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2,030 results

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Page 1
ATRX, a guardian of chromatin.
Aguilera P, López-Contreras AJ. Aguilera P, et al. Trends Genet. 2023 Jun;39(6):505-519. doi: 10.1016/j.tig.2023.02.009. Epub 2023 Mar 7. Trends Genet. 2023. PMID: 36894374 Free article. Review.
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, especially in glioma, and recent findings indicate roles for ATRX in key molecular pathways, such as the regulation of chromatin state …
ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated tumor suppressor genes in human cancers, e …
ATRX and DAXX: Mechanisms and Mutations.
Dyer MA, Qadeer ZA, Valle-Garcia D, Bernstein E. Dyer MA, et al. Cold Spring Harb Perspect Med. 2017 Mar 1;7(3):a026567. doi: 10.1101/cshperspect.a026567. Cold Spring Harb Perspect Med. 2017. PMID: 28062559 Free PMC article. Review.
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAXX-mutant tumors. Interestingly, ATRX and DAXX mutations are often found in pediatric tumors, suggesting a particular developmental co …
These regions include retrotransposons, pericentric heterochromatin, and telomeres, the latter of which show deregulation in ATRX/DAX …
Loss of ATRX suppresses anti-tumor immunity.
Diaz AA. Diaz AA. Neuro Oncol. 2022 Jun 1;24(6):901-902. doi: 10.1093/neuonc/noac059. Neuro Oncol. 2022. PMID: 35235678 Free PMC article. No abstract available.
Mutant ATRX: uncovering a new therapeutic target for glioma.
Haase S, Garcia-Fabiani MB, Carney S, Altshuler D, Núñez FJ, Méndez FM, Núñez F, Lowenstein PR, Castro MG. Haase S, et al. Expert Opin Ther Targets. 2018 Jul;22(7):599-613. doi: 10.1080/14728222.2018.1487953. Epub 2018 Jun 20. Expert Opin Ther Targets. 2018. PMID: 29889582 Free PMC article. Review.
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discuss the main molecular characteristics of ATRX, from its various functions in normal development to the effects of its loss in ATRX …
ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ...Areas covered: We discus …
ATRX and sex differentiation.
Tang P, Park DJ, Marshall Graves JA, Harley VR. Tang P, et al. Trends Endocrinol Metab. 2004 Sep;15(7):339-44. doi: 10.1016/j.tem.2004.07.006. Trends Endocrinol Metab. 2004. PMID: 15350606 Review.
Although the biochemical role of ATRX remains unknown, recent and emerging evidence implicates ATRX in chromatin remodeling. We review what is known about ATRX as a chromatin remodeling protein, and its role in mammalian sex differentiation....
Although the biochemical role of ATRX remains unknown, recent and emerging evidence implicates ATRX in chromatin remodeling. W …
ATRX: From Chromatin Remodeling to Disease.
Magaña-Acosta M, Valadez-Graham V. Magaña-Acosta M, et al. Genesis. 2025 Dec;63(6):e70031. doi: 10.1002/dvg.70031. Genesis. 2025. PMID: 41222108 Free PMC article. Review.
We further discuss and integrate current findings on pathologies associated with ATRX dysfunction such as ATR-X syndrome, focusing on its etiology, clinical features, and potential diagnostic tools. Finally, we propose that ATRX may contribute t …
We further discuss and integrate current findings on pathologies associated with ATRX dysfunction such as ATR-X synd …
Correlation between IDH, ATRX, and TERT promoter mutations in glioma.
Ohba S, Kuwahara K, Yamada S, Abe M, Hirose Y. Ohba S, et al. Brain Tumor Pathol. 2020 Apr;37(2):33-40. doi: 10.1007/s10014-020-00360-4. Epub 2020 Mar 29. Brain Tumor Pathol. 2020. PMID: 32227259 Review.
This study analyzed IDH, ATRX, and TERT promoter mutations, and the correlation between them. Immortalized cells overcome the telomere-related crisis by activating telomerase or ALT. In glioma, telomerase is mainly activated by TERT promoter mutation, while ALT is usually …
This study analyzed IDH, ATRX, and TERT promoter mutations, and the correlation between them. Immortalized cells overcome the telomer …
ATRX: the case of a peculiar chromatin remodeler.
Ratnakumar K, Bernstein E. Ratnakumar K, et al. Epigenetics. 2013 Jan;8(1):3-9. doi: 10.4161/epi.23271. Epub 2012 Dec 18. Epigenetics. 2013. PMID: 23249563 Free PMC article. Review.
The SWI/SNF-like chromatin remodeler ATRX has recently garnered renewed attention. ATRX mutations were first identified in patients bearing the syndrome after which it is named, alpha thalassemia/mental retardation, X-linked. While ATRX has long been implicat …
The SWI/SNF-like chromatin remodeler ATRX has recently garnered renewed attention. ATRX mutations were first identified in pat …
Prognostic Significance of Altered ATRX/DAXX Gene in Pancreatic Neuroendocrine Tumors: A Meta-Analysis.
Wang F, Xu X, Ye Z, Qin Y, Yu X, Ji S. Wang F, et al. Front Endocrinol (Lausanne). 2021 Jun 18;12:691557. doi: 10.3389/fendo.2021.691557. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34220718 Free PMC article.
Whole-exome sequencing recently has shown very frequent somatic mutations in the alpha-thalassemia/mental retardation X-linked (ATRX) and death domain-associated protein (DAXX) genes in PanNETs. And the prognostic significance of altered ATRX/DAXX genes in PanNETs p …
Whole-exome sequencing recently has shown very frequent somatic mutations in the alpha-thalassemia/mental retardation X-linked (ATRX) …
Clinical Relevance of ATRX/DAXX Gene Mutations and ALT in Functioning Pancreatic Neuroendocrine Tumors.
van T Veld BR, Hackeng WM, Luchini C, Brosens LAA, Dreijerink KMA. van T Veld BR, et al. Endocr Pathol. 2025 Feb 15;36(1):3. doi: 10.1007/s12022-025-09848-1. Endocr Pathol. 2025. PMID: 39954168 Free PMC article. Review.
ATRX/DAXX gene mutations and/or ALT have been reported in insulinoma, glucagonoma, gastrinoma, VIPoma and calcitoninoma. ...Although ATRX/DAXX mutation and ALT assessment may currently not be the standard of care in routine diagnostic pathology practice, the use of …
ATRX/DAXX gene mutations and/or ALT have been reported in insulinoma, glucagonoma, gastrinoma, VIPoma and calcitoninoma. ...Although …
2,030 results