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Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.
Nakamori D, Takayama K, Nagamoto Y, Mitani S, Sakurai F, Tachibana M, Mizuguchi H. Nakamori D, et al. Biochem Biophys Res Commun. 2016 Jan 15;469(3):424-9. doi: 10.1016/j.bbrc.2015.12.007. Epub 2015 Dec 9. Biochem Biophys Res Commun. 2016. PMID: 26679606 Free article.
However, recent hepatic characterization of human iPS-HLCs showed that these cells resemble fetal hepatocytes rather than adult hepatocytes. ...Because the gene expression levels of the hepatic transcription factors (activating transcription factor 5 (ATF5), CCAAT/e …
However, recent hepatic characterization of human iPS-HLCs showed that these cells resemble fetal hepatocytes rather than adult hepat …
Fasting induced up-regulation of activating transcription factor 5 in mouse liver.
Shimizu YI, Morita M, Ohmi A, Aoyagi S, Ebihara H, Tonaki D, Horino Y, Iijima M, Hirose H, Takahashi S, Takahashi Y. Shimizu YI, et al. Life Sci. 2009 Jun 19;84(25-26):894-902. doi: 10.1016/j.lfs.2009.04.002. Epub 2009 Apr 17. Life Sci. 2009. PMID: 19376136
MAIN METHODS: Adult mice were food-deprived for 48 h and the expression of two Atf5 mRNA subtypes (Atf5-R1 and Atf-R2) and gluconeogenic factors was investigated. ...KEY FINDINGS: The Atf5-R1 transcript was found to be abundant in liver and othe …
MAIN METHODS: Adult mice were food-deprived for 48 h and the expression of two Atf5 mRNA subtypes (Atf5-R1 and Atf-R2) …
T-cell senescence contributes to abnormal glucose homeostasis in humans and mice.
Yi HS, Kim SY, Kim JT, Lee YS, Moon JS, Kim M, Kang YE, Joung KH, Lee JH, Kim HJ, Chun K, Shong M, Ku BJ. Yi HS, et al. Cell Death Dis. 2019 Mar 13;10(3):249. doi: 10.1038/s41419-019-1494-4. Cell Death Dis. 2019. PMID: 30867412 Free PMC article.
Moreover, murine senescent T cells were tested functionally in the liver of normal or mice with metabolic deterioration caused by diet-induced obesity. ...
Moreover, murine senescent T cells were tested functionally in the liver of normal or mice with metabolic deterioration caused by die …
High ATF5 expression is a favorable prognostic indicator in patients with hepatocellular carcinoma after hepatectomy.
Wu Y, Wu B, Chen R, Zheng Y, Huang Z. Wu Y, et al. Med Oncol. 2014 Nov;31(11):269. doi: 10.1007/s12032-014-0269-0. Epub 2014 Oct 8. Med Oncol. 2014. PMID: 25294425

Low ATF5 expression was correlated significantly with liver cirrhosis, intrahepatic metastasis, and TNM stage (P < 0.05). Additionally, both Kaplan-Meier survival curve and multivariate analyses showed a relationship between ATF5 and RFS. ...ATF5 ma

Low ATF5 expression was correlated significantly with liver cirrhosis, intrahepatic metastasis, and TNM stage (P < 0.05). A

Re-expression of transcription factor ATF5 in hepatocellular carcinoma induces G2-M arrest.
Gho JW, Ip WK, Chan KY, Law PT, Lai PB, Wong N. Gho JW, et al. Cancer Res. 2008 Aug 15;68(16):6743-51. doi: 10.1158/0008-5472.CAN-07-6469. Cancer Res. 2008. PMID: 18701499 Free article.
By quantitative reverse transcription-PCR, profound down-regulations of ATF5 were further suggested in 78% of HCC tumors (60 of 77 cases) compared to their adjacent nontumoral liver (P = 0.0004). ...An inverse relationship between ATF5 expressions with ID1 tr …
By quantitative reverse transcription-PCR, profound down-regulations of ATF5 were further suggested in 78% of HCC tumors (60 of 77 ca …
Expression patterns of activating transcription factor 5 (atf5a and atf5b) in zebrafish.
Rodríguez-Morales R, Vélez-Negrón V, Torrado-Tapias A, Varshney G, Behra M. Rodríguez-Morales R, et al. Gene Expr Patterns. 2020 Sep;37:119126. doi: 10.1016/j.gep.2020.119126. Epub 2020 Jul 11. Gene Expr Patterns. 2020. PMID: 32663618
In whole animals, Atf5 function seems highly context dependent. Atf5 is strongly expressed in the rodent nose and mice knockout (KO) pups have defective olfactory sensory neurons (OSNs), smaller olfactory bulbs (OB), while adults are smell deficient. It was t …
In whole animals, Atf5 function seems highly context dependent. Atf5 is strongly expressed in the rodent nose and mice knockou …
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