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Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPalpha, and PROX1 transduction.
Nakamori D, Takayama K, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, Mizuguchi H. Nakamori D, et al. Biochem Biophys Res Commun. 2016 Jan 15;469(3):424-9. doi: 10.1016/j.bbrc.2015.12.007. Epub 2015 Dec 9. Biochem Biophys Res Commun. 2016. PMID: 26679606 Free article.
Because the gene expression levels of the hepatic transcription factors (activating transcription factor 5 (ATF5), CCAAT/enhancer-binding protein alpha (c/EBPalpha), and prospero homeobox protein 1 (PROX1)) in adult liver were significantly higher than those …
Because the gene expression levels of the hepatic transcription factors (activating transcription factor 5 (ATF5), CCAAT/enhancer-bin …
High ATF5 expression is a favorable prognostic indicator in patients with hepatocellular carcinoma after hepatectomy.
Wu Y, Wu B, Chen R, Zheng Y, Huang Z. Wu Y, et al. Med Oncol. 2014 Nov;31(11):269. doi: 10.1007/s12032-014-0269-0. Epub 2014 Oct 8. Med Oncol. 2014. PMID: 25294425
Low ATF5 expression was correlated significantly with liver cirrhosis, intrahepatic metastasis, and TNM stage (P < 0.05). ...ATF5 may be useful as a novel prognostic indicator in hepatocellular carcinoma....

Low ATF5 expression was correlated significantly with liver cirrhosis, intrahepatic metastasis, and TNM stage (P < 0.05). .

…
Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest.
Gho JW, Ip WK, Chan KY, Law PT, Lai PB, Wong N. Gho JW, et al. Cancer Res. 2008 Aug 15;68(16):6743-51. doi: 10.1158/0008-5472.CAN-07-6469. Cancer Res. 2008. PMID: 18701499
Array-based mapping in HCC highlighted a high and consistent incidence of transcription factor ATF5 repressions on regional chr.19q13. By quantitative reverse transcription-PCR, profound down-regulations of ATF5 were further suggested in 78% of HCC tumors (60 of 77 …
Array-based mapping in HCC highlighted a high and consistent incidence of transcription factor ATF5 repressions on regional chr.19q13 …
Expression patterns of activating transcription factor 5 (atf5a and atf5b) in zebrafish.
Rodríguez-Morales R, Vélez-Negrón V, Torrado-Tapias A, Varshney G, Behra M. Rodríguez-Morales R, et al. Gene Expr Patterns. 2020 Sep;37:119126. doi: 10.1016/j.gep.2020.119126. Epub 2020 Jul 11. Gene Expr Patterns. 2020. PMID: 32663618 Free PMC article.
In whole animals, Atf5 function seems highly context dependent. Atf5 is strongly expressed in the rodent nose and mice knockout (KO) pups have defective olfactory sensory neurons (OSNs), smaller olfactory bulbs (OB), while adults are smell deficient. It was t …
In whole animals, Atf5 function seems highly context dependent. Atf5 is strongly expressed in the rodent nose and mice knockou …
3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibroblasts.
Lu Z, Priya Rajan SA, Song Q, Zhao Y, Wan M, Aleman J, Skardal A, Bishop C, Atala A, Lu B. Lu Z, et al. Biomaterials. 2021 Feb;269:120668. doi: 10.1016/j.biomaterials.2021.120668. Epub 2021 Jan 8. Biomaterials. 2021. PMID: 33461059
Here, we simplify preparation of reprogramming reagents by expressing six transcriptional factors (HNF4A, FOXA2, FOXA3, ATF5, PROX1, and HNF1) from two lentiviral vectors, each expressing three factors. Transducing human fetal and adult fibroblasts with low vector d …
Here, we simplify preparation of reprogramming reagents by expressing six transcriptional factors (HNF4A, FOXA2, FOXA3, ATF5, PROX1, …
Fasting induced up-regulation of activating transcription factor 5 in mouse liver.
Shimizu YI, Morita M, Ohmi A, Aoyagi S, Ebihara H, Tonaki D, Horino Y, Iijima M, Hirose H, Takahashi S, Takahashi Y. Shimizu YI, et al. Life Sci. 2009 Jun 19;84(25-26):894-902. doi: 10.1016/j.lfs.2009.04.002. Epub 2009 Apr 17. Life Sci. 2009. PMID: 19376136
However, its role in the liver response to in vivo food deprivation has not yet been investigated. MAIN METHODS: Adult mice were food-deprived for 48 h and the expression of two Atf5 mRNA subtypes (Atf5-R1 and Atf-R2) and gluconeogenic factors was inve …
However, its role in the liver response to in vivo food deprivation has not yet been investigated. MAIN METHODS: Adult mice we …
T-cell senescence contributes to abnormal glucose homeostasis in humans and mice.
Yi HS, Kim SY, Kim JT, Lee YS, Moon JS, Kim M, Kang YE, Joung KH, Lee JH, Kim HJ, Chun K, Shong M, Ku BJ. Yi HS, et al. Cell Death Dis. 2019 Mar 13;10(3):249. doi: 10.1038/s41419-019-1494-4. Cell Death Dis. 2019. PMID: 30867412 Free PMC article.
Moreover, murine senescent T cells were tested functionally in the liver of normal or mice with metabolic deterioration caused by diet-induced obesity. Human senescent (CD28(-)CD57(+)) CD8(+) T cells are increased in the development of diabetes and proinflammatory cytokine …
Moreover, murine senescent T cells were tested functionally in the liver of normal or mice with metabolic deterioration caused by die …