Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1998 1
1999 1
2000 2
2001 2
2003 3
2005 1
2006 1
2007 2
2008 3
2009 2
2010 1
2011 2
2012 5
2013 6
2014 7
2015 9
2016 8
2017 7
2018 8
2019 15
2020 15
2021 13
2022 19
2023 17
2024 20
2025 21
2026 7

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

182 results

Results by year

Filters applied: . Clear all
Page 1
ASH1L in Hepatoma Cells and Hepatic Stellate Cells Promotes Fibrosis-Associated Hepatocellular Carcinoma by Modulating Tumor-Associated Macrophages.
Du Y, Wu S, Xi S, Xu W, Sun L, Yan J, Gao H, Wang Y, Zheng J, Wang F, Yang H, Xie D, Chen X, Ou X, Guan XY, Li Y. Du Y, et al. Adv Sci (Weinh). 2024 Dec;11(45):e2404756. doi: 10.1002/advs.202404756. Epub 2024 Oct 8. Adv Sci (Weinh). 2024. PMID: 39377228 Free PMC article.
To determine the role of ASH1L in vivo, transgenic mice with conditional Ash1l depletion in the hepatocyte cell lineage (Ash1l(flox/flox)Alb(cre)) or HSCs (Ash1l(flox/flox)GFAP(creERT2)) are generated, and these mice are challenged in a diethylnitrosam …
To determine the role of ASH1L in vivo, transgenic mice with conditional Ash1l depletion in the hepatocyte cell lineage (As …
Expansion of the Genotypic and Phenotypic Spectrum of ASH1L-Related Syndromic Neurodevelopmental Disorder.
Cordova I, Blesson A, Savatt JM, Sveden A, Mahida S, Hazlett H, Rooney Riggs E, Chopra M; Brain Gene Registry Subset of the ClinGen Intellectual Disability and Autism Gene Curation Expert Panel. Cordova I, et al. Genes (Basel). 2024 Mar 28;15(4):423. doi: 10.3390/genes15040423. Genes (Basel). 2024. PMID: 38674358 Free PMC article. Review.
Pathogenic ASH1L variants have been reported in probands with broad phenotypic presentations, including intellectual disability, autism spectrum disorder, attention deficit hyperactivity disorder, seizures, congenital anomalies, and other skeletal, muscular, and sleep diff …
Pathogenic ASH1L variants have been reported in probands with broad phenotypic presentations, including intellectual disability, auti …
Role of Ash1l in Tourette syndrome and other neurodevelopmental disorders.
Zhang C, Xu L, Zheng X, Liu S, Che F. Zhang C, et al. Dev Neurobiol. 2021 Mar;81(2):79-91. doi: 10.1002/dneu.22795. Epub 2020 Dec 14. Dev Neurobiol. 2021. PMID: 33258273 Free PMC article.
Ash1l potentially contributes to neurodevelopmental diseases. Although specific Ash1l mutations are rare, they have led to informative studies in animal models that may bring therapeutic advances. ...With the progress in functional genomic analysis (highlighted in t …
Ash1l potentially contributes to neurodevelopmental diseases. Although specific Ash1l mutations are rare, they have led to inf …
Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche.
Meng C, Lin K, Shi W, Teng H, Wan X, DeBruine A, Wang Y, Liang X, Leo J, Chen F, Gu Q, Zhang J, Van V, Maldonado KL, Gan B, Ma L, Lu Y, Zhao D. Meng C, et al. Nat Commun. 2025 May 20;16(1):4681. doi: 10.1038/s41467-025-59381-2. Nat Commun. 2025. PMID: 40394007 Free PMC article.
Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis in men with prostate cancer. ...Pharmacologic inhibition of the ASH1L-HIF-1alpha-macrophages axis elicits robust anti-metastasis responses in preclinica …
Here, we report that histone methyltransferase ASH1L is genetically amplified and is required for bone metastasis in men with prostat …
Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation.
Vann KR, Sharma R, Hsu CC, Devoucoux M, Tencer AH, Zeng L, Lin K, Zhu L, Li Q, Lachance C, Ospina RR, Tong Q, Cheung KL, Yang S, Biswas S, Xuan H, Gatchalian J, Alamillo L, Wang J, Jang SM, Klein BJ, Lu Y, Ernst P, Strahl BD, Rothbart SB, Walsh MJ, Cleary ML, Côté J, Shi X, Zhou MM, Kutateladze TG. Vann KR, et al. Nat Commun. 2025 Mar 6;16(1):2235. doi: 10.1038/s41467-025-57556-5. Nat Commun. 2025. PMID: 40044670 Free PMC article.
We find that ASH1L(PHD) recognizes H3K4me2/3, whereas the neighboring ASH1L(BD) and ASH1L(BAH) have DNA binding activities. The DNA binding function of ASH1L(BAH) is a driving force for the association of ASH1L with the linker DNA in the nucleos …
We find that ASH1L(PHD) recognizes H3K4me2/3, whereas the neighboring ASH1L(BD) and ASH1L(BAH) have DNA binding activit …
The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis.
Zhao X, Lin S, Ren H, Sun S, Zheng L, Chen LF, Wang Z. Zhao X, et al. Cell Death Differ. 2024 May;31(5):605-617. doi: 10.1038/s41418-024-01274-w. Epub 2024 Mar 2. Cell Death Differ. 2024. PMID: 38431690 Free PMC article.
Absent, small, or homeotic1-like (ASH1L) is a histone lysine methyltransferase that generally functions as a transcriptional activator in controlling cell fate. So far, its physiological relevance in bone homeostasis and osteoclast differentiation remains elusive. Here, by …
Absent, small, or homeotic1-like (ASH1L) is a histone lysine methyltransferase that generally functions as a transcriptional activato …
ASH1L guards cis-regulatory elements against cyclobutane pyrimidine dimer induction.
Yancoskie MN, Khaleghi R, Gururajan A, Raghunathan A, Gupta A, Diethelm S, Maritz C, Sturla SJ, Krishnan M, Naegeli H. Yancoskie MN, et al. Nucleic Acids Res. 2024 Aug 12;52(14):8254-8270. doi: 10.1093/nar/gkae517. Nucleic Acids Res. 2024. PMID: 38884271 Free PMC article.
Therefore, we analyzed DNA damage maps in ASH1L-proficient and ASH1L-deficient cells to understand how ASH1L controls enhancer stability. ...The loss of this protection results in a higher frequency of C->T transitions at enhancers of skin cancers carrying …
Therefore, we analyzed DNA damage maps in ASH1L-proficient and ASH1L-deficient cells to understand how ASH1L controls e …
ASH1L contributes to oocyte apoptosis by regulating DNA damage.
Zhang T, Ren T, Lin H, Tong Y, Zhang J, Nie J, Zhu Y, Wang Y, Jin B, Zhang C, Chen T, He M. Zhang T, et al. Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C1264-C1273. doi: 10.1152/ajpcell.00196.2022. Epub 2022 Sep 12. Am J Physiol Cell Physiol. 2022. PMID: 36094439 Free PMC article.
Overexpression of Ash1l also led to a deficiency in DNA double-strand break repair associated with premature upregulation of p63 and phosphorylated checkpoint kinase 2 (p-CHK2), the major genome guardian of the female germline, following Ash1l overexpression in feta …
Overexpression of Ash1l also led to a deficiency in DNA double-strand break repair associated with premature upregulation of p63 and …
Ash1l loss-of-function results in structural birth defects and altered cortical development.
Toolan KP, McGrath BT, Brinkmeier ML, Camper SA, Bielas SL. Toolan KP, et al. Brain. 2025 Jan 7;148(1):55-68. doi: 10.1093/brain/awae218. Brain. 2025. PMID: 38943682 Free PMC article.
Our investigation evaluated the impact of Ash1l loss-of-function on survival and craniofacial skeletal development. Using a tamoxifen-inducible cre strain, we targeted Ash1l knockout early in cortical development [Emx1-Cre-ERT2; embryonic Day (e) 10.5]. ...This stud …
Our investigation evaluated the impact of Ash1l loss-of-function on survival and craniofacial skeletal development. Using a tamoxifen …
Ash1L ameliorates psoriasis via limiting neuronal activity-dependent release of miR-let-7b.
Du WJ, Yang H, Tong F, Liu S, Zhang C, Chen Y, Yan Y, Xiang YW, Hua LY, Gong Y, Xu ZX, Liu X, Jiang X, Lu M, Guan JS, Han Q. Du WJ, et al. Br J Pharmacol. 2024 Apr;181(7):1107-1127. doi: 10.1111/bph.16254. Epub 2023 Nov 30. Br J Pharmacol. 2024. PMID: 37766518 Free article.
Whole-cell patch clamp recordings were used to evaluate neuronal excitability after Ash1L haploinsufficiency in primary sensory neurons. KEY RESULTS: The haploinsufficiency of ASH1L, a histone methyltransferase, in primary sensory neurons causes both neurite hyperin …
Whole-cell patch clamp recordings were used to evaluate neuronal excitability after Ash1L haploinsufficiency in primary sensory neuro …
182 results