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1998 1
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29 results

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Page 1
pANCA and ASCA in Children with IBD-Unclassified, Crohn's Colitis, and Ulcerative Colitis-A Longitudinal Report from the IBD Porto Group of ESPGHAN.
Birimberg-Schwartz L, Wilson DC, Kolho KL, Karolewska-Bochenek K, Afzal NA, Spray C, Romano C, Lionetti P, Hauer AC, Martinez-Vinson C, Veres G, Escher JC, Turner D; paediatric IBD Porto group of ESPGHAN. Birimberg-Schwartz L, et al. Inflamm Bowel Dis. 2016 Aug;22(8):1908-14. doi: 10.1097/MIB.0000000000000784. Inflamm Bowel Dis. 2016. PMID: 27135480
Median follow-up period was 2.8 years (interquartile range, 1.6-4.2). RESULTS: The most prevalent serologic profile in IBDU was pANCA-/ASCA- (41%), followed by pANCA+/ASCA- (34%) and pANCA-/ASCA+ (17%). pANCA-/ASCA+ d …
Median follow-up period was 2.8 years (interquartile range, 1.6-4.2). RESULTS: The most prevalent serologic profile in IBDU was pA
Diagnostic utility, disease activity, and disease phenotype correlation of serum ASCA, pANCA, and PR3-ANCA in pediatric inflammatory bowel disease.
Kim JM, Choi YM, Jung SA, Yang HR. Kim JM, et al. J Pediatr (Rio J). 2024 Mar-Apr;100(2):204-211. doi: 10.1016/j.jped.2023.10.005. Epub 2023 Nov 24. J Pediatr (Rio J). 2024. PMID: 38012956 Free PMC article.

RESULTS: In all, 229 pediatric patients with IBD (CD 147, UC 53, IBD-U 29) were included. The ASCA IgG seropositivity significantly differed among the three groups (CD 75.4%, UC 17.5%, and IBD-U 60.0%; p < 0.001). ...CONCLUSION: Serological biomarke

RESULTS: In all, 229 pediatric patients with IBD (CD 147, UC 53, IBD-U 29) were included. The ASCA IgG seropositivity s …
Serological Markers as Predictors of Anti-TNF Response in Children with Crohn's Disease.
Lisai-Goldstein Y, Focht G, Orlanski-Meyer E, Yogev D, Lev-Tzion R, Ledder O, Assa A, Navas-López VM, Baldassano RN, Otley A, Shouval DS, Griffiths AM, Turner D, Atia O. Lisai-Goldstein Y, et al. Dig Dis Sci. 2025 Jan;70(1):333-339. doi: 10.1007/s10620-024-08732-y. Epub 2024 Nov 27. Dig Dis Sci. 2025. PMID: 39604667
At baseline, 10 serological markers of the "PROMETHEUS IBD sgi Diagnostic test" were measured, including pANCA, ASCA IgG and IgA, anti-CBir1, anti-OmpC, anti-A4-Fla2, anti-Fla-X, SAA, ICAM-1 and VCAM-1. ...Further studies with larger sample sizes are needed …
At baseline, 10 serological markers of the "PROMETHEUS IBD sgi Diagnostic test" were measured, including pANCA, ASCA I …
Machine Learning in Antibody Diagnostics for Inflammatory Bowel Disease Subtype Classification.
Sokollik C, Pahud de Mortanges A, Leichtle AB, Juillerat P, Horn MP; Swiss IBD Cohort Study Group. Sokollik C, et al. Diagnostics (Basel). 2023 Jul 26;13(15):2491. doi: 10.3390/diagnostics13152491. Diagnostics (Basel). 2023. PMID: 37568854 Free PMC article.
Whether modern modeling techniques such as supervised and unsupervised machine learning are of value for finer distinction of subtypes such as IBD-unclassified (IBD-U) is not known. We determined the antibody profile of 100 adult IBD patients from the Swiss …
Whether modern modeling techniques such as supervised and unsupervised machine learning are of value for finer distinction of subtypes such …
Diagnostic role and clinical association of ASCA and ANCA in Brazilian patients with inflammatory bowel disease.
Nisihara RM, de Carvalho WB, Utiyama SR, Amarante H, Baptista ML. Nisihara RM, et al. Dig Dis Sci. 2010 Aug;55(8):2309-15. doi: 10.1007/s10620-009-0998-7. Epub 2009 Oct 14. Dig Dis Sci. 2010. PMID: 19826949
The combination of ASCA negativity and pANCA positivity (ASCA-/pANCA+) displayed sensitivity of 43% and specificity of 100% for diagnosis to UC. ...In UC patients, pANCA positivity was correlated with pancolitis or left colitis. CONCLUSIONS: The …
The combination of ASCA negativity and pANCA positivity (ASCA-/pANCA+) displayed sensitivity of 43% and specific …
Advances in clinical laboratory tests for inflammatory bowel disease.
Nakamura RM, Matsutani M, Barry M. Nakamura RM, et al. Clin Chim Acta. 2003 Sep;335(1-2):9-20. doi: 10.1016/s0009-8981(03)00286-9. Clin Chim Acta. 2003. PMID: 12927679 Review.
The CD and UC are considered to be distinct forms of IBD; but there is a subgroup of CD with a UC-like presentation. The genetic factors play a significant role in IBD. ...These markers include the following antibodies: (a) pANCA, (b) ASCA, (c) anti-pa …
The CD and UC are considered to be distinct forms of IBD; but there is a subgroup of CD with a UC-like presentation. The genetic fact …
Serological markers in inflammatory bowel disease: a review of their clinical utility.
Barahona-Garrido J, Sarti HM, Barahona-Garrido MK, Hernández-Calleros J, Coss-Adame E, Garcia-Saenz SM, Yamamoto-Furusho JK. Barahona-Garrido J, et al. Rev Gastroenterol Mex. 2009;74(3):230-7. Rev Gastroenterol Mex. 2009. PMID: 19858012 Review.
Assessing both ASCA and pANCA allows a better differentiation of Crohn's disease (CD) from ulcerative colitis (UC) than by using the individual tests alone. The ASCA+/pANCA- phenotype is characteristic of CD, while the ASCA-/pANCA+ …
Assessing both ASCA and pANCA allows a better differentiation of Crohn's disease (CD) from ulcerative colitis (UC) than by usi …
Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease.
Ruemmele FM, Targan SR, Levy G, Dubinsky M, Braun J, Seidman EG. Ruemmele FM, et al. Gastroenterology. 1998 Oct;115(4):822-9. doi: 10.1016/s0016-5085(98)70252-5. Gastroenterology. 1998. PMID: 9753483
The majority of patients with CD positive for pANCA had a UC-like presentation. Disease location, duration, activity, complications, and treatment with immunosuppressive drugs did not have an impact on the ASCA or pANCA assay results. ...CONCLUSIONS: ASCA
The majority of patients with CD positive for pANCA had a UC-like presentation. Disease location, duration, activity, complications, …
Utility of serological markers in inflammatory bowel diseases: gadget or magic?
Papp M, Norman GL, Altorjay I, Lakatos PL. Papp M, et al. World J Gastroenterol. 2007 Apr 14;13(14):2028-36. doi: 10.3748/wjg.v13.i14.2028. World J Gastroenterol. 2007. PMID: 17465443 Free PMC article. Review.
Creating homogenous disease sub-groups based on serologic response may help develop more standardized therapeutic approaches and may help in a better understanding of the pathomechanism of IBD. Further prospective clinical studies are needed to establish the clinica …
Creating homogenous disease sub-groups based on serologic response may help develop more standardized therapeutic approaches and may …
Characteristics of inflammatory bowel disease serology in patients with indeterminate colitis.
Sura SP, Ahmed A, Cheifetz AS, Moss AC. Sura SP, et al. J Clin Gastroenterol. 2014 Apr;48(4):351-5. doi: 10.1097/MCG.0000000000000083. J Clin Gastroenterol. 2014. PMID: 24492405 Free PMC article.
GOALS AND BACKGROUND: Inflammatory bowel disease (IBD) serology testing is often used in patients with indeterminate colitis (IC) to help distinguish between ulcerative colitis (UC) and Crohn's disease (CD). We investigated the performance of serology testing …
GOALS AND BACKGROUND: Inflammatory bowel disease (IBD) serology testing is often used in patients with indeterminate colitis ( …
29 results