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Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.
Xiao W, Wang J, Wang X, Cai S, Guo Y, Ye L, Li D, Hu A, Jin S, Yuan B, Zhou Y, Li Q, Tong Q, Zheng L. Xiao W, et al. Autophagy. 2022 Nov;18(11):2615-2635. doi: 10.1080/15548627.2022.2044651. Epub 2022 Mar 6. Autophagy. 2022. PMID: 35253629 Free PMC article.
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a nov …
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expre …
HIF-1alpha-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.
Li Q, Ni Y, Zhang L, Jiang R, Xu J, Yang H, Hu Y, Qiu J, Pu L, Tang J, Wang X. Li Q, et al. Signal Transduct Target Ther. 2021 Feb 23;6(1):76. doi: 10.1038/s41392-020-00453-8. Signal Transduct Target Ther. 2021. PMID: 33619246 Free PMC article.
Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possible involvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma (HCC). ...The results of methylated RNA immunoprecipit …
Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possible involvement of m6A modification …
MGCG regulates glioblastoma tumorigenicity via hnRNPK/ATG2A and promotes autophagy.
Chu F, Wu P, Mu M, Hu S, Niu C. Chu F, et al. Cell Death Dis. 2023 Jul 17;14(7):443. doi: 10.1038/s41419-023-05959-x. Cell Death Dis. 2023. PMID: 37460467 Free PMC article.
Glioblastoma (GBM) is the most common malignant primary brain cancer in adults and has constantly been a focus of research. Long noncoding RNAs (lncRNAs) play important roles in the development of cancers. ...The results of bioinformatic analysis showed that MGCG wa …
Glioblastoma (GBM) is the most common malignant primary brain cancer in adults and has constantly been a focus of research. Long nonc …
Highly Efficient Delivery of Novel MiR-13896 by Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Inhibits Gastric Cancer Progression by Targeting ATG2A-Mediated Autophagy.
Wu P, Wang M, Jin C, Li L, Tang Y, Wang Z, Wang X, Xu W, Qian H. Wu P, et al. Biomater Res. 2024 Dec 18;28:0119. doi: 10.34133/bmr.0119. eCollection 2024. Biomater Res. 2024. PMID: 39697182 Free PMC article.
Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. ...Mechanistic studies revealed that miR-13896 targets and down-regulates the ATG2A-mediated autophagy pathway, suppressing GC cell gr …
Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. . …
Exploring the ATG9A interactome uncovers interaction with VPS13A.
van Vliet AR, Jefferies HBJ, Faull PA, Chadwick J, Ibrahim F, Skehel MJ, Tooze SA. van Vliet AR, et al. J Cell Sci. 2024 Feb 15;137(4):jcs261081. doi: 10.1242/jcs.261081. Epub 2024 Feb 22. J Cell Sci. 2024. PMID: 38294121 Free PMC article.
ATG9A was recently shown to act as a lipid scramblase, and this function is thought to require its interaction with another core autophagy protein, ATG2A, which acts as a lipid transfer protein. Together, ATG9A and ATG2A are proposed to function to expand the growin …
ATG9A was recently shown to act as a lipid scramblase, and this function is thought to require its interaction with another core autophagy p …
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation.
van Vliet AR, Chiduza GN, Maslen SL, Pye VE, Joshi D, De Tito S, Jefferies HBJ, Christodoulou E, Roustan C, Punch E, Hervás JH, O'Reilly N, Skehel JM, Cherepanov P, Tooze SA. van Vliet AR, et al. Mol Cell. 2022 Nov 17;82(22):4324-4339.e8. doi: 10.1016/j.molcel.2022.10.017. Epub 2022 Nov 7. Mol Cell. 2022. PMID: 36347259 Free article.
ATG9A and ATG2A are essential core members of the autophagy machinery. ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer, whereas ATG2A facilitates lipid flow between tethered membranes. ...Using this integrative structure mod …
ATG9A and ATG2A are essential core members of the autophagy machinery. ATG9A is a lipid scramblase that allows equilibration of lipid …
A conserved ATG2-GABARAP family interaction is critical for phagophore formation.
Bozic M, van den Bekerom L, Milne BA, Goodman N, Roberston L, Prescott AR, Macartney TJ, Dawe N, McEwan DG. Bozic M, et al. EMBO Rep. 2020 Mar 4;21(3):e48412. doi: 10.15252/embr.201948412. Epub 2020 Feb 3. EMBO Rep. 2020. PMID: 32009292 Free PMC article.
We have identified a highly conserved motif driving the interaction between human ATG2 and GABARAP proteins that is in close proximity to the ATG2-WIPI4 interaction site. We show that the ATG2A-GABARAP interaction mutants are unable to form and close phagophores resulting …
We have identified a highly conserved motif driving the interaction between human ATG2 and GABARAP proteins that is in close proximity to th …
Genomic Signature of Mismatch Repair Deficiency in Areca Nut-Related Oral Cancer.
Yang WF, Qin N, Song X, Jiang C, Li T, Ji P, Li Y, Ding D, Wang C, Dai J, Jin G, Chen TW, Chang YS, Ouyang DQ, Liao GQ, Hu Z, Chang KP, Su YX, Ma H. Yang WF, et al. J Dent Res. 2020 Oct;99(11):1252-1261. doi: 10.1177/0022034520930641. Epub 2020 Jun 11. J Dent Res. 2020. PMID: 32527169
Here, we comprehensively describe the genomic and transcriptome alterations of 113 Chinese OSCC patients (89 AN related and 24 AN negative) by whole-exome sequencing and RNA sequencing, and we compared the genomic differences between AN-related and AN-negative samples by integrat …
Here, we comprehensively describe the genomic and transcriptome alterations of 113 Chinese OSCC patients (89 AN related and 24 AN negative) …
YF343, A Novel Histone Deacetylase Inhibitor, Combined with CQ to Inhibit- Autophagy, Contributes to Increased Apoptosis in Triple- Negative Breast Cancer.
Liu N, Luo T, Zhang J, Han LN, Duan WQ, Lu WX, Qiu H, Lin Y, Wu YM, Zhang H, Yang FF, Ge D. Liu N, et al. Curr Med Chem. 2023;30(40):4605-4621. doi: 10.2174/0929867330666230120152815. Curr Med Chem. 2023. PMID: 36683315
E2F7, a transcription factor, promoted the expression of ATG2A via binding to the ATG2A promoter region and then induced autophagy in triple-negative breast cancer cells treated with YF-343. CONCLUSION: Our studies have illustrated the mechanisms for potentia …
E2F7, a transcription factor, promoted the expression of ATG2A via binding to the ATG2A promoter region and then induced autop …
The expression characteristics and prognostic roles of autophagy-related genes in gastric cancer.
Wang M, Jing J, Li H, Liu J, Yuan Y, Sun L. Wang M, et al. PeerJ. 2021 Feb 3;9:e10814. doi: 10.7717/peerj.10814. eCollection 2021. PeerJ. 2021. PMID: 33604190 Free PMC article.
The aim of the study was to identify the role of autophagy-related (ATG) genes in the occurrence and development of gastric cancer (GC). METHODS: Data from Oncomine dataset was used for the differential expression analysis between cancer and normal tissues. ...ATG9A …
The aim of the study was to identify the role of autophagy-related (ATG) genes in the occurrence and development of gastric cancer (G …
19 results