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ATP6V0B promotes the tumorigenesis of bladder cancer by activating PAQR4/PI3K/AKT signaling.
Wang X, Qu Y, Sun Y, Yang T, Wang W, Dou X, Jia Y. Wang X, et al. BMC Cancer. 2025 Apr 28;25(1):789. doi: 10.1186/s12885-025-14183-z. BMC Cancer. 2025. PMID: 40295930 Free PMC article.
However, information on its role and mechanism of action in bladder cancer (BCa) and other tumors is not clear. METHODS: In this study, we evaluated the expression of ATP6V0B in BCa and its correlation with patient survival outcomes by performing public database ana …
However, information on its role and mechanism of action in bladder cancer (BCa) and other tumors is not clear. METHODS: In this stud …
Understanding the heterogeneity in liver hepatocellular carcinoma with a special focus on malignant cell through single-cell analysis.
Bao M, Wu A. Bao M, et al. Discov Oncol. 2024 Jun 24;15(1):241. doi: 10.1007/s12672-024-01115-9. Discov Oncol. 2024. PMID: 38913193 Free PMC article.
INTRODUCTION: Hepatocellular carcinoma (HCC) is the most common form of liver cancer globally and remains a major cause of cancer-related deaths. HCC exhibits significant intra-tumoral and interpatient heterogeneity, impacting treatment efficacy and patient prognosi …
INTRODUCTION: Hepatocellular carcinoma (HCC) is the most common form of liver cancer globally and remains a major cause of cancer …
Dihydroartemisinin inhibits ATP6 activity, reduces energy metabolism of hepatocellular carcinoma cells, promotes apoptosis and inhibits metastasis via CANX.
Chang J, Yang Q, Liu X, Li W, Gao L. Chang J, et al. Oncol Lett. 2024 Aug 2;28(4):474. doi: 10.3892/ol.2024.14607. eCollection 2024 Oct. Oncol Lett. 2024. PMID: 39161338 Free PMC article.
Western blotting was used to assess changes in CANX, ATP6V1 domain (ATP6V1F) and V0 domain (ATP6V0B) protein expression levels. The results demonstrated that CANX is highly expressed in liver cancer tissues. ...However, these effects were inhibited by DHA, which dec …
Western blotting was used to assess changes in CANX, ATP6V1 domain (ATP6V1F) and V0 domain (ATP6V0B) protein expression levels. The r …
V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy.
Meo-Evoli N, Almacellas E, Massucci FA, Gentilella A, Ambrosio S, Kozma SC, Thomas G, Tauler A. Meo-Evoli N, et al. Oncotarget. 2015 Sep 29;6(29):28057-70. doi: 10.18632/oncotarget.4812. Oncotarget. 2015. PMID: 26356814 Free PMC article.
Analysis of v-ATPase subunit expression identified B subunit of V0 complex, ATP6V0B, as a transcriptional target of E2F1. Importantly, ATP6V0B ectopic-expression increased v-ATPase and mTORC1 activity, consistent with ATP6V0B being responsible for mediating t …
Analysis of v-ATPase subunit expression identified B subunit of V0 complex, ATP6V0B, as a transcriptional target of E2F1. Importantly …
Genetic modifiers of neurofibromatosis type 1-associated café-au-lait macule count identified using multi-platform analysis.
Pemov A, Sung H, Hyland PL, Sloan JL, Ruppert SL, Baldwin AM, Boland JF, Bass SE, Lee HJ, Jones KM, Zhang X; NISC Comparative Sequencing Program; Mullikin JC, Widemann BC, Wilson AF, Stewart DR. Pemov A, et al. PLoS Genet. 2014 Oct 16;10(10):e1004575. doi: 10.1371/journal.pgen.1004575. eCollection 2014 Oct. PLoS Genet. 2014. PMID: 25329635 Free PMC article.
Two correlated, common SNPs (rs4660761 and rs7161) between DPH2 and ATP6V0B were significantly associated with the CALM count. Analysis with tiled regression also identified SNP rs4660761 as significantly associated with CALM count. ...SNP rs4660761 is predicted to regulat …
Two correlated, common SNPs (rs4660761 and rs7161) between DPH2 and ATP6V0B were significantly associated with the CALM count. Analys …
Analysis of whole genomic expression profiles of Helicobacter pylori related chronic atrophic gastritis with IL-1B-31CC/-511TT genotypes.
Wang SY, Shen XY, Wu CY, Pan F, Shen YY, Sheng HH, Chen XM, Gao HJ. Wang SY, et al. J Dig Dis. 2009 May;10(2):99-106. doi: 10.1111/j.1751-2980.2009.00367.x. J Dig Dis. 2009. PMID: 19426391
OBJECTIVE: Many studies have linked cytokine interleukin-1B gene polymorphisms to H. pylori-related gastric cancer development. The current study evaluated the characterization of whole genomic expression profiles of the premalignant condition: H. pylori-related chronic at …
OBJECTIVE: Many studies have linked cytokine interleukin-1B gene polymorphisms to H. pylori-related gastric cancer development. The c …
A cellular senescence-related classifier based on a tumorigenesis- and immune infiltration-guided strategy can predict prognosis, immunotherapy response, and candidate drugs in hepatocellular carcinoma.
Luo Y, Liu H, Fu H, Ding GS, Teng F. Luo Y, et al. Front Immunol. 2022 Nov 15;13:974377. doi: 10.3389/fimmu.2022.974377. eCollection 2022. Front Immunol. 2022. PMID: 36458010 Free PMC article.
RESULTS: A five-gene TIS, composed of NET1, ATP6V0B, MMP1, GTDC1, and CPEB3, was constructed and validated using TCGA and ICGC datasets, respectively, and showed a highly robust and plausible signature for overall survival (OS) prediction of HCC in both training and valida …
RESULTS: A five-gene TIS, composed of NET1, ATP6V0B, MMP1, GTDC1, and CPEB3, was constructed and validated using TCGA and ICGC datase …
A Novel Oxidative Phosphorylation-Associated Gene Signature for Prognosis Prediction in Patients with Hepatocellular Carcinoma.
Chen W, Yang Z, Chen Y. Chen W, et al. Dis Markers. 2022 Sep 5;2022:3594901. doi: 10.1155/2022/3594901. eCollection 2022. Dis Markers. 2022. PMID: 36105252 Free PMC article.
This research was dedicated to identifying an OXPHOS-associated signature for the assessment of prognosis of HCC patients. A total of 371 HCC patients from the Cancer Genome Atlas (TCGA) and 231 HCC patients from the International Cancer Genome Consortium (ICGC) wit …
This research was dedicated to identifying an OXPHOS-associated signature for the assessment of prognosis of HCC patients. A total of 371 HC …
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Oliveira ÉA, Lima DS, Cardozo LE, Souza GF, de Souza N, Alves-Fernandes DK, Faião-Flores F, Quincoces JAP, Barros SBM, Nakaya HI, Monteiro G, Maria-Engler SS. Oliveira ÉA, et al. Pharmacol Res. 2017 Nov;125(Pt B):178-187. doi: 10.1016/j.phrs.2017.08.018. Epub 2017 Sep 4. Pharmacol Res. 2017. PMID: 28882690
Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven by activating mutations in BRAF that has led to the development of potent anti-BRAF inhibitors. ...Further analysis identified 7 target gen …
Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven …
Identification of biological targets of therapeutic intervention for clear cell renal cell carcinoma based on bioinformatics approach.
Chen Y, Teng L, Liu W, Cao Y, Ding D, Wang W, Chen H, Li C, An R. Chen Y, et al. Cancer Cell Int. 2016 Mar 3;16:16. doi: 10.1186/s12935-016-0291-8. eCollection 2016. Cancer Cell Int. 2016. PMID: 26941587 Free PMC article.
Thereinto, miRNA-15a that could regulate ATPase, H(+) transporting, lysosomal 21 kDa, V0 subunit b (ATP6V0B) and miRNA-155 were found to be the most significant. CONCLUSIONS: miRNA-200c that could regulate COL5A2 and COL5A3, miRNA-15a that could regulate ATP6V0B and …
Thereinto, miRNA-15a that could regulate ATPase, H(+) transporting, lysosomal 21 kDa, V0 subunit b (ATP6V0B) and miRNA-155 were found …
11 results