Abstract
The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the most common human cancer. Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene. The ptc gene encodes a transmembrane protein that in Drosophila acts in opposition to the Hedgehog signaling protein, controlling cell fates, patterning, and growth in numerous tissues. The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Amino Acid Sequence
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Animals
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Basal Cell Nevus Syndrome / genetics*
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Base Sequence
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Cloning, Molecular
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DNA, Neoplasm
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Drosophila
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Drosophila Proteins*
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Female
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Frameshift Mutation
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Genes, Tumor Suppressor*
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Humans
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Insect Hormones / genetics
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Male
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Membrane Proteins / genetics*
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Middle Aged
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Molecular Sequence Data
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Patched Receptors
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Patched-1 Receptor
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Polymerase Chain Reaction
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Polymorphism, Single-Stranded Conformational
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Protein Conformation
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Receptors, Cell Surface
Substances
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DNA, Neoplasm
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Drosophila Proteins
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Insect Hormones
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Membrane Proteins
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PTCH1 protein, human
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Patched Receptors
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Patched-1 Receptor
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Receptors, Cell Surface
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ptc protein, Drosophila