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1998 1
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140 results

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Page 1
Identification of essential genes for cancer immunotherapy.
Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia L, Steinberg SM, Yamamoto TN, Merchant AS, Mehta GU, Chichura A, Shalem O, Tran E, Eil R, Sukumar M, Guijarro EP, Day CP, Robbins P, Feldman S, Merlino G, Zhang F, Restifo NP. Patel SJ, et al. Nature. 2017 Aug 31;548(7669):537-542. doi: 10.1038/nature23477. Epub 2017 Aug 7. Nature. 2017. PMID: 28783722 Free PMC article.
The genes that were most enriched in the screen have key roles in antigen presentation and interferon-gamma signalling, and correlate with cytolytic activity in patient tumours from The Cancer Genome Atlas. Among the genes validated using different cancer cell lines …
The genes that were most enriched in the screen have key roles in antigen presentation and interferon-gamma signalling, and correlate with c …
APLNR inhibited nasopharyngeal carcinoma growth and immune escape by downregulating PD-L1.
Liu Y, Li N, Guo Y, Zhou Q, Yang Y, Lu J, Tian Z, Zhou J, Yan S, Li X, Shi L, Jiang S, Ge J, Feng R, Huang D, Zeng Z, Fan S, Xiong W, Li G, Zhang W. Liu Y, et al. Int Immunopharmacol. 2024 Aug 20;137:112523. doi: 10.1016/j.intimp.2024.112523. Epub 2024 Jun 22. Int Immunopharmacol. 2024. PMID: 38909500
BACKGROUND: APLNR is a G protein-coupled receptor and our previous study had revealed that APLNR could inhibit nasopharyngeal carcinoma (NPC) growth and metastasis. However, the role of APLNR in regulating PD-L1 expression and immune escape in NPC is unknown. …
BACKGROUND: APLNR is a G protein-coupled receptor and our previous study had revealed that APLNR could inhibit nasopharyngeal …
The Apelin/APLNR system modulates tumor immune response by reshaping the tumor microenvironment.
Yang Y, Chen M, Qiu Y, Li X, Huang Y, Zhang W. Yang Y, et al. Gene. 2022 Aug 5;834:146564. doi: 10.1016/j.gene.2022.146564. Epub 2022 May 20. Gene. 2022. PMID: 35598689 Review.
Apelin is an endogenous ligand of the Apelin receptor (APLNR), a seven-transmembrane G protein-coupled receptor, which is widely distributed in human tissue. ...These endeavors provide new insights into the translational application of Apelin/APLNR …
Apelin is an endogenous ligand of the Apelin receptor (APLNR), a seven-transmembrane G protein-coupled receptor, which …
APLNR Regulates IFN-gamma signaling via beta-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells.
Liu Y, Ma X, Yang H, Li X, Ma Y, Ason B, Liu S, Hu LA. Liu Y, et al. Biochem J. 2022 Feb 11;479(3):385-399. doi: 10.1042/BCJ20210813. Biochem J. 2022. PMID: 35084016
The apelin receptor (APLNR) regulates many biological processes including metabolism, angiogenesis, circulating blood volume and cardiovascular function. Additionally, APLNR is overexpressed in various types of cancer and influences cancer progr …
The apelin receptor (APLNR) regulates many biological processes including metabolism, angiogenesis, circulating blood volume a …
Silencing APLNR enhances the radiosensitivity of prostate cancer by modulating the PI3K/AKT/mTOR signaling pathway.
Li P, Cui Y, Hu K, Wang X, Yu Y. Li P, et al. Clin Transl Oncol. 2025 Apr;27(4):1728-1737. doi: 10.1007/s12094-024-03692-1. Epub 2024 Sep 10. Clin Transl Oncol. 2025. PMID: 39251496
BACKGROUND: Aberrant expression of apelin receptor (APLNR) has been found to be involved in various cancers' development, however, its function in prostate cancer (PCa) remains unclear. ...Next, silencing APLNR inhibited the PI3K/AKT/mTOR pathwa …
BACKGROUND: Aberrant expression of apelin receptor (APLNR) has been found to be involved in various cancers' developmen …
Apelin/APJ system and cancer.
Yang Y, Lv SY, Ye W, Zhang L. Yang Y, et al. Clin Chim Acta. 2016 Jun 1;457:112-6. doi: 10.1016/j.cca.2016.04.001. Epub 2016 Apr 13. Clin Chim Acta. 2016. PMID: 27083318 Review.
Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G protein-coupled receptor. ...In this article, we summarize the role of apelin/APJ system on lung cancer, gastroesophageal and colonic cancer, hepatocellular car …
Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G protein-coupled receptor. ...In this arti …
APLN/APLNR Signaling Controls Key Pathological Parameters of Glioblastoma.
Kälin RE, Glass R. Kälin RE, et al. Cancers (Basel). 2021 Aug 2;13(15):3899. doi: 10.3390/cancers13153899. Cancers (Basel). 2021. PMID: 34359800 Free PMC article. Review.
Furthermore, leaky vessels support edema-formation, which can result in severe neurological deficits. The secreted signaling peptide Apelin (APLN) plays an important role in the formation of GBM blood vessels. Both APLN and the Apelin receptor (APLNR) are upr …
Furthermore, leaky vessels support edema-formation, which can result in severe neurological deficits. The secreted signaling peptide Apel …
APLNR is involved in ATRA-induced growth inhibition of nasopharyngeal carcinoma and may suppress EMT through PI3K-Akt-mTOR signaling.
Liu Y, Liu Q, Chen S, Liu Y, Huang Y, Chen P, Li X, Gao G, Xu K, Fan S, Zeng Z, Xiong W, Tan M, Li G, Zhang W. Liu Y, et al. FASEB J. 2019 Nov;33(11):11959-11972. doi: 10.1096/fj.201802416RR. Epub 2019 Aug 13. FASEB J. 2019. PMID: 31408612
The apelin receptor (APLNR) is a GPCR involved in many pathophysiological processes; however, the correlation between APLNR expression and nasopharyngeal carcinoma (NPC) has not been reported. ...Taken together, our data suggest that APLNR could potent …
The apelin receptor (APLNR) is a GPCR involved in many pathophysiological processes; however, the correlation between APLNR …
Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target.
Chen J, Li Z, Zhao Q, Chen L. Chen J, et al. J Cell Physiol. 2022 Oct;237(10):3734-3751. doi: 10.1002/jcp.30845. Epub 2022 Aug 7. J Cell Physiol. 2022. PMID: 35933701 Review.
The treatment of cancer has always been an important research direction of scientific research. A number of studies have shown that the apelin/APJ system is involved in the development and poor prognosis of a variety of cancers, such as lung cancer, li …
The treatment of cancer has always been an important research direction of scientific research. A number of studies have shown that t …
APLNR stimulates the development of glioma via the NFAT5/AKT feedback loop.
Zhang ZP, Sun XQ, Yuan SJ. Zhang ZP, et al. Eur Rev Med Pharmacol Sci. 2020 Oct;24(20):10594-10600. doi: 10.26355/eurrev_202010_23416. Eur Rev Med Pharmacol Sci. 2020. PMID: 33155216 Free article.
Glioma patients expressing higher level of APLNR had more advanced stage and worse prognosis. Knockdown of APLNR inhibited proliferative ability of glioma. NFAT5 level was negatively regulated by APLNR. Notably, NFAT5 could partially abolish the regulatory ef …
Glioma patients expressing higher level of APLNR had more advanced stage and worse prognosis. Knockdown of APLNR inhibited pro …
140 results