive disorder (MDD) is prevalent and has significant impact on individuals and society. Cognitive symp …
Non-invasive transcranial brain modulation for neurological disorders treatment: A narrative review.
Mosilhy EA, Alshial EE, Eltaras MM, Rahman MMA, Helmy HI, Elazoul AH, Hamdy O, Mohammed HS. Mosilhy EA, et al. Life Sci. 2022 Oct 15;307:120869. doi: 10.1016/j.lfs.2022.120869. Epub 2022 Aug 6. Life Sci. 2022. PMID: 35940222 Review.
The commonly noninvasive techniques used in neurological manipulations include photobiomodulation (PBM), transcranial electrical stimulation (TES), transcranial magnetic stimulation (TMS), and ultrasound stimulation (USS). ...However, each technique owns its unique mechani …
The commonly noninvasive techniques used in neurological manipulations include photobiomodulation (PBM), transcranial electrical stim …
Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization.
Khoodoruth MAS, Estudillo-Guerra MA, Pacheco-Barrios K, Nyundo A, Chapa-Koloffon G, Ouanes S. Khoodoruth MAS, et al. Front Psychiatry. 2022 Apr 14;13:886918. doi: 10.3389/fpsyt.2022.886918. eCollection 2022. Front Psychiatry. 2022. PMID: 35492692 Free PMC article. Review.
Depressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the use of antidepressants revolutionized the management of depression and had a tremendous positive impact on the patient's outcome, a …
Depressive disorders are among the most common psychiatric conditions and contribute to significant morbidity. Even though the …
Photobiomodulation: shining a light on depression.
Wang L, Mao L, Huang Z, Switzer JA, Hess DC, Zhang Q. Wang L, et al. Theranostics. 2025 Jan 1;15(2):362-383. doi: 10.7150/thno.104502. eCollection 2025. Theranostics. 2025. PMID: 39744683 Free PMC article. Review.
Depression is a prevalent public health issue, characterized by persistent low mood, impaired concentration, and diminished motivation. Photobiomodulation (PBM), which involves the application of red or near-infrared light, modulates physiological processes b …
Depression is a prevalent public health issue, characterized by persistent low mood, impaired concentration, and diminished motivatio …
Light Therapy in Chronic Migraine.
Hou TW, Yang CC, Lai TH, Wu YH, Yang CP. Hou TW, et al. Curr Pain Headache Rep. 2024 Jul;28(7):621-626. doi: 10.1007/s11916-024-01258-y. Epub 2024 Jun 12. Curr Pain Headache Rep. 2024. PMID: 38865075 Review.
PURPOSE OF REVIEW: This review assesses the effectiveness and safety of light therapy, particularly green light therapy, as an emerging non-pharmacological treatment for chronic migraine (CM). ...In addition to green light, other forms of lig …
PURPOSE OF REVIEW: This review assesses the effectiveness and safety of light therapy, particularly green light ther …
Photobiomodulation: An Emerging Treatment Modality for Depression.
Vieira WF, Iosifescu DV, McEachern KM, Gersten M, Cassano P. Vieira WF, et al. Psychiatr Clin North Am. 2023 Jun;46(2):331-348. doi: 10.1016/j.psc.2023.02.013. Epub 2023 Mar 25. Psychiatr Clin North Am. 2023. PMID: 37149348 Review.
Major depressive disorder (MDD) is considered a global crisis. Conventional treatments for MDD consist of pharmacotherapy and psychotherapy, although a significant number of patients with depression respond poorly to conventional treatments and are diagnosed …
Major depressive disorder (MDD) is considered a global crisis. Conventional treatments for MDD consist of pharmacotherapy and …
Current application and future directions of photobiomodulation in central nervous diseases.
Yang M, Yang Z, Wang P, Sun Z. Yang M, et al. Neural Regen Res. 2021 Jun;16(6):1177-1185. doi: 10.4103/1673-5374.300486. Neural Regen Res. 2021. PMID: 33269767 Free PMC article. Review.
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neurological and psychological conditions. ...We reviewed 95 papers and analyzed. Photobiomodulation has wide applicability in the treatm …
Photobiomodulation using light in the red or near-infrared region is an innovative treatment strategy for a wide range of neur …
Protocol for a Single-Arm Feasibility Study of Photobiomodulation for Fatigue, Depression, and Pain in Inflammatory Bowel Disease.
Ewais T, Begun J, Laakso EL. Ewais T, et al. Biomedicines. 2023 Aug 2;11(8):2179. doi: 10.3390/biomedicines11082179. Biomedicines. 2023. PMID: 37626676 Free PMC article.
BACKGROUND: There are limited treatment options for mental health comorbidities associated with Inflammatory Bowel Disease (IBD), although they have been shown to negatively affect the course of IBD and multiple important areas of functioning. Photobiomodulation (PBM) is a …
BACKGROUND: There are limited treatment options for mental health comorbidities associated with Inflammatory Bowel Disease (IBD), although t …
Comparative effectiveness of photobiomodulation and manual therapy alone or combined in TMD patients: a randomized clinical trial.
Brochado FT, Jesus LH, Carrard VC, Freddo AL, Chaves KD, Martins MD. Brochado FT, et al. Braz Oral Res. 2018 Jul 10;32:e50. doi: 10.1590/1807-3107bor-2018.vol32.0050. Braz Oral Res. 2018. PMID: 29995062 Free article. Clinical Trial.
The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensity, mandibular movements, psychosocial aspects, and anxiety symptoms of temporomandibular disorder (TMD) patients. ...Seven eva …
The effectiveness of photobiomodulation (PBM) and manual therapy (MT), alone or combined (CT), were evaluated in pain intensit …
Emerging lasers and light-based therapies in the management of acne: a review.
Jean-Pierre P, Tordjman L, Ghodasara A, Nwosu C, Nouri K. Jean-Pierre P, et al. Lasers Med Sci. 2024 Sep 28;39(1):245. doi: 10.1007/s10103-024-04196-8. Lasers Med Sci. 2024. PMID: 39340675 Free PMC article. Review.
All these pharmacologic treatments have a risk of side effects ranging from mild ones, like skin irritation and dryness, to severe ones, like depression. Thus, there is a demand for exploring other treatment modalities in treating acne, and laser and light-based the …
All these pharmacologic treatments have a risk of side effects ranging from mild ones, like skin irritation and dryness, to severe ones, lik …
Potential application of PBM use in hair follicle organoid culture for the treatment of androgenic alopecia.
Roets B. Roets B. Mater Today Bio. 2023 Nov 3;23:100851. doi: 10.1016/j.mtbio.2023.100851. eCollection 2023 Dec. Mater Today Bio. 2023. PMID: 38024838 Free PMC article. Review.
However, the main challenges are to maintain the cell populations within the organoid in a proliferative and inductive state, as well as to promote the maturation of organoids. Photobiomodulation is a form of light therapy that stimulates endogenous chromopho …
However, the main challenges are to maintain the cell populations within the organoid in a proliferative and inductive state, as well as to …
Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser.
Eshaghi E, Sadigh-Eteghad S, Mohaddes G, Rasta SH. Eshaghi E, et al. Lasers Surg Med. 2019 Sep;51(7):634-642. doi: 10.1002/lsm.23082. Epub 2019 Mar 18. Lasers Surg Med. 2019. PMID: 30883832
OBJECTIVES: The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders is a demonstrated and identified issue. ...MATERIALS AND METHODS: CRS procedure (3 hours/day, over 3 weeks) was performed as a typical …
OBJECTIVES: The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders …
Photobiomodulation therapy mitigates depressive-like behaviors by remodeling synaptic links and mitochondrial function.
Chen H, Shi X, Liu N, Jiang Z, Ma C, Luo G, Liu S, Wei X, Liu Y, Ming D. Chen H, et al. J Photochem Photobiol B. 2024 Sep;258:112998. doi: 10.1016/j.jphotobiol.2024.112998. Epub 2024 Jul 31. J Photochem Photobiol B. 2024. PMID: 39096719
Depression, a multifactorial mental disorder, characterized by cognitive slowing, anxiety, and impaired cognitive function, imposes a significant burden on public health. ...It is recognized for its therapeutic efficacy in treating depression, yet its …
Depression, a multifactorial mental disorder, characterized by cognitive slowing, anxiety, and impaired cognitive funct …
Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stress.
Farazi N, Mahmoudi J, Sadigh-Eteghad S, Farajdokht F, Rasta SH. Farazi N, et al. Lasers Med Sci. 2022 Mar;37(2):1181-1191. doi: 10.1007/s10103-021-03370-6. Epub 2021 Aug 25. Lasers Med Sci. 2022. PMID: 34432186
The development of anxiety and depression due to chronic exposure to noise stress has remained as an unsolved health problem so far. ...Also, there is no available data on the relationship between the application of tPBM and hippocampal brain-derived neurotro …
The development of anxiety and depression due to chronic exposure to noise stress has remained as an unsolved health pr …
Transcranial Photobiomodulation For The Management Of Depression: Current Perspectives.
Askalsky P, Iosifescu DV. Askalsky P, et al. Neuropsychiatr Dis Treat. 2019 Nov 22;15:3255-3272. doi: 10.2147/NDT.S188906. eCollection 2019. Neuropsychiatr Dis Treat. 2019. PMID: 31819453 Free PMC article. Review.
Major depressive disorder (MDD) is a prevalent condition associated with high rates of disability, as well as suicidal ideation and behavior. ...In this paper, we review a novel neuromodulation strategy, transcranial photobiomodulation (t-PBM) with near-infra …
Major depressive disorder (MDD) is a prevalent condition associated with high rates of disability, as well as suicidal ideatio …
Transcranial photobiomodulation increases cognition and serum BDNF levels in adults over 50 years: A randomized, double-blind, placebo-controlled trial.
de Oliveira BH, Lins EF, Kunde NF, Salgado ASI, Martins LM, Bobinski F, Vieira WF, Cassano P, Quialheiro A, Martins DF. de Oliveira BH, et al. J Photochem Photobiol B. 2024 Nov;260:113041. doi: 10.1016/j.jphotobiol.2024.113041. Epub 2024 Oct 5. J Photochem Photobiol B. 2024. PMID: 39423445 Clinical Trial.
NIR t-PBM has recently emerged as a potential therapy for various neurodegenerative conditions, including memory issues. AIMS: This study aimed to evaluate cognition scores (primary outcome), depression, anxiety, resilience scores, neuroplasticity, and neurod …
NIR t-PBM has recently emerged as a potential therapy for various neurodegenerative conditions, including memory issues. AIMS: This s …
Photobiomodulation and the brain: a new paradigm.
Hennessy M, Hamblin MR. Hennessy M, et al. J Opt. 2017 Jan;19(1):013003. doi: 10.1088/2040-8986/19/1/013003. Epub 2016 Dec 14. J Opt. 2017. PMID: 28580093 Free PMC article.
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. ...Other groups have studied stroke (animal models and clinical trial …
Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR …
A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms.
Laakso EL, Ewais T. Laakso EL, et al. Biomedicines. 2023 May 22;11(5):1497. doi: 10.3390/biomedicines11051497. Biomedicines. 2023. PMID: 37239169 Free PMC article.
To add quality to life, alternate methods of symptom management need to be identified. OBJECTIVE: To demonstrate how photobiomodulation, through its numerous mechanisms, may offer an adjunctive therapy in inflammatory bowel disease. ...MAIN FINDINGS: In this paper, …
To add quality to life, alternate methods of symptom management need to be identified. OBJECTIVE: To demonstrate how photobiomodulation …
Transcranial and systemic photobiomodulation for major depressive disorder: A systematic review of efficacy, tolerability and biological mechanisms.
Caldieraro MA, Cassano P. Caldieraro MA, et al. J Affect Disord. 2019 Jan 15;243:262-273. doi: 10.1016/j.jad.2018.09.048. Epub 2018 Sep 17. J Affect Disord. 2019. PMID: 30248638
BACKGROUND: Photobiomodulation (PBM) with red and near-infrared light (NIR) -also known as Low-Level Light Therapy-is a low risk, inexpensive treatment-based on non-retinal exposure-under study for several neuropsychiatric conditions. The …
BACKGROUND: Photobiomodulation (PBM) with red and near-infrared light (NIR) -also known as Low-Level Light …
Mood Disorders in Youth: Complementary and Integrative Medicine.
Saxena K, Kurian S, Kumar R, Arnold LE, Simkin DR. Saxena K, et al. Child Adolesc Psychiatr Clin N Am. 2023 Apr;32(2):367-394. doi: 10.1016/j.chc.2022.08.012. Child Adolesc Psychiatr Clin N Am. 2023. PMID: 37147043 Review.
Omega-3 polyunsaturated fatty acids, probiotics, vitamin C, vitamin D, folic acid and L-methyl folate, broad-spectrum micronutrients, N-acetylcysteine, physical activity, herbs, bright light therapy, melatonin, saffron, meditation, school-based interventions, and tr …
Omega-3 polyunsaturated fatty acids, probiotics, vitamin C, vitamin D, folic acid and L-methyl folate, broad-spectrum micronutrients, N-acet …
Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.
Salehpour F, Gholipour-Khalili S, Farajdokht F, Kamari F, Walski T, Hamblin MR, DiDuro JO, Cassano P. Salehpour F, et al. Rev Neurosci. 2020 Apr 28;31(3):269-286. doi: 10.1515/revneuro-2019-0063. Rev Neurosci. 2020. PMID: 31812948 Free PMC article. Review.
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant …
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in hum …
Photobiomodulation therapy in mood disorders: a systematic review.
Montazeri K, Farhadi M, Fekrazad R, Chaibakhsh S, Mahmoudian S. Montazeri K, et al. Lasers Med Sci. 2022 Dec;37(9):3343-3351. doi: 10.1007/s10103-022-03641-w. Epub 2022 Nov 21. Lasers Med Sci. 2022. PMID: 36404359 Review.
Photobiomodulation therapy (PBMT) uses photons of light to repair, modulate and improve the function of target tissue. ...Based on grade practice recommendations, PBMT can be classified as strongly recommended for moderate grade of major depressive …
Photobiomodulation therapy (PBMT) uses photons of light to repair, modulate and improve the function of target tissue. …
Photobiomodulation prevents PTSD-like memory impairments in rats.
Li Y, Dong Y, Yang L, Tucker L, Zong X, Brann D, Hamblin MR, Vazdarjanova A, Zhang Q. Li Y, et al. Mol Psychiatry. 2021 Nov;26(11):6666-6679. doi: 10.1038/s41380-021-01088-z. Epub 2021 Apr 15. Mol Psychiatry. 2021. PMID: 33859360 Free PMC article.
An impaired fear memory (contextual amnesia), however, puts the individual at risk of developing posttraumatic stress disorder (PTSD) due to the inability to identify a safe context when encountering trauma-associated cues later in life. Although it is gainin …
An impaired fear memory (contextual amnesia), however, puts the individual at risk of developing posttraumatic stress disorder …
Treating neuropathic pain and comorbid affective disorders: Preclinical and clinical evidence.
Coelho DRA, Gersten M, Jimenez AS, Fregni F, Cassano P, Vieira WF. Coelho DRA, et al. Pain Pract. 2024 Sep;24(7):937-955. doi: 10.1111/papr.13370. Epub 2024 Apr 4. Pain Pract. 2024. PMID: 38572653 Review.
INTRODUCTION: Neuropathic pain (NP) significantly impacts quality of life and often coexists with affective disorders such as anxiety and depression. Addressing both NP and its psychiatric manifestations requires a comprehensive understanding of therapeutic o …
INTRODUCTION: Neuropathic pain (NP) significantly impacts quality of life and often coexists with affective disorders such as anxi …
A case control series for the effect of photobiomodulation in patients with low back pain and concurrent depression.
Gabel CP, Petrie SR, Mischoulon D, Hamblin MR, Yeung A, Sangermano L, Cassano P. Gabel CP, et al. Laser Ther. 2018 Sep 30;27(3):167-173. doi: 10.5978/islsm.27_18-OR-18. Laser Ther. 2018. PMID: 32158062 Free PMC article.
BACKGROUND AND AIMS: To present incidental findings in patients with low back pain (LBP) who received photobiomodulation (PBM) administered to the back and thighs as an adjunct to physical therapy (PT) and then experienced improvement in concurrent depression …
BACKGROUND AND AIMS: To present incidental findings in patients with low back pain (LBP) who received photobiomodulation (PBM) admini …
Brain photobiomodulation therapy on neurological and psychological diseases.
Chamkouri H, Liu Q, Zhang Y, Chen C, Chen L. Chamkouri H, et al. J Biophotonics. 2024 Jan;17(1):e202300145. doi: 10.1002/jbio.202300145. Epub 2023 Oct 1. J Biophotonics. 2024. PMID: 37403428 Review.
Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the mitochondrial respiratory chain can be stimulated by red light, which increases ATP synthesis. In addition, the ion channels' light …
Photobiomodulation (PBM) therapy is an innovative treatment for neurological and psychological conditions. Complex IV of the m …
Brain-gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation.
Sancho-Balsells A, Borràs-Pernas S, Flotta F, Chen W, Del Toro D, Rodríguez MJ, Alberch J, Blivet G, Touchon J, Xifró X, Giralt A. Sancho-Balsells A, et al. J Affect Disord. 2024 Jun 1;354:574-588. doi: 10.1016/j.jad.2024.03.075. Epub 2024 Mar 14. J Affect Disord. 2024. PMID: 38490587 Free article.
BACKGROUND: Chronic stress is an important risk factor for the development of major depressive disorder (MDD). ...CONCLUSIONS: Our results suggest that non-invasive photobiomodulation of both the brain and the gut microbiome could be beneficial in the …
BACKGROUND: Chronic stress is an important risk factor for the development of major depressive disorder (MDD). ...CONCL …
Light Modulation of Brain and Development of Relevant Equipment.
Li X, Liu C, Wang R. Li X, et al. J Alzheimers Dis. 2020;74(1):29-41. doi: 10.3233/JAD-191240. J Alzheimers Dis. 2020. PMID: 32039856 Review.
Light modulation plays an important role in understanding the pathology of brain disorders and improving brain function. Optogenetic techniques can activate or silence targeted neurons with high temporal and spatial accuracy and provide precise control, and have rec …
Light modulation plays an important role in understanding the pathology of brain disorders and improving brain function. Optog …
Comparative efficacy of pharmaceutical (Ibuprofen) and non-pharmaceutical (photobiomodulation, and chewing gum) interventions for pain reduction after elastomeric separator placement in orthodontic patients: a randomized clinical trial.
Azizi F, Zaseh MMS, Golshah A, Imani MM, Safari-Faramani R. Azizi F, et al. Lasers Med Sci. 2024 Sep 25;39(1):239. doi: 10.1007/s10103-024-04186-w. Lasers Med Sci. 2024. PMID: 39317795 Clinical Trial.
This study compared the efficacy of pharmaceutical (ibuprofen) and non-pharmaceutical (photobiomodulation and chewing gum) interventions for pain reduction after elastomeric separator placement in orthodontic patients. This 3-arm, parallel-group randomized clinical trial w …
This study compared the efficacy of pharmaceutical (ibuprofen) and non-pharmaceutical (photobiomodulation and chewing gum) interventi …
Photobiomodulation as a promising new tool in the management of psychological disorders: A systematic review.
Gutiérrez-Menéndez A, Marcos-Nistal M, Méndez M, Arias JL. Gutiérrez-Menéndez A, et al. Neurosci Biobehav Rev. 2020 Dec;119:242-254. doi: 10.1016/j.neubiorev.2020.10.002. Epub 2020 Oct 15. Neurosci Biobehav Rev. 2020. PMID: 33069687 Review.
This systematic review collects studies up to 2019 about the beneficial effects of photobiomodulation as a therapy for treating psychological disorders and a tool for modulating cognitive processes. This technique is mostly used for the treatment of depres …
This systematic review collects studies up to 2019 about the beneficial effects of photobiomodulation as a therapy for treatin …
Effects of low-level laser therapy on burning pain and quality of life in patients with burning mouth syndrome: a systematic review and meta-analysis.
Lu C, Yang C, Li X, Du G, Zhou X, Luo W, Du Q, Tang G. Lu C, et al. BMC Oral Health. 2023 Oct 9;23(1):734. doi: 10.1186/s12903-023-03441-w. BMC Oral Health. 2023. PMID: 37814265 Free PMC article.
BACKGROUND: Burning mouth syndrome (BMS) is a complex chronic pain disorder that significantly impairs patients' quality of life. Low-level laser therapy (LLLT) uses infrared or near-infrared light to produce analgesic, anti-inflammatory, and bi …
BACKGROUND: Burning mouth syndrome (BMS) is a complex chronic pain disorder that significantly impairs patients' quality of life. …
Transcranial photobiomodulation prevents PTSD-like comorbidities in rats experiencing underwater trauma.
Li Y, Dong Y, Yang L, Tucker L, Yang B, Zong X, Hamblin MR, Zhang Q. Li Y, et al. Transl Psychiatry. 2021 May 5;11(1):270. doi: 10.1038/s41398-021-01389-5. Transl Psychiatry. 2021. PMID: 33953158 Free PMC article.
Maladaptive fear memory processing after a traumatic event is a major contributor to the development of the comorbidities related to posttraumatic stress disorder (PTSD). An intervention to normalize this process could be a first-line treatment to prevent …
Maladaptive fear memory processing after a traumatic event is a major contributor to the development of the comorbidities related to posttra …
Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies.
Cardoso FDS, Salehpour F, Coimbra NC, Gonzalez-Lima F, Gomes da Silva S. Cardoso FDS, et al. Front Neurosci. 2022 Sep 20;16:1006031. doi: 10.3389/fnins.2022.1006031. eCollection 2022. Front Neurosci. 2022. PMID: 36203812 Free PMC article.
We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficient anti-inflammatory therapy. METHODS: We conducted a systematic search on the bibliographic databases (PubMed and ScienceDirect) with …
We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficien …
Near-infrared photobiomodulation combined with coenzyme Q(10) for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis.
Salehpour F, Farajdokht F, Cassano P, Sadigh-Eteghad S, Erfani M, Hamblin MR, Salimi MM, Karimi P, Rasta SH, Mahmoudi J. Salehpour F, et al. Brain Res Bull. 2019 Jan;144:213-222. doi: 10.1016/j.brainresbull.2018.10.010. Epub 2018 Oct 29. Brain Res Bull. 2019. PMID: 30385146 Free PMC article.
This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q(10) (CoQ(10)) on depressive-like behavior, cerebral oxidative stress, inflammation, and apoptosis markers in mice. To induce a depressive …
This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q(10) (CoQ(10)) o …
Transcranial Photobiomodulation Therapy as an Intervention for Opioid Cravings and Depression: A Pilot Cohort Study.
Flora J, Watson Huffer K. Flora J, et al. Photobiomodul Photomed Laser Surg. 2024 Aug;42(8):509-513. doi: 10.1089/photob.2024.0032. Epub 2024 Aug 7. Photobiomodul Photomed Laser Surg. 2024. PMID: 39110620
Introduction: The opioid crisis, a declared national health emergency, has prompted the exploration of innovative treatments to address the pervasive issues of opioid cravings and associated depression. Aims: This pilot cohort study investigated the efficacy of transcrania …
Introduction: The opioid crisis, a declared national health emergency, has prompted the exploration of innovative treatments to address the …
Photobiomodulation in the aging brain: a systematic review from animal models to humans.
Rodríguez-Fernández L, Zorzo C, Arias JL. Rodríguez-Fernández L, et al. Geroscience. 2024 Dec;46(6):6583-6623. doi: 10.1007/s11357-024-01231-y. Epub 2024 Jun 11. Geroscience. 2024. PMID: 38861125 Free PMC article.
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmacological therapy that shows promising results in the treatment or prevention of age-related cognitive impairments. ...In healthy aged …
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmac …
Comparative effectiveness of low-level laser therapy versus muscle energy technique among diabetic patients with frozen shoulder: a study protocol for a parallel group randomised controlled trial.
Hassan HI, Kaka B, Bello F, Fatoye F, Ibrahim AA. Hassan HI, et al. J Orthop Surg Res. 2024 Apr 30;19(1):272. doi: 10.1186/s13018-024-04735-7. J Orthop Surg Res. 2024. PMID: 38689290 Free PMC article.
It is associated with musculoskeletal complications, with frozen shoulder being commonly reported. While low-level laser therapy (LLLT) and muscle energy technique (MET) are commonly used to manage this condition, there remains a lack of agreement on the most …
It is associated with musculoskeletal complications, with frozen shoulder being commonly reported. While low-level laser th …
The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioid craving in patients undergoing methadone maintenance treatment: a double-blind, randomized, controlled trial.
Helali H, Samani N, Tabeie F, Eiliaei S, Kheradmand A. Helali H, et al. BMC Psychiatry. 2025 Feb 3;25(1):94. doi: 10.1186/s12888-025-06555-3. BMC Psychiatry. 2025. PMID: 39901090 Free PMC article. Clinical Trial.
The levels of anxiety, depression, and opioid craving were compared between the two groups before and after the intervention, as well as at one-month and three-month follow-up assessments. ...CONCLUSION: tPBMT led to significant improvements in anxiety, de …
The levels of anxiety, depression, and opioid craving were compared between the two groups before and after the intervention, …
Efficacy of Photobiomodulation in Reducing Symptomatology and Improving the Quality of Life in Patients with Xerostomia and Hyposalivation: A Randomized Controlled Trial.
Ferrandez-Pujante A, Pons-Fuster E, López-Jornet P. Ferrandez-Pujante A, et al. J Clin Med. 2022 Jun 14;11(12):3414. doi: 10.3390/jcm11123414. J Clin Med. 2022. PMID: 35743485 Free PMC article.
Xerostomia was assessed using a salivary flow visual analog scale (VAS) and the Xerostomia Inventory (XI). The Hospital Anxiety and Depression (HAD) scale, Oral Health Impact Profile (OHIP-14), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) …
Xerostomia was assessed using a salivary flow visual analog scale (VAS) and the Xerostomia Inventory (XI). The Hospital Anxiety and …
Long-pulsed nd: YAG laser treatment of nail psoriasis: clinical and ultrasonographic assessment.
El-Basiony MAS, El-Komy MHM, Samy NA, Aly DG, El-Gendy H, Hassan MFAS, El Sayed H, Soliman MM. El-Basiony MAS, et al. Arch Dermatol Res. 2024 Jun 8;316(7):365. doi: 10.1007/s00403-024-03036-7. Arch Dermatol Res. 2024. PMID: 38850336 Free PMC article. Clinical Trial.
Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associated with anxiety and significant functional impairment of the quality of life. The 1064 nm Nd: YAG laser was reported to yield satisfa …
Nail psoriasis is a chronic, inflammatory condition which is difficult to treat, linked with greater psoriasis severity, and may be associat …
Photobiomodulation for Major Depressive Disorder: Linking Transcranial Infrared Light, Biophotons and Oxidative Stress.
Vieira WF, Gersten M, Caldieraro MAK, Cassano P. Vieira WF, et al. Harv Rev Psychiatry. 2023 May-Jun 01;31(3):124-141. doi: 10.1097/HRP.0000000000000363. Harv Rev Psychiatry. 2023. PMID: 37171473 Review.
Incompletely treated major depressive disorder (MDD) poses an enormous global health burden. Conventional treatment for MDD consists of pharmacotherapy and psychotherapy, though a significant number of patients do not achieve remission with such treatments. Transcra …
Incompletely treated major depressive disorder (MDD) poses an enormous global health burden. Conventional treatment for MDD co …
Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review.
Orliaguet M, Misery L. Orliaguet M, et al. Biomolecules. 2021 Aug 18;11(8):1237. doi: 10.3390/biom11081237. Biomolecules. 2021. PMID: 34439903 Free PMC article.
On the other hand, the role of psychological factors in BMS has also been the focus of several studies and has shown a link with psychiatric disorders such as anxiety and/or depression symptoms. Depending on the patient, the neuropathic and psychogenic compon …
On the other hand, the role of psychological factors in BMS has also been the focus of several studies and has shown a link with psychiatric …
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3.
Hong N, Kim HJ, Kang K, Park JO, Mun S, Kim HG, Kang BH, Chung PS, Lee MY, Ahn JC. Hong N, et al. Cell Biosci. 2023 Jan 12;13(1):8. doi: 10.1186/s13578-022-00949-6. Cell Biosci. 2023. PMID: 36635704 Free PMC article.
Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to represent a pathogen that characterizes the neurobiology of TLE. Photobiomodulation (PBM) is a rapidly growing therapy for the attenuation of neurona …
Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to represent a pathogen th …
Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity.
Huang Z, Zhang Y, Ma X, Feng Y, Zong X, Jordan JD, Zhang Q. Huang Z, et al. Theranostics. 2023 Jan 16;13(3):913-930. doi: 10.7150/thno.78777. eCollection 2023. Theranostics. 2023. PMID: 36793860 Free PMC article.
Furthermore, there is no available treatment that prevents or alleviates the neurologic sequelae of ELA, especially traumatic stress. Hence, the present study aims to investigate the mechanisms for these associations and evaluate whether photobiomodulation (PBM), a …
Furthermore, there is no available treatment that prevents or alleviates the neurologic sequelae of ELA, especially traumatic stress. …
Effects of Photobiomodulation on Burning Mouth Syndrome: A Systematic Review and Meta-Analysis.
Okuhara MR, Trevisani VFM, Macedo CR. Okuhara MR, et al. J Oral Rehabil. 2025 Apr;52(4):540-553. doi: 10.1111/joor.13931. Epub 2025 Jan 28. J Oral Rehabil. 2025. PMID: 39871648 Review.
OBJECTIVE: The objective of this research is to evaluate the effectiveness and safety of photobiomodulation or low-level laser therapy on burning mouth syndrome compared to placebo, no-laser, clonazepam and alpha-lipoic acid. ...Likewise, the compariso …
OBJECTIVE: The objective of this research is to evaluate the effectiveness and safety of photobiomodulation or low-level …
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety.
Schiffer F, Johnston AL, Ravichandran C, Polcari A, Teicher MH, Webb RH, Hamblin MR. Schiffer F, et al. Behav Brain Funct. 2009 Dec 8;5:46. doi: 10.1186/1744-9081-5-46. Behav Brain Funct. 2009. PMID: 19995444 Free PMC article.
BACKGROUND: Many studies have reported beneficial effects from the application of near-infrared (NIR) light photobiomodulation (PBM) to the body, and one group has reported beneficial effects applying it to the brain in stroke patients. ...METHODS: We gave 10 patien …
BACKGROUND: Many studies have reported beneficial effects from the application of near-infrared (NIR) light photobiomodulation …
Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis.
Cassano P, Petrie SR, Hamblin MR, Henderson TA, Iosifescu DV. Cassano P, et al. Neurophotonics. 2016 Jul;3(3):031404. doi: 10.1117/1.NPh.3.3.031404. Epub 2016 Mar 4. Neurophotonics. 2016. PMID: 26989758 Free PMC article. Review.
We examined the use of near-infrared and red radiation (photobiomodulation, PBM) for treating major depressive disorder (MDD). While still experimental, preliminary data on the use of PBM for brain disorders are promising. ...We found clinical and prec …
We examined the use of near-infrared and red radiation (photobiomodulation, PBM) for treating major depressive disorder …
Effects of transcranial photobiomodulation and methylene blue on biochemical and behavioral profiles in mice stress model.
Meynaghizadeh-Zargar R, Sadigh-Eteghad S, Mohaddes G, Salehpour F, Rasta SH. Meynaghizadeh-Zargar R, et al. Lasers Med Sci. 2020 Apr;35(3):573-584. doi: 10.1007/s10103-019-02851-z. Epub 2019 Aug 1. Lasers Med Sci. 2020. PMID: 31372913
The effectiveness of transcranial photobiomodulation (tPBM) and methylene Blue (MB) in treating learning and memory impairments is previously reported. ...Elevated plus maze (EPM) was used to evaluate anxiety-like behaviors. Novel object recognition (NOR) test and B …
The effectiveness of transcranial photobiomodulation (tPBM) and methylene Blue (MB) in treating learning and memory impairments is pr …
Experimental, controversial, and futuristic treatments for chronic tinnitus.
Folmer RL, Theodoroff SM, Martin WH, Shi Y. Folmer RL, et al. J Am Acad Audiol. 2014 Jan;25(1):106-25. doi: 10.3766/jaaa.25.1.7. J Am Acad Audiol. 2014. PMID: 24622863 Review.
Effective and noninvasive treatments for tinnitus include acoustic therapy (which includes hearing aids and other types of environmental sound enrichment); cognitive-behavioral therapy; psychological counseling; hypnosis; biofeedback; and relaxation training. Over-t …
Effective and noninvasive treatments for tinnitus include acoustic therapy (which includes hearing aids and other types of environmen …
Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy.
Morries LD, Cassano P, Henderson TA. Morries LD, et al. Neuropsychiatr Dis Treat. 2015 Aug 20;11:2159-75. doi: 10.2147/NDT.S65809. eCollection 2015. Neuropsychiatr Dis Treat. 2015. PMID: 26347062 Free PMC article. Review.
In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, and hyperbaric oxygen therapy. All available literature suggests a marginal benefit with prolonged treatment courses. ...The extant li …
In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, a …
Photodynamic Therapy, Photobiomodulation and Acetonide Triamcinolone 0.1% in the Treatment of Oral Lichen Planus: A Randomized Clinical Trial.
Salinas-Gilabert C, Gómez García F, Galera Molero F, Pons-Fuster E, Vander Beken S, Lopez Jornet P. Salinas-Gilabert C, et al. Pharmaceutics. 2022 Dec 22;15(1):30. doi: 10.3390/pharmaceutics15010030. Pharmaceutics. 2022. PMID: 36678659 Free PMC article.
Objective: To evaluate the efficacy of photodynamic therapy (PDT) and photobiomodulation (PBM) in the treatment of oral lichen planus (OLP) in comparison with the use of topical corticosteroids. ...Patient pain was evaluated, and the Thongprasom severity score, the …
Objective: To evaluate the efficacy of photodynamic therapy (PDT) and photobiomodulation (PBM) in the treatment of oral lichen …
Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury.
Naeser MA, Martin PI, Ho MD, Krengel MH, Bogdanova Y, Knight JA, Yee MK, Zafonte R, Frazier J, Hamblin MR, Koo BB. Naeser MA, et al. Photomed Laser Surg. 2016 Dec;34(12):610-626. doi: 10.1089/pho.2015.4037. Photomed Laser Surg. 2016. PMID: 28001756 Review.
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM imp …
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to impr …
Photobiomodulation improves frontal lobe cognitive functions and mental health of older adults with non-amnestic mild cognitive impairment: Case studies.
Cheung MC, Lee TL, Sze SL, Chan AS. Cheung MC, et al. Front Psychol. 2023 Jan 10;13:1095111. doi: 10.3389/fpsyg.2022.1095111. eCollection 2022. Front Psychol. 2023. PMID: 36704674 Free PMC article.
METHODS: Three older adults with mild cognitive impairment (MCI) of the non-amnestic type received 18-session tPBM stimulation for 9 weeks and were assessed with neuropsychological tests of memory and executive functions and standardized questionnaires on depressive and …
METHODS: Three older adults with mild cognitive impairment (MCI) of the non-amnestic type received 18-session tPBM stimulation for 9 weeks a …
Synergy Between Neurofeedback and Biofeedback Enhances Therapeutic Outcomes.
Thompson L. Thompson L. Appl Psychophysiol Biofeedback. 2025 Jun;50(2):305-314. doi: 10.1007/s10484-025-09706-0. Appl Psychophysiol Biofeedback. 2025. PMID: 40293646 Review.
Then comes discussion of the history of combining modalities along with discussion of which combinations of treatments should be considered for different disorders. Attention-Deficit/Hyperactivity Disorder (ADHD), for example, requires more than one intervention bec …
Then comes discussion of the history of combining modalities along with discussion of which combinations of treatments should be considered …
Transcranial Photobiomodulation Treatment: Significant Improvements in Four Ex-Football Players with Possible Chronic Traumatic Encephalopathy.
Naeser MA, Martin PI, Ho MD, Krengel MH, Bogdanova Y, Knight JA, Hamblin MR, Fedoruk AE, Poole LG, Cheng C, Koo B. Naeser MA, et al. J Alzheimers Dis Rep. 2023 Jan 31;7(1):77-105. doi: 10.3233/ADR-220022. eCollection 2023. J Alzheimers Dis Rep. 2023. PMID: 36777329 Free PMC article.
There was significant improvement at 1 month on post-traumatic stress disorder (PTSD), depression, pain, and sleep. One case discontinued narcotic pain medications and had reduced tinnitus. ...Significant correlations for increased SN fun …
There was significant improvement at 1 month on post-traumatic stress disorder (PTSD), depression, …
Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial.
Noda Y, Taniguchi K, Takano M, Mimura Y, Yanagisawa N, Hayano M, Kitahata R, Ogawa Y, Mimura M, Tsubota K. Noda Y, et al. J Affect Disord. 2025 May 1;376:325-332. doi: 10.1016/j.jad.2025.02.031. Epub 2025 Feb 15. J Affect Disord. 2025. PMID: 39961441 Clinical Trial.
BACKGROUND: Medication-supplemented psychotherapy is the primary treatment for mild major depressive disorder (MDD). However, limited resources and patient non-adherence present challenges, necessitating innovative and less burdensome interventions. ...Neuromodulati …
BACKGROUND: Medication-supplemented psychotherapy is the primary treatment for mild major depressive disorder (MDD). However, …
A Brief Review of Low-Level Light Therapy in Depression Disorder.
Shirkavand A, Akhavan Tavakoli M, Ebrahimpour Z. Shirkavand A, et al. J Lasers Med Sci. 2023 Nov 11;14:e55. doi: 10.34172/jlms.2023.55. eCollection 2023. J Lasers Med Sci. 2023. PMID: 38028864 Free PMC article. Review.
Introduction: Low-level laser therapy (LLLT), also called Photobiomodulation, has gained widespread acceptance as a mainstream modality, particularly in the form of photobiostimulation (PBM). ...In addition, it helps Parkinson's patients with their mov …
Introduction: Low-level laser therapy (LLLT), also called Photobiomodulation, has gained widespread acceptance a …
Effect of laser biostimulation and a low-calorie diet vs. a low-calorie diet alone on insulin resistance, inflammatory biomarkers, and depression among obese postmenopausal women: a randomized controlled trial.
Elsayed MM, Rakha M, Elsheimy HA, Abdelaziz NE, Nagy EN. Elsayed MM, et al. Eur Rev Med Pharmacol Sci. 2022 May;26(9):3269-3277. doi: 10.26355/eurrev_202205_28745. Eur Rev Med Pharmacol Sci. 2022. PMID: 35587078 Free article. Clinical Trial.
OBJECTIVE: Postmenopausal women are significantly predisposed to a multitude of disorders. Laser biostimulation (LB) and a healthy diet have been linked to multiple health benefits. ...Before and after the intervention, IR [measured by the Homeostatic Model Assessment of I …
OBJECTIVE: Postmenopausal women are significantly predisposed to a multitude of disorders. Laser biostimulation (LB) and a healthy di …
Whole-Body Photobiomodulation Therapy for Fibromyalgia: A Feasibility Trial.
Fitzmaurice BC, Heneghan NR, Rayen ATA, Grenfell RL, Soundy AA. Fitzmaurice BC, et al. Behav Sci (Basel). 2023 Aug 29;13(9):717. doi: 10.3390/bs13090717. Behav Sci (Basel). 2023. PMID: 37753995 Free PMC article.
Effective treatment for fibromyalgia (FM) is lacking and further treatment options are needed. Photobiomodulation therapy (PBMT) represents one potential treatment option. Whilst favourable findings have been reported using localised PBMT, no investigations have est …
Effective treatment for fibromyalgia (FM) is lacking and further treatment options are needed. Photobiomodulation therapy (PBM …
Transcranial photobiomodulation in children aged 2-6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology.
Fradkin Y, De Taboada L, Naeser M, Saltmarche A, Snyder W, Steingold E. Fradkin Y, et al. Front Neurol. 2024 Apr 26;15:1221193. doi: 10.3389/fneur.2024.1221193. eCollection 2024. Front Neurol. 2024. PMID: 38737349 Free PMC article.
BACKGROUND: Small pilot studies have suggested that transcranial photobiomodulation (tPBM) could help reduce symptoms of neurological conditions, such as depression, traumatic brain injury, and autism spectrum disorder (ASD). ...METHOD: We conducted a randomi …
BACKGROUND: Small pilot studies have suggested that transcranial photobiomodulation (tPBM) could help reduce symptoms of neurological …
Penetration Profiles of Visible and Near-Infrared Lasers and Light-Emitting Diode Light Through the Head Tissues in Animal and Human Species: A Review of Literature.
Salehpour F, Cassano P, Rouhi N, Hamblin MR, De Taboada L, Farajdokht F, Mahmoudi J. Salehpour F, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):581-595. doi: 10.1089/photob.2019.4676. Epub 2019 Sep 25. Photobiomodul Photomed Laser Surg. 2019. PMID: 31553265 Review.
Background and objective: Photobiomodulation (PBM) therapy is a promising and noninvasive approach to stimulate neuronal function and improve brain repair. ...Conclusions: In conclusion, it is worthwhile mentioning that since the effectiveness of brain PBM is closel …
Background and objective: Photobiomodulation (PBM) therapy is a promising and noninvasive approach to stimulate neuronal funct …
Recent advances in light energy biotherapeutic strategies with photobiomodulation on central nervous system disorders.
Ma H, Du Y, Xie D, Wei ZZ, Pan Y, Zhang Y. Ma H, et al. Brain Res. 2024 Jan 1;1822:148615. doi: 10.1016/j.brainres.2023.148615. Epub 2023 Oct 14. Brain Res. 2024. PMID: 37783261 Review.
Transcranial photobiomodulation refers to irradiation of the brain through the skull using low-intensity red or near-infrared light, which is the most commonly studied method of light energy biotherapy for central nervous system disorders. ...Multiple …
Transcranial photobiomodulation refers to irradiation of the brain through the skull using low-intensity red or near-infrared ligh …
Neuromodulation in the Treatment of Alzheimer's Disease: Current and Emerging Approaches.
Pople CB, Meng Y, Li DZ, Bigioni L, Davidson B, Vecchio LM, Hamani C, Rabin JS, Lipsman N. Pople CB, et al. J Alzheimers Dis. 2020;78(4):1299-1313. doi: 10.3233/JAD-200913. J Alzheimers Dis. 2020. PMID: 33164935 Review.
Neuromodulation as a treatment strategy for psychiatric and neurological diseases has grown in popularity in recent years, with the approval of repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression being one such example. These approaches offe …
Neuromodulation as a treatment strategy for psychiatric and neurological diseases has grown in popularity in recent years, with the approval …
The potential of transcranial photobiomodulation therapy for treatment of major depressive disorder.
Salehpour F, Rasta SH. Salehpour F, et al. Rev Neurosci. 2017 May 24;28(4):441-453. doi: 10.1515/revneuro-2016-0087. Rev Neurosci. 2017. PMID: 28231069 Review.
Major depressive disorder is a common debilitating mood disorder that affects quality of life. ...In this review, we focus on some issue relating to the application of photobiomodulation therapy for major depressive disorder. There …
Major depressive disorder is a common debilitating mood disorder that affects quality of life. ...In this review, we fo …
Role of Photobiomodulation Therapy in Neurological Primary Burning Mouth Syndrome. A Systematic Review and Meta-Analysis of Human Randomised Controlled Clinical Trials.
Hanna R, Dalvi S, Bensadoun RJ, Raber-Durlacher JE, Benedicenti S. Hanna R, et al. Pharmaceutics. 2021 Nov 2;13(11):1838. doi: 10.3390/pharmaceutics13111838. Pharmaceutics. 2021. PMID: 34834253 Free PMC article. Review.
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). Photobiomodulation therapy (PBMT) has been utilised in npBMS management, however, its role of intervention remains controversial. …
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). …
Wearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: A randomized, double blind, sham-controlled trial.
Guu TW, Cassano P, Li WJ, Tseng YH, Ho WY, Lin YT, Lin SY, Chang JP, Mischoulon D, Su KP. Guu TW, et al. J Affect Disord. 2025 Mar 1;372:635-642. doi: 10.1016/j.jad.2024.12.065. Epub 2024 Dec 18. J Affect Disord. 2025. PMID: 39706483 Free article. Clinical Trial.
METHODS: We randomized 48 outpatients with major depressive disorder (MDD) into tPBM or sham with 1:1 ratio. All participants were advised to receive the device-based intervention for at least 20 min daily at their preferred time and place for 8 weeks. ...CONCLUSION …
METHODS: We randomized 48 outpatients with major depressive disorder (MDD) into tPBM or sham with 1:1 ratio. All participants …
Can mild cognitive impairment be stabilized by showering brain mitochondria with laser photons?
de la Torre JC, Olmo AD, Valles S. de la Torre JC, et al. Neuropharmacology. 2020 Jul;171:107841. doi: 10.1016/j.neuropharm.2019.107841. Epub 2019 Nov 5. Neuropharmacology. 2020. PMID: 31704275 Review.
This intervention uses transcranial infrared brain stimulation (TIBS), a form of photobiomodulation (PBM). PBM is a bioenergetic non-ionizing, therapeutic approach using low level light emission from laser or light emitting diodes. ...This artic …
This intervention uses transcranial infrared brain stimulation (TIBS), a form of photobiomodulation (PBM). PBM is a bioenergetic non- …
Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy.
Cardoso FDS, de Souza Oliveira Tavares C, Araujo BHS, Mansur F, Lopes-Martins RÁB, Gomes da Silva S. Cardoso FDS, et al. Cell Mol Neurobiol. 2022 Aug;42(6):1875-1886. doi: 10.1007/s10571-021-01069-4. Epub 2021 Mar 11. Cell Mol Neurobiol. 2022. PMID: 33704604 Free PMC article.
We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their exploratory activity and habituation in open field, anxiety in elevated plus maze, spatial memory in Barnes maze, and aversive memory in a step …
We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their explorator …
Nonpharmacological interventions for acute pain management in patients with opioid abuse or opioid tolerance: a scoping review.
Hargett J, Criswell A, Palokas M. Hargett J, et al. JBI Evid Synth. 2022 Nov 1;20(11):2697-2720. doi: 10.11124/JBIES-21-00169. JBI Evid Synth. 2022. PMID: 36065876
Nonpharmacological techniques have shown potential in reducing postoperative pain, opioid consumption, stress, and anxiety. INCLUSION CRITERIA: Eligible studies included participants in either inpatient or outpatient health care settings who were experiencing acute …
Nonpharmacological techniques have shown potential in reducing postoperative pain, opioid consumption, stress, and anxiety. IN …
Local and systemic photobiomodulation using a 650 nm LED on skin temperature and hyperalgesia in cellulite: a randomized, placebo-controlled and double-blinded clinical trial.
Lopes-Martins RAB, Bueno F, Ferreira HODC, Faria LA, Sousa MMB, Lobo AB, Freitas VFDS, Lopes-Martins PSL, Aimbire F, Leonardo PS. Lopes-Martins RAB, et al. Lasers Med Sci. 2024 Nov 13;39(1):275. doi: 10.1007/s10103-024-04232-7. Lasers Med Sci. 2024. PMID: 39535674 Clinical Trial.
Cellulite is a skin condition that significantly affects women, characterized by "holes" or depressions in the skin, affecting approximately 95% of women at some point in their lives. ...This study investigates the effects of local and systemic photobiomodulation on …
Cellulite is a skin condition that significantly affects women, characterized by "holes" or depressions in the skin, affecting approx …
Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model.
Yang L, Wu C, Tucker L, Dong Y, Li Y, Xu P, Zhang Q. Yang L, et al. J Alzheimers Dis. 2021;83(4):1415-1429. doi: 10.3233/JAD-201616. J Alzheimers Dis. 2021. PMID: 34219711
We hypothesize that photobiomodulation (PBM) could be an effective method to alleviate depression and anxiety at the early stage of AD pathogenesis. ...CONCLUSION: Our findings support our hypothesis that PBM could be an effective method to alleviate depre …
We hypothesize that photobiomodulation (PBM) could be an effective method to alleviate depression and anxiety at the ea …
Transcranial Photobiomodulation Improves Cognitive Performance in Young Healthy Adults: A Systematic Review and Meta-Analysis.
Salehpour F, Majdi A, Pazhuhi M, Ghasemi F, Khademi M, Pashazadeh F, Hamblin MR, Cassano P. Salehpour F, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):635-643. doi: 10.1089/photob.2019.4673. Epub 2019 Sep 24. Photobiomodul Photomed Laser Surg. 2019. PMID: 31549906 Free PMC article.
Background: Transcranial photobiomodulation (t-PBM) is a noninvasive modality that may improve cognitive function in both healthy and diseased subjects. ...
Background: Transcranial photobiomodulation (t-PBM) is a noninvasive modality that may improve cognitive function in both healthy and …
Analysis of the psychopathological profile, quality of life, and cost-effectiveness of oral lichen planus patients treated with photobiomodulation.
Sobral SS, da Silva Brandão EH, de Barros Gallo C, Molon A, Sobral APT, de Fátima Teixeira da Silva D, Motta LJ, Dos Santos Franco AL, Rodrigues MFSD. Sobral SS, et al. Clin Oral Investig. 2022 Jan;26(1):719-728. doi: 10.1007/s00784-021-04050-z. Epub 2021 Jul 12. Clin Oral Investig. 2022. PMID: 34251533 Clinical Trial.
MATERIALS AND METHODS: Patients were randomized into two groups: Control (clobetasol propionate 0.05%) and Photobiomodulation (660 nm, 100mW, 177 J/cm(2), 5 s, 0.5 J) twice a week for 30 days. The Hospital Anxiety and Depression Scale (HADS) and OHIP-14 were …
MATERIALS AND METHODS: Patients were randomized into two groups: Control (clobetasol propionate 0.05%) and Photobiomodulation (660 nm …
Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS-EEG and pilot study.
Hao W, Dai X, Wei M, Li S, Peng M, Xue Q, Lin H, Wang H, Song P, Wang Y. Hao W, et al. Photodermatol Photoimmunol Photomed. 2024 Mar;40(2):e12957. doi: 10.1111/phpp.12957. Photodermatol Photoimmunol Photomed. 2024. PMID: 38470033
BACKGROUND: Major depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability of left frontal pole (FP) and abnormal brain connections. ...The purpose of our study was to establish how clinical symptoms and time-varyi …
BACKGROUND: Major depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability …
The 2910-nm Fiber Laser Is Safe and Effective for Improving Acne Scarring.
Bernstein E, Alajmi A, Wang J, Hochman E, Biesman B, Sanzo JF. Bernstein E, et al. Lasers Surg Med. 2024 Nov;56(9):755-761. doi: 10.1002/lsm.23845. Epub 2024 Sep 22. Lasers Surg Med. 2024. PMID: 39308036 Clinical Trial.
BACKGROUND: Acne scarring results from the inflammation associated with acne papules, which alters dermal collagen, typically producing depressed scars. Lasers have been used to remodel skin improving the texture and appearance of acne scars. ...
BACKGROUND: Acne scarring results from the inflammation associated with acne papules, which alters dermal collagen, typically producing d …
Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.
Xu Z, Guo X, Yang Y, Tucker D, Lu Y, Xin N, Zhang G, Yang L, Li J, Du X, Zhang Q, Xu X. Xu Z, et al. Mol Neurobiol. 2017 Aug;54(6):4551-4559. doi: 10.1007/s12035-016-9983-2. Epub 2016 Jul 5. Mol Neurobiol. 2017. PMID: 27379735 Free PMC article.
Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobility, neurotransmitter deficiency, and energy metabolic decline. Low-level laser therapy (LLLT) has been investigated i …
Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobi …
The efficacy of photobiomodulation on dental injection pain: a systematic review of randomized clinical trials.
Altuhafy M, Baig V, Jabr L, Khan J. Altuhafy M, et al. J Dent Anesth Pain Med. 2024 Jun;24(3):145-159. doi: 10.17245/jdapm.2024.24.3.145. Epub 2024 May 27. J Dent Anesth Pain Med. 2024. PMID: 38840646 Free PMC article. Review.
Dental injections are routinely performed and can result in pain and anxiety in patients. This systematic review aimed to evaluate the efficacy of photobiomodulation therapy (PBMT) in dental injections for pain management in patients undergoing dental treatme …
Dental injections are routinely performed and can result in pain and anxiety in patients. This systematic review aimed to evaluate th …
Efficacy and safety of photobiomodulation combined with oral cryotherapy on oral mucosa pain in patients with burning mouth syndrome: a multi-institutional, randomized, controlled trial.
Lu C, Zhou X, Yang C, Jiang X, Li X, Huang Z, Du Q, Tang G. Lu C, et al. BMC Med. 2025 Apr 7;23(1):196. doi: 10.1186/s12916-025-04015-z. BMC Med. 2025. PMID: 40189502 Free PMC article. Clinical Trial.
BACKGROUND: The prevalence of burning mouth syndrome (BMS) is approximately 8% in clinical patients; thus, BMS remains a therapeutic challenge. Photobiomodulation (PBM) and oral cryotherapy (OCT) have been evaluated for the treatment of burning pain, but no confirmatory tr …
BACKGROUND: The prevalence of burning mouth syndrome (BMS) is approximately 8% in clinical patients; thus, BMS remains a therapeutic challen …
Photobiomodulation therapy alleviates repeated closed head injury-induced anxiety-like behaviors.
Chen Z, Li M, Wu C, Su Y, Feng S, Deng Q, Zou P, Liu TC, Duan R, Yang L. Chen Z, et al. J Biophotonics. 2024 Feb;17(2):e202300343. doi: 10.1002/jbio.202300343. Epub 2023 Nov 1. J Biophotonics. 2024. PMID: 37909411
Although extensive studies have focused on how to treat rCHI-induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI-induced anxiety has received little research attention. The current study was designed to assess the effects o …
Although extensive studies have focused on how to treat rCHI-induced brain injury and reduce the possibility of developing memory deficits, …
Advanced Intervention Effects of Pulsed and Steady Transcranial Photobiomodulation on Sleep, Mood, and EEG Signal Regulation.
Zhang X, Miao X, Jiang H, Ren Y, Huo L, Liu M, Chen H. Zhang X, et al. J Biophotonics. 2025 Mar 18:e70004. doi: 10.1002/jbio.70004. Online ahead of print. J Biophotonics. 2025. PMID: 40101768
Outcomes were assessed using the Karolinska Sleepiness Scale (KSS) (for measuring sleepiness), State-Trait Anxiety Inventory (STAI) (for assessing anxiety), Visual Analog Scale (VAS) (for measuring stress), and Beck Depression Inventory-II (BDI-II) (fo …
Outcomes were assessed using the Karolinska Sleepiness Scale (KSS) (for measuring sleepiness), State-Trait Anxiety Inventory (STAI) ( …
Efficacy and Safety of Photobiomodulation in MELAS: Protocol for a Series of N-of-1 Trials.
Laakso EL, Ewais T, McMahon K, Forbes J, Phillips L. Laakso EL, et al. J Clin Med. 2025 Mar 17;14(6):2047. doi: 10.3390/jcm14062047. J Clin Med. 2025. PMID: 40142856 Free PMC article.
Medical treatment varies and focuses on managing symptoms. Photobiomodulation (PBM) can decrease mitochondrial damage thereby increasing energy production and decreasing cell death. ...The primary outcome is patient-reported fatigue assessed using the Checklist of Individu …
Medical treatment varies and focuses on managing symptoms. Photobiomodulation (PBM) can decrease mitochondrial damage thereby increas …
Photobiomodulation for modulation of neuropathic pain and improvement of scar tissue.
Santiago R, Gomes S, Ozsarfati J, Zitney M. Santiago R, et al. Scars Burn Heal. 2022 Oct 26;8:20595131221134052. doi: 10.1177/20595131221134052. eCollection 2022 Jan-Dec. Scars Burn Heal. 2022. PMID: 36310679 Free PMC article.
BACKGROUND: This case-report explores the effects of photobiomodulation therapy (PBMT) on the healing of scar tissue. The patient was a 32-year old female two years post cholecystectomy resulting in a 15 cm linear scar that was causing severe pain. ...LAY SUMMARY: D …
BACKGROUND: This case-report explores the effects of photobiomodulation therapy (PBMT) on the healing of scar tissue. The pati …
Sensory-motor and cardiorespiratory sensory rehabilitation associated with transcranial photobiomodulation in patients with central nervous system injury: Trial protocol for a single-center, randomized, double-blind, and controlled clinical trial.
Pinto AP, Guimarães CL, Souza GADS, Leonardo PS, Neves MFD, Lima FPS, Lima MO, Lopes-Martins RAB. Pinto AP, et al. Medicine (Baltimore). 2019 Jun;98(25):e15851. doi: 10.1097/MD.0000000000015851. Medicine (Baltimore). 2019. PMID: 31232920 Free PMC article.
Aerobic exercises bring benefits in terms of fatigue retardation, gait improvement, regulation of the autonomic nervous system, neuroprotection of the brain, stimulation of the production of endogenous neutrotransmitters related to general well-being, and a favoring of neuroplast …
Aerobic exercises bring benefits in terms of fatigue retardation, gait improvement, regulation of the autonomic nervous system, neuroprotect …
Central nervous system abnormalities in fibromyalgia and chronic fatigue syndrome: new concepts in treatment.
Gur A, Oktayoglu P. Gur A, et al. Curr Pharm Des. 2008;14(13):1274-94. doi: 10.2174/138161208799316348. Curr Pharm Des. 2008. PMID: 18537652 Review.
Because of the similarities between both disorders it was suggested that they share a common pathophysiological mechanisms, namely, central nervous system (CNS) dysfunction. ...Researches suggest that the (CNS) is primarily involved in both disorders in regard to th …
Because of the similarities between both disorders it was suggested that they share a common pathophysiological mechanisms, namely, c …
UC-USP collaborative exercise on photobiomodulation therapy in neurological orofacial disturbances.
Nunes T, Caetano C, Pimenta M, Saraiva J, Rocha S, Freitas P, Figueiredo J, Pereira SA, Corte-Real A. Nunes T, et al. J Clin Exp Dent. 2020 Jul 1;12(7):e650-e655. doi: 10.4317/jced.56839. eCollection 2020 Jul. J Clin Exp Dent. 2020. PMID: 32904953 Free PMC article.
BACKGROUND: Neurosensory peripheral disorders are one of the most common risks associated with iatrogenic and/or post-traumatic injuries. ...CONCLUSIONS: Our results supported the improvement of quality of life and impairment reduction in the individuals subm …
BACKGROUND: Neurosensory peripheral disorders are one of the most common risks associated with iatrogenic and/or post-traum …
The history of light therapy in hospital physiotherapy and medicine with emphasis on Australia: Evolution into novel areas of practice.
Liebert A, Kiat H. Liebert A, et al. Physiother Theory Pract. 2021 Mar;37(3):389-400. doi: 10.1080/09593985.2021.1887060. Epub 2021 Mar 7. Physiother Theory Pract. 2021. PMID: 33678141 Review.
Objective: The objective of this narrative review was to investigate the history of light therapy in hospital settings, with reference to physiotherapy and particularly in an Australian context.Types of articles and search method:a review of available literature was …
Objective: The objective of this narrative review was to investigate the history of light therapy in hospital settings, with r …
Photobiomodulation therapy for repeated closed head injury in rats.
Yang B, Xu J, Li Y, Dong Y, Li Y, Tucker L, Yang L, Zong X, Wu C, Xu T, Hu S, Zhang Q, Yan X. Yang B, et al. J Biophotonics. 2020 Feb;13(2):e201960117. doi: 10.1002/jbio.201960117. Epub 2019 Nov 25. J Biophotonics. 2020. PMID: 31657525
Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here, we examined PBM in a repeated closed head injury (rCHI) rat model. ...We found that PBM-treated rCHI rats had a significant reduction in m …
Growing interest is building in the use of transcranial photobiomodulation (PBM) therapy to treat traumatic brain injury. Here …
Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with Alzheimer's disease and related dementia living in long-term care facilities.
Figueiro MG, Plitnick BA, Lok A, Jones GE, Higgins P, Hornick TR, Rea MS. Figueiro MG, et al. Clin Interv Aging. 2014 Sep 12;9:1527-37. doi: 10.2147/CIA.S68557. eCollection 2014. Clin Interv Aging. 2014. PMID: 25246779 Free PMC article.
BACKGROUND: Light therapy has shown great promise as a nonpharmacological method to improve symptoms associated with Alzheimer's disease and related dementias (ADRD), with preliminary studies demonstrating that appropriately timed light exposure can improve n …
BACKGROUND: Light therapy has shown great promise as a nonpharmacological method to improve symptoms associated with Alzheimer …
Effect of modified intravascular laser irradiation of blood in the oral and systemic conditions during dental treatment-A systematic review.
Oliveira MC, Silva DFB, de Oliveira Andrade A, Pita de Melo D, de Sousa YAB, da Silva LOP, de Castro Gomes DQ. Oliveira MC, et al. Lasers Med Sci. 2024 Dec 20;39(1):300. doi: 10.1007/s10103-024-04264-z. Lasers Med Sci. 2024. PMID: 39704836 Review.
This systematic literature review study aimed to answer the question, "Is modified-ILIB an effective adjuvant therapy in the control of systemic conditions and/or oral changes in children and adults during dental treatment?". ...The outcomes were periodontal parameters and …
This systematic literature review study aimed to answer the question, "Is modified-ILIB an effective adjuvant therapy in the control …
Photobiomodulation therapy and transcutaneous electrical nerve stimulation on chronic neck pain patients: Study protocol clinical trial (SPIRIT Compliant).
Rampazo ÉP, de Andrade ALM, da Silva VR, Back CGN, Liebano RE. Rampazo ÉP, et al. Medicine (Baltimore). 2020 Feb;99(8):e19191. doi: 10.1097/MD.0000000000019191. Medicine (Baltimore). 2020. PMID: 32080103 Free PMC article.
This study will be performed in Department of Physical Therapy at Federal University of Sao Carlos, Sao Carlos/SP, Brazil. One hundred and forty-four patients with chronic neck pain will be randomized into 4 groups: active photobiomodulation therapy with acti …
This study will be performed in Department of Physical Therapy at Federal University of Sao Carlos, Sao Carlos/SP, Brazil. One hundre …
Evaluation of photobiomodulation effects on pain, edema, paresthesia, and bone regeneration after surgically assisted rapid maxillary expansion: Study protocol for a randomized, controlled, and double blind clinical trial.
da Fonseca EV, Bussadori SK, da Silva Martinho LFC, de Sousa Melo MC, de Andrade FL, Gonçalves MLL, Mesquita-Ferrari RA, Horliana ACRT, Fernandes KPS. da Fonseca EV, et al. Medicine (Baltimore). 2019 Nov;98(48):e17756. doi: 10.1097/MD.0000000000017756. Medicine (Baltimore). 2019. PMID: 31770194 Free PMC article.
There are few studies on the effect of photobiomodulation (PBM) after SARME and it was not possible to find studies on the efficacy of light emitted by diode (LED) after this type of intervention. ...Secondarily, data regarding the occurrence of headache; otalgia; n …
There are few studies on the effect of photobiomodulation (PBM) after SARME and it was not possible to find studies on the efficacy o …
Dual-Brain Psychology: A novel theory and treatment based on cerebral laterality and psychopathology.
Schiffer F. Schiffer F. Front Psychol. 2022 Oct 19;13:986374. doi: 10.3389/fpsyg.2022.986374. eCollection 2022. Front Psychol. 2022. PMID: 36337511 Free PMC article.
Stimulating the positive hemisphere in most therapy patients rapidly relieves symptoms such as anxiety, depression, or substance cravings. Two randomized controlled trials used unilateral transcranial photobiomodulation to the positive hemisphere as a …
Stimulating the positive hemisphere in most therapy patients rapidly relieves symptoms such as anxiety, depression, or …
[Low Level Laser Therapy in Nursing Care].
Wu JH. Wu JH. Hu Li Za Zhi. 2024 Feb;71(1):15-21. doi: 10.6224/JN.202402_71(1).03. Hu Li Za Zhi. 2024. PMID: 38253849 Chinese.
The high pressure nature of their work makes nursing staffs relatively susceptible to high levels of anxiety and insomnia and to poor mental health. Low level laser therapy (photobiomodulation therapy, PBMT) is an alternative approach to …
The high pressure nature of their work makes nursing staffs relatively susceptible to high levels of anxiety and insomnia and to poor …
Antidepressant and antioxidant effects of transcranial irradiation with 830-nm low-power laser in an animal model of depression.
Mohammed HS, Khadrawy YA. Mohammed HS, et al. Lasers Med Sci. 2022 Apr;37(3):1615-1623. doi: 10.1007/s10103-021-03410-1. Epub 2021 Sep 6. Lasers Med Sci. 2022. PMID: 34487275
The present study aimed at investigating the antidepressant and antioxidant actions of near-infrared (NIR) laser at a wavelength of 830 nm and power of 100 mW which applied transcranially on an animal model of depression induced by repeated doses of reserpine (0.2 mg/kg). …
The present study aimed at investigating the antidepressant and antioxidant actions of near-infrared (NIR) laser at a wavelength of 830 nm a …
Efficacy of Transcranial Photobiomodulation on Depressive Symptoms: A Meta-Analysis.
Cho Y, Tural U, Iosifescu DV. Cho Y, et al. Photobiomodul Photomed Laser Surg. 2023 Sep;41(9):460-466. doi: 10.1089/photob.2023.0041. Epub 2023 Aug 31. Photobiomodul Photomed Laser Surg. 2023. PMID: 37651208 Free PMC article.
Background: Transcranial photobiomodulation (tPBM) is a novel, noninvasive, device-based intervention, which has been tested as a possible treatment for various neurological and psychiatric conditions. Recently, it has been investigated as an innovative treatment for major …
Background: Transcranial photobiomodulation (tPBM) is a novel, noninvasive, device-based intervention, which has been tested as a pos …
Photobiomodulation as part of multimodal analgesia to improve pain relief and wound healing after elective caesarean section: A protocol for randomized controlled trial.
Khaled M, Baranov A, Diaz A, Patel M, Clements S, Farsinejad P, Khatana K, Gnanapragasam A, Selvanayagam S, Muhsen Z, Chan J, Hunjan S, Kazi A, Sharma S, Luketic L, Ewusie JE, Cordovani D, Shanthanna H. Khaled M, et al. PLoS One. 2024 Dec 26;19(12):e0314010. doi: 10.1371/journal.pone.0314010. eCollection 2024. PLoS One. 2024. PMID: 39724020 Free PMC article.
Photobiomodulation therapy (PBMT) uses light-emitting diode (LED) and laser and has suggested potential for improving pain control and wound healing. ...Patients will receive a maximum of 5 post-surgical treatment sessions of active PBMT (intervention: LED …
Photobiomodulation therapy (PBMT) uses light-emitting diode (LED) and laser and has suggested potential for improving p …
Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment.
Baumgartner J, Šimaljaková M. Baumgartner J, et al. J Cosmet Laser Ther. 2017 Dec;19(8):459-464. doi: 10.1080/14764172.2017.1343953. Epub 2017 Jun 30. J Cosmet Laser Ther. 2017. PMID: 28665237
The treatment, usually asked from patients as the result of anxiety and social embarrassment, should be performed in a non-aggressive manner. OBJECTIVES: To determine the safety and effectiveness of 595-nm variable-pulse pulsed dye laser (VPPDL) with a Dynamic Cooling Devi …
The treatment, usually asked from patients as the result of anxiety and social embarrassment, should be performed in a non-aggressive …
The clinical efficacy of intravascular laser irradiation of blood (ILIB): A narrative review of randomized controlled trial.
Díaz L, Gil AC, Marttens AV, Basualdo J, Sotomayor C, Becerra AV, Beltrán V, Jorquera G, Caviedes R, Fernández E. Díaz L, et al. Photodiagnosis Photodyn Ther. 2025 May 3;53:104618. doi: 10.1016/j.pdpdt.2025.104618. Online ahead of print. Photodiagnosis Photodyn Ther. 2025. PMID: 40324571 Free article. Review.
BACKGROUND: Intravascular Laser Irradiation of Blood (ILIB) is a systemic application of photobiomodulation therapy (PBMT), proposed to modulate oxidative stress, inflammation, and mitochondrial function. ...RESULTS: Eight RCTs comprising 340 participants wer …
BACKGROUND: Intravascular Laser Irradiation of Blood (ILIB) is a systemic application of photobiomodulation therapy (PBMT), pr …
A Protocol for Transcranial Photobiomodulation Therapy in Mice.
Salehpour F, De Taboada L, Cassano P, Kamari F, Mahmoudi J, Ahmadi-Kandjani S, Rasta SH, Sadigh-Eteghad S. Salehpour F, et al. J Vis Exp. 2018 Nov 18;(141). doi: 10.3791/59076. J Vis Exp. 2018. PMID: 30507909
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain function in a wide range of neurological and psychiatric disorders, and memory enhancement in age-related cognitive decline and neurod …
Transcranial photobiomodulation is a potential innovative noninvasive therapeutic approach for improving brain bioenergetics, brain f …
[Burning mouth syndrome: pathogenic and therapeutic concepts].
Ferensztajn E, Łojko D, Rybakowski J. Ferensztajn E, et al. Psychiatr Pol. 2013 Nov-Dec;47(6):973-88. Psychiatr Pol. 2013. PMID: 25007531 Review. Polish.
The psychiatric aspect of BMS is significant: the most frequent co-morbidities are depression and anxiety disorders, and a number of psychotropic drugs play an essential role in its treatment. ...
The psychiatric aspect of BMS is significant: the most frequent co-morbidities are depression and anxiety disorders, an …
Transcranial Photobiomodulation with Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study.
Maiello M, Losiewicz OM, Bui E, Spera V, Hamblin MR, Marques L, Cassano P. Maiello M, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):644-650. doi: 10.1089/photob.2019.4677. Photobiomodul Photomed Laser Surg. 2019. PMID: 31647775 Free PMC article. Clinical Trial.
Objective: Our aim was to test the anxiolytic effect of transcranial photobiomodulation (t-PBM) with near-infrared light (NIR) in subjects suffering from generalized anxiety disorder (GAD). Background: t-PBM with NIR is an experimental, noninvasive tre …
Objective: Our aim was to test the anxiolytic effect of transcranial photobiomodulation (t-PBM) with near-infrared light (NIR) …
The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model.
Buendía D, Guncay T, Oyanedel M, Lemus M, Weinstein A, Ardiles ÁO, Marcos J, Fernandes A, Zângaro R, Muñoz P. Buendía D, et al. Brain Sci. 2022 Sep 21;12(10):1272. doi: 10.3390/brainsci12101272. Brain Sci. 2022. PMID: 36291206 Free PMC article.
Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial light therapy (TLTC) on sy …
Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive fun …
Transcranial Photobiomodulation to Improve Cognition in Gulf War Illness.
Martin PI, Chao L, Krengel MH, Ho MD, Yee M, Lew R, Knight J, Hamblin MR, Naeser MA. Martin PI, et al. Front Neurol. 2021 Jan 21;11:574386. doi: 10.3389/fneur.2020.574386. eCollection 2020. Front Neurol. 2021. PMID: 33551948 Free PMC article.
Introduction: Approximately 25-30% of veterans deployed to Kuwait, 1990-91, report persistent multi-symptom Gulf War Illness (GWI) likely from neurotoxicant exposures. Photobiomodulation (PBM) in red/near-infrared (NIR) wavelengths is a safe, non-invasive modality shown to …
Introduction: Approximately 25-30% of veterans deployed to Kuwait, 1990-91, report persistent multi-symptom Gulf War Illness (GWI) likely fr …
Dose-dependent effects of transcranial photobiomodulation on brain temperature in patients with major depressive disorder: a spectroscopy study.
Weerasekera A, Coelho DRA, Ratai EM, Collins KA, Puerto AMH, De Taboada L, Gersten MB, Clancy JA, Hoptman MJ, Irvin MK, Sparpana AM, Sullivan EF, Song X, Adib A, Cassano P, Iosifescu DV. Weerasekera A, et al. Lasers Med Sci. 2024 Oct 7;39(1):249. doi: 10.1007/s10103-024-04198-6. Lasers Med Sci. 2024. PMID: 39370461 Clinical Trial.
This study aimed to evaluate the dose-dependent brain temperature effects of transcranial photobiomodulation (t-PBM). Thirty adult subjects with major depressive disorder were randomized to three t-PBM sessions with different doses (low: 50 mW/cm(2), medium: …
This study aimed to evaluate the dose-dependent brain temperature effects of transcranial photobiomodulation (t-PBM). Thirty adult su …
Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress-Induced Depression.
Zhang D, Shen Q, Wu X, Xing D. Zhang D, et al. Oxid Med Cell Longev. 2021 Mar 29;2021:6678276. doi: 10.1155/2021/6678276. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33859781 Free PMC article.
Accumulating evidence indicates that dysfunction of the glutamatergic neurotransmission has been widely involved in the pathophysiology and treatment of depression. Photobiomodulation therapy (PBMT) has been demonstrated to regulate neuronal function both in …
Accumulating evidence indicates that dysfunction of the glutamatergic neurotransmission has been widely involved in the pathophysiology and …
Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia.
Nizamutdinov D, Qi X, Berman MH, Dougal G, Dayawansa S, Wu E, Yi SS, Stevens AB, Huang JH. Nizamutdinov D, et al. Aging Dis. 2021 Jul 1;12(4):954-963. doi: 10.14336/AD.2021.0229. eCollection 2021 Jul. Aging Dis. 2021. PMID: 34221541 Free PMC article.
Low emission of transcranial near-infrared (tNIR) light can reach human brain parenchyma and be beneficial to a number of neurological and neurodegenerative disorders. ...Active treatment consisted of low power tNIR light stimulations with an active photob …
Low emission of transcranial near-infrared (tNIR) light can reach human brain parenchyma and be beneficial to a number of neurologica …
Evaluation of the effectiveness of photobiomodulation therapy as an alternative method to local anesthesia injection in pediatric dentistry.
Diab HM, El-Malt MA, Mourad YO. Diab HM, et al. J Indian Soc Pedod Prev Dent. 2023 Jul-Sep;41(3):222-227. doi: 10.4103/jisppd.jisppd_305_23. J Indian Soc Pedod Prev Dent. 2023. PMID: 37861636 Free article. Clinical Trial.
BACKGROUND: The idea of receiving local anesthesia (LA) via an injection is a major source of dental fear and anxiety. In children, dental anxiety is considered the main reason for avoiding dental treatments. ...AIM: This study was performed to evaluate the effectiv …
BACKGROUND: The idea of receiving local anesthesia (LA) via an injection is a major source of dental fear and anxiety. In children, d …
An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation.
Schiffer F, Khan A, Bolger E, Flynn E, Seltzer WP, Teicher MH. Schiffer F, et al. Front Psychiatry. 2021 Aug 10;12:713686. doi: 10.3389/fpsyt.2021.713686. eCollection 2021. Front Psychiatry. 2021. PMID: 34447323 Free PMC article.
We report here our findings from our second randomized controlled trial to evaluate unilateral transcranial photobiomodulation as a treatment for opioid use disorder. Methods: We enrolled 39 participants with active opioid cravings at 2 sites, 19 received the active …
We report here our findings from our second randomized controlled trial to evaluate unilateral transcranial photobiomodulation as a t …
The effectiveness of transmeatal low-power laser stimulation in treating tinnitus.
Ngao CF, Tan TS, Narayanan P, Raman R. Ngao CF, et al. Eur Arch Otorhinolaryngol. 2014 May;271(5):975-80. doi: 10.1007/s00405-013-2491-3. Epub 2013 Apr 19. Eur Arch Otorhinolaryngol. 2014. PMID: 23605244 Clinical Trial.
In term of VAS scores, there seems to be no statistically significant improvement in patients' annoyance, sleep disruption, depression, concentration and tinnitus loudness and pitch heard between the two groups. Transmeatal low-power laser stimulation did not demonstrate s …
In term of VAS scores, there seems to be no statistically significant improvement in patients' annoyance, sleep disruption, depression …
Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice.
Lepicard EM, Joubert C, Hagneau I, Perez-Diaz F, Chapouthier G. Lepicard EM, et al. Pharmacol Biochem Behav. 2000 Dec;67(4):739-48. doi: 10.1016/s0091-3057(00)00419-6. Pharmacol Biochem Behav. 2000. PMID: 11166064
The study in an ethological perspective of inbred strains of mice offers a more accurate description of anxiety-related behavior. In this context, behavioral performances of the BALB/cByJ and C57BL/6J strains were systematically compared in the staircase test, the light …
The study in an ethological perspective of inbred strains of mice offers a more accurate description of anxiety-related behavior. In …
Efficacy of photobiomodulation on oral lichen planus: a protocol study for a double-blind, randomised controlled clinical trial.
Ferri EP, Gallo CB, Abboud CS, Yanaguizawa WH, Horliana ACRT, Silva DFTD, Pavani C, Bussadori SK, Nunes FD, Mesquita-Ferrari RA, Fernandes KPS, Rodrigues MFSD. Ferri EP, et al. BMJ Open. 2018 Oct 8;8(10):e024083. doi: 10.1136/bmjopen-2018-024083. BMJ Open. 2018. PMID: 30297352 Free PMC article.
Photobiomodulation (PBM) has been shown to be a potential therapeutic tool to treat inflammatory disorders, including OLP. ...Pain will be evaluated using visual analogue scale and clinical characteristics will be scored using the Thongprasom Index. The quality of l …
Photobiomodulation (PBM) has been shown to be a potential therapeutic tool to treat inflammatory disorders, including OLP. ... …
Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study.
Henderson TA, Morries LD. Henderson TA, et al. Front Psychiatry. 2017 Sep 29;8:187. doi: 10.3389/fpsyt.2017.00187. eCollection 2017. Front Psychiatry. 2017. PMID: 29033859 Free PMC article.
Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain injury (TBI). The current objective is to explore multi-Watt NILT efficacy in a proof-of-concept study as a treatment for depression …
Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain …
Clinical Efficacy of 830 nm LED Photobiomodulation Therapy on Postoperative Blepharoplasty Complications.
Ye H, Xiang Y. Ye H, et al. Aesthetic Plast Surg. 2025 Feb;49(3):655-663. doi: 10.1007/s00266-024-04374-7. Epub 2024 Oct 23. Aesthetic Plast Surg. 2025. PMID: 39443322 Clinical Trial.
In this research, the authors introduce a photobiomodulation therapy and to investigate the efficacy and safety of 830 nm light-emitting diode (LED) phototherapy in improving complications after incisional blepharoplasty. ...CONCLUSION: Photobiomodulation …
In this research, the authors introduce a photobiomodulation therapy and to investigate the efficacy and safety of 830 nm l …
Photobiomodulation therapy in diabetes: Benefits for pain relief, quality of life, and wound healing.
da Silva Oliveira VR, de Paula Oliveira I, Alonso-Matielo H, Oliveira VT, Kremer JL, Casalverini MCD, Ribeiro FQ, Maria-Engler SS, Assis SR, Teixeira MJ, Lotfi CFP, Otoch JP, Dale CS. da Silva Oliveira VR, et al. Photochem Photobiol. 2025 Jan 20. doi: 10.1111/php.14053. Online ahead of print. Photochem Photobiol. 2025. PMID: 39829285
A 5 mm skin biopsy was taken for fibroblast culture. PBM therapy, using 660 nm red light, was administered twice weekly for 7 weeks on lower limb wounds. Results indicated that DM patients faced significant sensory impairments, impacting their quality of life. PBM …
A 5 mm skin biopsy was taken for fibroblast culture. PBM therapy, using 660 nm red light, was administered twice weekly for 7 …
Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review.
Chow R, Armati P, Laakso EL, Bjordal JM, Baxter GD. Chow R, et al. Photomed Laser Surg. 2011 Jun;29(6):365-81. doi: 10.1089/pho.2010.2928. Epub 2011 Apr 1. Photomed Laser Surg. 2011. PMID: 21456946 Review.
The findings were then evaluated with special reference to the neurophysiology of pain and implications for the analgesic effects of low-level laser therapy (LLLT). BACKGROUND: LLLT is used in the treatment of pain, and laser-induced neural inhibition has bee …
The findings were then evaluated with special reference to the neurophysiology of pain and implications for the analgesic effects of low …
Long-Term Benefits of Photobiomodulation Therapy on Health-Related Quality of Life in Burning Mouth Syndrome Patients: A Prospective Study.
de Abreu JM, Nunes T, Almiro PA, Figueiredo J, Corte-Real A. de Abreu JM, et al. J Clin Med. 2024 Jul 22;13(14):4272. doi: 10.3390/jcm13144272. J Clin Med. 2024. PMID: 39064312 Free PMC article.
This study aimed to evaluate the impact of prolonged Photobiomodulation with low-level laser therapy on BMS patients by examining the efficacy of an outpatient protocol in a real-world setting. ...Conclusions: Therefore, Photobiomodulation with …
This study aimed to evaluate the impact of prolonged Photobiomodulation with low-level laser therapy on BMS pati …
Non-specific effects and clusters of women with painful TMD responders and non-responders to LLLT: double-blind randomized clinical trial.
Magri LV, Carvalho VA, Rodrigues FCC, Bataglion C, Leite-Panissi CRA. Magri LV, et al. Lasers Med Sci. 2018 Feb;33(2):385-392. doi: 10.1007/s10103-017-2406-4. Epub 2017 Dec 5. Lasers Med Sci. 2018. PMID: 29209867 Clinical Trial.
The aim was to analyze the non-specific effects (placebo, spontaneous remission, and regression to the mean) of the low-level laser therapy (LLLT) in women with myofascial pain (painful temporomandibular disorder (TMD)), as well as to differentiate bet …
The aim was to analyze the non-specific effects (placebo, spontaneous remission, and regression to the mean) of the low-level …
Effect of low-level laser therapy (LLLT) on cognitive impairment among patients with chronic schizophrenia: a double-blind randomized placebo-controlled clinical trial.
Kheradmand A, Tabeie F, Seif P, Rezaei O, Yasamy MT. Kheradmand A, et al. Lasers Med Sci. 2022 Aug;37(6):2717-2725. doi: 10.1007/s10103-022-03545-9. Epub 2022 Mar 22. Lasers Med Sci. 2022. PMID: 35314926 Clinical Trial.
Low-level laser therapy (LLLT) is a noninvasive technique used in different medical fields. ...Nevertheless, the depression/anxiety subscale in the PANSS test showed a significant reduction after 6 sessions but did not persist after 2 months. .. …
Low-level laser therapy (LLLT) is a noninvasive technique used in different medical fields. ...Nevertheless, the dep …
Very Low-Level Transcranial Photobiomodulation for Major Depressive Disorder: The ELATED-3 Multicenter, Randomized, Sham-Controlled Trial.
Iosifescu DV, Norton RJ, Tural U, Mischoulon D, Collins K, McDonald E, De Taboada L, Foster S, Cusin C, Yeung A, Clain A, Schoenfeld D, Hamblin MR, Cassano P. Iosifescu DV, et al. J Clin Psychiatry. 2022 Aug 8;83(5):21m14226. doi: 10.4088/JCP.21m14226. J Clin Psychiatry. 2022. PMID: 35950904 Clinical Trial.
Background: Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light might represent a treatment for major depressive disorder (MDD). ...The primary outcome was reduction in depression severity (Hamilton Depression Rating Sc …
Background: Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light might represent a treatment for major de …
Low-level Laser Therapy to Alleviate Pain of Local Anesthesia Injection in Children: A Randomized Control Trial.
Khan BS, Setty JV, Srinivasan I, Kibriya S, Anu S, Radhakrishna S, Milit Y. Khan BS, et al. Int J Clin Pediatr Dent. 2023 Nov;16(Suppl 3):283-287. doi: 10.5005/jp-journals-10005-2699. Int J Clin Pediatr Dent. 2023. PMID: 38268643 Free PMC article.
RESULTS: The study showed PBM exhibited the lowest mean scores of anxiety/pain using VAS, Wong-Baker Faces Pain Rating Scale, FLACC scale and pulse rate as compared to precooling, vibration, and topical anesthesia. ...HOW TO CITE THIS ARTICLE: Khan BS, Setty JV, Srinivasan …
RESULTS: The study showed PBM exhibited the lowest mean scores of anxiety/pain using VAS, Wong-Baker Faces Pain Rating Scale, FLACC s …
Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.
Li Q, Zhang X, Yang X, Pan N, Li X, Kemp GJ, Wang S, Gong Q. Li Q, et al. Neurobiol Stress. 2023 Oct 1;27:100578. doi: 10.1016/j.ynstr.2023.100578. eCollection 2023 Nov. Neurobiol Stress. 2023. PMID: 37842018 Free PMC article.
BACKGROUND: Social anxiety (SA) is a negative emotional response that can lead to mental health issues, which some have experienced during the coronavirus disease 2019 (COVID-19) pandemic. ...In terms of nodal network parameters, SA alterations were positively linked to a …
BACKGROUND: Social anxiety (SA) is a negative emotional response that can lead to mental health issues, which some have experienced d …
Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.
Disner SG, Beevers CG, Gonzalez-Lima F. Disner SG, et al. Brain Stimul. 2016 Sep-Oct;9(5):780-787. doi: 10.1016/j.brs.2016.05.009. Epub 2016 May 24. Brain Stimul. 2016. PMID: 27267860 Free PMC article. Clinical Trial.
BACKGROUND: Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. ...Minimal change in depression was observed in the left and sham LLLT. CONCLUSION …
BACKGROUND: Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement sh …
Reported Side Effects, Weight and Blood Pressure, After Repeated Sessions of Transcranial Photobiomodulation.
Cassano P, Caldieraro MA, Norton R, Mischoulon D, Trinh NH, Nyer M, Dording C, Hamblin MR, Campbell B, Iosifescu DV. Cassano P, et al. Photobiomodul Photomed Laser Surg. 2019 Oct;37(10):651-656. doi: 10.1089/photob.2019.4678. Photobiomodul Photomed Laser Surg. 2019. PMID: 31647774 Clinical Trial.
NIR t-PBM recently emerged as a potential therapy for depression, although safety of repeated treatments has not been adequately explored. Objective: This study assessed incidence of side effects, including weight and blood pressure changes, during repeated sessions …
NIR t-PBM recently emerged as a potential therapy for depression, although safety of repeated treatments has not been adequate …
Photobiomodulation's potential as a non-invasive therapy for alzheimer's disease and minimal cognitive impairment: A 12-week investigation.
Razzaghi M, Sheibani F, Kimia N, Razzaghi Z, Chenari Z, Ashrafi F, Barati M, Advani S. Razzaghi M, et al. Photodiagnosis Photodyn Ther. 2024 Apr;46:103991. doi: 10.1016/j.pdpdt.2024.103991. Epub 2024 Feb 16. Photodiagnosis Photodyn Ther. 2024. PMID: 38367922 Free article.
RESULTS: The mean reduction of Hamilton's anxiety questionnaire score was 3.336.08 in the intervention group and 2.003.46 in the control group (p-value=0.836). The mean score reduction of the Hamilton depression questionnaire was 3.163.86 in the intervention group a …
RESULTS: The mean reduction of Hamilton's anxiety questionnaire score was 3.336.08 in the intervention group and 2.003.46 in the cont …
Botulinum toxin A (BT-A) versus low-level laser therapy (LLLT) in chronic migraine treatment: a comparison.
Loeb LM, Amorim RP, Mazzacoratti MDGN, Scorza FA, Peres MFP. Loeb LM, et al. Arq Neuropsiquiatr. 2018 Oct;76(10):663-667. doi: 10.1590/0004-282X20180109. Arq Neuropsiquiatr. 2018. PMID: 30427505 Free article. Clinical Trial.
OBJECTIVE: The aim of this work was to evaluate patients with chronic migraine treated with botulinum toxin A (BT-A) and compare this with low level laser therapy (LLLT), referencing: pain days, pain intensity, intake of drugs/self-medication, anxiety …
OBJECTIVE: The aim of this work was to evaluate patients with chronic migraine treated with botulinum toxin A (BT-A) and compare this with …
Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial.
Germano Maciel D, Trajano da Silva M, Rodrigues JA, Viana Neto JB, de França IM, Melo ABM, Barros da Silva TYP, de Brito Vieira WH. Germano Maciel D, et al. Lasers Med Sci. 2018 Dec;33(9):1949-1959. doi: 10.1007/s10103-018-2561-2. Epub 2018 Jun 21. Lasers Med Sci. 2018. PMID: 29931588 Clinical Trial.
This study aims to investigate the effects of low-level laser therapy (LLLT) combined to a functional exercise program on treatment of FM. ...Pre- and post-intervention evaluations regarding pain (sites, intensity, and threshold), functional performance (bala …
This study aims to investigate the effects of low-level laser therapy (LLLT) combined to a functional exercise program …
Effects of transcranial photobiomodulation with near-infrared light on sexual dysfunction.
Cassano P, Dording C, Thomas G, Foster S, Yeung A, Uchida M, Hamblin MR, Bui E, Fava M, Mischoulon D, Iosifescu DV. Cassano P, et al. Lasers Surg Med. 2019 Feb;51(2):127-135. doi: 10.1002/lsm.23011. Epub 2018 Sep 17. Lasers Surg Med. 2019. PMID: 30221776 Free PMC article. Clinical Trial.
NIR t-PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessions of NIR t-PBM on sexual dysfunction. METHODS: We performed a secondary analysis of a double-blind clinical trial on t-PBM for major dep …
NIR t-PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessio …
Photobiomodulation using low-level laser therapy (LLLT) for patients with chronic traumatic brain injury: a randomized controlled trial study protocol.
Poiani GDCR, Zaninotto AL, Carneiro AMC, Zangaro RA, Salgado ASI, Parreira RB, de Andrade AF, Teixeira MJ, Paiva WS. Poiani GDCR, et al. Trials. 2018 Jan 8;19(1):17. doi: 10.1186/s13063-017-2414-5. Trials. 2018. PMID: 29310710 Free PMC article.
BACKGROUND: Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). ...Memory domain, attention, executive functioning, and visual construction will …
BACKGROUND: Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimi …
Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment.
da Silva MM, Albertini R, de Tarso Camillo de Carvalho P, Leal-Junior ECP, Bussadori SK, Vieira SS, Bocalini DS, de Oliveira LVF, Grandinetti V, Silva JA Jr, Serra AJ. da Silva MM, et al. Lasers Med Sci. 2018 Feb;33(2):343-351. doi: 10.1007/s10103-017-2388-2. Epub 2017 Nov 23. Lasers Med Sci. 2018. PMID: 29170901 Clinical Trial.
There was an overlap of therapies to reduce the tender point numbers, anxiety, depression, fatigue, sleep, and difficulty sleeping on FIQ/RDC scores. Moreover, quality of life was improved with both therapies. ...A more substantial effect was noticed for the combine …
There was an overlap of therapies to reduce the tender point numbers, anxiety, depression, fatigue, sleep, and difficulty slee …
Selective photobiomodulation for emotion regulation: model-based dosimetry study.
Cassano P, Tran AP, Katnani H, Bleier BS, Hamblin MR, Yuan Y, Fang Q. Cassano P, et al. Neurophotonics. 2019 Jan;6(1):015004. doi: 10.1117/1.NPh.6.1.015004. Epub 2019 Feb 7. Neurophotonics. 2019. PMID: 30796882 Free PMC article.
The transcranial photobiomodulation (t-PBM) technique is a promising approach for the treatment of a wide range of neuropsychiatric disorders, including disorders characterized by poor regulation of emotion such as major depressive disorder (MDD …
The transcranial photobiomodulation (t-PBM) technique is a promising approach for the treatment of a wide range of neuropsychiatric …
Investigating factors associated with depression of older women in Macau.
Chan MF, Zeng W. Chan MF, et al. J Clin Nurs. 2009 Nov;18(21):2969-77. doi: 10.1111/j.1365-2702.2009.02867.x. Epub 2009 Sep 3. J Clin Nurs. 2009. PMID: 19732244

The results showed that variables like having hypertension (p = 0.010), a poor social network (p < 0.001), low self-perceived scores on health status (p < 0.001) and ability to meet living costs (p < 0.001), and a low level of ability to do housework (p &lt

…

The results showed that variables like having hypertension (p = 0.010), a poor social network (p < 0.001), low self-perceived scores on h

…
Non-pharmacological interventions for acute pain management in patients with opioid abuse or opioid tolerance: a scoping review protocol.
Hargett JL, Criswell AC. Hargett JL, et al. JBI Database System Rev Implement Rep. 2019 Jul;17(7):1283-1289. doi: 10.11124/JBISRIR-2017-003878. JBI Database System Rev Implement Rep. 2019. PMID: 30864979
Non-pharmacological techniques have shown potential in reducing postoperative pain, opioid consumption, stress and anxiety. INCLUSION CRITERIA: Eligible studies will include participants in a hospital or healthcare facility who are experiencing acute pain and have a …
Non-pharmacological techniques have shown potential in reducing postoperative pain, opioid consumption, stress and anxiety. IN …
Acne Treatment With 3-Step Broadband Light Protocol.
Bitter P Jr. Bitter P Jr. J Drugs Dermatol. 2016 Nov 1;15(11):1382-1388. J Drugs Dermatol. 2016. PMID: 28095551
BACKGROUND AND OBJECTIVE: A new 3-step protocol using broadband light allows patients with moderate to severe in ammatory acne to avoid potential side effects of systemic acne treatments and the risks and uncertainties associated with laser and light treatments to d …
BACKGROUND AND OBJECTIVE: A new 3-step protocol using broadband light allows patients with moderate to severe in ammatory acne to avo …
Therapeutic effects of 10-HzPulsed wave lasers in rat depression model: A comparison between near-infrared and red wavelengths.
Salehpour F, Rasta SH, Mohaddes G, Sadigh-Eteghad S, Salarirad S. Salehpour F, et al. Lasers Surg Med. 2016 Sep;48(7):695-705. doi: 10.1002/lsm.22542. Epub 2016 Jul 1. Lasers Surg Med. 2016. PMID: 27367569
BACKGROUND AND OBJECTIVE: The application of transcranial low-level light/laser therapy (tLLLT) in the range of red to near-infrared (NIR) spectrum for psychological disorders is a new area that is attracting growing interest in recent years. .. …
BACKGROUND AND OBJECTIVE: The application of transcranial low-level light/laser therapy (tLLLT) in the range of …
The effects of music and muscle relaxation on patient anxiety in a coronary care unit.
Elliott D. Elliott D. Heart Lung. 1994 Jan-Feb;23(1):27-35. Heart Lung. 1994. PMID: 8150641 Clinical Trial.
OUTCOME MEASURES: Psychologic (State Trait Anxiety Inventory, Hospital Anxiety and Depression Scale, Linear Analogue Anxiety Scale) and physiologic (systolic and diastolic blood pressure and heart rate) variables were measured as indicators of anxie …
OUTCOME MEASURES: Psychologic (State Trait Anxiety Inventory, Hospital Anxiety and Depression Scale, Linear Analogue …
Unilateral transcranial photobiomodulation for opioid addiction in a clinical practice: A clinical overview and case series.
Schiffer F. Schiffer F. J Psychiatr Res. 2021 Jan;133:134-141. doi: 10.1016/j.jpsychires.2020.12.004. Epub 2020 Dec 3. J Psychiatr Res. 2021. PMID: 33340792 Free article.
INTRODUCTION: Opioid Use Disorders (OUD) cause great disfunction and pain to individuals, families, and societies. ...This paper presents a novel, easily applied, painless, therapy that can be applied as an adjunct to psychotherapies and medications. METHODS: The au …
INTRODUCTION: Opioid Use Disorders (OUD) cause great disfunction and pain to individuals, families, and societies. ...This paper pres …
A Novel Treatment of Opioid Cravings With an Effect Size of .73 for Unilateral Transcranial Photobiomodulation Over Sham.
Schiffer F, Reichmann W, Flynn E, Hamblin MR, McCormack H. Schiffer F, et al. Front Psychiatry. 2020 Aug 19;11:827. doi: 10.3389/fpsyt.2020.00827. eCollection 2020. Front Psychiatry. 2020. PMID: 32973577 Free PMC article.
BACKGROUND: Opioid use disorders (OUDs) are an epidemic causing catastrophic consequences to individuals, families, and society despite treatments including psychotherapy, substitution therapy or receptor blockers, and psychoeducation. ...Secondary outcomes were wee …
BACKGROUND: Opioid use disorders (OUDs) are an epidemic causing catastrophic consequences to individuals, families, and society despi …
Comparison of low-level laser treatment and extracorporeal shock wave therapy in subacromial impingement syndrome: a randomized, prospective clinical study.
Badıl Güloğlu S. Badıl Güloğlu S. Lasers Med Sci. 2021 Jun;36(4):773-781. doi: 10.1007/s10103-020-03093-0. Epub 2020 Jul 7. Lasers Med Sci. 2021. PMID: 32638239 Clinical Trial.
The aim of this study was to compare the efficacy of low-level laser treatment (LLLT) and extracorporeal shock wave therapy (ESWT) in the treatment of subacromial impingement syndrome (SIS). ...All patients, before treatment, at the end of treatment, and 3 mo …
The aim of this study was to compare the efficacy of low-level laser treatment (LLLT) and extracorporeal shock wave therapy …
Treatment of chronic symptoms following mild traumatic brain injury with transcranial LED: a sham run-in pilot study of photobiomodulation therapy.
Karr JE, Iverson GL, Boudreau N, Zafonte R. Karr JE, et al. Brain Inj. 2024 May 11;38(6):425-435. doi: 10.1080/02699052.2024.2309258. Epub 2024 Feb 8. Brain Inj. 2024. PMID: 38329020
PRIMARY OBJECTIVE: We evaluated whether photobiomodulation with red/near infrared light applied transcranially via light emitting diodes (LED) was associated with reduced symptoms and improved cognitive functioning in patients with chronic symptoms following …
PRIMARY OBJECTIVE: We evaluated whether photobiomodulation with red/near infrared light applied transcranially via light …
Photobiomodulation therapy for the treatment of vulvar pain among those with provoked vestibulodynia: a randomized controlled trial.
I Antonio F, Pukall C, McLean L. I Antonio F, et al. J Sex Med. 2025 Apr 15;22(4):579-587. doi: 10.1093/jsxmed/qdaf011. J Sex Med. 2025. PMID: 39940084 Clinical Trial.
OBJECTIVE: To determine whether a 15-session photobiomodulation (PBM) intervention is more effective than sham-PBM for reducing vulvar pain. ...Secondary outcomes: pain-related domains reported on the VPAQ, sexual function, depression, anxiety and stress …
OBJECTIVE: To determine whether a 15-session photobiomodulation (PBM) intervention is more effective than sham-PBM for reducing vulva …
User Personas for eHealth Regarding the Self-Management of Depressive Symptoms in People Living With HIV: Mixed Methods Study.
Zhao T, Tang C, Ma J, Yan H, Su X, Zhong X, Wang H. Zhao T, et al. J Med Internet Res. 2025 Feb 17;27:e56289. doi: 10.2196/56289. J Med Internet Res. 2025. PMID: 39960763 Free PMC article.
Low-level self-managers had relatively low levels of self-efficacy, self-management abilities of depressive symptoms, and eHealth literacy. Low-level self-managers had an acceptable attitude toward using eHealth for the self-management of dep …
Low-level self-managers had relatively low levels of self-efficacy, self-management abilities of depressive symptoms, a …
Laser acupuncture for depression: a randomised double blind controlled trial using low intensity laser intervention.
Quah-Smith I, Smith C, Crawford JD, Russell J. Quah-Smith I, et al. J Affect Disord. 2013 Jun;148(2-3):179-87. doi: 10.1016/j.jad.2012.11.058. Epub 2013 Jan 19. J Affect Disord. 2013. PMID: 23337655 Clinical Trial.
Participants aged 18-50 years with DSM-IV major depressive disorder were eligible to join the study. Forty-seven participants were randomised to receive laser acupuncture or placebo laser at acupoints LR14, CV14, LR8, HT7 and KI3. ...The primary outcome assessed the …
Participants aged 18-50 years with DSM-IV major depressive disorder were eligible to join the study. Forty-seven participants …
Phototherapy and Tailored Brushing Method. Personalized Oral Care in Patients with Facial and Dental Trauma. A Report of a Case.
Nardi GM, Guerra F, Ndokaj A, Corridore D, Straker MA, Sportelli P, Di Giorgio R, Grassi FR, Grassi R, Ottolenghi L. Nardi GM, et al. Healthcare (Basel). 2021 May 11;9(5):561. doi: 10.3390/healthcare9050561. Healthcare (Basel). 2021. PMID: 34064547 Free PMC article.
Dental trauma often results in augmented dental anxiety. Phototherapy can improve stress and pain control thereby improving compliance in young patients with the necessary dental treatments, after dental trauma has occurred. (2) Methods: Phototherapy was performed t …
Dental trauma often results in augmented dental anxiety. Phototherapy can improve stress and pain control thereby improving co …
Changes in Brain Function and Structure After Self-Administered Home Photobiomodulation Treatment in a Concussion Case.
Chao LL, Barlow C, Karimpoor M, Lim L. Chao LL, et al. Front Neurol. 2020 Sep 8;11:952. doi: 10.3389/fneur.2020.00952. eCollection 2020. Front Neurol. 2020. PMID: 33013635 Free PMC article.
Traumatic brain injury (TBI) is a common neurological disorder among athletes. Although there are no widely accepted treatments for TBI, new investigational approaches, such as photobiomodulation (PBM), are being tested. PBM is a light therapy that use …
Traumatic brain injury (TBI) is a common neurological disorder among athletes. Although there are no widely accepted treatments for T …
Successful Treatment of a Cervical Injury and Myopathy Using Integrative Medicine Techniques in an Eclectus Parrot (Eclectus roratus) Following Cervical Entrapment.
Hale Mitchell LK, Koh RB, Nevarez JG. Hale Mitchell LK, et al. J Avian Med Surg. 2023 Sep;37(2):175-179. doi: 10.1647/22-00013. J Avian Med Surg. 2023. PMID: 37733456
Severe ventroflexion of the cervical spine and mental depression were identified during the physical examination. The bird was responsive to stimuli but otherwise quiet. ...Treatment was initiated with supportive therapy for presumptive shock, dehydration, pain, myo …
Severe ventroflexion of the cervical spine and mental depression were identified during the physical examination. The bird was respon …
A randomized pilot study to assess the safety and the value of low-level laser therapy versus clonazepam in patients with burning mouth syndrome.
Arduino PG, Cafaro A, Garrone M, Gambino A, Cabras M, Romagnoli E, Broccoletti R. Arduino PG, et al. Lasers Med Sci. 2016 May;31(4):811-6. doi: 10.1007/s10103-016-1897-8. Epub 2016 Feb 12. Lasers Med Sci. 2016. PMID: 26873501 Free article. Clinical Trial.
Comparison between low-level laser therapy (LLLT) and clonazepam for treating burning mouth syndrome (BMS) patients has never been documented; the aim of this study was to assess the effects of LLLT photobiomodulation versus medical therapy with …
Comparison between low-level laser therapy (LLLT) and clonazepam for treating burning mouth syndrome (BMS) patients has …
Effect of Low-level LASER Therapy on P6 Acupoint to Control Gag Reflex in Children: A Clinical Trial.
Goel H, Mathur S, Sandhu M, Jhingan P, Sachdev V. Goel H, et al. J Acupunct Meridian Stud. 2017 Oct;10(5):317-323. doi: 10.1016/j.jams.2017.07.002. Epub 2017 Jul 28. J Acupunct Meridian Stud. 2017. PMID: 29078966 Free article. Clinical Trial.
OBJECTIVE: To investigate the effect of low level laser therapy (LLLT) on PC6 acupuncture point in suppressing gag reflex, regulating pulse rates and oxygen saturation, thereby reducing the anxiety levels. ...In group B (20 patients), steps were revers …
OBJECTIVE: To investigate the effect of low level laser therapy (LLLT) on PC6 acupuncture point in suppressing gag refl …
Effectiveness of low-level laser therapy in reducing pain perception of children during dental local anesthetic administration using laser acupuncture pen on the LI4 point: a randomized clinical trial.
Pooja B, Kamatham R, Anchala K, Avisa P. Pooja B, et al. Eur Arch Paediatr Dent. 2023 Apr;24(2):219-227. doi: 10.1007/s40368-023-00780-8. Epub 2023 Jan 16. Eur Arch Paediatr Dent. 2023. PMID: 36645646 Clinical Trial.
Hence, the present study aims to determine the effect of low-level laser therapy on the LI4 point, using a laser acupuncture pen, in reducing children's pain during local anesthetic (LA) administration. ...CONCLUSION: Based on the study findings, within the l …
Hence, the present study aims to determine the effect of low-level laser therapy on the LI4 point, using a laser acupun …
Transcranial Laser Therapy Does Not Improve Cognitive and Post-Traumatic Stress Disorder-Related Behavioral Traits in Rats Exposed to Repetitive Low-Level Blast Injury.
Perez Garcia G, Perez GM, Otero-Pagan A, Abutarboush R, Kawoos U, De Gasperi R, Gama Sosa MA, Pryor D, Hof PR, Cook DG, Gandy S, Ahlers ST, Elder GA. Perez Garcia G, et al. Neurotrauma Rep. 2021 Dec 2;2(1):548-563. doi: 10.1089/neur.2021.0005. eCollection 2021. Neurotrauma Rep. 2021. PMID: 34901948 Free PMC article.
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from chronic cognitive and mental health problems, including post-traumatic stress disorder (PTSD). Transcranial …
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from ch …
High energy density LED-based photobiomodulation inhibits squamous cell carcinoma progression in co-cultures in vitro.
Takemoto MM, Garcez AS, Sperandio M. Takemoto MM, et al. J Photochem Photobiol B. 2019 Oct;199:111592. doi: 10.1016/j.jphotobiol.2019.111592. Epub 2019 Aug 14. J Photochem Photobiol B. 2019. PMID: 31479916
Current management of oral potentially malignant disorders is careful monitoring. Unfortunately, the 'watch and wait' approach only generates anxiety and a feeling of powerlessness, especially to those caring for patients. Photobiomodulation (PBM) has emerged …
Current management of oral potentially malignant disorders is careful monitoring. Unfortunately, the 'watch and wait' approach only g …
Integrated Cooling-Vacuum-Assisted Non-Fractional 1540 nm Erbium:Glass Laser is Effective in Treating Acne Scars.
Politi Y, Levi A, Lapidoth M. Politi Y, et al. J Drugs Dermatol. 2016 Nov 1;15(11):1359-1363. J Drugs Dermatol. 2016. PMID: 28095548
Among which, atrophic scars are the most prevalent form, presenting as dermal depressions caused by inflammatory degeneration of dermal collagen. Mid-infrared laser skin interaction is characterized by its modest absorption in water and nite penetration to the mid-dermis. …
Among which, atrophic scars are the most prevalent form, presenting as dermal depressions caused by inflammatory degeneration of derm …
Study of transcranial therapy 904 nm in experimental model of stroke.
de Jesus Fonseca EG, Pedroso A, Neuls D, Barbosa D, Cidral-Filho FJ, Salgado ASI, Dubiela A, Carraro E, Kerppers II. de Jesus Fonseca EG, et al. Lasers Med Sci. 2019 Oct;34(8):1619-1625. doi: 10.1007/s10103-019-02758-9. Epub 2019 Mar 2. Lasers Med Sci. 2019. PMID: 30826952
The objective of the present study was to evaluate the effects of photobiomodulation with a light-emitting diode (LED) device (904 nm, 110 mW, 7 J/cm(2)) on neurogenesis, muscle resistance, and motor behavior in animals submitted to an experimental model of hemipleg …
The objective of the present study was to evaluate the effects of photobiomodulation with a light-emitting diode (LED) device …
Near-Infrared Stimulation in Psychiatry Disorders: A Systematic Review of Efficacy and Biological Mechanisms.
Woźniak J, Pazdrak M, Domanasiewicz A, Kaźmierski J. Woźniak J, et al. NeuroSci. 2025 Mar 17;6(1):26. doi: 10.3390/neurosci6010026. NeuroSci. 2025. PMID: 40137870 Free PMC article. Review.
BACKGROUND: Photobiomodulation (PBM), also referred to as low-level light therapy (LLLT), is an emerging non-pharmacological approach. ...Publications focused on PBM treatment in psychiatric disorders such as major depressive di …
BACKGROUND: Photobiomodulation (PBM), also referred to as low-level light therapy (LLLT), is an emerging …
Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study.
Naeser MA, Zafonte R, Krengel MH, Martin PI, Frazier J, Hamblin MR, Knight JA, Meehan WP 3rd, Baker EH. Naeser MA, et al. J Neurotrauma. 2014 Jun 1;31(11):1008-17. doi: 10.1089/neu.2013.3244. Epub 2014 May 8. J Neurotrauma. 2014. PMID: 24568233 Free PMC article.
Application of red/NIR light improves mitochondrial function (especially in hypoxic/compromised cells) promoting increased adenosine triphosphate (ATP) important for cellular metabolism. ...Participants reported improved sleep, and fewer post-traumatic str …
Application of red/NIR light improves mitochondrial function (especially in hypoxic/compromised cells) promoting increased adenosine …
Effect of Photobiomodulation Therapy with 915 nm Diode Laser on Pain Perception during Local Anesthesia of Maxillary Incisors: A Randomized Controlled Trial.
Kermanshah H, Chiniforush N, Kolahdouz Mohammadi M, Motevasselian F. Kermanshah H, et al. Photochem Photobiol. 2022 Nov;98(6):1471-1475. doi: 10.1111/php.13644. Epub 2022 Jun 6. Photochem Photobiol. 2022. PMID: 35546299 Clinical Trial.
This study aimed to evaluate the effect of photobiomodulation therapy (PBMT) with 915 nm wavelength on pain reduction during maxillary incisors' local infiltration in a randomized clinical trial study. ...In this study's condition, diode PBMT reduced pain during inf …
This study aimed to evaluate the effect of photobiomodulation therapy (PBMT) with 915 nm wavelength on pain reduction during m …
The effect of Laser and taping on pain, functional status and quality of life in patients with fibromyalgia syndrome: A placebo- randomized controlled clinical trial.
Vayvay ES, Tok D, Turgut E, Tunay VB. Vayvay ES, et al. J Back Musculoskelet Rehabil. 2016;29(1):77-83. doi: 10.3233/BMR-150600. J Back Musculoskelet Rehabil. 2016. PMID: 26406218 Clinical Trial.
OBJECTIVE: The aim of this study was to investigate the effects of Laser and taping applications on pain, flexibility, anxiety, depression, functional status and quality of life in patients with fibromyalgia syndrome. ...Visual analogue scale for pain intensity, tru …
OBJECTIVE: The aim of this study was to investigate the effects of Laser and taping applications on pain, flexibility, anxiety, de …
Is low-level laser therapy useful as an adjunctive treatment for canine acral lick dermatitis? A randomized, double-blinded, sham-controlled study.
Schnedeker AH, Cole LK, Diaz SF, Lorch G, Rajala-Shultz PJ, Jennings RN, Hostnik ET, Daniels JB. Schnedeker AH, et al. Vet Dermatol. 2021 Apr;32(2):148-e35. doi: 10.1111/vde.12921. Epub 2021 Jan 20. Vet Dermatol. 2021. PMID: 33471429
BACKGROUND: Conventional therapy for canine acral lick dermatitis (ALD) consists of systemic antibiotics and anti-anxiety medications. Low-level laser therapy (LLLT) is a noninvasive therapy used to treat inflammatory and painful conditio …
BACKGROUND: Conventional therapy for canine acral lick dermatitis (ALD) consists of systemic antibiotics and anti-anxiety medi …
Space-making effect for new bone formation by suppressing scar contraction of mucosal epithelium of rat tooth extraction wound using diode laser and CO2 laser treatment.
Taniguchi Y, Matsuzaki E, Daigo Y, Tsutsumi T, Fukuoka H, Kakura K, Egashira K, Takahashi K, Kido H. Taniguchi Y, et al. J Dent Sci. 2022 Apr;17(2):1001-1008. doi: 10.1016/j.jds.2021.11.004. Epub 2021 Nov 26. J Dent Sci. 2022. PMID: 35756813 Free PMC article.
Thus, the height of the alveolar crest decreases, causing significant depression of the alveolar mucosa. In this study, we created a rat tooth extraction model and examined the effects of laser irradiation by CO(2) and diode on the dynamics of myofibroblast expression thro …
Thus, the height of the alveolar crest decreases, causing significant depression of the alveolar mucosa. In this study, we created a …
The use of low-level laser therapy for controlling the gag reflex in children during intraoral radiography.
Elbay M, Tak Ö, Şermet Elbay Ü, Kaya C, Eryılmaz K. Elbay M, et al. Lasers Med Sci. 2016 Feb;31(2):355-61. doi: 10.1007/s10103-016-1869-z. Epub 2016 Jan 11. Lasers Med Sci. 2016. PMID: 26754182 Clinical Trial.
The current literature suggests that low-level laser stimulation of the PC 6 acupuncture points may prevent gagging. This study aimed to determine if low-level laser therapy (LLLT) can reduce the gag reflex in children undergoing intraoral maxil …
The current literature suggests that low-level laser stimulation of the PC 6 acupuncture points may prevent gagging. This stud …
Transcranial photobiomodulation with near-infrared light from childhood to elderliness: simulation of dosimetry.
Yuan Y, Cassano P, Pias M, Fang Q. Yuan Y, et al. Neurophotonics. 2020 Jan;7(1):015009. doi: 10.1117/1.NPh.7.1.015009. Epub 2020 Feb 24. Neurophotonics. 2020. PMID: 32118086 Free PMC article.
Significance: Major depressive disorder (MDD) affects over 40 million U.S. adults in their lifetime. Transcranial photobiomodulation (t-PBM) has been shown to be effective in treating MDD, but the current treatment dosage does not account for head and brain a …
Significance: Major depressive disorder (MDD) affects over 40 million U.S. adults in their lifetime. Transcranial photobiom …
Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial.
Cassano P, Petrie SR, Mischoulon D, Cusin C, Katnani H, Yeung A, De Taboada L, Archibald A, Bui E, Baer L, Chang T, Chen J, Pedrelli P, Fisher L, Farabaugh A, Hamblin MR, Alpert JE, Fava M, Iosifescu DV. Cassano P, et al. Photomed Laser Surg. 2018 Dec;36(12):634-646. doi: 10.1089/pho.2018.4490. Epub 2018 Oct 20. Photomed Laser Surg. 2018. PMID: 30346890 Free PMC article.
Objective: Our objective was to test the antidepressant effect of transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light in subjects suffering from major depressive disorder (MDD). Background: t-PBM with NIR light is a new treatm …
Objective: Our objective was to test the antidepressant effect of transcranial photobiomodulation (t-PBM) with near-infrared (NIR) …
Efficacy of diode-emitting diode (LED) photobiomodulation in pain management, facial edema, trismus, and quality of life after extraction of retained lower third molars: A randomized, double-blind, placebo-controlled clinical trial.
Tenis CA, Martins MD, Gonçalves MLL, Silva DFTD, Cunha Filho JJD, Martins MAT, Mesquita-Ferrari RA, Bussadori SK, Fernandes KPS. Tenis CA, et al. Medicine (Baltimore). 2018 Sep;97(37):e12264. doi: 10.1097/MD.0000000000012264. Medicine (Baltimore). 2018. PMID: 30212961 Free PMC article. Clinical Trial.
The objective of the present study is to evaluate the efficacy of photobiomodulation with light emitting diode (LED) in the control of pain, facial edema, trismus, and quality of life resulting from the extraction of retained lower third molars. ...The oral health i …
The objective of the present study is to evaluate the efficacy of photobiomodulation with light emitting diode (LED) in the co …
Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury.
Wu C, Li M, Chen Z, Feng S, Deng Q, Duan R, Liu TC, Yang L. Wu C, et al. Transl Psychiatry. 2025 Jan 11;15(1):8. doi: 10.1038/s41398-025-03228-3. Transl Psychiatry. 2025. PMID: 39799140 Free PMC article.
This study assessed the prophylactic efficacy of remote photobiomodulation (PBM) targeted at the lungs against rCHI-induced brain injury and associated behavioral deficits. ...Results demonstrated that remote PBM significantly improved depressive-like behaviors, mot …
This study assessed the prophylactic efficacy of remote photobiomodulation (PBM) targeted at the lungs against rCHI-induced brain inj …
Effects of low-level laser therapy on burning mouth syndrome.
Valenzuela S, Lopez-Jornet P. Valenzuela S, et al. J Oral Rehabil. 2017 Feb;44(2):125-132. doi: 10.1111/joor.12463. Epub 2016 Dec 22. J Oral Rehabil. 2017. PMID: 27893167 Clinical Trial.
To investigate low-level laser therapy (LLLT) applied to treat burning mouth syndrome (BMS). This prospective, comparative, partially blinded, single-centre, clinical trial of GaAlAs Laser, with 815 nm wavelength, included 44 BMS patients divided randomly int …
To investigate low-level laser therapy (LLLT) applied to treat burning mouth syndrome (BMS). This prospective, comparat …
Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrared Laser Stimulation.
Barrett DW, Beevers CG, Gonzalez-Lima F. Barrett DW, et al. Biol Psychiatry Glob Open Sci. 2025 Jan 9;5(2):100449. doi: 10.1016/j.bpsgos.2025.100449. eCollection 2025 Mar. Biol Psychiatry Glob Open Sci. 2025. PMID: 39990627 Free PMC article.
Cognitive behavioral therapy is a mainstream treatment for major depressive disorder. This is the first study to investigate whether TILS would augment the antidepressant effects of internet-based cognitive behavioral therapy. METHODS: Sixty participan …
Cognitive behavioral therapy is a mainstream treatment for major depressive disorder. This is the first study to invest …
Photobiomodulation therapy on puncture-associated pain: A controlled randomized double-blind clinical trial.
Ferreira GF, Machado GGA, Roncolato VL, Ramalho KM, Motta LJ, Bussadori SK, Duran CCG, Fernandes KPS, Mesquita Ferrari RA, Chiniforush N, Horliana ACRT. Ferreira GF, et al. Photochem Photobiol. 2025 May-Jun;101(3):771-781. doi: 10.1111/php.14027. Epub 2024 Oct 14. Photochem Photobiol. 2025. PMID: 39400883 Clinical Trial.
This study aimed to determine whether photobiomodulation therapy (PBMT), used as a pre-anesthetic, could modulate puncture pain and enhance the effectiveness of local anesthesia. ...Pain levels were measured using the visual analog scale, and anesthetic efficacy was …
This study aimed to determine whether photobiomodulation therapy (PBMT), used as a pre-anesthetic, could modulate puncture pai …
Singular and combined effects of transcranial infrared laser stimulation and exposure therapy: A randomized clinical trial.
Zaizar ED, Gonzalez-Lima F, Telch MJ. Zaizar ED, et al. Contemp Clin Trials. 2018 Sep;72:95-102. doi: 10.1016/j.cct.2018.07.012. Epub 2018 Aug 6. Contemp Clin Trials. 2018. PMID: 30092284
This RCT will test whether transcranial infrared laser stimulation (TILS) administered immediately following standard exposure therapy enhances the retention of fear extinction for naturally acquired pathological fear. ...Participants with elevated fear in any one of the f …
This RCT will test whether transcranial infrared laser stimulation (TILS) administered immediately following standard exposure therapy …
Low Energy Ultrapulse CO2 Fractional Laser Combined with Autologous Platelet-Rich Plasma in Periorbital Rejuvenation Treatment.
Qi Y, Sun C, Zhou Y, Luo L, Wang C. Qi Y, et al. J Invest Surg. 2025 Dec;38(1):2484543. doi: 10.1080/08941939.2025.2484543. Epub 2025 Apr 20. J Invest Surg. 2025. PMID: 40254943 Free article. Clinical Trial.
VISIA (wrinkles, texture), SOFT (skin elasticity, moisture), upper eyelid depression, and infraorbital hollowing were evaluated before and at 1, 3, and 6 months post-treatment. ...RESULTS: The combination group exhibited higher overall effective rate of GAIS, greater impro …
VISIA (wrinkles, texture), SOFT (skin elasticity, moisture), upper eyelid depression, and infraorbital hollowing were evaluated befor …
A novel 1565 nm non-ablative fractional device for stretch marks: A preliminary report.
Tretti Clementoni M, Lavagno R. Tretti Clementoni M, et al. J Cosmet Laser Ther. 2015 Jun;17(3):148-55. doi: 10.3109/14764172.2015.1007061. Epub 2015 Feb 27. J Cosmet Laser Ther. 2015. PMID: 25633176 Free PMC article. Clinical Trial.
Most patients showed improvement of > 50% in the volume of depressions and in lesion color (91.7% and 83.3% of patients, respectively). The average pain during treatment was generally defined as tolerable and the average downtime was 4 days. ...
Most patients showed improvement of > 50% in the volume of depressions and in lesion color (91.7% and 83.3% of patients, respectiv …
A Prospective, Split-Face, Comparative Study of Combined Treatment With Fractional Microneedle Radiofrequency and Nonablative 1927-nm Fractional Thulium Fiber Laser for Wrinkle Treatment.
Park MY, Hwang S, Chun SI, Kim SM, Almurayshid A, Oh SH. Park MY, et al. Dermatol Surg. 2021 Mar 1;47(3):e101-e105. doi: 10.1097/DSS.0000000000002672. Dermatol Surg. 2021. PMID: 32804892 Clinical Trial.
Overall improvement was assessed by patient global assessment (PGA) and investigator global assessment (IGA). Depression scores for the evaluation of wrinkles were objectively assessed by Antera 3D system. ...In addition, wrinkle grading scales and depression scores …
Overall improvement was assessed by patient global assessment (PGA) and investigator global assessment (IGA). Depression scores for t …
Achieving Dental Analgesia with the Erbium Chromium Yttrium Scandium Gallium Garnet Laser (2780 nm): A Protocol for Painless Conservative Treatment.
Poli R, Parker S. Poli R, et al. Photomed Laser Surg. 2015 Jul;33(7):364-71. doi: 10.1089/pho.2015.3928. Photomed Laser Surg. 2015. PMID: 26154724
The patient experience was tested before and after the treatment using a modified Visual Analogue Scale (VAS) and Children's Fear Survey Schedule-Dental Subscale (CFSS-DS) to evaluate pain and anxiety. RESULTS: Pain analysis indicated that 80% of patients (24 out of 30) fe …
The patient experience was tested before and after the treatment using a modified Visual Analogue Scale (VAS) and Children's Fear Survey Sch …
DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave® and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of "Dopamine Homeostasis" in the Face of the Opioid Crisis.
Bajaj A, Blum K, Bowirrat A, Gupta A, Baron D, Fugel D, Nicholson A, Fitch T, Downs BW, Bagchi D, Dennen CA, Badgaiyan RD. Bajaj A, et al. J Pers Med. 2022 Aug 30;12(9):1416. doi: 10.3390/jpm12091416. J Pers Med. 2022. PMID: 36143203 Free PMC article.
Established genetic factors can provide clear guidance in assessing the risk of addiction to substances and behaviors. Chronic stress can accumulate, forming difficult to recognize addiction patterns from both genetic and epigenetic (environmental) factors. ...This case st …
Established genetic factors can provide clear guidance in assessing the risk of addiction to substances and behaviors. Chronic stress …
Serotonin 5-HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model.
Depoortère R, Bardin L, Varney MA, Newman-Tancredi A. Depoortère R, et al. ACS Chem Neurosci. 2019 Jul 17;10(7):3101-3107. doi: 10.1021/acschemneuro.8b00661. Epub 2019 Apr 2. ACS Chem Neurosci. 2019. PMID: 30929419
When placed in an unfamiliar and brightly lit open-field, two adult male rats that have not previously interacted display a low level of social interaction (SI) attributed to an anxiety-like state. The SI test has therefore been used to explore anxiolytic/ant …
When placed in an unfamiliar and brightly lit open-field, two adult male rats that have not previously interacted display a low le …
Laser acupuncture for chronic non-specific low back pain: a controlled clinical trial.
Glazov G, Schattner P, Lopez D, Shandley K. Glazov G, et al. Acupunct Med. 2009 Sep;27(3):94-100. doi: 10.1136/aim.2009.000521. Acupunct Med. 2009. PMID: 19734378 Clinical Trial.
Secondary outcomes were patient global assessment, psychological distress (Depression Anxiety Stress Scale) and subjective wellbeing (Personal Wellbeing Index). Follow up was performed at 6 weeks and 6 months after completion of treatment. ...
Secondary outcomes were patient global assessment, psychological distress (Depression Anxiety Stress Scale) and subject …
Effects of low power laser and low dose amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial.
Gür A, Karakoc M, Nas K, Cevik R, Sarac J, Ataoglu S. Gür A, et al. Rheumatol Int. 2002 Sep;22(5):188-93. doi: 10.1007/s00296-002-0221-z. Epub 2002 Jul 6. Rheumatol Int. 2002. PMID: 12215864 Clinical Trial.
Depression was evaluated by a psychiatrist according to the Hamilton Depression Rate Scale and DSM IV criteria. ...Additionally, a significant difference was observed in depression score (P = 0.000) in the amitriptyline group in comparison to the laser group …
Depression was evaluated by a psychiatrist according to the Hamilton Depression Rate Scale and DSM IV criteria. ...Additionall …
[Prediction of depression by locus of control, learned resourcefulness and sociotropy-autonomy in hemodialysis patients].
Baydoğan M, Dağ I. Baydoğan M, et al. Turk Psikiyatri Derg. 2008 Spring;19(1):19-28. Turk Psikiyatri Derg. 2008. PMID: 18330740 Free article. Turkish.
OBJECTIVE: The aims of the present study were to investigate the effects of various personality variables, namely, the locus of control beliefs, learned resourcefulness and sociotropy-autonomy in the prediction of the level of depressiveness in hemodialysis patients. The d …
OBJECTIVE: The aims of the present study were to investigate the effects of various personality variables, namely, the locus of control beli …
Effects of Near-Infrared Light on Cerebral Bioenergetics Measured with Phosphorus Magnetic Resonance Spectroscopy.
Mintzopoulos D, Gillis TE, Tedford CE, Kaufman MJ. Mintzopoulos D, et al. Photomed Laser Surg. 2017 Aug;35(8):395-400. doi: 10.1089/pho.2016.4238. Epub 2017 Feb 9. Photomed Laser Surg. 2017. PMID: 28186868 Free PMC article.
OBJECTIVE: Cerebral photobiomodulation (PBM) improves mood and cognition. Cerebral metabolic enhancement is a mechanism proposed to underlie PBM effects. ...
OBJECTIVE: Cerebral photobiomodulation (PBM) improves mood and cognition. Cerebral metabolic enhancement is a mechanism proposed to u …
Effects of low-power laser auriculotherapy on the physical and emotional aspects in patients with temporomandibular disorders: A blind, randomized, controlled clinical trial.
Rodrigues MDF, Rodrigues ML, Bueno KS, Aroca JP, Camilotti V, Busato MCA, Mendonça MJ. Rodrigues MDF, et al. Complement Ther Med. 2019 Feb;42:340-346. doi: 10.1016/j.ctim.2018.12.010. Epub 2018 Dec 18. Complement Ther Med. 2019. PMID: 30670264 Clinical Trial.
OBJECTIVES: This study evaluated the effects of low-power laser auriculotherapy (LA) on the physical and emotional symptoms of patients with temporomandibular disorders (TMDs), in comparison with occlusal splints (OS). DESIGN: Randomized, blinded, prospective, non-inferior …
OBJECTIVES: This study evaluated the effects of low-power laser auriculotherapy (LA) on the physical and emotional symptoms of patients with …
Effect of nanohydroxyapatite associated with photobiomodulation in the control of dentin hypersensitivity: A randomized, double-blind, placebo-controlled clinical trial.
Alencar CD, Ortiz MI, Silva FA, Alves EB, Araújo JL, Silva CM. Alencar CD, et al. Am J Dent. 2020 Jun;33(3):138-144. Am J Dent. 2020. PMID: 32470239 Clinical Trial.
PURPOSE: To evaluate the effect of nanohydroxyapatite ( nHAP) associated with photobiomodulation (PBM) in the control of dentin hypersensitivity (DH). (C-Shape It). METHODS: 32 subjects with 83 hypersensitive teeth were randomized into four groups (N =8) : GPlacebo - simul …
PURPOSE: To evaluate the effect of nanohydroxyapatite ( nHAP) associated with photobiomodulation (PBM) in the control of dentin hyper …
Transcranial low-level infrared laser irradiation ameliorates depression induced by reserpine in rats.
Mohammed HS. Mohammed HS. Lasers Med Sci. 2016 Nov;31(8):1651-1656. doi: 10.1007/s10103-016-2033-5. Epub 2016 Jul 20. Lasers Med Sci. 2016. PMID: 27437987
Transcranial low-level infrared laser is a modality of therapy based on the principle of photons delivered in a non-invasive manner through the skull for the treatment of some neurological conditions such as psychological disorders, traumatic brain inj …
Transcranial low-level infrared laser is a modality of therapy based on the principle of photons delivered in a non-inv …
Low-Fluence Q-Switch 1064 Nm Laser Combined With Oral Tranexamic Acid: A Quicker Treatment for Laser-Induced Postinflammatory Hyperpigmentation.
Feng W, Yang L. Feng W, et al. J Cosmet Dermatol. 2025 Feb;24(2):e70018. doi: 10.1111/jocd.70018. J Cosmet Dermatol. 2025. PMID: 39927593 Free PMC article.
Obvious hyperpigmentation can lead to an ugly appearance and severe anxiety. Therefore, a fast and effective treatment for laser-induced PIH is necessary. ...
Obvious hyperpigmentation can lead to an ugly appearance and severe anxiety. Therefore, a fast and effective treatment for laser-indu …
Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice.
Ando T, Xuan W, Xu T, Dai T, Sharma SK, Kharkwal GB, Huang YY, Wu Q, Whalen MJ, Sato S, Obara M, Hamblin MR. Ando T, et al. PLoS One. 2011;6(10):e26212. doi: 10.1371/journal.pone.0026212. Epub 2011 Oct 18. PLoS One. 2011. PMID: 22028832 Free PMC article.
BACKGROUND AND OBJECTIVE: Transcranial low-level laser therapy (LLLT) using near-infrared light can efficiently penetrate through the scalp and skull and could allow non-invasive treatment for traumatic brain injury (TBI). In the present study, we comp …
BACKGROUND AND OBJECTIVE: Transcranial low-level laser therapy (LLLT) using near-infrared light can efficiently …
Transcranial photobiomodulation for reducing symptoms of autism spectrum disorder and modulating brain electrophysiology in children aged 2-7: an open label study.
Fradkin Y, Anguera JA, Simon AJ, De Taboada L, Steingold E. Fradkin Y, et al. Front Child Adolesc Psychiatry. 2025 Jan 29;4:1477839. doi: 10.3389/frcha.2025.1477839. eCollection 2025. Front Child Adolesc Psychiatry. 2025. PMID: 39944746 Free PMC article.
BACKGROUND: Small pilot studies have indicated that transcranial photobiomodulation (tPBM) may help alleviate symptoms of neurological conditions like depression, traumatic brain injury and Autism Spectrum Disorder (ASD). ...We delivered non-invasively to all …
BACKGROUND: Small pilot studies have indicated that transcranial photobiomodulation (tPBM) may help alleviate symptoms of neurologica …
Treatment of angiokeratoma of Fordyce with pulsed dye laser.
Lapidoth M, Ad-El D, David M, Azaria R. Lapidoth M, et al. Dermatol Surg. 2006 Sep;32(9):1147-50. doi: 10.1111/j.1524-4725.2006.32252.x. Dermatol Surg. 2006. PMID: 16970695
Although considered benign, the lesions may bleed, either spontaneously or secondary to rupture, leading to patient anxiety and social embarrassment. OBJECTIVE: The objective was to determine the safety and effectiveness of 585-nm pulsed dye laser for the treatment of angi …
Although considered benign, the lesions may bleed, either spontaneously or secondary to rupture, leading to patient anxiety and socia …
Efficiency of Early Sequential Laser Treatment for Facial Linear Scars in Cross-Sectional Regions.
Guo L, Xue P, Fan X, Yin Y, Dou W, Li T, Yang Q. Guo L, et al. J Cosmet Dermatol. 2025 Feb;24(2):e70053. doi: 10.1111/jocd.70053. J Cosmet Dermatol. 2025. PMID: 39943911 Free PMC article.
Antera 3D analysis revealed substantial improvements in average roughness, depression depth, and elevation depth across facial regions. The significance of improvements in color variation, texture elevation span, melanin hyperconcentration, and hemoglobin hyperconcentratio …
Antera 3D analysis revealed substantial improvements in average roughness, depression depth, and elevation depth across facial region …
Efficacy and safety of the 589/1319 nm solid-state dual-wavelength laser combined with topical benzoyl peroxide for inflammatory acne vulgaris: a split-face randomized controlled trial.
Boonpethkaew S, Ratanapokasatit Y, Chirasuthat S, Wattanakrai P. Boonpethkaew S, et al. Arch Dermatol Res. 2025 Mar 26;317(1):635. doi: 10.1007/s00403-025-04146-6. Arch Dermatol Res. 2025. PMID: 40140055 Free PMC article. Clinical Trial.
Inflammatory lesion count (ILC) and acne-related skin parameters, including hemoglobin level, melanin level, skin depression, and skin roughness were measured. Adverse events (AEs) and patients' satisfaction were assessed. ...On the adjunctive laser side, the change in ILC …
Inflammatory lesion count (ILC) and acne-related skin parameters, including hemoglobin level, melanin level, skin depression, and ski …
231 results