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Year Number of Results
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708 results

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AREG Upregulation in Cancer Cells via Direct Interaction with Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression Through EGFR-Erk/p38 MAPK Signaling.
Nakanishi T, Koma YI, Miyako S, Torigoe R, Yokoo H, Omori M, Yamanaka K, Ishihara N, Tsukamoto S, Kodama T, Nishio M, Shigeoka M, Yokozaki H, Kakeji Y. Nakanishi T, et al. Cells. 2024 Oct 19;13(20):1733. doi: 10.3390/cells13201733. Cells. 2024. PMID: 39451251 Free PMC article.
Cancer-associated fibroblasts (CAFs) are a key component of the tumor microenvironment and significantly contribute to the progression of various cancers, including esophageal squamous cell carcinoma (ESCC). ...Bioinformatics analysis confirmed significant upregulat …
Cancer-associated fibroblasts (CAFs) are a key component of the tumor microenvironment and significantly contribute to the progressio …
AREG mediates the epithelial-mesenchymal transition in pancreatic cancer cells via the EGFR/ERK/NF-kappaB signalling pathway.
Wang L, Wang L, Zhang H, Lu J, Zhang Z, Wu H, Liang Z. Wang L, et al. Oncol Rep. 2020 May;43(5):1558-1568. doi: 10.3892/or.2020.7523. Epub 2020 Feb 27. Oncol Rep. 2020. PMID: 32323797 Free PMC article.
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. ...Tumour growth and metastasis were decreased by AREG silencing in an orthotopic model of pancreatic cancer. AREG may play a …
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. ...Tumo …
Amphiregulin couples IL1RL1(+) regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity.
Sun R, Zhao H, Gao DS, Ni A, Li H, Chen L, Lu X, Chen K, Lu B. Sun R, et al. Sci Adv. 2023 Aug 25;9(34):eadd7399. doi: 10.1126/sciadv.add7399. Epub 2023 Aug 23. Sci Adv. 2023. PMID: 37611111 Free PMC article.
Regulatory T (T(reg)) cells and cancer-associated fibroblasts (CAFs) jointly promote tumor immune tolerance and tumorigenesis. ...Moreover, AREG mAbs and IL-33 concertedly inhibited tumor growth. Our study reveals a previously unidentified AREG/EGFR-mediated …
Regulatory T (T(reg)) cells and cancer-associated fibroblasts (CAFs) jointly promote tumor immune tolerance and tumorigenesis. ...Mor …
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis.
Savage TM, Fortson KT, de Los Santos-Alexis K, Oliveras-Alsina A, Rouanne M, Rae SS, Gamarra JR, Shayya H, Kornberg A, Cavero R, Li F, Han A, Haeusler RA, Adam J, Schwabe RF, Arpaia N. Savage TM, et al. Immunity. 2024 Feb 13;57(2):303-318.e6. doi: 10.1016/j.immuni.2024.01.009. Epub 2024 Feb 2. Immunity. 2024. PMID: 38309273 Free PMC article.
Areg-producing Treg cells were enriched in the livers of mice and humans with NASH. Deletion of Areg in Treg cells, but not in myeloid cells, reduced NASH-induced liver fibrosis. ...Areg from Treg cells promoted hepatocyte gluconeogenesis through hepatocyte d …
Areg-producing Treg cells were enriched in the livers of mice and humans with NASH. Deletion of Areg in Treg cells, but not in …
miR-33a-3p regulates METTL3-mediated AREG stability and alters EMT to inhibit pancreatic cancer invasion and metastasis.
Su X, Lai T, Tao Y, Zhang Y, Zhao C, Zhou J, Chen E, Zhu M, Zhang S, Wang B, Mao Y, Hu H. Su X, et al. Sci Rep. 2023 Aug 21;13(1):13587. doi: 10.1038/s41598-023-39506-7. Sci Rep. 2023. PMID: 37604948 Free PMC article.
Recent studies have shown that amphoteric regulatory protein (AREG), a member of the epidermal growth factor (EGF) family, is expressed in many cancers and is an independent prognostic indicator for patients with pancreatic cancer, but whether AREG is …
Recent studies have shown that amphoteric regulatory protein (AREG), a member of the epidermal growth factor (EGF) family, is express …
Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.
Zaiss DMW, Gause WC, Osborne LC, Artis D. Zaiss DMW, et al. Immunity. 2015 Feb 17;42(2):216-226. doi: 10.1016/j.immuni.2015.01.020. Immunity. 2015. PMID: 25692699 Free PMC article. Review.
Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of type 2-mediated resistance and tolerance. Notably, numerous studies demonstrate that i …
Emerging data suggest that in addition to characteristic type 2-associated cytokines, the epidermal growth factor (EGF)-like molecule Amphir …
Renal cancer secretome induces migration of mesenchymal stromal cells.
Popławski P, Zarychta-Wiśniewska W, Burdzińska A, Bogusławska J, Adamiok-Ostrowska A, Hanusek K, Rybicka B, Białas A, Kossowska H, Iwanicka-Nowicka R, Koblowska M, Pączek L, Piekiełko-Witkowska A. Popławski P, et al. Stem Cell Res Ther. 2023 Aug 10;14(1):200. doi: 10.1186/s13287-023-03430-4. Stem Cell Res Ther. 2023. PMID: 37563650 Free PMC article.
AREG and FN1 stimulated, while DPP4 attenuated MSCs migration. RCC CM induced MSCs' transcriptional reprogramming, stimulating the expression of CD44, PTX3 and RAB27B. RCC cells secreted hyaluronic acid (HA), a CD44 ligand mediating MSCs' homing to the kidney. AREG …
AREG and FN1 stimulated, while DPP4 attenuated MSCs migration. RCC CM induced MSCs' transcriptional reprogramming, stimulating the ex …
Amphiregulin.
Berasain C, Avila MA. Berasain C, et al. Semin Cell Dev Biol. 2014 Apr;28:31-41. doi: 10.1016/j.semcdb.2014.01.005. Epub 2014 Jan 23. Semin Cell Dev Biol. 2014. PMID: 24463227 Review.
AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. ...Here we review the essential aspects of AREG structure, function and regulation, discuss the basis for its differential role within the EGFR fa …
AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. ...Here we re …
γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors.
Harmon C, Zaborowski A, Moore H, St Louis P, Slattery K, Duquette D, Scanlan J, Kane H, Kunkemoeller B, McIntyre CL, Scannail AN, Moran B, Anderson AC, Winter D, Brennan D, Brehm MA, Lynch L. Harmon C, et al. Nat Cancer. 2023 Aug;4(8):1122-1137. doi: 10.1038/s43018-023-00589-w. Epub 2023 Jul 20. Nat Cancer. 2023. PMID: 37474835
gammadelta T cells are important tissue-resident, innate T cells that are critical for tissue homeostasis. gammadelta cells are associated with positive prognosis in most tumors; however, little is known about their heterogeneity in human cancers. Here, we phenotyped innat …
gammadelta T cells are important tissue-resident, innate T cells that are critical for tissue homeostasis. gammadelta cells are associated w …
Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer.
Randon G, Pietrantonio F. Randon G, et al. Clin Cancer Res. 2023 Oct 13;29(20):4021-4023. doi: 10.1158/1078-0432.CCR-23-1954. Clin Cancer Res. 2023. PMID: 37594733 Free PMC article.
Overexpression of the EGFR ligands amphiregulin (AREG)/epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidedness in metastatic colorectal cancer. High AREG/EREG may be coupled with negative hyper-selection (i.e., lack of genomic drivers …
Overexpression of the EGFR ligands amphiregulin (AREG)/epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidednes …
708 results